Association Between 5-HTTLPR Polymorphism and the Risk of Autism: A Meta-Analysis Based on Case-Control Studies.


:Background: Recently, many case-control studies have reported the association between 5-HTTLPR polymorphism and autism risk. However, the results are inconclusive and conflicting. To investigate the genetic association of 5-HTTLPR polymorphism and autism risk, we conducted a comprehensive meta-analysis based on previous case-control studies. Methods: Literature search was performed through PubMed, Embase, Web of Knowledge and CNKI databases until June 27, 2018. The strength of the association was assessed by relative risk (RR) and its corresponding 95% confidence interval (CI). Fixed or random effect model was selected based on the results of heterogeneity test. Further, subgroup analyses were conducted to explore the association of 5-HTTLPR polymorphism and autism risk in different population. Results: Eleven studies with 930 cases and 1234 controls were identified. Although there was a significant association between 5-HTTLPR polymorphism and autism risk under the dominant model after removing the studies causing heterogeneity, the significance did not exist after Bonferroni's correction. Subgroup analyses also showed similar results after Bonferroni's correction. In addition, there was no obvious publication bias in our meta-analysis. Conclusions: Our present meta-analysis does not support a direct effect of 5-HTTLPR polymorphism on autism risk according to present results. Further analyses of the effect of genetic networks and more well designed studies with larger sample size are required.


Front Psychiatry


Frontiers in psychiatry


Wang H,Yin F,Gao J,Fan X




Has Abstract


2019-02-13 00:00:00








  • Unmet Needs in Children With Attention Deficit Hyperactivity Disorder-Can Transcranial Direct Current Stimulation Fill the Gap? Promises and Ethical Challenges.

    abstract::Attention deficit hyperactivity disorder (ADHD) is a disorder most frequently diagnosed in children and adolescents. Although ADHD can be effectively treated with psychostimulants, a significant proportion of patients discontinue treatment because of adverse events or insufficient improvement of symptoms. In addition,...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Sierawska A,Prehn-Kristensen A,Moliadze V,Krauel K,Nowak R,Freitag CM,Siniatchkin M,Buyx A

    更新日期:2019-05-16 00:00:00

  • Atherogenic Lipid Ratios Related to Myeloperoxidase and C-Reactive Protein Levels in Psychotic Disorders.

    abstract:Background:Cardiovascular disease (CVD) is a major cause of premature death in patients with psychotic disorders, where dyslipidemia occurs frequently. In the pathogenesis of these serious mental disorders, a low-grade inflammation seems to be a possible contributor. Concurrently, systemic inflammation and its interpla...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Reponen EJ,Dieset I,Tesli M,Mørch RH,Aas M,Vedal TSJ,Haug E,Drange OK,Steen NE,Hope S,Szabo A,Gohar SM,Wedervang-Resell K,Djurovic S,Melle I,Aukrust P,Andreassen OA,Ueland T

    更新日期:2020-07-10 00:00:00

  • Effects of COVID-19 Epidemic Lockdown on Postpartum Depressive Symptoms in a Sample of Italian Mothers.

    abstract::The extraordinary health emergency of the COVID-19 pandemic represents a new challenge for mental health researchers and clinical practitioners. The related containment measures may be a risk factor for psychological distress and mood disorders, especially in at-risk populations. This study aims to explore the impact ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Spinola O,Liotti M,Speranza AM,Tambelli R

    更新日期:2020-11-17 00:00:00

  • Gene × Environment interactions in autism spectrum disorders: role of epigenetic mechanisms.

    abstract::Several studies support currently the hypothesis that autism etiology is based on a polygenic and epistatic model. However, despite advances in epidemiological, molecular and clinical genetics, the genetic risk factors remain difficult to identify, with the exception of a few chromosomal disorders and several single g...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Tordjman S,Somogyi E,Coulon N,Kermarrec S,Cohen D,Bronsard G,Bonnot O,Weismann-Arcache C,Botbol M,Lauth B,Ginchat V,Roubertoux P,Barburoth M,Kovess V,Geoffray MM,Xavier J

    更新日期:2014-08-04 00:00:00

  • Abnormal Connectional Fingerprint in Schizophrenia: A Novel Network Analysis of Diffusion Tensor Imaging Data.

    abstract::The graph theoretical analysis of structural magnetic resonance imaging (MRI) data has received a great deal of interest in recent years to characterize the organizational principles of brain networks and their alterations in psychiatric disorders, such as schizophrenia. However, the characterization of networks in cl...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Edwin Thanarajah S,Han CE,Rotarska-Jagiela A,Singer W,Deichmann R,Maurer K,Kaiser M,Uhlhaas PJ

    更新日期:2016-06-30 00:00:00

  • Comparison of Psychological Stress Levels and Associated Factors Among Healthcare Workers, Frontline Workers, and the General Public During the Novel Coronavirus Pandemic.

