New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis.

abstract：:The Iowa Gambling Task (IGT) has been widely used to assess differences in decision-making under uncertainty. Recently, several studies have shown that healthy subjects do not meet the basic predictions of the task (i.e., prefer options with positive long-term outcome), hence questioning its basic assumptions. Since c...

journal_title：Frontiers in neuroscience

authors： Horstmann A,Villringer A,Neumann J

更新日期：2012-05-14 00:00:00

abstract：:There are few behavioral effects as ubiquitous as the speed-accuracy tradeoff (SAT). From insects to rodents to primates, the tendency for decision speed to covary with decision accuracy seems an inescapable property of choice behavior. Recently, the SAT has received renewed interest, as neuroscience approaches begin ...

journal_title：Frontiers in neuroscience

authors： Heitz RP

更新日期：2014-06-11 00:00:00

abstract：:It is undisputed that presenting a rhythmic stimulus leads to a measurable brain response that follows the rhythmic structure of this stimulus. What is still debated, however, is the question whether this brain response exclusively reflects a regular repetition of evoked responses, or whether it also includes entraine...

journal_title：Frontiers in neuroscience

authors： Zoefel B,Ten Oever S,Sack AT

更新日期：2018-03-07 00:00:00

abstract：:Persons diagnosed with disorders of consciousness (DOC) typically suffer from motor and cognitive disabilities. Recent research has shown that non-invasive brain-computer interface (BCI) technology could help assess these patients' cognitive functions and command following abilities. 20 DOC patients participated in th...

journal_title：Frontiers in neuroscience

authors： Murovec N,Heilinger A,Xu R,Ortner R,Spataro R,La Bella V,Miao Y,Jin J,Chatelle C,Laureys S,Allison BZ,Guger C

更新日期：2020-04-09 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disorder affecting motor neurons (MNs). Evidences indicate that ALS is a non-cell autonomous disease in which glial cells participate in both disease onset and progression. Exosomal transfer of mutant copper-zinc superoxide dismutase 1 (mSOD1...

journal_title：Frontiers in neuroscience

authors： Pinto S,Cunha C,Barbosa M,Vaz AR,Brites D

更新日期：2017-05-17 00:00:00

abstract：:Rodent models have opened the door to a better understanding of the neurobiology of brain disorders and increased our ability to evaluate novel treatments. Resting-state functional magnetic resonance imaging (rs-fMRI) allows for in vivo exploration of large-scale brain networks with high spatial resolution. Its applic...

journal_title：Frontiers in neuroscience

authors： Bajic D,Craig MM,Mongerson CRL,Borsook D,Becerra L

更新日期：2017-12-12 00:00:00

abstract：:Despite evolutionary musicology's interdisciplinary nature, and the diverse methods it employs, the field has nevertheless tended to divide into two main positions. Some argue that music should be understood as a naturally selected adaptation, while others claim that music is a product of culture with little or no rel...

journal_title：Frontiers in neuroscience

authors： van der Schyff D,Schiavio A

更新日期：2017-09-29 00:00:00

abstract：:Cochlear outer hair cells (OHC) receive direct efferent feedback from the caudal auditory brainstem via the medial olivocochlear (MOC) bundle. This circuit provides the neural substrate for the MOC reflex, which inhibits cochlear amplifier gain and is believed to play a role in listening in noise and protection from a...

journal_title：Frontiers in neuroscience

authors： Smith SB,Lichtenhan JT,Cone BK

更新日期：2017-04-04 00:00:00

abstract：:Animal functional magnetic resonance imaging (fMRI) has provided key insights into the physiological mechanisms underlying healthy and diseased brain states. In non-human primates, resting-state fMRI studies are commonly conducted under isoflurane anesthesia, where anesthetic concentration is used to roughly infer ane...

journal_title：Frontiers in neuroscience

authors： Zhang Z,Cai DC,Wang Z,Zeljic K,Wang Z,Wang Y

更新日期：2019-04-11 00:00:00

abstract：:Roughly one-third of the human lifetime is spent in sleep, yet the reason for sleep remains unclear. Understanding the physiologic function of sleep is crucial toward establishing optimal health. Several proposed concepts address different aspects of sleep physiology, including humoral and circuit-based theories of sl...

journal_title：Frontiers in neuroscience

authors： Lazarus M,Oishi Y,Bjorness TE,Greene RW

更新日期：2019-07-17 00:00:00

abstract：:The role of Histamine H3 receptors (H3Rs) in memory, and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer disease (AD) is well-accepted. For that reason, the procognitive effects of the H3R antagonist DL77 on cognitive impairments induced with MK801 were tes...

