Autism Pathogenesis: The Superior Colliculus.

abstract：:Neural stem cells-based therapies have shown great potential for central nervous system regeneration, with three-dimensional (3D) culture systems representing a key technique for tissue engineering applications, as well as disease modeling and drug screenings. Self-assembling peptides (SAPs), providing biomimetic synt...

journal_title：Frontiers in neuroscience

authors： Marchini A,Favoino C,Gelain F

更新日期：2020-05-05 00:00:00

abstract：:Sensorineural hearing loss (SNHL), sometimes accompanied with tinnitus, is associated with dysfunctions within and outside the classical auditory pathway. The salience network, which is anchored in bilateral anterior insula and dorsal anterior cingulate cortex, has been implicated in sensory integration. Partial audit...

journal_title：Frontiers in neuroscience

authors： Xu XM,Jiao Y,Tang TY,Lu CQ,Zhang J,Salvi R,Teng GJ

更新日期：2019-03-19 00:00:00

abstract：:Glutamate-induced excitotoxicity is one of the main causes of neuronal cell death in stroke. Compound 22a has been previously reported as a promising neuroprotective compound derived from tetramethylpyrazine, which is a widely used active ingredient of traditional Chinese medicine Chuanxiong (Ligusticum wallichii Fran...

journal_title：Frontiers in neuroscience

authors： Chen H,Cao J,Zhu Z,Zhang G,Shan L,Yu P,Wang Y,Sun Y,Zhang Z

更新日期：2018-08-15 00:00:00

abstract：:In healthy older adults, resveratrol supplementation has been shown to improve long-term glucose control, resting-state functional connectivity (RSFC) of the hippocampus, and memory function. Here, we aimed to investigate if these beneficial effects extend to individuals at high-risk for dementia, i.e., patients with ...

journal_title：Frontiers in neuroscience

authors： Köbe T,Witte AV,Schnelle A,Tesky VA,Pantel J,Schuchardt JP,Hahn A,Bohlken J,Grittner U,Flöel A

更新日期：2017-03-07 00:00:00

abstract：:A growing understanding of music therapy with patients with disorders of consciousness (DOC) has developed from observing behavioral changes and using these to gain new ways of experiencing this research environment and setting. Neuroscience provides further insight into the effects of music therapy; however, various ...

journal_title：Frontiers in neuroscience

authors： Vogl J,Heine AM,Steinhoff N,Weiss K,Tucek G

更新日期：2015-08-04 00:00:00

abstract：:The enteric glia, a neural crest-derived cell type that composes the Enteric Nervous System, is involved in controlling gut functions, including motility, gut permeability, and neuronal communication. Moreover this glial cell could to give rise to new neurons. It is believed that enteric neurons are generated up to 21...

journal_title：Frontiers in neuroscience

authors： Veríssimo CP,Carvalho JDS,da Silva FJM,Campanati L,Moura-Neto V,Coelho-Aguiar JM

更新日期：2019-09-03 00:00:00

abstract：:Regaining communication abilities in patients who are unable to speak or move is one of the main goals in decoding brain waves for brain-computer interface (BCI) control. Many BCI approaches designed for communication rely on attention to visual stimuli, commonly applying an oddball paradigm, and require both eye move...

journal_title：Frontiers in neuroscience

authors： Reichert C,Tellez Ceja IF,Sweeney-Reed CM,Heinze HJ,Hinrichs H,Dürschmid S

更新日期：2020-12-01 00:00:00

abstract：:Studies of delay discounting typically have involved choices between smaller, immediate outcomes and larger, delayed outcomes. In a study of delay discounting in humans, Green et al. (2005) added a period of time prior to both outcomes, creating a delay common to both. They found that the subjective value of the more ...

journal_title：Frontiers in neuroscience

authors： Calvert AL,Green L,Myerson J

更新日期：2011-08-17 00:00:00

abstract：:Changes in sleep behavior and sleep-related cortical activity have been reported in conditions associated with abnormal alpha-synuclein (α-syn) expression, in particular Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Notably, changes can occur in patients years before the onset of cognitive decline. Sle...

journal_title：Frontiers in neuroscience

authors： Stylianou M,Zaaimi B,Thomas A,Taylor JP,LeBeau FEN

更新日期：2020-09-17 00:00:00

abstract：OBJECTIVES:The thickness of the brain's cortical gray matter (GM) and the fractional anisotropy (FA) of the cerebral white matter (WM) each follow an inverted U-shape trajectory with age. The two measures are positively correlated and may be modulated by common biological mechanisms. We employed four types of genetic a...

journal_title：Frontiers in neuroscience

authors： Kochunov P,Glahn DC,Nichols TE,Winkler AM,Hong EL,Holcomb HH,Stein JL,Thompson PM,Curran JE,Carless MA,Olvera RL,Johnson MP,Cole SA,Kochunov V,Kent J,Blangero J