    abstract::Objective: We aimed to conduct a comparative analysis of the psychological stress experienced by healthcare workers, frontline workers, and the general public and to assess the factors associated with psychological stress in each of these groups. Methods: We conducted an online survey targeting healthcare workers, fro...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Luan R,Pu W,Dai L,Yang R,Wang P

    更新日期:2020-12-01 00:00:00

  • Repeated Exposure to the "Spice" Cannabinoid JWH-018 Induces Tolerance and Enhances Responsiveness to 5-HT1A Receptor Stimulation in Male Rats.

    abstract::Naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) is a synthetic compound found in psychoactive "spice" products that activates cannabinoid receptors. Preclinical evidence suggests that exposure to synthetic cannabinoids increases 5-HT2A/2C receptor function in the brain, an effect which might contribute to psyc...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Elmore JS,Baumann MH

    更新日期:2018-02-27 00:00:00

  • Fragile X-Associated Neuropsychiatric Disorders (FXAND).

    abstract::Fragile X syndrome (FXS) is caused by the full mutation (>200 CGG repeats) in the Fragile X Mental Retardation 1 (FMR1) gene. It is the most common inherited cause of intellectual disability (ID) and autism. This review focuses on neuropsychiatric disorders frequently experienced by premutation carriers with 55 to 200...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Hagerman RJ,Protic D,Rajaratnam A,Salcedo-Arellano MJ,Aydin EY,Schneider A

    更新日期:2018-11-13 00:00:00

  • Posttraumatic Stress Disorder and Related Disorders among Female Yazidi Refugees following Islamic State of Iraq and Syria Attacks-A Case Series and Mini-Review.

    abstract::Following the severe attacks by the so-called "Islamic State of Iraq and Syria" on the Yazidi population, which started in summer 2014, the state government of Baden-Württemberg, Germany, funded a Special-Quota Project to bring 1,000 very ill or left-behind women and children who were being held hostage to 22 cities a...

    journal_title:Frontiers in psychiatry



    authors: Gerdau I,Kizilhan JI,Noll-Hussong M

    更新日期:2017-12-13 00:00:00

  • Longer Cortical Silent Period Length Is Associated to Binge Eating Disorder: An Exploratory Study.

    abstract::Introduction: Although binge eating disorder (BED) is an eating disorder and obesity is a clinical disease, it is known that both conditions present overlapped symptoms related to, at least partially, the disruption of homeostatic and hedonistic eating behavior pathways. Therefore, the understanding of neural substrat...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Antunes LC,Elkfury JL,Parizotti CS,Brietzke AP,Bandeira JS,Torres ILDS,Fregni F,Caumo W

    更新日期:2020-10-14 00:00:00

  • Gastric Necrosis After Binge Eating in Bulimia: Recovery From Eating Disorder After Total Gastrectomy.

    abstract:Background:Gastric necrosis following acute gastric dilatation is rare but more common in females with eating disorders, such as anorexia nervosa or bulimia, during which patients often alternate restriction and binge eating behaviors. Case Presentation:A 37-year old female patient with a history of 15 years of bulimi...

    journal_title:Frontiers in psychiatry



    authors: Achamrah N,Grigioni S,Coëffier M,Ainseba N,Déchelotte P

    更新日期:2020-07-31 00:00:00

  • The Modified Yale Food Addiction Scale 2.0: Validation Among Non-Clinical and Clinical French-Speaking Samples and Comparison With the Full Yale Food Addiction Scale 2.0.

    abstract:Objectives:The modified Yale Food Addiction Scale 2.0 (mYFAS 2.0) was designed to assess food addiction using a shorter version than the YFAS 2.0. We lack data about the psychometric properties of the mYFAS 2.0 in patients with obesity, as well as studies comparing the psychometric properties of the mYFAS 2.0 versus th...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Brunault P,Berthoz S,Gearhardt AN,Gierski F,Kaladjian A,Bertin E,Tchernof A,Biertho L,de Luca A,Hankard R,Courtois R,Ballon N,Benzerouk F,Bégin C

    更新日期:2020-09-08 00:00:00

  • Frequency-Specific Regional Homogeneity Alterations in Tourette Syndrome.

    abstract::Tourette syndrome (TS) is a developmental neuropsychiatric disorder with onset during childhood. Because of its complex spectrum of phenotypes, the underlying pathophysiology of TS is still unclear. Resting-state functional magnetic resonance imaging demonstrated aberrant spontaneous neural synchronization in conventi...

    journal_title:Frontiers in psychiatry

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    authors: Lou YT,Li XL,Wang Y,Ji GJ,Zang YF,Wang J,Feng JH

