The use of very high-doses of baclofen for the treatment of alcohol-dependence: a case series.

abstract：:Due to advances over the last several decades, many fields of medicine are moving toward a precision medicine approach where treatments are tailored to nuanced patient factors. While in some disciplines these innovations are commonplace leading to unique biomarker-guided experimental medicine trials, there are no such...

journal_title：Frontiers in psychiatry

authors： Joshi YB,Light GA

更新日期：2018-11-19 00:00:00

abstract：:The worldwide prevalence of sleep disorders is approximately 50%, with an even higher occurrence in a psychiatric population. Bipolar disorder (BD) is a severe mental illness characterized by shifts in mood and activity. The BD syndrome also involves heterogeneous symptomatology, including cognitive dysfunctions and i...

journal_title：Frontiers in psychiatry

authors： Steardo L Jr,de Filippis R,Carbone EA,Segura-Garcia C,Verkhratsky A,De Fazio P

更新日期：2019-07-18 00:00:00

abstract：:Background: There is a trade-off between drug-related impulsive process and cognitive reflective process among ex-drug abusers. The present study aimed to investigate the impulsive effects of methamphetamine-related stimuli on working memory (WM) performance by manipulating WM load in abstinent ex-methamphetamine user...

journal_title：Frontiers in psychiatry

authors： Deldar Z,Ekhtiari H,Pouretemad HR,Khatibi A

更新日期：2019-10-22 00:00:00

abstract：:Background: Disrupted sleep is common among nursing home patients with dementia and is associated with increased agitation, depression, and cognitive impairment. Detecting and treating sleep problems in this population are therefore of great importance, albeit challenging. Systematic observation and objective recordin...

journal_title：Frontiers in psychiatry

authors： Hjetland GJ,Nordhus IH,Pallesen S,Cummings J,Tractenberg RE,Thun E,Kolberg E,Flo E

更新日期：2020-03-13 00:00:00

abstract：:The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for osteoporosis, the mechanisms t...

journal_title：Frontiers in psychiatry

authors： Kelly RR,McDonald LT,Jensen NR,Sidles SJ,LaRue AC

更新日期：2019-04-09 00:00:00

abstract：:Inflammatory processes associated with persistent (chronic) infection have long been discussed as etiological factors in psychiatric disorders. Studies have found that people with major depression have higher levels of pro-inflammatory cytokines, for example, IL-1, IL-6, and tumor necrosis factor-alpha, and C-reactive...

journal_title：Frontiers in psychiatry

authors： Müller N

更新日期：2019-05-31 00:00:00

abstract：:Current diagnoses of schizophrenia and related psychiatric disorders are classified by phenomenological principles and clinical descriptions while ruling out other symptoms and conditions. Specific biomarkers are needed to assist the current diagnostic system. However, complicated gene and environment interactions ind...

journal_title：Frontiers in psychiatry

authors： Jiang W,King TZ,Turner JA

更新日期：2019-07-12 00:00:00

abstract：:Objective: The ACCESS treatment model offers assertive community treatment (ACT) embedded in an integrated care program to patients with severe psychotic disorders. Compared to standard care, it proved to be more effective in terms of service disengagement and other outcomes in patients with psychotic disorders over 1...

journal_title：Frontiers in psychiatry

authors： Schöttle D,Ruppelt F,Schimmelmann BG,Karow A,Bussopulos A,Gallinat J,Wiedemann K,Luedecke D,Rohenkohl AC,Huber CG,Bock T,Lambert M

更新日期：2019-10-24 00:00:00

abstract：:Studies have shown a direct link between memory for emotionally salient experiences and false memories. In particular, emotionally arousing material of negative and positive valence enhanced reality monitoring compared to neutral material since emotional stimuli can be encoded with more contextual details and thereby ...

journal_title：Frontiers in psychiatry

authors： Fairfield B,Altamura M,Padalino FA,Balzotti A,Di Domenico A,Mammarella N

更新日期：2016-11-30 00:00:00

abstract：:Aim: Acute psychosis is not an uncommon presenting feature in immune-mediated encephalitides. Most patients improve if properly diagnosed and treated expediently with immunotherapy. Our study aimed to describe the frequency, clinical spectrum, and long-term outcomes in patients presenting with acute psychosis who have...

journal_title：Frontiers in psychiatry

authors： Tang C,Tan K,Lim G,Tan L,Tay KY,Kandiah N,Abdin E,Verma SK

更新日期：2019-12-13 00:00:00

abstract：:In depression, brain and behavioral correlates of decision-making differ between individuals with and without suicidal thoughts and behaviors. Though promising, it remains unknown if these potential biomarkers of suicidality will generalize to other high-risk clinical populations. To preliminarily assess whether brain...

