Abstract：
:Investigation into the neural and computational bases of decision-making has proceeded in two parallel but distinct streams. Perceptual decision-making (PDM) is concerned with how observers detect, discriminate, and categorize noisy sensory information. Economic decision-making (EDM) explores how options are selected on the basis of their reinforcement history. Traditionally, the sub-fields of PDM and EDM have employed different paradigms, proposed different mechanistic models, explored different brain regions, disagreed about whether decisions approach optimality. Nevertheless, we argue that there is a common framework for understanding decisions made in both tasks, under which an agent has to combine sensory information (what is the stimulus) with value information (what is it worth). We review computational models of the decision process typically used in PDM, based around the idea that decisions involve a serial integration of evidence, and assess their applicability to decisions between good and gambles. Subsequently, we consider the contribution of three key brain regions - the parietal cortex, the basal ganglia, and the orbitofrontal cortex (OFC) - to perceptual and EDM, with a focus on the mechanisms by which sensory and reward information are integrated during choice. We find that although the parietal cortex is often implicated in the integration of sensory evidence, there is evidence for its role in encoding the expected value of a decision. Similarly, although much research has emphasized the role of the striatum and OFC in value-guided choices, they may play an important role in categorization of perceptual information. In conclusion, we consider how findings from the two fields might be brought together, in order to move toward a general framework for understanding decision-making in humans and other primates.
journal_name
Front Neuroscijournal_title
Frontiers in neuroscienceauthors
Summerfield C,Tsetsos Kdoi
10.3389/fnins.2012.00070subject
Has Abstractpub_date
2012-05-24 00:00:00pages
70eissn
1662-4548issn
1662-453Xjournal_volume
6pub_type
杂志文章abstract：:Metallothioneins (MTs) are proteins that function by metal exchange to regulate the bioavailability of metals, such as zinc and copper. Copper functions in the brain to regulate mitochondria, neurotransmitter production, and cell signaling. Inappropriate copper binding can result in loss of protein function and Cu(I)/...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章,评审
doi：10.3389/fnins.2017.00114
更新日期：2017-04-04 00:00:00
abstract：:We hypothesized that assessment of brain connectivity may shed light on the underpinnings of ocular hypertension (OHT), characterized by raised intraocular pressure (IOP) and no typical glaucomatous findings. OHT carries a risk for future glaucoma development, thus representing a model of presymptomatic condition. In ...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2020.00146
更新日期：2020-03-05 00:00:00
abstract：:In the present review, we deliver an overview of the involvement of metabotropic glutamate receptor 5 (mGluR5) activity and density in pathological anxiety, mood disorders and addiction. Specifically, we will describe mGluR5 studies in humans that employed Positron Emission Tomography (PET) and combined the findings w...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章,评审
doi：10.3389/fnins.2015.00086
更新日期：2015-03-18 00:00:00
abstract：:Transcutaneous Vagus Nerve Stimulation (tVNS) on the auricular branch of the vagus nerve has been receiving attention due to its therapeutic potential for neuropsychiatric disorders. Although the mechanism of tVNS is not yet completely understood, studies have demonstrated the potential role of vagal afferent nerve st...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2016.00609
更新日期：2017-01-20 00:00:00
abstract：:Precise diagnosis of psychiatric diseases and a comprehensive assessment of a patient's symptom severity are important in order to establish a successful treatment strategy for each patient. Although great efforts have been devoted to searching for diagnostic biomarkers of schizophrenia over the past several decades, ...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2017.00436
更新日期：2017-08-03 00:00:00
abstract：:There is increasing interest in understanding how the phase and amplitude of distinct neural oscillations might interact to support dynamic communication within the brain. In particular, previous work has demonstrated a coupling between the phase of low frequency oscillations and the amplitude (or power) of high frequ...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2017.00487
更新日期：2017-09-01 00:00:00
abstract：:Both anodal transcranial direct current stimulation (tDCS) of the left IFG and cathodal stimulation of the right IFG were shown to improve rehabilitation of stroke patients with Broca's aphasia. The study aimed at assessing the impact of a bihemispheric IFG stimulation compared to sham on postacute non-fluent aphasia....
