Abstract:
:Although there is general consensus that altered brain structure and function underpins addictive disorders, clinicians working in addiction treatment rarely incorporate neuroscience-informed approaches into their practice. We recently launched the Neuroscience Interest Group within the International Society of Addiction Medicine (ISAM-NIG) to promote initiatives to bridge this gap. This article summarizes the ISAM-NIG key priorities and strategies to achieve implementation of addiction neuroscience knowledge and tools for the assessment and treatment of substance use disorders. We cover two assessment areas: cognitive assessment and neuroimaging, and two interventional areas: cognitive training/remediation and neuromodulation, where we identify key challenges and proposed solutions. We reason that incorporating cognitive assessment into clinical settings requires the identification of constructs that predict meaningful clinical outcomes. Other requirements are the development of measures that are easily-administered, reliable, and ecologically-valid. Translation of neuroimaging techniques requires the development of diagnostic and prognostic biomarkers and testing the cost-effectiveness of these biomarkers in individualized prediction algorithms for relapse prevention and treatment selection. Integration of cognitive assessments with neuroimaging can provide multilevel targets including neural, cognitive, and behavioral outcomes for neuroscience-informed interventions. Application of neuroscience-informed interventions including cognitive training/remediation and neuromodulation requires clear pathways to design treatments based on multilevel targets, additional evidence from randomized trials and subsequent clinical implementation, including evaluation of cost-effectiveness. We propose to address these challenges by promoting international collaboration between researchers and clinicians, developing harmonized protocols and data management systems, and prioritizing multi-site research that focuses on improving clinical outcomes.
journal_name
Front Psychiatryjournal_title
Frontiers in psychiatryauthors
Verdejo-Garcia A,Lorenzetti V,Manning V,Piercy H,Bruno R,Hester R,Pennington D,Tolomeo S,Arunogiri S,Bates ME,Bowden-Jones H,Campanella S,Daughters SB,Kouimtsidis C,Lubman DI,Meyerhoff DJ,Ralph A,Rezapour T,Tavakoli Hdoi
10.3389/fpsyt.2019.00877subject
Has Abstractpub_date
2019-12-23 00:00:00pages
877issn
1664-0640journal_volume
10pub_type
杂志文章,评审abstract:BACKGROUND:Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder affecting children, adolescents, and adults. Its etiology is not well understood, but it is increasingly believed to result from diverse pathophysiologies that affect the structure and function of specific brain circui...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2016.00128
更新日期:2016-07-25 00:00:00
abstract:Objectives:Deviations from typical word use have been previously reported in clinical depression, but language patterns of mild depression (MD), as distinct from normal sadness (NS) and euthymic state, are unknown. In this study, we aimed to apply the linguistic approach as an additional diagnostic key for understandin...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2018.00105
更新日期:2018-04-10 00:00:00
abstract::Autobiographical memory (AM) impairment in schizophrenia affects the richness of detail in personal memories and is one of the major predictors of patients' social functioning. Despite the empirical evidence attributing these difficulties to a defective encoding process, cognitive remediation interventions targeting A...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00397
更新日期:2020-05-08 00:00:00
abstract::The rapidly increasing number of patients with Alzheimer's disease (AD) worldwide has become a major public concern. Mild cognitive impairment (MCI), characterized with accelerated memory decline than normal aging, is a stage between cognitively unimpaired and dementia. Identification of MCI in the Alzheimer's continu...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2018.00671
更新日期:2018-12-06 00:00:00
abstract::Background: Children of parents with a mental illness (COPMI) are more likely to experience negative long-term adversities. However, interventions to support their needs early can significantly enhance adjustment and reduce negative outcomes. Approximately one in four children currently lives with a parent with mental...
