Increased Absolute Glutamate Concentrations and Glutamate-to-Creatine Ratios in Patients With Methamphetamine Use Disorders.

Abstract:

:Introduction: Previous studies have indicated that changes in the concentration of glutamate and related metabolites may mediate the progression of addiction in patients with methamphetamine (MA) use disorders. In the present study, we utilized magnetic resonance spectroscopy (MRS) to investigate absolute glutamate concentrations and metabolite ratios in patients with MA addiction. We further analyzed the association between glutamate concentration and various clinical indicators. Methods: The present study included 31 unmedicated patients with clinically diagnosed MA dependence (mean age: 30.5 ± 8.0 years) and 32 age-matched healthy controls (mean age: 32.9 ± 8.2 years). Patients were evaluated using the Barratt Impulsiveness Scale (BIS-11). We also collected general information regarding the duration and dosage of drug use. Point-resolved spectroscopy was used to quantify the absolute concentrations of metabolites (glutamate, choline, N-acetylaspartate, glutamine, and creatine), as well as the ratio of metabolites to total creatine, using LCModel software. We then compared differences in glutamate levels and psychometric scores between the two groups. Results: Glutamate-to-creatine ratios in the brainstem were significantly higher in the MA group than in the control group (t = 2.764, p = 0.008). Glutamate concentrations in the brainstem were also significantly higher in the MA group than in the control group (t = 2.390, p = 0.020). However, no significant differences in the concentrations or ratios of other metabolites were observed between the two groups (all p > 0.05). Glutamate concentration was positively correlated with the duration of drug use (r = 0.401, p = 0.035) and the total dose of regular addiction (duration of addiction × regular addiction dose; r = 0.207, p = .040), but not with BIS-11 scores. Conclusions: Our findings indicated that glutamate levels in the brainstem are significantly elevated in patients with MA use disorders, and that these levels are significantly associated with the duration and dose of drug use.Such findings suggest that glutamate concentration can be used as an objective biological marker for evaluating/monitoring disease status and treatment efficacy in patients with MA dependence.

journal_name

Front Psychiatry

journal_title

Frontiers in psychiatry

authors

Yang W,Yang R,Luo J,He L,Liu J,Zhang J

doi

10.3389/fpsyt.2018.00368

subject

Has Abstract

pub_date

2018-08-31 00:00:00

pages

368

issn

1664-0640

journal_volume

9

pub_type

杂志文章
  • Resilience as a Mediator Between Interpersonal Risk Factors and Hopelessness in Depression.

    abstract::Several studies investigated the role of resilience as a mediating factor for psychopathological phenotypes. The aim of the current study is to explore the putative role of resilience as a mediator between different vulnerability factors and depressive symptoms. One hundred and fifty patients with a major depressive d...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00010

    authors: Collazzoni A,Stratta P,Pacitti F,Rossi A,Santarelli V,Bustini M,Talevi D,Socci V,Rossi R

    更新日期:2020-02-28 00:00:00

  • Integrated Mental Health Services for the Developmental Period (0 to 25 Years): A Critical Review of the Evidence.

    abstract::Background: The developmental period from 0 to 25 years is a vulnerable time during which children and young people experience many psychosocial and neurobiological changes and an increased incidence of mental illness. New clinical services for children and young people aged 0 to 25 years may represent a radical trans...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2019.00355

    authors: Fusar-Poli P

    更新日期:2019-06-07 00:00:00

  • Identifying Individuals at High Risk for Permanent Disability From Depression and Anxiety.

    abstract::Mental illnesses, among which depression and anxiety are most common, are the leading cause for permanent disability. It is of interest to know what case characteristics determine if a person returns to the work force in spite of mental illness to tailor specific interventions. So far, there has been little research i...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00740

    authors: Behrens-Wittenberg E,Wedegaertner F

    更新日期:2020-07-31 00:00:00

  • Using multivariate machine learning methods and structural MRI to classify childhood onset schizophrenia and healthy controls.

    abstract:INTRODUCTION:Multivariate machine learning methods can be used to classify groups of schizophrenia patients and controls using structural magnetic resonance imaging (MRI). However, machine learning methods to date have not been extended beyond classification and contemporaneously applied in a meaningful way to clinical...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2012.00053

    authors: Greenstein D,Malley JD,Weisinger B,Clasen L,Gogtay N

    更新日期:2012-06-01 00:00:00

  • Deficits in agency in schizophrenia, and additional deficits in body image, body schema, and internal timing, in passivity symptoms.

    abstract::Individuals with schizophrenia, particularly those with passivity symptoms, may not feel in control of their actions, believing them to be controlled by external agents. Cognitive operations that contribute to these symptoms may include abnormal processing in agency as well as body representations that deal with body ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2014.00126

    authors: Graham KT,Martin-Iverson MT,Holmes NP,Jablensky A,Waters F

    更新日期:2014-09-10 00:00:00

  • Depressive Symptoms in Late Pregnancy Disrupt Attentional Processing of Negative-Positive Emotion: An Eye-Movement Study.

