Gating and the Need for Sleep: Dissociable Effects of Adenosine A1 and A2A Receptors.

abstract：:Tinnitus is unusual for such a common symptom in that there are few treatment options and those that are available are aimed at reducing the impact rather than specifically addressing the tinnitus percept. In particular, there is no drug recommended specifically for the management of tinnitus. Whilst some of the curre...

journal_title：Frontiers in neuroscience

authors： McFerran DJ,Stockdale D,Holme R,Large CH,Baguley DM

更新日期：2019-08-06 00:00:00

abstract：:Platelet-rich plasma (PRP) is prepared by centrifuging fresh blood in an anticoagulant state, and harvesting the platelet-rich portion or condensing platelets. Studies have consistently demonstrated that PRP concentrates are an abundant source of growth factors, such as platelet-derived growth factor (PDGF), transform...

journal_title：Frontiers in neuroscience

authors： Chen NF,Sung CS,Wen ZH,Chen CH,Feng CW,Hung HC,Yang SN,Tsui KH,Chen WF

更新日期：2018-04-23 00:00:00

abstract：:Brain-behavior correlations are commonly used to explore the associations between the brain and human behavior in cognitive neuroscience studies. There are many critics of the correlation approach, however. Most problems associated with correlation approaches originate in the weak statistical power of traditional corr...

journal_title：Frontiers in neuroscience

authors： Zhou X,Li M,Zhou H,Li L,Cui J

更新日期：2018-11-06 00:00:00

abstract：:Cerebral function is associated with exceptionally high metabolic activity, and requires continuous supply of oxygen and nutrients from the blood stream. Since the mid-twentieth century the idea that brain energy metabolism is coupled to neuronal activity has emerged, and a number of studies supported this hypothesis....

journal_title：Frontiers in neuroscience

authors： Sonnay S,Gruetter R,Duarte JMN

更新日期：2017-05-26 00:00:00

abstract：:The analysis of spontaneous functional connectivity (sFC) reveals the statistical connections between regions of the brain consistent with underlying functional communication networks within the brain. In this work, we describe the implementation of a complete all-to-all network analysis of resting state neuronal acti...

journal_title：Frontiers in neuroscience

authors： Schmidt BT,Ghuman AS,Huppert TJ

更新日期：2014-06-11 00:00:00

abstract：:The feedback-related negativity (FRN) is a mid-frontal event-related potential (ERP) recorded in various cognitive tasks and associated with the onset of sensory feedback signaling decision outcome. Some properties of the FRN are still debated, notably its sensitivity to positive and negative reward prediction error (...

journal_title：Frontiers in neuroscience

authors： Sallet J,Camille N,Procyk E

更新日期：2013-11-14 00:00:00

abstract：:Neuromodulation technologies, such as transcranial magnetic stimulation (TMS), are promising tools for neurorehabilitation, aphasia therapy included, but not yet in common clinical use. Combined with behavioral techniques, in particular treatment-efficient Intensive Language-Action Therapy (ILAT, previously CIAT or CI...

journal_title：Frontiers in neuroscience

authors： Heikkinen PH,Pulvermüller F,Mäkelä JP,Ilmoniemi RJ,Lioumis P,Kujala T,Manninen RL,Ahvenainen A,Klippi A

更新日期：2019-02-04 00:00:00

abstract：:Spinal cord injury (SCI), one of the most severe types of neurological damage, results in persistent motor and sensory dysfunction and involves complex gene alterations. Circular RNAs (circRNAs) are a recently discovered class of regulatory molecules, and their roles in SCI still need to be addressed. This study compr...

journal_title：Frontiers in neuroscience

authors： Wu R,Mao S,Wang Y,Zhou S,Liu Y,Liu M,Gu X,Yu B

更新日期：2019-12-10 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disorder affecting motor neurons (MNs). Evidences indicate that ALS is a non-cell autonomous disease in which glial cells participate in both disease onset and progression. Exosomal transfer of mutant copper-zinc superoxide dismutase 1 (mSOD1...

journal_title：Frontiers in neuroscience

authors： Pinto S,Cunha C,Barbosa M,Vaz AR,Brites D

更新日期：2017-05-17 00:00:00

abstract：:Disruption of iron homeostasis and increased glial response are known to occur in brains afflicted by Alzheimer's disease (AD). While the APP/PS1 transgenic mouse model recapitulates the hallmark amyloid-beta plaque pathology of AD, it does so in a different neuronal mileu than humans. Understanding the iron character...

journal_title：Frontiers in neuroscience

authors： Meadowcroft MD,Connor JR,Yang QX

更新日期：2015-07-23 00:00:00

abstract：:We investigated whether the C9orf72 repeat expansion is associated with specific clinical features, comorbidities, and prognosis in patients with amyotrophic lateral sclerosis (ALS). A cohort of 1417 ALS patients, diagnosed between January 1, 2009 and December 31, 2013 by 13 Italian ALS Referral Centers, was screened ...

