Advanced glycosylation end products (AGEs), insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) in patients with type 2 diabetes mellitus.


BACKGROUND:Advanced glycosylation end product (AGE) formation is a major mechanism for the development of complications in diabetes, and the possible roles of insulin-like growth factor 1 (IGF-1) and IGF binding protein 3 (IGFBP-3) are not clearly established. METHODS:We examined the associations of AGEs, free IGF-I and IGFBP-3 in Type 2 diabetes mellitus (DM) patients under diverse conditions. In a cross-sectional design we studied 110 subjects (67 women and 43 men): non-diabetic controls in group 1, (n = 15) and diabetes patients as follows: group 2, without complications (n = 25); group 3, with chronic complications (n = 25); group 4, with acute or chronic infections (n = 24); group 5, hospitalized for reasons unrelated to diabetes (n = 9); group 6, with end-stage renal disease (ESRD) (n = 12). AGEs were determined by a spectrofluorometric method (HPLC). Insulin and IGFBP-3 were measured by RIA and free IGF-1 with an IRMA method. RESULTS:AGEs were 13-fold higher in patients with ESRD (p<0.001), and lower in healthy individuals. Free IGF-1 was lower in the patients with complications (p = 0.017), with infections (p = 0.006) and hospitalized (p = 0.04). IGFBP-3 was higher in hospitalized patients (p=0.017). AGEs were associated with free IGF-1 (r = 0.41, p = 0.04) in the group with complications, and with HbA(1c) (r = -0.90, p = 0.002) in hospitalized patients. In the total group, free IGF-1 (r = -0.25, p = 0.008), and IGFBP-3 (r = -0.22, p = 0.021) were associated with HbA(1c). CONCLUSION:We concluded that AGEs were markedly increased in diabetic patients with ESRD, IGF-1 was decreased in patients with infections and hospitalized, and was negatively associated with HbA(1c). IGFBP-3 was increased in hospitalized patients, with higher levels in patients with long bone fractures. A complex interaction of humoral factors may participate in the acceleration of complications of diabetes.


Diabetes Metab Res Rev


Garay-Sevilla ME,Nava LE,Malacara JM,Wróbel K,Wróbel K,Pérez U





Has Abstract


2000-03-01 00:00:00














  • Validity of diagnostic codes and estimation of prevalence of diabetic foot ulcers using a large electronic medical record database.

    abstract:AIMS:To assess the validity of the diagnostic codes relating to diabetic foot ulcer (DFU) in the electronic medical records of a large integrated care provider and to assess the prevalence of DFU among its members. MATERIALS AND METHODS:Data were obtained from the diabetes registry of Maccabi Healthcare Services (MHS)...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Cahn A,Altaras T,Agami T,Liran O,Touaty CE,Drahy M,Pollack R,Raz I,Chodick G,Zucker I

    更新日期:2019-02-01 00:00:00

  • Retinal capillary basement membrane thickness in diabetic mice genetically modified at the haptoglobin locus.

    abstract:BACKGROUND:Individuals with diabetes mellitus (DM) homozygous for the haptoglobin (Hp) 1 allele are at decreased risk of retinopathy as compared to DM individuals with the Hp 2 allele. We sought to recapitulate these findings in DM mice genetically modified at the Hp locus. METHODS:An early morphological characteristi...

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    pub_type: 杂志文章


    authors: Miller-Lotan R,Miller B,Nakhoul F,Aronson D,Asaf R,Levy AP

    更新日期:2007-02-01 00:00:00

  • The association between fasting plasma glucose and all-cause and cause-specific mortality by gender: The rural Chinese cohort study.

    abstract:BACKGROUND:To evaluate the association between fasting plasma glucose (FPG) and mortality by gender. METHODS:A total of 17 248 eligible participants from a rural Chinese prospective cohort population were included. The same questionnaire interview and anthropometric and laboratory measurements were performed at both b...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Liu L,Chen X,Liu Y,Sun X,Yin Z,Li H,Zhang M,Wang B,Ren Y,Zhao Y,Liu D,Zhou J,Liu X,Zhang D,Cheng C,Liu F,Zhou Q,Xu Q,Xiong Y,Liu J,You Z,Hong S,Wang C,Hu D

    更新日期:2019-05-01 00:00:00

  • The metabolic demands of driving for drivers with type 1 diabetes mellitus.

    abstract:BACKGROUND:The active cognitive-motor demands of driving may have a significant metabolic demand that could contribute to the development of hypoglycemia. Conversely, symptoms caused by the stress of driving may be confused with hypoglycemia and lead to false alarms. This study examined the metabolic demand and the phy...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Cox DJ,Gonder-Frederick LA,Kovatchev BP,Clarke WL

    更新日期:2002-09-01 00:00:00

  • The global challenge of type 2 diabetes and the strategies for response in ethnic minority groups.

    abstract::Ethnic minorities living in high-income countries usually exhibit a greater risk of developing diabetes along with higher morbidity and mortality rates. We evaluated the effectiveness of interventions to improve glycaemic control in ethnic minority groups. Results of major controlled trials, systematic reviews and met...