journal_title:Frontiers in psychiatry
pub_type:
doi:10.3389/fpsyt.2019.00233
更新日期:2019-04-17 00:00:00
abstract:INTRODUCTION:Despite the importance of dopamine neurotransmission in schizophrenia, very few studies have addressed anomalies in the mesencephalic dopaminergic neurons of the substantia nigra/ventral tegmental area (SN/VTA). Tyrosine hydroxylase (TH) is the rate-limiting enzyme for the production of dopamine, and a pos...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2012.00031
更新日期:2012-04-09 00:00:00
abstract::Motivated behaviors are often initiated in response to perturbations of homeostasis. Indeed, animals and humans have fundamental drives to procure (appetitive behaviors) and eventually ingest (consummatory behaviors) substances based on deficits in body fluid (e.g., thirst) and energy balance (e.g., hunger). Consumpti...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2018.00410
更新日期:2018-09-03 00:00:00
abstract::Background: Individuals with severe mental disorder (SMD) have a higher risk of somatic comorbidity and mortality than the rest of the population. We set up a population-based study to assess whether individuals with SMD had a higher risk of death associated with a COVID-19 infection (COVID-19 associated death) than i...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.609579
更新日期:2021-01-08 00:00:00
abstract:Background:High rates of non-psychotic psychopathological symptoms have been observed in clinical population at clinical high risk (CHR) for psychosis. These comorbid disorders affected the baseline functional level of CHR patients. However, little is known about the comorbid mental disorder in CHR individuals in non-c...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2017.00209
更新日期:2017-10-23 00:00:00
abstract::Introduction: Recent research in Western countries has indicated that family interventions in schizophrenia and other psychotic disorders can reduce patient relapse and improve medication compliance. Few studies have addressed Chinese and Asian populations. This study tested the long-term effects of a 9-month family-l...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2018.00710
更新日期:2018-12-18 00:00:00
abstract:Objectives:The modified Yale Food Addiction Scale 2.0 (mYFAS 2.0) was designed to assess food addiction using a shorter version than the YFAS 2.0. We lack data about the psychometric properties of the mYFAS 2.0 in patients with obesity, as well as studies comparing the psychometric properties of the mYFAS 2.0 versus th...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.480671
更新日期:2020-09-08 00:00:00
abstract::Objective: We aimed to determine the prevalence of burnout among hospital healthcare workers in Libya during the coronavirus disease (COVID-19) pandemic and civil war. Methods: A cross-sectional study was conducted from April 18 to May 2, 2020 among Libyan healthcare workers. Data on participant characteristics were c...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.579563
更新日期:2020-12-11 00:00:00
abstract::Background: Psychiatric comorbidity is common in gambling disorder, a condition with low rates of treatment seeking. There is a paucity of documented nationwide data on gambling disorder and its co-occurring psychiatric comorbidities in the health care system. Methods: This is a nationwide register-based study of all ...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2018.00426
更新日期:2018-09-07 00:00:00
abstract::Recent work on the mechanisms underlying auditory verbal hallucination (AVH) has been heavily informed by self-monitoring accounts that postulate defects in an internal monitoring mechanism as the basis of AVH. A more neglected alternative is an account focusing on defects in auditory processing, namely a spontaneous ...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2013.00155
更新日期:2013-11-27 00:00:00
abstract::Background: The human striatum is a heterogeneous structure involved in diverse functional domains that related to distinct striatum subregions. Striatal dysfunction was thought to be a fundamental element in schizophrenia. However, the connectivity pattern of striatum solely based on functional or structural characte...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2019.00756
更新日期:2019-10-18 00:00:00
abstract:Background:Contemporary psychiatric research focuses its attention on the patient's dysfunction of metacognition in relation to the basic cognitive processes of mental activity. The current study investigated dysfunctional metacognition in relation to self-monitoring of memory in patients diagnosed with schizophrenia. ...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00725
更新日期:2020-07-29 00:00:00
abstract::Abnormal amplitude of low-frequency fluctuation has been implicated in heroin addiction. However, previous studies lacked consistency and didn't consider the impact of confounding factors such as methadone and alcohol. Fifty-one heroin-dependent (HD) individuals and 40 healthy controls underwent resting-state function...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00492
更新日期:2020-07-03 00:00:00
abstract::Social cognition has become recognized as an important driver of functional outcomes and overall recovery in patients with schizophrenia, mediating the relationship between neurocognition and social functioning. Since antipsychotic therapy targeting remission of clinical symptoms has been shown to have a limited impac...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2018.00157
更新日期:2018-04-24 00:00:00
abstract::Therapies for Tourette syndrome (TS) are insufficient, and novel therapies are needed. Fecal microbiota transplantation (FMT) has been a potential therapy for several neurological diseases. Here, we report a preliminary study to investigate the effects of FMT on patients with TS. Five patients with TS received a singl...