journal_title：Frontiers in psychiatry

authors： Barredo J,Aiken E,van 't Wout-Frank M,Greenberg BD,Carpenter LL,Philip NS

更新日期：2019-02-12 00:00:00

abstract：Objectives:The modified Yale Food Addiction Scale 2.0 (mYFAS 2.0) was designed to assess food addiction using a shorter version than the YFAS 2.0. We lack data about the psychometric properties of the mYFAS 2.0 in patients with obesity, as well as studies comparing the psychometric properties of the mYFAS 2.0 versus th...

journal_title：Frontiers in psychiatry

authors： Brunault P,Berthoz S,Gearhardt AN,Gierski F,Kaladjian A,Bertin E,Tchernof A,Biertho L,de Luca A,Hankard R,Courtois R,Ballon N,Benzerouk F,Bégin C

更新日期：2020-09-08 00:00:00

abstract：PURPOSE:Excessive daytime sleepiness is highly prevalent in the general population, is the hallmark of narcolepsy, and is linked to significant morbidity. Clinical assessment of sleepiness remains challenging and the common objective multiple sleep latency test (MSLT) and subjective Epworth sleepiness scale (ESS) metho...

journal_title：Frontiers in psychiatry

authors： Prasad B,Choi YK,Weaver TE,Carley DW

更新日期：2011-06-07 00:00:00

abstract：:Background: In the past 3 decades, there has been an increase in the number of studies assessing exercise as a form of treatment for substance use disorders (SUDs). While a variety of substance types and outcomes have been assessed, exercise intensities have never been systematically examined. Consequently, it remains...

journal_title：Frontiers in psychiatry

authors： Colledge F,Gerber M,Pühse U,Ludyga S

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:Evidence indicates that early life stress (ELS) can induce persistent changes in the hypothalamic-pituitary-adrenal (HPA) axis to respond to stress in the adult life that leads to depression. These appear to be related to the impairment of HPA hormones through binding to glucocorticoid (GR) and mineralocorti...

journal_title：Frontiers in psychiatry

authors： Baes Cv,Martins CM,Tofoli SM,Juruena MF

更新日期：2014-01-24 00:00:00

abstract：:Elevation of the blood ethanol concentration (BEC) to > 80 mg/dL (17.4 mM) after binge drinking enhances inflammation in brain and neuroimmune signaling pathways. Morphine abuse is frequently linked to excessive drinking. Morphine exerts its actions mainly via the seven transmembrane G-protein-coupled mu opioid recept...

journal_title：Frontiers in psychiatry

authors： Chang SL,Huang W,Han H,Sariyer IK

更新日期：2019-01-22 00:00:00

abstract：:The rapidly increasing number of patients with Alzheimer's disease (AD) worldwide has become a major public concern. Mild cognitive impairment (MCI), characterized with accelerated memory decline than normal aging, is a stage between cognitively unimpaired and dementia. Identification of MCI in the Alzheimer's continu...

journal_title：Frontiers in psychiatry

authors： Lin L,Xing G,Han Y

更新日期：2018-12-06 00:00:00

abstract：INTRODUCTION:Despite the importance of dopamine neurotransmission in schizophrenia, very few studies have addressed anomalies in the mesencephalic dopaminergic neurons of the substantia nigra/ventral tegmental area (SN/VTA). Tyrosine hydroxylase (TH) is the rate-limiting enzyme for the production of dopamine, and a pos...

journal_title：Frontiers in psychiatry

authors： Perez-Costas E,Melendez-Ferro M,Rice MW,Conley RR,Roberts RC

更新日期：2012-04-09 00:00:00

abstract：:Naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) is a synthetic compound found in psychoactive "spice" products that activates cannabinoid receptors. Preclinical evidence suggests that exposure to synthetic cannabinoids increases 5-HT2A/2C receptor function in the brain, an effect which might contribute to psyc...

journal_title：Frontiers in psychiatry

authors： Elmore JS,Baumann MH

更新日期：2018-02-27 00:00:00

abstract：:What is the role and value of pleasure in addiction? Foddy and Savulescu (1) have claimed that substance use is just pleasure-oriented behavior. They describe addiction as "strong appetites toward pleasure" and argue that addicts suffer in significant part because of strong social and moral disapproval of lives domina...

journal_title：Frontiers in psychiatry

authors： Kennett J,Matthews S,Snoek A

更新日期：2013-09-25 00:00:00

abstract：:THE MIRROR SYSTEM HYPOTHESIS AND INVESTIGATIONS OF BIRDSONG ARE REVIEWED IN RELATION TO THE SIGNIFICANCE FOR THE DEVELOPMENT OF HUMAN SYMBOLIC AND LANGUAGE CAPACITY, IN TERMS OF THREE FUNDAMENTAL FORMS OF COGNITIVE REFERENCE: iconic, indexical, and symbolic. Mirror systems are initially iconic but can progress to inde...