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2019.00295
更新日期：2019-04-26 00:00:00
abstract：:The neural generators of the frequency-following response (FFR), a neural response widely used to study the human auditory system, remain unclear. There is evidence that the balance between cortical and subcortical contributions to the FFR varies with stimulus frequency. In this study, we tried to clarify whether this...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2019.00130
更新日期：2019-02-26 00:00:00
abstract：:Previous works exploring the challenges of ensuring information security for neuroprosthetic devices and their users have typically built on the traditional InfoSec concept of the "CIA Triad" of confidentiality, integrity, and availability. However, we argue that the CIA Triad provides an increasingly inadequate found...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2017.00605
更新日期：2017-11-07 00:00:00
abstract：:Motor recovery following nerve transfer surgery depends on the successful re-innervation of the new target muscle by regenerating axons. Cortical plasticity and motor relearning also play a major role during functional recovery. Successful neuromuscular rehabilitation requires detailed afferent feedback. Surface elect...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2018.00906
更新日期：2018-12-04 00:00:00
abstract：:Introduction: The presence of a temporomandibular disorder is one of the most frequent causes of orofacial pain (OFP). When pain continues beyond tissue healing time, it becomes chronic and may be caused, among other factors, by the sensitization of higher-order neurons. The aim of this study is to describe psychologi...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2020.552650
更新日期：2020-11-12 00:00:00
abstract：:Progranulin (PGRN) is a tightly regulated, secreted glycoprotein involved in a wide range of biological processes that is of tremendous interest to the scientific community due to its involvement in neoplastic, neurodevelopmental, and neurodegenerative diseases. In particular, progranulin haploinsufficiency leads to f...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2020.602235
更新日期：2020-12-14 00:00:00
abstract：:In contrast to mammals, the adult zebrafish brain shows neurogenic activity in a multitude of niches present in almost all brain subdivisions. Irrespectively, constitutive neurogenesis in the adult zebrafish and mouse telencephalon share many similarities at the cellular and molecular level. However, upon injury durin...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章,评审
doi：10.3389/fnins.2020.568930
更新日期：2020-09-23 00:00:00
abstract：:Neurodegenerative diseases, including Alzheimer, Parkinson, Huntington, and amyotrophic lateral sclerosis, are a prominent class of neurological diseases currently without a cure. They are characterized by an inexorable loss of a specific type of neurons. The selective vulnerability of specific neuronal clusters (typi...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章,评审
doi：10.3389/fnins.2020.00213
更新日期：2020-03-31 00:00:00
abstract：:Rett syndrome (RTT) is a neurodevelopmental disease in children that is mainly caused by mutations in the MeCP2 gene, which codes for a transcriptional regulator. The expression of insulin-like growth factor-1 (IGF-1) is reduced in RTT patients and animal models, and IGF-1 treatment is a promising therapeutic strategy...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2020.00020
更新日期：2020-01-29 00:00:00
abstract：:Metabolic confusion has been linked to the pathogenesis of Parkinson's disease (PD), while the dynamic changes associated with the onset and progression of PD remain unclear. Herein, dynamic changes in metabolites were detected from the initiation to the development of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPT...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2018.00090
更新日期：2018-02-20 00:00:00
abstract：:Adult neural stem cells (NSCs) are perceived as a homogeneous population of cells that divide infrequently and are capable of multi-lineage differentiation. However, recent data revealed that independent stem cell lineages act in parallel to maintain neurogenesis and provide a cellular source for tissue repair. In add...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章,评审
doi：10.3389/fnins.2014.00032
更新日期：2014-02-25 00:00:00
abstract：:The Embden-Meyerhof-Parnas (EMP) pathway comprises eleven cytosolic enzymes interacting to metabolize glucose to lactic acid [CH3CH(OH)COOH]. Glycolysis is largely considered as the conversion of glucose to pyruvate (CH3COCOO-). We consider glycolysis to be a cellular process and as such, transporters mediating glucos...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章,评审
doi：10.3389/fnins.2018.00404
更新日期：2018-06-15 00:00:00
