Abstract:
Background:Ethiopia is one of the 22 high tuberculosis burden countries. In our country. there are limited published data to show the trend analysis of tuberculosis. Hence, we designed this trend analysis to fill the information gap in our study area. Institutional based retrospective cross-sectional study was employed from 2013 to 2018 to determine the trend analysis of tuberculosis among tuberculosis presumptive clients in Northwestern Tigrai. We have used a standard checklist to extract the data. There were some missing data from the logbooks which are then excluded from the analysis. Results:A total of 7793 tuberculosis presumptive clients were requested for laboratory diagnosis of which about 7639 results had a valid result for X-pert MTB/Rif assay. The overall detection rate of tuberculosis was found to be 9.9% (756/7639). Of the total tuberculosis cases, 8.7 % (66/756) were rifampicin-resistant. The trend of tuberculosis across the six years was fluctuating with a declining trend in the recent three years. HIV infection and being presumptive to drug resistance were associated with tuberculosis detection. Conclusion:Although there was a cumulative declining trend of tuberculosis within the last six years, prevention and control strategies still need to be improved to achieve the stop tuberculosis strategy. To create a world free of tuberculosis, there should be quality service provision regarding tuberculosis case detection and treatment.
journal_name
Infect Drug Resistjournal_title
Infection and drug resistanceauthors
Negash H,Legese H,Adhanom G,Mardu F,Tesfay K,Gebreslasie Gebremeskel S,Berhe Bdoi
10.2147/IDR.S239717subject
Has Abstractpub_date
2020-02-24 00:00:00pages
643-649issn
1178-6973pii
239717journal_volume
13pub_type
杂志文章abstract:Introduction:Understanding drug resistance is important in drug selection for Helicobacter pylori (H. pylori) eradication, and drug resistance data are lacking in Beijing. Purpose:This cross-sectional study aimed to isolate H. pylori from patients with gastroduodenal diseases and to analyze drug resistance to clarithr...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S249370
更新日期:2020-07-06 00:00:00
abstract:Introduction:Schistosomiasis is an important neglected tropical disease (NTD) in several developing countries. Praziquantel is the principle and efficacious chemotherapeutic agent that has been used to treat schistosomiasis for decades. Unfortunately, emerging resistance to praziquantel with accompanying reduced effica...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S266928
更新日期:2020-10-15 00:00:00
abstract:Background:Tachyplesin I is a cationic antimicrobial peptide with a typical cyclic antiparallel β-sheet structure. We previously demonstrated that long-term continuous exposure to increased concentration of tachyplesin I can induce resistant Gram-negative bacteria. However, no significant information is available about...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S226687
更新日期:2020-01-16 00:00:00
abstract::Raltegravir, an inhibitor of the HIV-1 integrase enzyme, is the first available agent in a new class of antiretroviral drugs. Raltegravir has been studied extensively in clinical trials, and has been well tolerated and highly effective in both treatment-naïve and -experienced patients. Resistance to raltegravir is unu...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/idr.s9689
更新日期:2010-01-01 00:00:00
abstract::We present here the first report of an OXA-181-producing Klebsiella pneumoniae isolated from the fecal specimen of a patient in China. The OXA-181-encoding gene blaOXA-181 was located on a 51 kb IncX3-type plasmid. Conjugation assay and whole-genome sequencing analysis revealed that this transferrable plasmid in the K...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S237793
更新日期:2020-04-06 00:00:00
abstract:Introduction:Management of ventilator-associated pneumonia (VAP), the most common infection in patients on mechanical ventilation, should be tailored to local microbiological data. The aim of this study was to determine susceptibility patterns of organisms causing VAP to develop a treatment algorithm based on these fin...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S145827
更新日期:2017-12-22 00:00:00
abstract:Aim:Plasmodium falciparum malaria predominantly affects children residing in endemic areas. However, recently a significant number of Malawian adults, who otherwise should have attained some malaria-specific immunity, have been observed to succumb to either uncomplicated malaria (UM) or severe malaria (SM). In addition...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S230112
更新日期:2020-01-07 00:00:00
abstract:Background:Hepatitis E virus (HEV) is an emerging infectious agent that causes acute hepatitis in developing and developed countries. Diagnosis of HEV infection has not been routinely done in Egyptian hospitals, and clinicians do not prescribe ribavirin (RBV) for acute hepatitis cases of unknown etiology (AHUE). We aim...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S289766