journal_title：Frontiers in neuroscience

authors： Eissa N,Khan N,Ojha SK,Łazewska D,Kieć-Kononowicz K,Sadek B

更新日期：2018-02-12 00:00:00

abstract：:HIGHLIGHTS Many AD target combinations are being explored for multi-target drug design.New databases and models increase the potential of computational drug designLiraglutide and other antidiabetics are strong candidates for repurposing to AD.Donecopride a dual 5-HT/AChE inhibitor shows promise in pre-clinical studies...

journal_title：Frontiers in neuroscience

authors： Hughes RE,Nikolic K,Ramsay RR

更新日期：2016-04-25 00:00:00

abstract：:Analog arrays are a promising emerging hardware technology with the potential to drastically speed up deep learning. Their main advantage is that they employ analog circuitry to compute matrix-vector products in constant time, irrespective of the size of the matrix. However, ConvNets map very unfavorably onto analog a...

journal_title：Frontiers in neuroscience

authors： Rasch MJ,Gokmen T,Rigotti M,Haensch W

更新日期：2019-07-30 00:00:00

abstract：:In adult mammals, neural stem cells (NSCs) are found in two niches of the brain; the subventricular zone by the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. Neurogenesis is a complex process that is tightly controlled on a molecular level. Recently, microRNAs (miRNAs) have been ...

journal_title：Frontiers in neuroscience

authors： Akerblom M,Sachdeva R,Jakobsson J

更新日期：2012-02-07 00:00:00

abstract：:Traumatic brain injury (TBI) is a kind of severe brain injury characterized with a high incidence rate and a high disability rate. Low-intensity transcranial ultrasound stimulation (LITUS) is a promising neuroprotective method for improving the functional prognosis of TBI. The fractional anisotropy (FA) value and mean...

journal_title：Frontiers in neuroscience

authors： Zheng T,Du J,Yuan Y,Wu S,Jin Y,Wang Z,Liu D,Shi Q,Wang X,Liu L

更新日期：2020-03-10 00:00:00

abstract：:This work presents sPyNNaker 4.0.0, the latest version of the software package for simulating PyNN-defined spiking neural networks (SNNs) on the SpiNNaker neuromorphic platform. Operations underpinning realtime SNN execution are presented, including an event-based operating system facilitating efficient time-driven ne...

journal_title：Frontiers in neuroscience

authors： Rhodes O,Bogdan PA,Brenninkmeijer C,Davidson S,Fellows D,Gait A,Lester DR,Mikaitis M,Plana LA,Rowley AGD,Stokes AB,Furber SB

更新日期：2018-11-20 00:00:00

abstract：:The Ossification of the Posterior Longitudinal Ligament (OPLL) is an idiopathic degenerative spinal disease which may cause motor deficit. For patients presenting myelopathy or severe stenosis, surgical decompression is the treatment of choice; however, despite adequate decompression residual motor impairment is found...

journal_title：Frontiers in neuroscience

authors： Puentes S,Kadone H,Kubota S,Abe T,Shimizu Y,Marushima A,Sankai Y,Yamazaki M,Suzuki K

更新日期：2018-03-02 00:00:00

abstract：:Intermittent theta burst stimulation (iTBS), a patterned repetitive transcranial magnetic stimulation, was applied over the posterior superior temporal sulcus (pSTS) or dorsolateral prefrontal cortex (DLPFC) to explore its impact in adults with autism spectrum disorder (ASD). Among 25 adults with ASD, 19 (mean age: 20...

journal_title：Frontiers in neuroscience

authors： Ni HC,Hung J,Wu CT,Wu YY,Chang CJ,Chen RS,Huang YZ

更新日期：2017-05-09 00:00:00

abstract：:In order to characterize the genetic architecture of epilepsy in a pediatric population from the Iberian Peninsula (including the Canary Islands), we conducted targeted exome sequencing of 246 patients with infantile-onset seizures with or without neurodevelopmental delay. We detected 107 variants in 48 different gene...

journal_title：Frontiers in neuroscience

authors： Fernández-Marmiesse A,Roca I,Díaz-Flores F,Cantarín V,Pérez-Poyato MS,Fontalba A,Laranjeira F,Quintans S,Moldovan O,Felgueroso B,Rodríguez-Pedreira M,Simón R,Camacho A,Quijada P,Ibanez-Mico S,Domingno MR,Benito C,Calvo

更新日期：2019-11-08 00:00:00

abstract：:A novel low cost interconnected architecture (LCIA) is proposed in this paper, which is an efficient solution for the neuron interconnections for the hardware spiking neural networks (SNNs). It is based on an all-to-all connection that takes each paired input and output nodes of multi-layer SNNs as the source and dest...