    更新日期:2020-12-17 00:00:00

  • Measuring Psychological Change and Predicting Recidivism Following the Swedish One-to-One Program.

    abstract::The One-to-One program aims to reduce criminal recidivism among prisoners shortly awaiting release, and among probationers. Of 1,484 program participants in Sweden, 776 contained adequate data for analysis. Pre- and post-program scores were available for the Alternative Thinking Test, Levenson's Locus of Control Scale...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Berman AH,Gajecki M,Morien P,Priestley P

    更新日期:2019-11-29 00:00:00

  • Rejection Sensitivity Mediates the Relationship Between Social-Interpersonal Stressors and Depressive Symptoms in Military Context.

    abstract:Background:Depression is pervasive in the military context and is likely to elicit lasting negative effects on health. Based on interpersonal models, social-interpersonal stressors are significantly associated with the development and maintenance of depression. However, little is known about the mechanisms by which the...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Wang J,Cheng X,Xu K,Xu H,Wang H,Feng Z

    更新日期:2020-06-18 00:00:00

  • Reduction of Involuntary Admissions in Patients With Severe Psychotic Disorders Treated in the ACCESS Integrated Care Model Including Therapeutic Assertive Community Treatment.

    abstract::Objective: The ACCESS treatment model offers assertive community treatment (ACT) embedded in an integrated care program to patients with severe psychotic disorders. Compared to standard care, it proved to be more effective in terms of service disengagement and other outcomes in patients with psychotic disorders over 1...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Schöttle D,Ruppelt F,Schimmelmann BG,Karow A,Bussopulos A,Gallinat J,Wiedemann K,Luedecke D,Rohenkohl AC,Huber CG,Bock T,Lambert M

    更新日期:2019-10-24 00:00:00

  • Eyeblink Conditioning in Schizophrenia: A Critical Review.

    abstract::There is accruing evidence of cerebellar abnormalities in schizophrenia. The theory of cognitive dysmetria considers cerebellar dysfunction a key component of schizophrenia. Delay eyeblink conditioning (EBC), a cerebellar-dependent translational probe, is a behavioral index of cerebellar integrity. The circuitry under...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Kent JS,Bolbecker AR,O'Donnell BF,Hetrick WP

    更新日期:2015-12-18 00:00:00

  • Housing Orientations and Needs of Above-Average Length of Stay Hospitalized Psychiatric Patients.

    abstract::A small number of severely and persistently mentally ill in-patients awaiting residential or long-stay facilities represent an obstacle to the efficient utilization of acute care beds. These facilities are costly and currently reputed to be contrary to recovery principles. In 2013, all acute psychiatric care wards in ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Rapisarda F,Felx A,Gagnon S,De Benedictis L,Luyet A,Boutin M,Corbière M,Lesage A

    更新日期:2020-04-07 00:00:00

  • Association of frontal gray matter volume and cerebral perfusion in heroin addiction: a multimodal neuroimaging study.

    abstract::Structure and function are closely related in the healthy human brain. In patients with chronic heroin exposure, brain imaging studies have identified long-lasting changes in gray matter (GM) volume. More recently, we showed that acute application of heroin in dependent patients results in hypoperfusion of fronto-temp...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Denier N,Schmidt A,Gerber H,Schmid O,Riecher-Rössler A,Wiesbeck GA,Huber CG,Lang UE,Radue EW,Walter M,Borgwardt S

    更新日期:2013-10-21 00:00:00

  • Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode Schizophrenia.

    abstract::Background: The human striatum is a heterogeneous structure involved in diverse functional domains that related to distinct striatum subregions. Striatal dysfunction was thought to be a fundamental element in schizophrenia. However, the connectivity pattern of striatum solely based on functional or structural characte...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Zhang B,Lin P,Wang X,Öngür D,Ji X,Situ W,Yao S,Wang X

    更新日期:2019-10-18 00:00:00

  • Craving Responses to Methamphetamine and Sexual Visual Cues in Individuals With Methamphetamine Use Disorder After Long-Term Drug Rehabilitation.

    abstract::Studies utilizing functional magnetic resonance imaging (fMRI) cue-reactivity paradigms have demonstrated that short-term abstinent or current methamphetamine (MA) users have increased brain activity in the ventral striatum, caudate nucleus and medial frontal cortex, when exposed to MA-related visual cues. However, pa...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Huang S,Zhang Z,Dai Y,Zhang C,Yang C,Fan L,Liu J,Hao W,Chen H

    更新日期:2018-04-19 00:00:00

  • Prevalence and Socio-Demographic Correlates of Poor Mental Health Among Older Adults in Agricultural Areas of China.

