Seven years' experience with etidronate in a woman with anorexia nervosa and vertebral fractures.

Abstract:

:We report the case of a 30-year-old Japanese woman with anorexia nervosa and vertebral fractures who was treated with etidronate. She had a history of anorexia nervosa, chronic back pain, osteoporosis, and multiple vertebral fractures (morphometric fractures) that responded poorly to treatment with alfacalcidol (1 μg daily) for 1 year and was treated with cyclical etidronate (200 mg for 2 weeks every 3 months) for 7 years. The lumbar spine bone mineral density (BMD) increased, and the serum alkaline phosphatase and urinary cross-linked N-terminal telopeptides of type I collagen levels and back pain decreased. During the 7-year period of treatment with etidronate, no osteoporotic fractures occurred. The patient experienced neither renal dysfunction nor hyperparathyroidism caused by osteomalacia. No gastrointestinal tract symptoms were observed. Thus, etidronate was effective for increasing the lumbar spine BMD and reducing back pain over a 7-year period without causing either osteoporotic fractures or adverse events.

journal_name

Ther Clin Risk Manag

authors

Iwamoto J,Sato Y,Uzawa M,Takeda T,Matsumoto H

doi

10.2147/TCRM.S21357

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

275-81

eissn

1176-6336

issn

1178-203X

pii

tcrm-7-275

journal_volume

7

pub_type

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