journal_title:Frontiers in psychiatry
pub_type:
doi:10.3389/fpsyt.2020.554441
更新日期:2020-12-23 00:00:00
abstract::Patients with cancer are more likely to develop depression than the general population, which negatively impacts their quality of life and prognosis. In order to identify effective antidepressants catered toward cancer patients, the biology of depression in the context of cancer must be well-understood. Many theories ...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2018.00299
更新日期:2018-07-10 00:00:00
abstract::This article discusses yoga as a potential tool for children to deal with stress and regulate themselves. Yoga provides training of mind and body to bring emotional balance. We argue that children and young people need such tools to listen inward to their bodies, feelings, and ideas. Yoga may assist them in developing...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2014.00035
更新日期:2014-04-02 00:00:00
abstract::Magnetic seizure therapy (MST) is a potential alternative to electroconvulsive therapy (ECT), but there is currently a lack of reports about MST in Chinese patients with schizophrenia. Our objective was to investigate the feasibility and acceptability of add-on MST in the treatment of patients with schizophrenia. Eigh...
journal_title:Frontiers in psychiatry
pub_type:
doi:10.3389/fpsyt.2018.00224
更新日期:2018-05-29 00:00:00
abstract:INTRODUCTION:Ruminative (abstract verbal) processing during recall of aversive autobiographical memories may serve to dampen their short-term affective impact. Experimental studies indeed demonstrate that verbal processing of non-autobiographical material and positive autobiographical memories evokes weaker affective r...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2017.00082
更新日期:2017-05-30 00:00:00
abstract::Studies utilizing functional magnetic resonance imaging (fMRI) cue-reactivity paradigms have demonstrated that short-term abstinent or current methamphetamine (MA) users have increased brain activity in the ventral striatum, caudate nucleus and medial frontal cortex, when exposed to MA-related visual cues. However, pa...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2018.00145
更新日期:2018-04-19 00:00:00
abstract::Background: Left-behind children (LBC) are becoming a widespread phenomenon and face higher risks of psychological and educational problems. Our study aimed to explore school bullying in LBC and examine the effectiveness of art therapy intervention for reducing bullying victimization affecting LBC in rural areas. Meth...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2019.00040
更新日期:2019-02-07 00:00:00
abstract:Objective:There is increasing interest in the utility of gamma-band activity for assessing various brain functions, including perception, language, memory, and cognition. The auditory steady-state response (ASSR) involves neural activity in the brain elicited by trains of a click sound, and its maximum response is obta...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00876
更新日期:2020-09-02 00:00:00
abstract:Background:Previous studies suggested bipolar disorder caused an aberrant alteration in the insular, putamen, and left superior frontal gyrus, which are the main components of the hate circuit. However, the relationship between the hate circuit and the pathophysiologic substrate underlying different phases of bipolar d...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.556126
更新日期:2020-10-27 00:00:00
abstract:Background:Studies have shown that patients with major depressive disorder (MDD) exhibit elevated dysfunctional attitudes (DAs). However, it remains controversial whether the DAs are state-dependent or trait-like features of MDD. Methods:This study recruited 172 patients and 159 healthy controls (HCs) at baseline. DAs...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00645
更新日期:2020-07-10 00:00:00
abstract::Mental illnesses, among which depression and anxiety are most common, are the leading cause for permanent disability. It is of interest to know what case characteristics determine if a person returns to the work force in spite of mental illness to tailor specific interventions. So far, there has been little research i...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00740
更新日期:2020-07-31 00:00:00
abstract::Suicide is a serious public health issue worldwide, yet current clinical methods for assessing a person's risk of taking their own life remain unreliable and new methods for assessing suicide risk are being explored. The widespread adoption of electronic health records (EHRs) has opened up new possibilities for epidem...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2020.553463
更新日期:2020-11-27 00:00:00