abstract：:Although flight is regarded as a key behavior of birds this review argues that the perceptual demands for its control are met within constraints set by the perceptual demands of two other key tasks: the control of bill (or feet) position, and the detection of food items/predators. Control of bill position, or of the f...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章,评审
doi：10.3389/fnins.2017.00619
更新日期：2017-11-07 00:00:00
abstract：:This study was to explore the mechanisms underlying 1,2-dichloroethane (1,2-DCE) induced brain edema by focusing on alteration of matrix metalloproteinase-2 (MMP-2) in rat astrocytes induced by 2-chloroethanol (2-CE), an intermediate metabolite of 1,2-DCE in vivo. Protein and mRNA levels of MMP-2, and the phosphorylat...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2016.00593
更新日期：2017-01-04 00:00:00
abstract：:Achromatopsia type 2 (ACHM2) is a severe, inherited eye disease caused by mutations in the CNGA3 gene encoding the α subunit of the cone photoreceptor cyclic nucleotide-gated (CNG) channel. Patients suffer from strongly impaired daylight vision, photophobia, nystagmus, and lack of color discrimination. We have previou...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2017.00292
更新日期：2017-05-24 00:00:00
abstract：Background:Cochlear implants (CIs) are auditory prostheses designed to support spoken communication in persons with severe to profound hearing loss. Many post-lingually deaf adult CI users achieve good speech recognition in quiet; unfortunately, CI technology conveys a degraded representation of pitch and timbre, essen...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2019.01368
更新日期：2019-12-24 00:00:00
abstract：:The cocaine- and amphetamine-regulated transcript (CART) has been the subject of significant interest for over a decade. Work to decipher the detailed mechanism of CART function has been hampered by the lack of specific pharmacological tools like antagonists and the absence of a specific CART receptor(s). However, ext...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章,评审
doi：10.3389/fnins.2014.00313
更新日期：2014-10-13 00:00:00
abstract：:Gene Expression Programming (GEP), a variant of Genetic Programming (GP), is a well established technique for automatic generation of computer programs. Due to the flexible representation, GEP has long been concerned as a classification algorithm for various applications. Whereas, GEP cannot be extended to multi-class...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2019.01396
更新日期：2020-01-17 00:00:00
abstract：:Neurodegenerative diseases are among the leading causes of disability and death worldwide. The disease-related socioeconomic burden is expected to increase with the steadily increasing life expectancy. In spite of decades of clinical and basic research, most strategies designed to manage degenerative brain diseases ar...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章,评审
doi：10.3389/fnins.2019.00728
更新日期：2019-07-24 00:00:00
abstract：:Blood-brain barrier opening (BBBO) with pulsed Focused Ultrasound (pFUS) and microbubbles (MB) has received increasing interest as a method for neurotherapeutics of the central nervous system. In general, conventional MRI [i.e., T2w, T2∗w, gadolinium (Gd) enhanced T1w] is used to monitor the effects of pFUS+MB on BBBO...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2020.00908
更新日期：2020-08-25 00:00:00
abstract：:Hemispheric asymmetry of hippocampal volume is a common finding that has biological relevance, including associations with dementia and cognitive performance. However, a recent study has reported the possibility of systematic error in measurements of hippocampal asymmetry by magnetic resonance volumetry. We manually t...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2012.00179
更新日期：2012-12-13 00:00:00
abstract：Purpose:The aim of this study was to explore experiences of upper limb somatosensory discrimination retraining in persons with stroke. Methods:A qualitative methodology was used within the context of a randomized control trial of somatosensory retraining: the CoNNECT trial. Participants in the CoNNECT trial completed ...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2019.00756
更新日期：2019-07-24 00:00:00
abstract：:Posterior parietal cortex is frequently activated during episodic memory retrieval but its role during retrieval and its interactions with the hippocampus are not yet clear. In this fMRI study, we investigated the neural bases of recognition memory when study repetitions and retrieval goals were manipulated. During en...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2020.563768
更新日期：2020-11-03 00:00:00
abstract：:A growing body of work underlines striking similarities between biological neural networks and recurrent, binary neural networks. A relatively smaller body of work, however, addresses the similarities between learning dynamics employed in deep artificial neural networks and synaptic plasticity in spiking neural networ...
journal_title：Frontiers in neuroscience
pub_type： 杂志文章
doi：10.3389/fnins.2020.00424
更新日期：2020-05-12 00:00:00