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    pub_type: 杂志文章,评审


    authors: Lirussi F

    更新日期:2010-09-01 00:00:00

  • Nocturnal hypoglycaemia in type 1 diabetes--consequences and assessment.

    abstract::Hypoglycaemia is inevitable when striving for low HbA1c values. Nocturnal hypoglycaemia often occurs without symptoms, but results in diminished next day well-being and hypoglycaemia unawareness. Frequency of nocturnal hypoglycaemia was first assessed in research ward settings, but suffered from insufficient glucose s...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: DeVries JH,Wentholt IM,Masurel N,Mantel I,Poscia A,Maran A,Heine RJ

    更新日期:2004-11-01 00:00:00

  • Blood group AB is protective factor for gestational diabetes mellitus: a prospective population-based study in Tianjin, China.

    abstract:BACKGROUND:The ABO blood types are associated with cancers, cardiovascular diseases and type 2 diabetes mellitus but whether they are also associated with gestational diabetes mellitus (GDM) is unknown. We examined the relationship between the ABO blood types and the risk of GDM in a prospective population-based Chines...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Zhang C,Li Y,Wang L,Sun S,Liu G,Leng J,Guo J,Lv L,Li W,Zhang C,Hu G,Yu Z,Yang X

    更新日期:2015-09-01 00:00:00

  • MicroRNA-296-5p promotes healing of diabetic wound by targeting sodium-glucose transporter 2 (SGLT2).

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    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Liu X,Wang Y,Zhang X,Zhang X,Guo J,Zhou J,Chai Y,Ma ZL

    更新日期:2019-02-01 00:00:00

  • Birth weight influences the clinical phenotype and the metabolic control of patients with type 1 diabetes (T1D).

    abstract:BACKGROUND:High birth weight has been related to an increased risk of type 1 diabetes (T1D), while suboptimal birth weight (both high and low) has been related to obesity, insulin resistance and type 2 diabetes. Insulin resistance, as a consequence of poor metabolic control, has been described in T1D patients. The aims...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Benevento D,Bizzarri C,Patera IP,Ravà L,Schiaffini R,Ciampalini P,Cianfarani S,Cappa M

    更新日期:2013-01-01 00:00:00

  • Birth weight in newborn infants with different diabetes-associated HLA genotypes in three neighbouring countries: Finland, Estonia and Russian Karelia.

    abstract:BACKGROUND:Human leukocyte antigen (HLA) genotypes associated with increased risk for type 1 diabetes mellitus (T1D) have been reported to be associated with increased birth weight. We set out to investigate the association between HLA haplotypes conferring risk for T1D and birth weight and search for possible differen...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,多中心研究


    authors: Peet A,Kool P,Ilonen J,Knip M,Tillmann V,DIABIMMUNE Study Group.

    更新日期:2012-07-01 00:00:00

  • Insulin pump therapy in type 1 pediatric patients: now and into the year 2000.

    abstract::There are a number of medical conditions such as growth failure in children, pregnancy, lipid abnormalities, and early complications that are improved by the meticulous glycemic control that can be achieved with insulin pump therapy (CSII). By using an insulin pump, many patients with severe hypoglycemia, the dawn phe...

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    pub_type: 杂志文章,评审


    authors: Kaufman FR,Halvorson M,Miller D,Mackenzie M,Fisher LK,Pitukcheewanont P

    更新日期:1999-09-01 00:00:00

  • Can molecular DNA-based techniques unravel the truth about diabetic foot infections?

    abstract::Diabetes foot infections are a common condition and a major causal pathway to lower extremity amputation. Identification of causative pathogens is vital in directing antimicrobial therapy. Historically, clinicians have relied upon culture-dependent techniques that are now acknowledged as both being selective for micro...