    abstract::Objective: Poor mental health is associated with impaired social functioning, lower quality of life, and increased risk of suicide and mortality. This study examined the prevalence of poor general mental health among older adults (aged 65 years and above) and its sociodemographic correlates in Hebei province, which is...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Jin Y,Zhang YS,Zhang Q,Rao WW,Zhang LL,Cui LJ,Li JF,Li L,Ungvari GS,Jackson T,Li KQ,Xiang YT

    更新日期:2020-11-05 00:00:00

  • Efficacy and Acceptability of Interventions for Attenuated Positive Psychotic Symptoms in Individuals at Clinical High Risk of Psychosis: A Network Meta-Analysis.

    abstract::Background: Attenuated positive psychotic symptoms represent the defining features of the clinical high-risk for psychosis (CHR-P) criteria. The effectiveness of each available treatment for reducing attenuated positive psychotic symptoms remains undetermined. This network meta-analysis (NMA) investigates the consiste...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Davies C,Radua J,Cipriani A,Stahl D,Provenzani U,McGuire P,Fusar-Poli P

    更新日期:2018-06-12 00:00:00

  • Correlations between awareness of illness (insight) and history of addiction in heroin-addicted patients.

    abstract::In a group of 1066 heroin addicts, who were seeking treatment for opioid agonist treatment, we looked for differences in historical, demographic, and clinical characteristics, between patients with different levels of awareness of illness (insight). The results showed that, in the cohort studied, a majority of subject...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Maremmani AG,Rovai L,Rugani F,Pacini M,Lamanna F,Bacciardi S,Perugi G,Deltito J,Dell'osso L,Maremmani I

    更新日期:2012-07-09 00:00:00

  • Vitamin-D Deficiency As a Potential Environmental Risk Factor in Multiple Sclerosis, Schizophrenia, and Autism.

    abstract::In this short review, we want to summarize the current findings on the role of vitamin-D in multiple sclerosis (MS), schizophrenia, and autism. Many studies have highlighted hypovitaminosis-D as a potential environmental risk factor for a variety of conditions such as MS, asthma, cardiovascular disease, and, more rece...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Kočovská E,Gaughran F,Krivoy A,Meier UC

    更新日期:2017-03-27 00:00:00

  • Raising Placebo Efficacy in Antidepressant Trials Across Decades Explained by Small-Study Effects: A Meta-Reanalysis.

    abstract:Background:Recent meta-analyses reported placebo response rate in antidepressant trials to be stable since the 1970s. These meta-analyses however were limited in considering only linear time trends, assessed trial-level covariates based on single-model hypothesis testing only, and did not adjust for small-study effects...

    journal_title:Frontiers in psychiatry



    authors: Holper L

    更新日期:2020-07-28 00:00:00

  • Metabonomic Profile and Signaling Pathway Prediction of Depression-Associated Suicidal Behavior.

    abstract::Suicide is the most severe consequence of depression which has become a leading cause of disability and a global disease burden. Recent evidence indicates a central role of small molecules in the pathogenesis of depression and associated suicidal behaviors. However, there lacks a systemic exploration of small molecule...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Liu S

    更新日期:2020-04-16 00:00:00

  • Relationship Between Stressful Life Events and Sleep Quality: Rumination as a Mediator and Resilience as a Moderator.

    abstract::Purpose: The aim of this study was to investigate the relationship between stressful life events and sleep quality and to probe the role of rumination and resilience in the relationship. Method: The Adolescent Self-Rating Life Events Checklist, Ruminative Responses Scale, Connor-Davidson Resilience Scale, and Pittsbur...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Li Y,Gu S,Wang Z,Li H,Xu X,Zhu H,Deng S,Ma X,Feng G,Wang F,Huang JH

    更新日期:2019-05-27 00:00:00

  • Sleep Disturbance in Bipolar Disorder: Neuroglia and Circadian Rhythms.

    abstract::The worldwide prevalence of sleep disorders is approximately 50%, with an even higher occurrence in a psychiatric population. Bipolar disorder (BD) is a severe mental illness characterized by shifts in mood and activity. The BD syndrome also involves heterogeneous symptomatology, including cognitive dysfunctions and i...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Steardo L Jr,de Filippis R,Carbone EA,Segura-Garcia C,Verkhratsky A,De Fazio P

    更新日期:2019-07-18 00:00:00

  • Associations Between Anxiety, Body Mass Index, and Sex Hormones in Women.

    abstract::Background: Several studies have shown a positive association between anxiety and obesity, particularly in women. We aimed to study whether sex hormone alterations related to obesity might play a role in this association. Patients and methods: Data for this study were obtained from a population-based cohort study (the...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Stanikova D,Luck T,Pabst A,Bae YJ,Hinz A,Glaesmer H,Stanik J,Sacher J,Engel C,Enzenbach C,Wirkner K,Ceglarek U,Thiery J,Kratzsch J,Riedel-Heller SG

    更新日期:2019-07-04 00:00:00