Abstract:
:In the past decade, much has been elucidated regarding the functional organization of the axonal connection of olfactory sensory neurons to olfactory bulb (OB) glomeruli. However, the manner in which projection neurons of the OB process odorant input and send this information to higher brain centers remains unclear. Here, we report long-range, large-scale tracing of the axonal projection patterns of OB neurons using two-photon microscopy. Tracer injection into a single glomerulus demonstrated widely distributed mitral/tufted cell axonal projections on the lateroventral surface of the mouse brain, including the anterior/posterior piriform cortex (PC) and olfactory tubercle (OT). We noted two distinct groups of labeled axons: PC-orienting axons and OT-orienting axons. Each group occupied distinct parts of the lateral olfactory tract. PC-orienting axons projected axon collaterals to a wide area of the PC but only a few collaterals to the OT. OT-orienting axons densely projected axon collaterals primarily to the anterolateral OT (alOT). Different colored dye injections into the superficial and deep portions of the OB external plexiform layer revealed that the PC-orienting axon populations originated in presumed mitral cells and the OT-orienting axons in presumed tufted cells. These data suggest that although mitral and tufted cells receive similar odor signals from a shared glomerulus, they process the odor information in different ways and send their output to different higher brain centers via the PC and alOT.
journal_name
Front Neural Circuitsjournal_title
Frontiers in neural circuitsauthors
Nagayama S,Enerva A,Fletcher ML,Masurkar AV,Igarashi KM,Mori K,Chen WRdoi
10.3389/fncir.2010.00120subject
Has Abstractpub_date
2010-09-23 00:00:00issn
1662-5110journal_volume
4pub_type
杂志文章abstract::A fluorescent voltage sensor protein "Flare" was created from a Kv1.4 potassium channel with YFP situated to report voltage-induced conformational changes in vivo. The RNA virus Sindbis introduced Flare into neurons in the binocular region of visual cortex in rat. Injection sites were selected based on intrinsic optic...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2012.00015
更新日期:2012-03-22 00:00:00
abstract::[This corrects the article DOI: 10.3389/fncir.2018.00028.]. ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,已发布勘误
doi:10.3389/fncir.2018.00080
更新日期:2018-09-25 00:00:00
abstract::Methods of functional connectivity are applied ubiquitously in studies involving non-invasive whole-brain signals, but may be not optimal for exploring the propagation of the steady-state responses, which are strong oscillatory patterns of neurodynamics evoked by periodic stimulation. In our study, we explore a functi...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2018.00118
更新日期:2019-01-15 00:00:00
abstract::The most typical and well known inhibitory action in the cortical microcircuit is a strong inhibition on the target neuron by axo-somatic synapses. However, it has become clear that synaptic inhibition in the cortex is much more diverse and complicated. Firstly, at least ten or more inhibitory non-pyramidal cell subty...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2016.00027
更新日期:2016-04-25 00:00:00
abstract::The intracerebral local field potential (LFP) is a measure of brain activity that reflects the highly dynamic flow of information across neural networks. This is a composite signal that receives contributions from multiple neural sources, yet interpreting its nature and significance may be hindered by several confound...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2016.00101
更新日期:2016-12-15 00:00:00
abstract::FOXP2 is a transcription factor functionally relevant for learned vocalizations in humans and songbirds. In songbirds, FoxP2 mRNA expression in the medium spiny neurons of the basal ganglia song nucleus Area X is developmentally regulated and varies with singing conditions in different social contexts. How individual ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2013.00024
更新日期:2013-02-28 00:00:00
abstract::We have made use of the δ subunit-selective allosteric modulator DS2 (4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridine-3-yl benzamide) to assay the contribution of δ-GABAARs to tonic and phasic conductance changes in the cerebellum, thalamus and neocortex. In cerebellar granule cells, an enhancement of the tonic conduc...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2013.00203
更新日期:2013-12-23 00:00:00
abstract::Recent advances in imaging tools are inspiring zebrafish researchers to tackle ever more ambitious questions in the neurosciences. Behaviorally fundamental conserved neural networks can now be potentially studied using zebrafish from a brain-wide scale to molecular resolution. In this perspective, we offer a roadmap b...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2013.00076
更新日期:2013-04-24 00:00:00
abstract::mRNP granules at adult central synapses are postulated to regulate local mRNA translation and synapse plasticity. However, they are very poorly characterized in vivo. Here, in Drosophila olfactory synapses, we present early observations and characterization of candidate synaptic mRNP particles, one of which contains a...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2010.00121
更新日期:2010-11-03 00:00:00
abstract::In this review, we provide a brief overview over the current knowledge about the role of dopamine transmission in the prefrontal cortex during learning and memory. We discuss work in humans, monkeys, rats, and birds in order to provide a basis for comparison across species that might help identify crucial features and...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2014.00093
更新日期:2014-08-05 00:00:00
abstract::The central vocal pathway of the African clawed frog, Xenopus laevis, is a powerful vertebrate model to understand mechanisms underlying central pattern generation. However, fast and efficient methods of introducing exogenous genes into the neurons of adult X. laevis are currently not available. Here, we systematicall...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2018.00092
更新日期:2018-10-26 00:00:00
abstract::In the mammalian central nervous system, most sensory information passes through primary sensory thalamic nuclei, however the consequence of this remains unclear. Various propositions exist, likening the thalamus to a gate, or a high pass filter. Here, using a simple leaky integrate and fire model based on physiologic...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2015.00089
更新日期:2016-01-14 00:00:00
abstract::The olfactory system has a unique capacity for recovery from peripheral damage. After injury to the olfactory epithelium (OE), olfactory sensory neurons (OSNs) regenerate and re-converge on target glomeruli of the olfactory bulb (OB). Thus far, this process has been described anatomically for only a few defined popula...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2013.00207
