Review of novel therapeutic targets for improving heart failure treatment based on experimental and clinical studies.

abstract：Purpose:We aimed to present our experience with total hip arthroplasty in patients with previous hip arthrodesis. Patients and methods:This was a retrospective study, in which clinical and radiological outcomes of total hip arthroplasty performed in 17 patients (mean age 54.2±8.5 years; age range 33-68 years; female t...

journal_title：Therapeutics and clinical risk management

authors： Çalbıyık M

更新日期：2018-04-11 00:00:00

abstract：:We report the case of a 30-year-old Japanese woman with anorexia nervosa and vertebral fractures who was treated with etidronate. She had a history of anorexia nervosa, chronic back pain, osteoporosis, and multiple vertebral fractures (morphometric fractures) that responded poorly to treatment with alfacalcidol (1 μg ...

journal_title：Therapeutics and clinical risk management

authors： Iwamoto J,Sato Y,Uzawa M,Takeda T,Matsumoto H

更新日期：2011-01-01 00:00:00

abstract：:Some specific features of the 24 h blood pressure (BP) pattern are linked to the progressive injury of target tissues and the triggering of cardiac and cerebrovascular events. In particular, many studies show the extent of the nocturnal BP decline relative to the diurnal BP mean (the diurnal/nocturnal ratio, an index ...

journal_title：Therapeutics and clinical risk management

authors： Hermida RC,Ayala DE,Calvo C

更新日期：2007-03-01 00:00:00

abstract：:Opioid analgesics are essential in the treatment of moderate to severe cancer-related pain. Opioids are also recognized as important in the management of other severe, persistent refractory painful conditions, such as sickle cell disease and arthritis. In the clinical practice of pain management, stable opioid dosing ...

journal_title：Therapeutics and clinical risk management

authors： Weinstein SM

更新日期：2009-02-01 00:00:00

abstract：:Treatment of HIV-1 infection has produced dramatic success for many patients. Nevertheless, viral resistance continues to limit the efficacy of currently available agents in many patients. The CCR5 antagonists are a new class of antiretroviral agents that target a necessary coreceptor for viral entry of many strains o...

journal_title：Therapeutics and clinical risk management

authors： Schlecht HP,Schellhorn S,Dezube BJ,Jacobson JM

更新日期：2008-04-01 00:00:00

abstract：Background:Wells and Geneva scores are widely used in the assessment of pretest probability of pulmonary embolism (PE). Objective:The objective of this study was to examine the hypothesis that mean platelet volume (MPV) may better predict PE than the clinical prediction rules. Methods:A study was performed among pati...

journal_title：Therapeutics and clinical risk management

authors： Lipinska A,Ledakowicz-Polak A,Krauza G,Przybylak K,Zielinska M

更新日期：2018-11-09 00:00:00

abstract：Purpose:To analyze the treatment patterns of psoriatic arthritis (PSA) or ankylosing spondylitis (AS) patients under biological therapies and to evaluate in this population the health-care resource consumption and related costs. Patients and Methods:A retrospective analysis was performed on administrative databases of...

journal_title：Therapeutics and clinical risk management

authors： Perrone V,Giacomini E,Sangiorgi D,Andretta M,Menti AM,Naclerio M,Ritrovato D,Degli Esposti L

更新日期：2020-06-09 00:00:00

abstract：:Coronary and cerebrovascular atherothrombosis are the leading cause of mortality and morbidity worldwide. Novel antiplatelet agents have been established for the management of patients with clinically evident coronary atherothrombosis and are increasingly used in these patients. These agents, however, have shown limit...

journal_title：Therapeutics and clinical risk management

authors： Iannopollo G,Camporotondo R,De Ferrari GM,Leonardi S

更新日期：2014-05-02 00:00:00

abstract：Background:There are many surgical procedures that can be used to relieve compression caused by thoracic ossification of the ligamentum flavum (TOLF). The present study aims to retrospectively observe the differences in subsection laminectomy with pedicle screw fixation (SLPF) and lamina osteotomy and replantation with...

journal_title：Therapeutics and clinical risk management

authors： Zhang JT,Lei T,Yang L,Lin YS,Wang ZH,Cao JM

更新日期：2020-04-17 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the knowledge, attitude and barriers of pharmacy technicians and pharmacists toward pharmacovigilance, adverse drug reactions (ADRs) and ADR reporting in community pharmacies in Yemen. METHODS:This cross-sectional survey was conducted among community pharmacists and pharm...

journal_title：Therapeutics and clinical risk management

authors： Al-Worafi YM,Kassab YW,Alseragi WM,Almutairi MS,Ahmed A,Ming LC,Alkhoshaiban AS,Hadi MA