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    pub_type: 杂志文章,评审


    authors: Malone M,Gosbell IB,Dickson HG,Vickery K,Espedido BA,Jensen SO

    更新日期:2017-01-01 00:00:00

  • High glucose-induced changes in steroid production in adrenal cells.

    abstract:BACKGROUND:Increased activity of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in enhanced adrenocorticotropin (ACTH) and serum glucocorticoid levels, has been described in patients with diabetes mellitus and in animal models of this disease; however, altered steroid production by adrenocortical cells could ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Astort F,Repetto EM,Martínez Calejman C,Cipelli JM,Sánchez R,Di Gruccio JM,Mercau M,Pignataro OP,Arias P,Cymeryng CB

    更新日期:2009-07-01 00:00:00

  • Diabetic atrial fibrillation patients: mortality and risk for stroke or embolism during a 10-year follow-up.

    abstract:BACKGROUND:To compare in atrial fibrillation patients with and without diabetes, (1) baseline characteristics, (2) additional risk factors for stroke or peripheric or visceral embolism (hypertension, previous stroke, age >75 years), (3) mortality, (4) stroke or embolism, and (5) oral anticoagulation in the year 2000. ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Klem I,Wehinger C,Schneider B,Hartl E,Finsterer J,Stöllberger C

    更新日期:2003-07-01 00:00:00

  • Cardiovascular disease in patients with type 1 diabetes: Early evaluation, risk factors and possible relation with cardiac autoimmunity.

    abstract::Cardiovascular disease now is the leading cause of mortality among patients with type 1 diabetes (T1D). The risk of death from cardiovascular events in subjects with T1D is 2-10 times higher than the general population, depending on blood glucose control. Although complications of cardiovascular disease occur in middl...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Shi M,Tang R,Huang F,Zhong T,Chen Y,Li X,Zhou Z

    更新日期:2020-11-30 00:00:00

  • The ulcerated leg: when to revascularize.

    abstract::The role of peripheral arterial disease in ulcerated diabetic feet has long been underestimated. Progressive claudication, rest pain and the extent of irreversible tissue loss have frequently been indications for revascularization for neuroischaemic ulcers in diabetic patients. These typical ischaemic symptoms are war...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Apelqvist JA,Lepäntalo MJ

    更新日期:2012-02-01 00:00:00

  • Skeletal involvement in patients with diabetes mellitus.

    abstract::Studies on skeletal involvement in patients with diabetes mellitus have generated conflicting results, largely because of the pathogenetic complexity of the condition. Several mechanisms may contribute to skeletal damage, including the increased urinary excretion coupled with the lower intestinal absorption of calcium...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Carnevale V,Romagnoli E,D'Erasmo E

    更新日期:2004-05-01 00:00:00

  • Association of ELMO1 gene polymorphism and diabetic nephropathy among Egyptian patients with type 2 diabetes mellitus.

    abstract:BACKGROUND AND OBJECTIVE:Diabetic nephropathy (DN) is the most common cause of end stage renal failure or even death among patients with type 2 diabetes mellitus. Genetic predisposition is widely studied among these patients to identify manageable aspects of the disease pathogenesis. This study was carried out to test ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Bayoumy NMK,El-Shabrawi MM,Leheta OF,Abo El-Ela AEM,Omar HH

    更新日期:2020-07-01 00:00:00

  • The decrement in circulating endothelial progenitor cells (EPCs) in type 2 diabetes is independent of the severity of the hypoadiponectemia.

    abstract:BACKGROUND:Type 2 diabetes mellitus (DM) is associated with a decreased level of circulating endothelial progenitor cells (EPCs) and adiponectin. Experimental studies suggest a potential link between hypoadiponectinaemia and the depletion of the EPC level. This study investigated the relationships between adiponectin l...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Li M,Ho JC,Lai KW,Au KK,Xu A,Cheung BM,Lam KS,Tse HF

    更新日期:2011-02-01 00:00:00

  • The roles of NADPH-oxidase and nNOS for the increased oxidative stress and the oxygen consumption in the diabetic kidney.

    abstract:BACKGROUND:Sustained hyperglycaemia induces increased renal oxygen consumption resulting in reduced oxygen availability in the diabetic kidney. We investigated the roles of the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase and the neuronal nitric oxide synthase (nNOS) for the increased oxygen consumption ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Edlund J,Fasching A,Liss P,Hansell P,Palm F

    更新日期:2010-07-01 00:00:00

  • Implementation of a quality improvement initiative in Belgian diabetic foot clinics: feasibility and initial results.

    abstract:BACKGROUND:This article aims to describe the implementation and initial results of an audit-feedback quality improvement initiative in Belgian diabetic foot clinics. METHODS:Using self-developed software and questionnaires, diabetic foot clinics collected data in 2005, 2008 and 2011, covering characteristics, history ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Doggen K,Van Acker K,Beele H,Dumont I,Félix P,Lauwers P,Lavens A,Matricali GA,Randon C,Weber E,Van Casteren V,Nobels F,Initiative for Quality Improvement and Epidemiology in Diabetic Foot Clinics (IQED-Foot) Study Group.