    abstract::This study investigated biases for negative-positive information in component processes of visual attention (initial shift vs. maintenance of gaze) among women in late pregnancy with or without depressive symptoms. Eye movements were recorded while participants viewed a series of picture pairs depicting negative, posi...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00780

    authors: Tang W,Bao C,Xu L,Zhu J,Feng W,Zhang W,Lin C,Chen L,Cheng Q,Ding P,Zhou M,Bao Y,Yu X,Zhao K,He J

    更新日期:2019-10-31 00:00:00

  • Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention.

    abstract::Alcohol use disorder (AUD) is a devastating public health problem in which both genetic and environmental factors play a role. Growing evidence supports that epigenetic regulation is one major mechanism in neuroadaptation that contributes to development of AUD. Meanwhile, epigenetic patterns can be modified by various...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00594

    authors: Chen J,Hutchison KE,Bryan AD,Filbey FM,Calhoun VD,Claus ED,Lin D,Sui J,Du Y,Liu J

    更新日期:2018-11-15 00:00:00

  • Modulation of Social Cognition via Hallucinogens and "Entactogens".

    abstract::Social cognition is a fundamental ability in human everyday lives. Deficits in social functioning also represent a core aspect of many psychiatric disorders. Yet, despite its significance, deficits in social cognition skills are insufficiently targeted by current treatments. Hallucinogens and entactogens have been sho...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2019.00881

    authors: Preller KH,Vollenweider FX

    更新日期:2019-12-03 00:00:00

  • Neural Correlates of Duration Discrimination in Young Adults with Autism Spectrum Disorder, Attention-Deficit/Hyperactivity Disorder and Their Comorbid Presentation.

    abstract::Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) often co-occur and share neurocognitive deficits. One such shared impairment is in duration discrimination. However, no studies using functional magnetic resonance imaging (fMRI) have investigated whether these duration discrimination d...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00569

    authors: Lukito SD,O'Daly OG,Lythgoe DJ,Whitwell S,Debnam A,Murphy CM,Ashwood K,Stoencheva V,Simonoff E,Rubia K

    更新日期:2018-11-14 00:00:00

  • A Randomized Controlled Trial on Mutual Support Group Intervention for Families of People With Recent-Onset Psychosis: A Four-Year Follow-Up.

    abstract::Introduction: Recent research in Western countries has indicated that family interventions in schizophrenia and other psychotic disorders can reduce patient relapse and improve medication compliance. Few studies have addressed Chinese and Asian populations. This study tested the long-term effects of a 9-month family-l...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00710

    authors: Chien WT,Bressington D,Chan SWC

    更新日期:2018-12-18 00:00:00

  • Working Memory Modulates Glutamate Levels in the Dorsolateral Prefrontal Cortex during 1H fMRS.

    abstract::Glutamate is involved in excitatory neurotransmission and metabolic processes related to brain function. Previous studies using proton functional magnetic resonance spectroscopy (1H fMRS) have demonstrated elevated cortical glutamate levels by 2-4% during visual and motor stimulation, relative to periods of no stimula...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00066

    authors: Woodcock EA,Anand C,Khatib D,Diwadkar VA,Stanley JA

    更新日期:2018-03-06 00:00:00

  • Freedom Restrictive Coercive Measures in Forensic Psychiatry.

    abstract::Background: In Germany, people suffering from severe mental illness who have committed serious offenses and have considerably reduced or suspended criminal responsibility can be detained and treated in forensic psychiatric hospitals. In the German federal state of Baden-Wuerttemberg, all psychiatric hospitals includin...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00146

    authors: Flammer E,Frank U,Steinert T

    更新日期:2020-03-05 00:00:00

  • Associations Between Anxiety, Body Mass Index, and Sex Hormones in Women.

    abstract::Background: Several studies have shown a positive association between anxiety and obesity, particularly in women. We aimed to study whether sex hormone alterations related to obesity might play a role in this association. Patients and methods: Data for this study were obtained from a population-based cohort study (the...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00479

    authors: Stanikova D,Luck T,Pabst A,Bae YJ,Hinz A,Glaesmer H,Stanik J,Sacher J,Engel C,Enzenbach C,Wirkner K,Ceglarek U,Thiery J,Kratzsch J,Riedel-Heller SG

    更新日期:2019-07-04 00:00:00

  • Disadvantageous Decision-Making as a Predictor of Drop-Out among Cocaine-Dependent Individuals in Long-Term Residential Treatment.