更新日期：2017-09-07 00:00:00

abstract：:Experimental data indicate that several pharmacological agents that have long been used for the management of various diseases unrelated to cancer exhibit profound in vitro and in vivo anticancer activity. This is of major clinical importance, since it would possibly aid in reassessing the therapeutic use of currently...

journal_title：Therapeutics and clinical risk management

authors： Papanagnou P,Baltopoulos P,Tsironi M

更新日期：2015-05-18 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) and Candidal prosthetic joint infections (PJIs) are very rare, and the optimal management for these patients is still unknown. A 54-year-old man with traumatic arthritis due to previous electric injury successfully retained the implant despite the successive infection...

journal_title：Therapeutics and clinical risk management

authors： Xiang Y,Xuan YY,Li G

更新日期：2018-06-20 00:00:00

abstract：:Actinic keratoses (AKs) are epidermal cutaneous neoplasia observed predominantly in middle-aged and older subjects with mainly photo type I and photo type II on sun-exposed surfaces as a result of DNA damage. AKs have historically been characterized as being "precancerous"; however, now it is considered by many author...

journal_title：Therapeutics and clinical risk management

authors： Skroza N,Bernardini N,Proietti I,Potenza C

更新日期：2018-10-04 00:00:00

abstract：INTRODUCTION:The seven-year experience of elective abdominal aortic aneurysm (AAA) repair of a vascular surgical unit in a teaching hospital was reviewed to determine the factors associated with in-hospital mortality. METHODS:All patients who underwent elective open repair of an AAA between July 1, 1991, and June 30, ...

journal_title：Therapeutics and clinical risk management

authors： Mackenzie S,Swan JR,D'Este C,Spigelman AD

更新日期：2005-03-01 00:00:00

abstract：:Uncontrolled asthma continues to be a problem for many patients with moderate-to-severe allergic asthma. Dupilumab, which blocks the receptors for interleukin-4 and interleukin-13, has been effective in reducing asthma exacerbations, improving forced expiratory volume in one second (FEV1), and reducing oral corticoste...

journal_title：Therapeutics and clinical risk management

authors： Brooks GD

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:Adverse drug reactions are important determinants of inpatient and outpatient morbidity. Thiocolchicoside is a semisynthetic derivate of naturally occurring colchicoside, which is largely used in humans as a centrally acting muscle relaxant. Epileptic seizures after thiocolchicoside intake have been reported...

journal_title：Therapeutics and clinical risk management

authors： Giavina-Bianchi P,Giavina-Bianchi M,Tanno LK,Ensina LF,Motta AA,Kalil J

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Acute diarrhea is the major cause of child morbidity and mortality in low-income nations. It is the second most common cause of death among children <5 years of age globally. The indispensable role of community pharmacists is clearly observed in the prevention and treatment of diarrhea. However, there is a p...

journal_title：Therapeutics and clinical risk management

authors： Abegaz TM,Belachew SA,Abebe TB,Gebresilassie BM,Teni FS,Woldie HG

更新日期：2016-04-05 00:00:00

abstract：Introduction:Preservation of endodontically treated teeth (ETT) depends upon several patient-related and operator-related factors. The objectives of this study were to assess the effects of different types of coronal restoration and delayed placement on ETT survival. Methods:Data on dates of root canal treatment (RCT)...

journal_title：Therapeutics and clinical risk management

authors： Sadaf D

更新日期：2020-02-21 00:00:00

abstract：OBJECTIVES:The objective of this study is to mathematically evaluate the influence of multiple factors on implant stability quotient values in clinical practice. PATIENTS AND METHODS:Resonance frequency analysis was performed at T1 (measured immediately at the time of implant placement) and at T2 (measured before dent...

journal_title：Therapeutics and clinical risk management

authors： Huang H,Wismeijer D,Shao X,Wu G

更新日期：2016-10-11 00:00:00

abstract：:The treatment of ankylosing spondylitis (AS) and psoriatic arthritis (PsA) positively changed since the introduction of anti-TNFα drugs. These treatments were shown to reduce the symptoms and signs of the diseases and improve the quality of life. However, a variable percentage of patients do not respond to anti-TNFα o...

journal_title：Therapeutics and clinical risk management

authors： Lubrano E,Perrotta FM

更新日期：2016-10-21 00:00:00

abstract：:Background: To report our experience with retroperitoneal robot-assisted laparoscopic upper pole heminephrectomy in adult patients with duplex kidneys. Methods: We retrospectively reviewed the medical records of 7 patients who underwent retroperitoneal robot-assisted laparoscopic upper pole heminephrectomy at our inst...