journal_title：Frontiers in psychiatry

authors： Levy F

更新日期：2012-01-11 00:00:00

abstract：:Aim: With the introduction of "Electronic Medical Record" (EMR) a wealth of digital data has become available. This provides a unique opportunity for exploring precedents for seclusion. This study explored the feasibility of text mining analysis in the EMR to eventually help reduce the use of seclusion in psychiatry. ...

journal_title：Frontiers in psychiatry

authors： Hazewinkel MC,de Winter RFP,van Est RW,van Hyfte D,Wijnschenk D,Miedema N,Hoencamp E

更新日期：2019-04-11 00:00:00

abstract：:Abnormal amplitude of low-frequency fluctuation has been implicated in heroin addiction. However, previous studies lacked consistency and didn't consider the impact of confounding factors such as methadone and alcohol. Fifty-one heroin-dependent (HD) individuals and 40 healthy controls underwent resting-state function...

journal_title：Frontiers in psychiatry

authors： Luo J,Yang R,Yang W,Duan C,Deng Y,Zhang J,Chen J,Liu J

更新日期：2020-07-03 00:00:00

abstract：:Biomarkers are of interest as potential diagnostic and predictive instruments in personalized medicine. We present the first urinary metabolomics biomarker study of childhood aggression. We aim to examine the association of urinary metabolites and neurotransmitter ratios involved in key metabolic and neurotransmitter ...

journal_title：Frontiers in psychiatry

authors： Hagenbeek FA,Roetman PJ,Pool R,Kluft C,Harms AC,van Dongen J,Colins OF,Talens S,van Beijsterveldt CEM,Vandenbosch MMLJZ,de Zeeuw EL,Déjean S,Fanos V,Ehli EA,Davies GE,Hottenga JJ,Hankemeier T,Bartels M,Vermeiren RRJM

更新日期：2020-03-31 00:00:00

abstract：:Depression is one of the most prevalent and serious mental disorders with a worldwide significant health burden. Metabolic abnormalities and disorders in patients with depression have attracted great research attention. Thirty-six metabolic biomarkers of clinical plasma metabolomics were detected by platform technolog...

journal_title：Frontiers in psychiatry

authors： Gao Y,Xu T,Zhao YX,Ling-Hu T,Liu SB,Tian JS,Qin XM

更新日期：2020-07-15 00:00:00

abstract：:Cognitive neuroscience enables us now to decompose major depressive disorder into dysfunctional component processes and relate these processes to specific neural substrates. This approach can be used to illuminate the biological basis of altered psychological processes in depression, including abnormal decision-making...

journal_title：Frontiers in psychiatry

authors： Howlett JR,Paulus MP

更新日期：2013-11-08 00:00:00

abstract：:Therapies for Tourette syndrome (TS) are insufficient, and novel therapies are needed. Fecal microbiota transplantation (FMT) has been a potential therapy for several neurological diseases. Here, we report a preliminary study to investigate the effects of FMT on patients with TS. Five patients with TS received a singl...

journal_title：Frontiers in psychiatry

authors： Zhao HJ,Luo X,Shi YC,Li JF,Pan F,Ren RR,Peng LH,Shi XY,Yang G,Wang J,Hu LY,Zou LP,Yang YS

更新日期：2020-12-23 00:00:00

abstract：Objective:There is a growing interest in evaluating the effectiveness of compassion interventions for treating psychological disorders. The present study evaluated the effectiveness of "attachment-based compassion therapy" (ABCT) in the treatment of fibromyalgia (FM), and the role of psychological flexibility as a medi...

journal_title：Frontiers in psychiatry

authors： Montero-Marín J,Navarro-Gil M,Puebla-Guedea M,Luciano JV,Van Gordon W,Shonin E,García-Campayo J

更新日期：2018-01-16 00:00:00

abstract：:Previous studies have reported an association between verbal abuse in early childhood and structural and functional alterations in the young adult brain, supporting the existence of critical periods in human brain development. In addition, exposure to verbal abuse in early childhood is strongly correlated with lifetim...

journal_title：Frontiers in psychiatry

authors： Shin DW,Yoon T,Jeong B

更新日期：2019-04-16 00:00:00

abstract：:Background: The Maslach Burnout Inventory-Human Services Survey (MBI-HSS) is the most commonly used instrument to assess burnout. Although various factors have been reported to influence its validity, the influence of major depressive disorder (MDD) has not been previously considered. We developed this study to invest...

journal_title：Frontiers in psychiatry

authors： Trigo TR,de Freitas CCS,Wang YP,Ribeiro FG,de Lucia MCS,Siqueira JO,Iosifescu DV,Hallak JEC,Fraguas R

更新日期：2018-12-18 00:00:00