更新日期:2014-01-07 00:00:00
abstract::One of the large remaining challenges in the field of zebrafish neuroscience is the establishment of techniques and preparations that permit the recording and perturbation of neural activity in animals that can interact meaningfully with the environment. Since it is very difficult to do this in freely behaving zebrafi...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2012.00125
更新日期:2013-01-25 00:00:00
abstract::Serotonin (5-HT) selectively excites subpopulations of pyramidal neurons in the neocortex via activation of 5-HT2A (2A) receptors coupled to Gq subtype G-protein alpha subunits. Gq-mediated excitatory responses have been attributed primarily to suppression of potassium conductances, including those mediated by KV7 pot...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2018.00002
更新日期:2018-01-18 00:00:00
abstract::"Dye-coupling", whole-mount immunohistochemistry for gap junction channel protein connexin 35 (Cx35), and freeze-fracture replica immunogold labeling (FRIL) reveal an abundance of electrical synapses/gap junctions at glutamatergic mixed synapses in the 14th spinal segment that innervates the adult male gonopodium of W...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2014.00066
更新日期:2014-06-26 00:00:00
abstract::The characterization of the subthreshold, ongoing activity in cortical neurons has been the focus of numerous studies. This activity, described as spontaneous slow waves in membrane potential, has been observed in a span of species in diverse cortical and subcortical areas. We here characterized membrane potential flu...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2013.00116
更新日期:2013-07-11 00:00:00
abstract::Recent studies using primary neuronal cultures have revealed important roles of the microRNA pathway in the regulation of neuronal development and morphology. For example, miR-134 is involved in dendritogenesis and spine development in hippocampal neurons by regulating local mRNA translation in dendrites. The in vivo ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/neuro.04.016.2009
更新日期:2010-01-12 00:00:00
abstract::The assembly of neural circuits involves multiple sequential steps such as the specification of cell-types, their migration to proper brain locations, morphological and physiological differentiation, and the formation and maturation of synaptic connections. This intricate and often prolonged process is guided by elabo...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2012.00037
更新日期:2012-06-26 00:00:00
abstract::The primary (S1) and secondary (S2) somatosensory cortices project to several trigeminal sensory nuclei. One putative function of these corticofugal projections is the gating of sensory transmission through the trigeminal principal nucleus (Pr5), and some have proposed that S1 and S2 project differentially to the spin...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2015.00053
更新日期:2015-09-30 00:00:00
abstract::Two-photon imaging has become a useful tool for optical monitoring of neural circuits, but it requires high laser power and serial scanning of each pixel in a sample. This results in slow imaging rates, limiting the measurements of fast signals such as neuronal activity. To improve the speed and signal-to-noise ratio ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/neuro.04.006.2009
更新日期:2009-07-06 00:00:00
abstract::Recently, by using a combination of two viral vectors, we developed a technique for pathway-selective and reversible synaptic transmission blockade, and successfully induced a behavioral deficit of dexterous hand movements in macaque monkeys by affecting a population of spinal interneurons. To explore the capacity of ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2013.00162
更新日期:2013-10-11 00:00:00
abstract::The firing rates of neurons in primate motor cortex have been related to multiple parameters of voluntary movement. This finding has been corroborated by stimulation-based studies that have mapped complex movements in rodent and primate motor cortex. However, it has been difficult to link the movement tuning of a neur...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2012.00127
更新日期:2013-01-18 00:00:00
abstract::Parental migration has caused millions of children left behind, especially in China and India. Left-behind children (LBC) have a high risk of mental disorders and may present negative life outcomes in the future. However, little is known whether there are cerebral structural alterations in LBC in relative to those wit...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2019.00033
更新日期:2019-05-08 00:00:00
abstract::Local field potentials (LFPs) in cortex reflect synchronous fluctuations in the synaptic activity of local populations of neurons. The power of high frequency (>30 Hz) oscillations in LFPs is locked to the phase of low frequency (<30 Hz) oscillations, an effect known as phase-amplitude coupling (PAC). While PAC has be...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2015.00082
更新日期:2015-12-22 00:00:00
abstract::[This corrects the article on p. 33 in vol. 8, PMID: 24782714.]. ...
journal_title:Frontiers in neural circuits
pub_type: 已发布勘误
doi:10.3389/fncir.2014.00142
更新日期:2014-12-02 00:00:00
abstract::The brain contains a large diversity of unique cell types that use specific genetic programs to control development and instruct the intricate wiring of sensory, motor, and cognitive brain regions. In addition to their cellular diversity and specialized connectivity maps, each region's dedicated function is also expre...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2018.00083
更新日期:2018-10-10 00:00:00
abstract::Fluorescent calcium (Ca(2+)) indicator proteins (FCIPs) are promising tools for functional imaging of cellular activity in living animals. However, they have still not reached their full potential for in vivo imaging of neuronal activity due to limitations in expression levels, dynamic range, and sensitivity for repor...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2010.00009
更新日期:2010-04-29 00:00:00
abstract::How complex natural sounds are represented by the main converging center of the auditory midbrain, the central inferior colliculus, is an open question. We applied neural discrimination to determine the variation of detailed encoding of individual vocalizations across the best frequency gradient of the central inferio...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2015.00091
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Major depressive disorder (MDD) is a public health problem worldwide. There is increasing interest in using non-invasive therapies such as repetitive transcranial magnetic stimulation (rTMS) to treat MDD. However, the changes induced by rTMS on neural circuits remain poorly characterized. The present study a...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2016.00050
更新日期:2016-07-29 00:00:00