    abstract:BACKGROUND:The treatment of cocaine-dependent individuals (CDI) is substantially challenged by high drop-out rates, raising questions regarding contributing factors. Recently, a number of studies have highlighted the potential of greater focus on the clinical significance of neurocognitive impairments in treatment-seek...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2013.00149

    authors: Stevens L,Betanzos-Espinosa P,Crunelle CL,Vergara-Moragues E,Roeyers H,Lozano O,Dom G,Gonzalez-Saiz F,Vanderplasschen W,Verdejo-García A,Pérez-García M

    更新日期:2013-11-15 00:00:00

  • Depression Reduces Accuracy While Parkinsonism Slows Response Time for Processing Positive Feedback in Patients with Parkinson's Disease with Comorbid Major Depressive Disorder Tested on a Probabilistic Category-Learning Task.

    abstract::Major depressive disorder (MDD) is the most common non-motor manifestation of Parkinson's disease (PD) affecting 50% of patients. However, little is known about the cognitive correlates of MDD in PD. Using a computer-based cognitive task that dissociates learning from positive and negative feedback, we tested four gro...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2017.00084

    authors: Herzallah MM,Khdour HY,Taha AB,Elmashala AM,Mousa HN,Taha MB,Ghanim Z,Sehwail MM,Misk AJ,Balsdon T,Moustafa AA,Myers CE,Gluck MA

    更新日期:2017-06-12 00:00:00

  • Burnout Syndrome and Logotherapy: Logotherapy as Useful Conceptual Framework for Explanation and Prevention of Burnout.

    abstract::Burnout syndrome is a state of total exhaustion related to work conditions and stress from work. Recent findings suggest that logotherapy and the concepts of existential meaning and life fulfilment could provide a useful framework for explaining and potentially preventing burnout. This review article summarizes and re...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2019.00382

    authors: Riethof N,Bob P

    更新日期:2019-06-14 00:00:00

  • Self and the Brain. The Immune Metaphor.

    abstract::One of the fundamental questions in neuroscience is how brain activity relates to conscious experience. Even though self-consciousness is considered an emergent property of the brain network, a quantum physics-based theory assigns a momentum of consciousness to the single neuron level. In this work, we present a brain...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.540676

    authors: Sánchez-Ramón S,Faure F

    更新日期:2020-09-29 00:00:00

  • Efficacy of Ketamine in the Treatment of Substance Use Disorders: A Systematic Review.

    abstract::Background: Despite advances in behavioral and pharmacotherapy interventions, substance use disorders (SUDs) are frequently refractory to treatment. Glutamatergic dysregulation has received increasing attention as one common neuropathology across multiple substances of abuse. Ketamine is a potent N-methyl-D-aspartate ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2018.00277

    authors: Jones JL,Mateus CF,Malcolm RJ,Brady KT,Back SE

    更新日期:2018-07-24 00:00:00

  • Association Analysis of Neuronal Nitric Oxide Synthase 1 Gene Polymorphism With Psychopathological Symptoms in Chronic Ketamine Users.

    abstract::Objective: We previously found that chronic ketamine usages were associated with various psychotic and cognitive symptoms mimicking schizophrenia. The blockade of the NMDA receptor and subsequent nitric oxide synthase 1 (NOS1) dysfunction were found to be closely correlated with schizophrenia including NOS1 gene polym...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.580771

    authors: Chen J,Zhang M,Zhou C,Ding Y,Fan N,He H

    更新日期:2020-12-23 00:00:00

  • System Development Guidelines From a Review of Motion-Based Technology for People With Dementia or MCI.

    abstract::As the population ages and the number of people living with dementia or mild cognitive impairment (MCI) continues to increase, it is critical to identify creative and innovative ways to support and improve their quality of life. Motion-based technology has shown significant potential for people living with dementia or...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2018.00189

    authors: Astell AJ,Czarnuch S,Dove E

    更新日期:2018-05-11 00:00:00

  • Using structural neuroimaging to make quantitative predictions of symptom progression in individuals at ultra-high risk for psychosis.

    abstract::Neuroimaging holds the promise that it may one day aid the clinical assessment of individual psychiatric patients. However, the vast majority of studies published so far have been based on average differences between groups, which do not permit accurate inferences at the level of the individual. We examined the potent...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2013.00187

    authors: Tognin S,Pettersson-Yeo W,Valli I,Hutton C,Woolley J,Allen P,McGuire P,Mechelli A

    更新日期:2014-01-29 00:00:00

  • Changes of Altruistic Behavior and Kynurenine Pathway in Late-Life Depression.

    abstract:Background:Depressive patients show less altruistic behavior. While, older adults present higher tendencies for altruism than younger adults. Depression and age are two of the influencing factors of altruism, kynurenine (KYN), and its metabolites. However, the characteristics of altruism in late-life depression (LLD) a...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00338

    authors: Wu Y,Mai N,Weng X,Liang J,Ning Y

    更新日期:2020-04-30 00:00:00

  • Frequency-Specific Regional Homogeneity Alterations in Tourette Syndrome.