journal_title：Frontiers in neuroscience

authors： Trojsi F,Siciliano M,Femiano C,Santangelo G,Lunetta C,Calvo A,Moglia C,Marinou K,Ticozzi N,Ferro C,Scialò C,Sorarù G,Conte A,Falzone YM,Tortelli R,Russo M,Sansone VA,Chiò A,Mora G,Silani V,Volanti P,Caponnetto C

更新日期：2019-05-17 00:00:00

abstract：:With emerging evidence showing a wide distribution of secretin (SCT) and its receptor (SCTR) in the central nervous system (CNS), the putative neuropeptide role of SCT has become more appreciated since the disruption of SCT/SCTR axis affects various neural functions. This mini review thus focuses on the effects of SCT...

journal_title：Frontiers in neuroscience

authors： Wang L,Zhang L

更新日期：2020-05-06 00:00:00

abstract：:The neuropeptide gonadotropin-releasing hormone (GnRH) plays an important role in the control of reproductive functions. Vertebrates possess multiple GnRH forms that are classified into three main groups, namely GnRH1, GnRH2, and GnRH3. In order to gain more insights into the GnRH gene family in vertebrates, we sought...

journal_title：Frontiers in neuroscience

authors： Gaillard AL,Tay BH,Pérez Sirkin DI,Lafont AG,De Flori C,Vissio PG,Mazan S,Dufour S,Venkatesh B,Tostivint H

更新日期：2018-09-06 00:00:00

abstract：:Aversive memory is essential for survival, but in some situations its exacerbation can be potentially dangerous. There are several ways to modulate memory, among them, through stress-related hormones physiological release or administration of exogenous substances analogous to them. Recently, our group shown that a chr...

journal_title：Frontiers in neuroscience

authors： Gonçalves R,de Vargas LDS,Mello-Carpes PB

更新日期：2019-10-31 00:00:00

abstract：:The classic view of auditory information flow depicts a simple serial route from the periphery through tonotopically-organized nuclei in the brainstem, midbrain and thalamus, ascending eventually to the neocortex. Yet, complicating this picture are numerous parallel ascending and descending pathways, whose roles in au...

journal_title：Frontiers in neuroscience

authors： Lee CC,Sherman SM

更新日期：2010-04-15 00:00:00

abstract：:Relative positions of neurons within mature murine pelvic ganglia based on expression of neurotransmitters have been described. However the spatial organization of developing innervation in the murine urogenital tract (UGT) and the gene networks that regulate specification and maturation of neurons within the pelvic g...

journal_title：Frontiers in neuroscience

authors： Wiese CB,Ireland S,Fleming NL,Yu J,Valerius MT,Georgas K,Chiu HS,Brennan J,Armstrong J,Little MH,McMahon AP,Southard-Smith EM

更新日期：2012-09-12 00:00:00

abstract：:Alzheimer's disease (AD) is associated with degeneration of cholinergic neurons in the basal forebrain. Administration of the immunotoxin 192IgG-saporin to rats, an animal model of AD, leads to degeneration of cholinergic neurons in the medial septal area. In the present study, cholinergic cell death was induced by in...

journal_title：Frontiers in neuroscience

authors： Dobryakova YV,Volobueva MN,Manolova AO,Medvedeva TM,Kvichansky AA,Gulyaeva NV,Markevich VA,Stepanichev MY,Bolshakov AP

更新日期：2019-03-12 00:00:00

abstract：:Artificial neural networks (ANNs) trained using backpropagation are powerful learning architectures that have achieved state-of-the-art performance in various benchmarks. Significant effort has been devoted to developing custom silicon devices to accelerate inference in ANNs. Accelerating the training phase, however, ...

journal_title：Frontiers in neuroscience

authors： Mostafa H,Pedroni B,Sheik S,Cauwenberghs G

更新日期：2017-09-06 00:00:00

abstract：:Modern high field and ultra high field magnetic resonance imaging (MRI) experiments routinely collect multi-dimensional data with high spatial resolution, whether multi-parametric structural, diffusion or functional MRI. While diffusion and functional imaging have benefited from recent advances in multi-dimensional si...

journal_title：Frontiers in neuroscience

authors： Bazin PL,Alkemade A,van der Zwaag W,Caan M,Mulder M,Forstmann BU

更新日期：2019-10-09 00:00:00

abstract：:Auditory stream segregation refers to a segregated percept of signal streams with different acoustic features. Different approaches have been pursued in studies of stream segregation. In psychoacoustics, stream segregation has mostly been investigated with a subjective task asking the subjects to report their percept....