journal_title：Therapeutics and clinical risk management

authors： Qin J,Wang P,Jing T,Kong D,Ye S,Xia D,Wang S

更新日期：2019-06-11 00:00:00

abstract：:The management of acute episodes in schizophrenia is frequently initiated in the psychiatric emergency department and requires rapid intervention to relieve distress and psychiatric symptoms. Both non-pharmacological and pharmacological interventions are needed to calm the patient and prevent potential harm to the pat...

journal_title：Therapeutics and clinical risk management

authors： Nuss P,Hummer M,Tessier C

更新日期：2007-03-01 00:00:00

abstract：:Poorly controlled asthma is currently treated by adding or removing asthma medication in a stepwise fashion to try and improve symptoms and maintain lung function. It is becoming apparent that asthma exacerbations are independent of asthma control and severity, and that the simple method of using rescue courses of cor...

journal_title：Therapeutics and clinical risk management

authors： Shaw DE,Green RH,Bradding P

更新日期：2005-12-01 00:00:00

abstract：Background:Although complications have been associated with head clamp systems, few reports have described head slippage. The present study aimed to determine risk factors for head slippage and speculated that the position of head holder pins might be associated. Patients and Methods:We reviewed medical records and co...

journal_title：Therapeutics and clinical risk management

authors： Sakakura K,Fujimoto A,Ichikawa N,Ishikawa E,Matsumura A,Enoki H,Okanishi T

更新日期：2020-03-25 00:00:00

abstract：Purpose:According to the WHO vancomycin-resistant Enterococcus faecium (VRE) belongs to the microorganisms for which new antibiotics are urgently needed. Depending on the type of vancomycin resistance vanA gene VRE is differentiated from vanB VRE and other types. In this retrospective analysis the results of VRE survei...

journal_title：Therapeutics and clinical risk management

authors： Borgmann S,Rieß B,Siegmund R,Werner G,Klare I

更新日期：2019-02-27 00:00:00

abstract：Background:Treatment-related problems (TRPs) may pose risks for patients if unaddressed. With the increased complexity of health care, it is important to target pharmacists' efforts to patients that are at high risk for TRPs. Objectives:The present study aimed to identify medications most commonly associated with TRPs...

journal_title：Therapeutics and clinical risk management

authors： Al-Taani GM,Al-Azzam SI,Alzoubi KH,Aldeyab MA

更新日期：2018-11-16 00:00:00

abstract：PURPOSE:To report two cases of chronic postoperative cystoid macular edema, resistant to topical therapy, treated with consecutive intravitreal injections of ketorolac tromethamine. METHODS:Four daily intravitreal injections of 500 μg/0.05 mL of ketorolac were given to each patient. Complete clinical examination and O...

journal_title：Therapeutics and clinical risk management

authors： Tsilimbaris MK,Tsika C,Kymionis GD

更新日期：2016-02-12 00:00:00

abstract：BACKGROUND:Iron-deficiency anemia is the most common nutritional cause of anemia in pregnancy and is often responsible for puerperal anemia. Puerperal anemia can impair postpartum maternal and neonatal well-being. OBJECTIVE:To determine the effect of treatment of moderate puerperal iron-deficiency anemia using a singl...

journal_title：Therapeutics and clinical risk management

authors： Iyoke CA,Emegoakor FC,Ezugwu EC,Lawani LO,Ajah LO,Madu JA,Ezegwui HU,Ezugwu FO

更新日期：2017-05-17 00:00:00

abstract：BACKGROUND:Multifactor cardiovascular disease is the leading cause of death; besides well-known cardiovascular risk factors, several emerging factors such as mental stress, diet type, and physical inactivity, have been associated to cardiovascular disease. To date, preventive strategies are based on the concept of abso...

journal_title：Therapeutics and clinical risk management

authors： Franchi D,Cini D,Iervasi G

更新日期：2011-01-01 00:00:00

abstract：Purpose:Postoperative urinary retention (POUR) is one of the most common complications following spinal anesthesia. Spinal anesthesia may influence urinary bladder function due to interruption of the micturition reflex. Urinary catheterization is the standard treatment of POUR. Urinary catheter insertion is an invasive...

journal_title：Therapeutics and clinical risk management

authors： Senapathi TGA,Wiryana M,Subagiartha IM,Suarjaya IPP,Widnyana IMG,Sutawan IBKJ,Jaya AAGPS,Thewidya A

更新日期：2018-09-11 00:00:00