    abstract::Tourette syndrome (TS) is a developmental neuropsychiatric disorder with onset during childhood. Because of its complex spectrum of phenotypes, the underlying pathophysiology of TS is still unclear. Resting-state functional magnetic resonance imaging demonstrated aberrant spontaneous neural synchronization in conventi...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.543049

    authors: Lou YT,Li XL,Wang Y,Ji GJ,Zang YF,Wang J,Feng JH

    更新日期:2020-12-17 00:00:00

  • Two Sides of the Same Coin: A Case Report of First-Episode Catatonic Syndrome in a High-Functioning Autism Patient.

    abstract::Background: Catatonic phenomena such as stupor, mutism, stereotypy, echolalia, echopraxia, affective flattening, psychomotor deficits, and social withdrawal are characteristic symptoms of both schizophrenia and autism spectrum disorders (ASD), suggesting overlapping pathophysiological similarities such as altered glut...

    journal_title:Frontiers in psychiatry

    pub_type:

    doi:10.3389/fpsyt.2019.00224

    authors: Hefter D,Topor CE,Gass P,Hirjak D

    更新日期:2019-04-12 00:00:00

  • Revisiting the Basic Symptom Concept: Toward Translating Risk Symptoms for Psychosis into Neurobiological Targets.

    abstract::In its initial formulation, the concept of basic symptoms (BSs) integrated findings on the early symptomatic course of schizophrenia and first in vivo evidence of accompanying brain aberrations. It argued that the subtle subclinical disturbances in mental processes described as BSs were the most direct self-experience...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2016.00009

    authors: Schultze-Lutter F,Debbané M,Theodoridou A,Wood SJ,Raballo A,Michel C,Schmidt SJ,Kindler J,Ruhrmann S,Uhlhaas PJ

    更新日期:2016-01-28 00:00:00

  • Manual Dexterity in Schizophrenia-A Neglected Clinical Marker?

    abstract::Impaired manual dexterity is commonly observed in schizophrenia. However, a quantitative description of key sensorimotor components contributing to impaired dexterity is lacking. Whether the key components of dexterity are differentially affected and how they relate to clinical characteristics also remains unclear. We...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2017.00120

    authors: Térémetz M,Carment L,Brénugat-Herne L,Croca M,Bleton JP,Krebs MO,Maier MA,Amado I,Lindberg PG

    更新日期:2017-07-10 00:00:00

  • Testing the Bidirectional Associations of Mobile Phone Addiction Behaviors With Mental Distress, Sleep Disturbances, and Sleep Patterns: A One-Year Prospective Study Among Chinese College Students.

    abstract:Background:Mobile phone addiction behaviors (MPAB) are extensively associated with several mental and sleep problems. Only a limited number of bidirectional longitudinal papers have focused on this field. This study aimed to examine the bidirectional associations of MPAB with mental distress, sleep disturbances, and sl...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00634

    authors: Kang Y,Liu S,Yang L,Xu B,Lin L,Xie L,Zhang W,Zhang J,Zhang B

    更新日期:2020-07-17 00:00:00

  • Analysis of the Deleterious Single-Nucleotide Polymorphisms Associated With Antidepressant Efficacy in Major Depressive Disorder.

    abstract::Major depressive disorder (MDD) is a serious mental disease with negative effects on both mental and physical health of the patient. Currently, antidepressants are among the major ways to ease or treat MDD. However, the existing antidepressants have limited efficacy in treating MDD, with a large fraction of patients e...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00151

    authors: Xin J,Yuan M,Peng Y,Wang J

    更新日期:2020-03-18 00:00:00

  • Employment, Studies and Feelings: Two to Nine Years After a Personalized Program of Cognitive Remediation in Psychiatric Patients.

    abstract::Employment rate in psychiatry is around 10 to 30%. Cognitive remediation (CR) associated with psychosocial rehabilitation shows good functional outcomes, with a high level of satisfaction in participants provided by tailored CR. However, few studies looked at the long-term outcome in participants who experienced such ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00609

    authors: Amado I,Moualla M,Jouve J,Brénugat-Herné L,Attali D,Willard D,Rigaut B,Malangin B,Kern L,Meyniel C,Gaillard R,Plaze M,Perquier F,Yannick M

    更新日期:2020-07-03 00:00:00

  • Offense-Related Issues in Forensic Psychiatric Treatment: A Thematic Analysis.

    abstract::Characteristics unique to forensic psychiatric treatment include coming to terms with the offenses committed, the long duration of treatment and the assessment of the risk of repeat offending. This study describes the views of both patients and staff on the significance of the patient's offense as a part of forensic p...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00925

    authors: Askola R,Soininen P,Seppänen A

    更新日期:2020-01-08 00:00:00