更新日期:2021-01-12 00:00:00
abstract:Background:Broad-scale evidence has shown the significant association between ambient air pollutants and the development of tuberculosis (TB). However, the impact of air quality on the risk of TB in Taiwan is still poorly understood. Objective:To develop a probabilistic integrated population-level risk assessment appr...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S227823
更新日期:2019-12-06 00:00:00
abstract:Background:Staphylococcus aureus is considered one of the major threats regarding food safety worldwide. Methicillin-resistant S. aureus (MRSA) strains in livestock, companion animals, and wild animals continue to be a potential risk to people working with them. Aim:The current research aims to investigate the potenti...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S252332
更新日期:2020-06-04 00:00:00
abstract::Aspergillus endocarditis (AE) accounts for a-quarter of all fungal endocarditis, mainly in immunocompromised hosts prior to heart-valve surgery with high mortality, even with treatment. Herein, we report a rare case of AE in a diabetic 60-year-old woman with a history of redo mitral valve prosthesis suspecious of acut...
journal_title:Infection and drug resistance
pub_type:
doi:10.2147/IDR.S258637
更新日期:2020-07-10 00:00:00
abstract:OBJECTIVES:Stenotrophomonas maltophilia shows wide-spectrum resistance to antimicrobials and causes various infections in immunocompromised or critically ill patients with high mortality. In this era of antibiotics resistance, a revival of old antibiotics is now featured. We examined the clinical usefulness of latamoxe...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S90726
更新日期:2015-10-20 00:00:00
abstract:BACKGROUND:Multidrug-resistant tuberculosis (MDR-TB) did not receive major attention until recently in sub-Saharan Africa where the tuberculosis incidence and risk factors are highest. Factors leading to development of drug resistance need to be understood to develop appropriate control strategies for national programs...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S126274
更新日期:2017-03-13 00:00:00
abstract:Introduction:Candida species, one among the opportunistic fungi, has become a common pathogen causing vaginal thrush and nosocomial bloodstream infections (BSIs). This study aims to evaluate the prevalence and antifungal susceptibility of various Candida species and slime production by Candida species in BSIs and vulvo...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S179462
更新日期:2018-11-23 00:00:00
abstract:Background:The risks of gastrointestinal disorders and cancer are higher in chronic kidney disease (CKD) patients than the general population. There are only a few published reports on the association of helicobacter pylori (H. pylori) infection, endoscopic findings, and histology in these patients. This study was desi...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S228026
更新日期:2019-11-29 00:00:00
abstract:Introduction:Helicobacter pylori was discovered first in the stomachs of patients with gastritis and ulcers by Marshall and Warren in 1982. This discovery majorly affected many research areas of gastroenterology. Since then, the main aim has been to eradicate this microaerophilic bacterium from the stomachs of infected...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S223602
更新日期:2019-11-01 00:00:00
abstract:Purpose:This study aims to 1) describe the distribution characteristics of teicoplanin trough concentration (Cmin) and explore the related influencing factors and 2) evaluate the nephrotoxicity of teicoplanin in children. Patients and Methods:A cohort of children who were treated with teicoplanin intravenously were in...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S272982
更新日期:2020-11-12 00:00:00
abstract::Echinocandin antifungal agents have become the first-line therapy for invasive candidiasis (IC) in many countries. Despite their increasing use, resistance to this class of drug is, overall, still uncommon. Here, we report two patients from the People's Republic of China with IC, one with infection caused by pan-echin...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S152785
更新日期:2018-01-23 00:00:00
abstract::Ceftaroline is an advanced-generation cephalosporin antibiotic recently approved by the US Food and Drug Administration for the treatment of complicated skin and skin-structure infections (cSSSIs). This intravenous broad-spectrum antibiotic exerts potent bactericidal activity by inhibiting bacterial cell wall synthesi...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S17432
更新日期:2012-01-01 00:00:00
abstract::Removal of the spleen had already been established as a routine technique to treat splenic trauma and other diseases affecting the spleen before the anatomy, physiology, and function of the spleen were known in the mid-twentieth century. It is now widely accepted that the splenectomized individual is at increased risk...