journal_title：Frontiers in neuroscience

authors： Luo Y,Wan L,Liu J,Harkin J,McDaid L,Cao Y,Ding X

更新日期：2018-11-21 00:00:00

abstract：:Retinal and cortical mechanisms provide for persistence of visual information across intervals of many hundreds of milliseconds, which supports the integration of partial shape cues. The present experiments displayed unknown shapes in a match recognition task, wherein a target shape was quickly followed by a compariso...

journal_title：Frontiers in neuroscience

authors： Geoly A,Greene E

更新日期：2019-03-13 00:00:00

abstract：:Value-based decision making relies on distributed neural systems that weigh the benefits of actions against the cost required to obtain a given outcome. Perturbations of these systems are thought to underlie abnormalities in action selection seen across many neuropsychiatric disorders. Genetic tools in mice provide a ...

journal_title：Frontiers in neuroscience

authors： Alabi OO,Fortunato MP,Fuccillo MV

更新日期：2019-02-07 00:00:00

abstract：:Beside diverse therapeutic properties of palmitoylethanolamide (PEA) including: neuroprotection, inflammation and pain alleviation, prophylactic effects have also been reported in animal models of infections, inflammation, and neurological diseases. The availability of PEA as (ultra)micronized nutraceutical formulatio...

journal_title：Frontiers in neuroscience

authors： Lerner R,Pascual Cuadrado D,Post JM,Lutz B,Bindila L

更新日期：2019-06-11 00:00:00

abstract：:Ischemic stroke places an increasing burden on individuals, families, and societies around the world. However, effective therapies or drugs for ischemic stroke are lacking. Therefore, animal models mimicking ischemic stroke in humans are of great value for preclinical experiments. middle cerebral artery occlusion (MCA...

journal_title：Frontiers in neuroscience

authors： Shi XF,Ai H,Lu W,Cai F

更新日期：2019-02-12 00:00:00

abstract：:The efficacy of neuronal function requires a well-balanced extracellular ion homeostasis and a steady supply with nutrients and metabolites. Therefore, all organisms equipped with a complex nervous system developed a so-called blood-brain barrier, protecting it from an uncontrolled entry of solutes, metabolites or pat...

journal_title：Frontiers in neuroscience

authors： Limmer S,Weiler A,Volkenhoff A,Babatz F,Klämbt C

更新日期：2014-11-14 00:00:00

abstract：:The classification of electroencephalogram (EEG) signals is of significant importance in brain-computer interface (BCI) systems. Aiming to achieve intelligent classification of EEG types with high accuracy, a classification methodology using sparse representation (SR) and fast compression residual convolutional neural...

journal_title：Frontiers in neuroscience

authors： Huang JS,Li Y,Chen BQ,Lin C,Yao B

更新日期：2020-09-30 00:00:00

abstract：:Transcutaneous vagus nerve stimulation (tVNS) is widely used for clinical applications, but its mechanism of action is poorly understood. One candidate pathway that might mediate the effects of tVNS is an increase in GABAergic neurotransmission. In this study, we investigated the effect of tVNS on visual bistable perc...

journal_title：Frontiers in neuroscience

authors： Keute M,Boehrer L,Ruhnau P,Heinze HJ,Zaehle T

更新日期：2019-03-08 00:00:00

abstract：:Dynamic Field Theory (DFT) is an established framework for modeling embodied cognition. In DFT, elementary cognitive functions such as memory formation, formation of grounded representations, attentional processes, decision making, adaptation, and learning emerge from neuronal dynamics. The basic computational element...

journal_title：Frontiers in neuroscience

authors： Sandamirskaya Y

更新日期：2014-01-22 00:00:00

abstract：:After been exposed to the visual input, in the first year of life, the brain experiences subtle but massive changes apparently crucial for communicative/emotional and social human development. Its lack could be the explanation of the very high prevalence of autism in children with total congenital blindness. The prese...

journal_title：Frontiers in neuroscience

authors： Jure R

更新日期：2019-01-09 00:00:00

abstract：:α-Synuclein is a 140-amino acid protein that readily misfolds and is associated with the Lewy body pathology found in sporadic and genetic forms of Parkinson's disease. We and others have shown that wild-type α-synuclein is a damage-associated molecular pattern that directly elicits a proinflammatory response in micro...

journal_title：Frontiers in neuroscience

authors： Sánchez K,Maguire-Zeiss K

更新日期：2020-12-02 00:00:00