更新日期：2011-10-19 00:00:00

abstract：:Brain-behavior correlations are commonly used to explore the associations between the brain and human behavior in cognitive neuroscience studies. There are many critics of the correlation approach, however. Most problems associated with correlation approaches originate in the weak statistical power of traditional corr...

journal_title：Frontiers in neuroscience

authors： Zhou X,Li M,Zhou H,Li L,Cui J

更新日期：2018-11-06 00:00:00

abstract：:Circadian rhythms of behavior and physiology are generated by central and peripheral circadian oscillators entrained by periodic environmental or physiological stimuli. A master circadian pacemaker in the hypothalamic suprachiasmatic nucleus (SCN) is directly entrained by daily light-dark (LD) cycles, and coordinates ...

journal_title：Frontiers in neuroscience

authors： Patton DF,Mistlberger RE

更新日期：2013-10-14 00:00:00

abstract：:Hormonal contraceptives are on the market for more than 50 years and used by 100 million women worldwide. However, while endogenous steroids have been convincingly associated with change in brain structure, function and cognitive performance, the effects of synthetic steroids contained in hormonal contraceptives on br...

journal_title：Frontiers in neuroscience

authors： Pletzer BA,Kerschbaum HH

更新日期：2014-08-21 00:00:00

abstract：:It is known that various endocrine modulators, including leptin and ghrelin, have neuroprotective roles in neurological diseases. Leptin is a hormone produced by adipocytes and was originally identified as a gene related to obesity in mice. The leptin receptors in the hypothalamus are the main target for the homeostat...

journal_title：Frontiers in neuroscience

authors： Fujita Y,Yamashita T

更新日期：2019-08-07 00:00:00

abstract：:Rett syndrome (RTT) is a neurodevelopmental disease in children that is mainly caused by mutations in the MeCP2 gene, which codes for a transcriptional regulator. The expression of insulin-like growth factor-1 (IGF-1) is reduced in RTT patients and animal models, and IGF-1 treatment is a promising therapeutic strategy...

journal_title：Frontiers in neuroscience

authors： Yuan ZF,Mao SS,Shen J,Jiang LH,Xu L,Xu JL,Gao F

更新日期：2020-01-29 00:00:00

abstract：:Neurodegenerative diseases are among the leading causes of disability and death worldwide. The disease-related socioeconomic burden is expected to increase with the steadily increasing life expectancy. In spite of decades of clinical and basic research, most strategies designed to manage degenerative brain diseases ar...

journal_title：Frontiers in neuroscience

authors： Castillo X,Castro-Obregón S,Gutiérrez-Becker B,Gutiérrez-Ospina G,Karalis N,Khalil AA,Lopez-Noguerola JS,Rodríguez LL,Martínez-Martínez E,Perez-Cruz C,Pérez-Velázquez J,Piña AL,Rubio K,García HPS,Syeda T,Vanoye-Carlo A,Vi

更新日期：2019-07-24 00:00:00

abstract：:HIGHLIGHTS Many AD target combinations are being explored for multi-target drug design.New databases and models increase the potential of computational drug designLiraglutide and other antidiabetics are strong candidates for repurposing to AD.Donecopride a dual 5-HT/AChE inhibitor shows promise in pre-clinical studies...

journal_title：Frontiers in neuroscience

authors： Hughes RE,Nikolic K,Ramsay RR

更新日期：2016-04-25 00:00:00

abstract：:Using BOLD functional magnetic resonance imaging (fMRI) techniques, we examined the relationships between activities in the neural systems elicited by the decision stage of the Iowa Gambling Task (IGT), and food choices of either vegetables or snacks high in fat and sugar. Twenty-three healthy normal weight adolescent...

journal_title：Frontiers in neuroscience

authors： He Q,Xiao L,Xue G,Wong S,Ames SL,Xie B,Bechara A

更新日期：2014-11-04 00:00:00

abstract：:Basic and neutral neurohypophyseal (NH) nonapeptides have evolved from vasotocin (VT) by a gene duplication at the base of the gnathostome lineage. In teleosts, VT and IT are the basic and neutral peptides, respectively. In the present study, VT and IT precursor genes of Heteropneustes fossilis and Clarias batrachus (...

journal_title：Frontiers in neuroscience

authors： Banerjee P,Chaube R,Joy KP

更新日期：2015-05-15 00:00:00

abstract：:Although the palatability of sucrose is the primary reason for why it is over consumed, it is not well understood how it is encoded in the nucleus accumbens shell (NAcSh), a brain region involved in reward, feeding, and sensory/motor transformations. Similarly, untouched are issues regarding how an external auditory s...