    更新日期:2014-07-01 00:00:00

  • Association of iron indices and type 2 diabetes: a meta-analysis of observational studies.

    abstract::The literature on the role of body iron status in the development of type 2 diabetes (T2D) in humans is inconsistent. We aimed to assess the association between iron indices and T2D by a meta-analysis of previously published studies. A systematic literature search was conducted in PubMed and EMBASE. Observational stud...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Orban E,Schwab S,Thorand B,Huth C

    更新日期:2014-07-01 00:00:00

  • Weighting approaches for a genetic risk score and an oxidative stress score for predicting the incidence of obesity.

    abstract:BACKGROUND:We aimed to predict the incidence of obesity in a Korean population using a genetic risk score (GRS) constructed with obesity-related single nucleotide polymorphisms (SNPs) along with an oxidative stress score (OSS). METHODS:A total of 9460 Korean subjects and 356 974 SNPs were included. The GRS was constru...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Park S,Yoo HJ,Jee SH,Lee JH,Kim M

    更新日期:2020-02-01 00:00:00

  • Angiotensin-converting enzyme 2 inhibits endoplasmic reticulum stress-associated pathway to preserve nonalcoholic fatty liver disease.

    abstract:BACKGROUND:Previous works indicated that the stress on the endoplasmic reticulum (ER) affected nonalcoholic fatty liver disease (NAFLD). However, there is no clear evident on the effect of the regulation of ER stress by angiotensin-converting enzyme 2 (ACE2) on the prevention of NAFLD. METHODS:HepG2 cells were treated...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Cao X,Song LN,Zhang YC,Li Q,Shi TT,Yang FY,Yuan MX,Xin Z,Yang JK

    更新日期:2019-05-01 00:00:00

  • Platelet mean volume, distribution width, and count in type 2 diabetes, impaired fasting glucose, and metabolic syndrome: a meta-analysis.

    abstract:BACKGROUND:Platelet activation contributes to cardiovascular disease (CVD), the main complication of type 2 diabetes mellitus (T2DM) and pre-diabetic conditions. Mean platelet volume is an easy-to-measure platelet parameter that has been associated with CVD. We sought to assess mean platelet volume, platelet distributi...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Zaccardi F,Rocca B,Pitocco D,Tanese L,Rizzi A,Ghirlanda G

    更新日期:2015-05-01 00:00:00

  • Diagnosis of infection in the foot in diabetes: a systematic review.

    abstract:BACKGROUND:Securing an early accurate diagnosis of diabetic foot infections and assessment of their severity are of paramount importance since these infections can cause great morbidity and potentially mortality and present formidable challenges in surgical and antimicrobial treatment. METHODS:In June 2018, we searche...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Senneville É,Lipsky BA,Abbas ZG,Aragón-Sánchez J,Diggle M,Embil JM,Kono S,Lavery LA,Malone M,van Asten SA,Urbančič-Rovan V,Peters EJG

    更新日期:2020-03-01 00:00:00

  • Neuromuscular dysfunction in type 2 diabetes: underlying mechanisms and effect of resistance training.

    abstract::Diabetic patients are at higher risk of developing physical disabilities than non-diabetic subjects. Physical disability appears to be related, at least in part, to muscle dysfunction. Several studies have reported reduced muscle strength and power under dynamic and static conditions in both the upper and lower limbs ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Orlando G,Balducci S,Bazzucchi I,Pugliese G,Sacchetti M

    更新日期:2016-01-01 00:00:00

  • Exosomes and diabetes.

    abstract::Diabetes is a group of metabolic diseases characterized by elevated blood glucose levels that drive the development of life-threatening complications. Diabetes results from a situation of insufficient insulin action, either by deficient production of the hormone by the pancreas, or by the development of insulin resist...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Castaño C,Novials A,Párrizas M

    更新日期:2019-03-01 00:00:00

  • Oestradiol levels may differ between premenopausal women, ages 18-50, with type 1 diabetes and matched controls.

    abstract:BACKGROUND:This study aimed to investigate whether oestradiol differs between premenopausal women with and without type 1 diabetes and whether levels are associated with such factors as age, reproductive history or diabetes management. METHODS:Oestradiol in premenopausal women with type 1 diabetes (n = 89; age = 18-50...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Hassan LS,Monson RS,Danielson KK

    更新日期:2017-02-01 00:00:00

  • The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes.

    abstract:BACKGROUND:The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM. METHODS:2445 non-diabetic subjects from the Botnia study received an OGTT at baseline and after 7-8 years of follow-up. RESULTS:NGT and IFG subjects who returned th...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Abdul-Ghani MA,Lyssenko V,Tuomi T,Defronzo RA,Groop L

    更新日期:2010-05-01 00:00:00