journal_title：Frontiers in neuroscience

authors： Dolležal LV,Brechmann A,Klump GM,Deike S

更新日期：2014-06-06 00:00:00

abstract：:A well-defined granular layer 4 is a defining cytoarchitectonic feature associated with sensory areas of mammalian cerebral cortex, and one with hodological significance: the local axons ascending from cells in thalamorecipient layer 4 and connecting to layer 2/3 pyramidal neurons form a major feedforward excitatory i...

journal_title：Frontiers in neuroscience

authors： Shepherd GM

更新日期：2009-12-15 00:00:00

abstract：Introduction:Our hands, with their exquisite sensors, work in concert with our sensing brain to extract sensory attributes of objects as we engage in daily activities. One in two people with stroke experience impaired body sensation, with negative impact on hand use and return to previous valued activities. Valid, quan...

journal_title：Frontiers in neuroscience

authors： Carey LM,Mak-Yuen YYK,Matyas TA

更新日期：2020-09-23 00:00:00

abstract：:The combination of electromyography (EMG) and transcranial magnetic stimulation (TMS) offers a powerful non-invasive approach for investigating corticospinal excitability in both humans and animals. Acquiring and analyzing the data produced with this combination of tools requires overcoming multiple technical hurdles....

journal_title：Frontiers in neuroscience

authors： Jackson N,Greenhouse I

更新日期：2019-09-13 00:00:00

abstract：:Although the palatability of sucrose is the primary reason for why it is over consumed, it is not well understood how it is encoded in the nucleus accumbens shell (NAcSh), a brain region involved in reward, feeding, and sensory/motor transformations. Similarly, untouched are issues regarding how an external auditory s...

journal_title：Frontiers in neuroscience

authors： Villavicencio M,Moreno MG,Simon SA,Gutierrez R

更新日期：2018-05-04 00:00:00

abstract：:Down syndrome (DS) is the most frequent chromosomal abnormality that causes intellectual disability, resulting from the presence of an extra complete or segment of chromosome 21 (HSA21). In addition, trisomy of HSA21 contributes to altered energy metabolism that appears to be a strong determinant in the development of...

journal_title：Frontiers in neuroscience

authors： Dierssen M,Fructuoso M,Martínez de Lagrán M,Perluigi M,Barone E

更新日期：2020-07-08 00:00:00

abstract：:Understanding the effects of environmental stimulation in autism can improve therapeutic interventions against debilitating sensory overload, social withdrawal, fear and anxiety. Here, we evaluate the role of environmental predictability on behavior and protein expression, and inter-individual differences, in the valp...

journal_title：Frontiers in neuroscience

authors： Favre MR,La Mendola D,Meystre J,Christodoulou D,Cochrane MJ,Markram H,Markram K

更新日期：2015-06-02 00:00:00

abstract：:We generally experience a stable visual world in spite of regular disruptions caused by our own movements (saccades, blinks) or by the visual input itself (flashes, occlusions). In trying to understand the mechanisms responsible for this stability, saccades have been particularly well-studied, and a number of peri-sac...

journal_title：Frontiers in neuroscience

authors： Chota S,McLelland D,Lavergne L,Zimmermann E,Cavanagh P,VanRullen R

更新日期：2020-03-17 00:00:00

abstract：:Although the genetic basis of Tourette Syndrome (TS) remains unclear, several candidate genes have been implicated. Using a set of 382 TS individuals of European ancestry we investigated four candidate genes for TS (HDC, SLITRK1, BTBD9, and SLC6A4) in an effort to identify possibly causal variants using a targeted re-...

journal_title：Frontiers in neuroscience

authors： Alexander J,Potamianou H,Xing J,Deng L,Karagiannidis I,Tsetsos F,Drineas P,Tarnok Z,Rizzo R,Wolanczyk T,Farkas L,Nagy P,Szymanska U,Androutsos C,Tsironi V,Koumoula A,Barta C,TSGeneSEE.,Sandor P,Barr CL,Tischfield

更新日期：2016-09-21 00:00:00

abstract：:Epilepsy is a serious neurological disorder and is characterized by recurrent and unprovoked seizures. A critical pathological factor in the seizure genesis is neuronal loss. Until now, apart from the known regulatory cell death pathways, ferroptosis is a newly discovered type of cell death with the features of iron a...

journal_title：Frontiers in neuroscience

authors： Mao XY,Zhou HH,Jin WL

更新日期：2019-07-17 00:00:00

abstract：:Central sleep apnea is a sudden arrest of breathing during sleep caused by the central commands to the thoracoabdominal muscles. It is a widespread phenomenon in both healthy and diseased people, as well as in some animals. However, there is an ongoing debate whether it can be considered as a pathological deviation of...

journal_title：Frontiers in neuroscience

authors： Limanskaya AV,Busygina II,Levichkina EV,Pigarev IN

更新日期：2020-06-17 00:00:00