journal_title：Frontiers in neuroscience

authors： Villavicencio M,Moreno MG,Simon SA,Gutierrez R

更新日期：2018-05-04 00:00:00

abstract：:SpiNNaker is a digital neuromorphic architecture, designed specifically for the low power simulation of large-scale spiking neural networks at speeds close to biological real-time. Unlike other neuromorphic systems, SpiNNaker allows users to develop their own neuron and synapse models as well as specify arbitrary conn...

journal_title：Frontiers in neuroscience

authors： Mikaitis M,Pineda García G,Knight JC,Furber SB

更新日期：2018-02-27 00:00:00

abstract：:A coordinate transformation framework for understanding how neurons compute sensorimotor behaviors has generated significant advances toward our understanding of basic brain function. This influential scaffold focuses on neuronal encoding of spatial information represented in different coordinate systems (e.g., eye-ce...

journal_title：Frontiers in neuroscience

authors： Chang SW

更新日期：2013-08-21 00:00:00

abstract：:Perinatal asphyxia (PA) is a clinical condition brought by a birth temporary oxygen deprivation associated with long-term damage in the corpus striatum, one of the most compromised brain areas. Palmitoylethanolamide (PEA) is a neuromodulator well known for its protective effects in brain injury models, including PA, a...

journal_title：Frontiers in neuroscience

authors： Udovin LD,Kobiec T,Herrera MI,Toro-Urrego N,Kusnier CF,Kölliker-Frers RA,Ramos-Hryb AB,Luaces JP,Otero-Losada M,Capani F

更新日期：2020-01-08 00:00:00

abstract：:People are very precise in the discrimination of a line orientation relative to the cardinal (vertical and horizontal) axes, while their orientation discrimination sensitivity along the oblique axes is less refined. This difference in discrimination sensitivity along cardinal and oblique axes is called the "oblique ef...

journal_title：Frontiers in neuroscience

authors： Sysoeva OV,Davletshina MA,Orekhova EV,Galuta IA,Stroganova TA

更新日期：2016-01-21 00:00:00

abstract：:Monoamine oxidase-A (MAO-A) and MAO-B have both been implicated in the pathology of Alzheimer disease (AD). We examined 60 autopsied control and AD donor brain samples to determine how well MAO function aligned with two major risk factors for AD, namely sex and APOE ε4 status. MAO-A activity was increased in AD cortic...

journal_title：Frontiers in neuroscience

authors： Quartey MO,Nyarko JNK,Pennington PR,Heistad RM,Klassen PC,Baker GB,Mousseau DD

更新日期：2018-06-26 00:00:00

abstract：Introduction:Optical coherence tomography angiography (OCT-A) is a novel diagnostic tool with increasing applications in ophthalmology clinics that provides non-invasive high-resolution imaging of the retinal microvasculature. Our aim is to report in detail an experimental protocol for analyzing both vasodilatory and v...

journal_title：Frontiers in neuroscience

authors： Sousa DC,Leal I,Moreira S,do Vale S,Silva-Herdade AS,Aguiar P,Dionísio P,Abegão Pinto L,Castanho MARB,Marques-Neves C

更新日期：2019-06-12 00:00:00

abstract：:Amputation of a sensory peripheral nerve induces severe anatomical and functional changes along the afferent pathway as well as perception alterations and neuropathic pain. In previous studies we showed that electrical stimulation applied to a transected infraorbital nerve protects the somatosensory cortex from the ab...

journal_title：Frontiers in neuroscience

authors： Virtuoso A,Herrera-Rincon C,Papa M,Panetsos F

更新日期：2019-05-01 00:00:00

abstract：UNLABELLED:α2-adrenoceptors (α2AR) lower central sympathetic output and peripheral catecholamine release, and may therefore prevent sympathetic hyperactivity and hypertension. The α2AR are dysfunctional in male spontaneously hypertensive rats (SHR). Premenopausal females are less hypertensive than males. The purpose of...

journal_title：Frontiers in neuroscience

authors： Berg T

更新日期：2016-03-30 00:00:00

abstract：:There has been evidence that during brain development, emerging thalamocortical (TC) and corticothalamic (CT) pathways converge in some brain regions and follow each other's trajectories to their final destinations. Corpus callosal (CC) pathways also emerge at a similar developmental stage, and are known to converge w...

journal_title：Frontiers in neuroscience

authors： Wang R,Wilkinson M,Kane T,Takahashi E

更新日期：2017-11-01 00:00:00

abstract：:Early detection is critical for effective management of Alzheimer's disease (AD) and screening for mild cognitive impairment (MCI) is common practice. Among several deep-learning techniques that have been applied to assessing structural brain changes on magnetic resonance imaging (MRI), convolutional neural network (C...

journal_title：Frontiers in neuroscience

authors： Pan D,Zeng A,Jia L,Huang Y,Frizzell T,Song X

更新日期：2020-05-13 00:00:00