journal_title:Infection and drug resistance
pub_type: 杂志文章,评审
doi:10.2147/IDR.S179902
更新日期:2019-09-12 00:00:00
abstract::[This corrects the article DOI: 10.2147/IDR.S258379.]. ...
journal_title:Infection and drug resistance
pub_type: 杂志文章,已发布勘误
doi:10.2147/IDR.S279086
更新日期:2020-09-04 00:00:00
abstract:Introduction:β-lactam and fluoroquinolone antibiotics are usually used for the treatment of urinary tract infections (UTIs). The aim of this study was to determine the prevalence of plasmid-mediated quinolone resistance (PMQR) and extended spectrum β-lactamases (ESBLs) in Enterobacteriaceae isolated from UTIs. Materia...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S160720
更新日期:2018-07-23 00:00:00
abstract:Objective:To genetically characterize clusters of virulence factors (VFs) among extended spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae and assess whether these clusters are associated with genetic determinants or clinical outcomes. Methods:One hundred forty-eight E. coli and 82 K. pn...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S179134
更新日期:2018-12-31 00:00:00
abstract::The loss of polycationic antimicrobial peptides, polymyxins, due to adhesion to plastics is an important subject matter that influences in vitro susceptibility testing, including minimum inhibitory concentration (MIC) assays. This review reminds us that this issue can serve as a significant source of variation in the ...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S219130
更新日期:2019-08-27 00:00:00
abstract:INTRODUCTION:The characteristics and antimicrobial resistance profiles of Staphylococcus aureus differs according to geographical regions and in relation to antibiotic usage. The aim of this study was to determine the biochemical characteristics of the prevalent S. aureus from Ekiti State, Nigeria, and to evaluate thre...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S48809
更新日期:2013-08-20 00:00:00
abstract:Background and purpose:Invasive nontyphoidal salmonellosis, mostly caused by serovars Typhimurium and Enteritidis of Salmonella enterica, has emerged as a major public health problem in sub-Saharan Africa. The aim of this study was the clinical and microbiological characterization of nontyphoidal salmonellosis episodes...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S147243
更新日期:2018-01-31 00:00:00
abstract::Purpose: To investigate antimicrobial resistance and risk factors for mortality of Klebsiella pneumoniae (KP) pneumonia in diabetics and nondiabetics. Patients and methods: A retrospective study was conducted among inpatients of KP pneumonia via electronic medical records in a territory hospital between January 2016 a...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S199642
更新日期:2019-05-07 00:00:00
abstract:Purpose:With the recommendation of World Health Organization (WHO) and as per the Ethiopian National Implementation Guideline, GeneXpert is used for rapid diagnosis of rifampicin (RIF)-resistant multidrug-resistant tuberculosis (MDR-TB) from the suspected TB patients; however, there were limited findings in Ethiopia pa...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S274589
更新日期:2020-10-20 00:00:00
abstract:Introduction:Intravenous (IV) β-lactam antibiotics, excreted through bile into the gastrointestinal (GI) tract, may disrupt the gut microbiome by eliminating the colonization resistance from beneficial bacteria. This increases the risk for Clostridium difficile infection (CDI) and can promote antimicrobial resistance b...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S260258
更新日期:2020-07-22 00:00:00
abstract::A lung abscess is an infectious pulmonary disease characterized by pus-filled cavity formation and often an air-fluid level. In this article, we described an indolent community-acquired lung abscess suspected as a tumor previously. A 56-year-old male presented with cough and expectoration for 2 months and hemoptysis f...
journal_title:Infection and drug resistance
pub_type: 杂志文章
doi:10.2147/IDR.S218921
更新日期:2019-08-08 00:00:00