Clinical utility of ingenol mebutate in the management of actinic keratosis: perspectives from clinical practice.

abstract：BACKGROUND:Internationally, there is a remarkable achievement in the areas of drug discovery, drug design, and clinical trials. New and efficient drug formulation techniques are widely available which have led to success in treatment of several diseases. Despite these achievements, large number of patients continue to ...

journal_title：Therapeutics and clinical risk management

authors： Abubakar AR,Ismail S,Rahman NI,Haque M

更新日期：2015-06-30 00:00:00

abstract：BACKGROUND:Adverse drug reactions are important determinants of inpatient and outpatient morbidity. Thiocolchicoside is a semisynthetic derivate of naturally occurring colchicoside, which is largely used in humans as a centrally acting muscle relaxant. Epileptic seizures after thiocolchicoside intake have been reported...

journal_title：Therapeutics and clinical risk management

authors： Giavina-Bianchi P,Giavina-Bianchi M,Tanno LK,Ensina LF,Motta AA,Kalil J

更新日期：2009-06-01 00:00:00

abstract：Objective:Retrospective studies and a meta-analysis were performed to evaluate the safety and effectiveness of the perioperative administration of recombinant human brain natriuretic peptide (rhBNP) during cardiac surgery under extracorporeal circulation. Methods:Computerized literature searches were performed in Medl...

journal_title：Therapeutics and clinical risk management

authors： Hua P,Liu J,Tao J,Lin X,Zou R,Zhang D,Yang S

更新日期：2018-02-20 00:00:00

abstract：:The development of nonsteroidal anti-inflammatory drugs (NSAIDs) selective for cyclooxygenase (COX)-2 (named coxibs) has been driven by the aim of reducing the incidence of serious gastrointestinal (GI) adverse events associated with the administration of traditional (t) NSAIDs - mainly dependent on the inhibition of ...

journal_title：Therapeutics and clinical risk management

authors： Patrignani P,Tacconelli S,Capone ML

更新日期：2008-10-01 00:00:00

abstract：:The lupus band test (LBT) is a diagnostic procedure that is used to detect deposits of immunoglobulins and complement components along the dermoepidermal junction in patients with lupus erythematosus (LE). The LBT is positive in about 70%-80% of sun-exposed non-lesional skin specimens obtained from patients with syste...

journal_title：Therapeutics and clinical risk management

authors： Reich A,Marcinow K,Bialynicki-Birula R

更新日期：2011-01-24 00:00:00

abstract：:Sodium disorders are the most common and most poorly understood electrolyte disorders in neurological patients. The aim of this study was to determine the incidence of sodium disorders and its association with different traumatic brain injuries. This prospective study was conducted in 80 patients diagnosed with modera...

journal_title：Therapeutics and clinical risk management

authors： Paiva WS,Bezerra DA,Amorim RL,Figueiredo EG,Tavares WM,De Andrade AF,Teixeira MJ

更新日期：2011-01-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) and Candidal prosthetic joint infections (PJIs) are very rare, and the optimal management for these patients is still unknown. A 54-year-old man with traumatic arthritis due to previous electric injury successfully retained the implant despite the successive infection...

journal_title：Therapeutics and clinical risk management

authors： Xiang Y,Xuan YY,Li G

更新日期：2018-06-20 00:00:00

abstract：Purpose:We aimed to build a model to qualitatively and quantitatively evaluate publications of research of spinal cord injury rehabilitation from 1997 to 2016. Methods:Data were obtained from the Web of Science Core Collection on October 6, 2017. We conducted a qualitative and quantitative analysis of publication outp...

journal_title：Therapeutics and clinical risk management

authors： Liu X,Liu N,Zhou M,Lu Y,Li F

更新日期：2018-12-17 00:00:00

abstract：:Coronary and cerebrovascular atherothrombosis are the leading cause of mortality and morbidity worldwide. Novel antiplatelet agents have been established for the management of patients with clinically evident coronary atherothrombosis and are increasingly used in these patients. These agents, however, have shown limit...

journal_title：Therapeutics and clinical risk management

authors： Iannopollo G,Camporotondo R,De Ferrari GM,Leonardi S

更新日期：2014-05-02 00:00:00

abstract：:Angioid streaks are visible irregular crack-like dehiscences in Bruch's membrane that are associated with atrophic degeneration of the overlying retinal pigmented epithelium. Angioid streaks may be associated with pseudoxanthoma elasticum, Paget's disease, sickle-cell anemia, acromegaly, Ehlers-Danlos syndrome, and di...

journal_title：Therapeutics and clinical risk management

authors： Georgalas I,Papaconstantinou D,Koutsandrea C,Kalantzis G,Karagiannis D,Georgopoulos G,Ladas I

更新日期：2009-02-01 00:00:00

abstract：:The purpose of this review was to test contraceptive efficacy, cycle control, tolerability, and acceptability as found in the non-comparative studies with NuvaRing((R)) by those found in the randomized trials comparing NuvaRing and combined oral contraceptives (COCs). All large non-comparative studies and all relevant...

journal_title：Therapeutics and clinical risk management

authors： Roumen FJ

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:To report two cases of chronic postoperative cystoid macular edema, resistant to topical therapy, treated with consecutive intravitreal injections of ketorolac tromethamine. METHODS:Four daily intravitreal injections of 500 μg/0.05 mL of ketorolac were given to each patient. Complete clinical examination and O...

journal_title：Therapeutics and clinical risk management

authors： Tsilimbaris MK,Tsika C,Kymionis GD

更新日期：2016-02-12 00:00:00

abstract：:Soft tissue sarcomas (STSs) are a group of rare tumors accounting for less than 1% of all adult malignant tumors, a heterogeneous group of more than 50 histological subtypes. Five percent to 30% of STS patients experience local recurrence and 10%-38% present with clinically detectable metastases. Doxorubicin either al...

journal_title：Therapeutics and clinical risk management

authors： Nakamura T,Matsumine A,Sudo A

更新日期：2016-01-13 00:00:00

abstract：:A formal risk assessment for identifying high-risk patients is essential in clinical practice and promoted in guidelines for the management of anterior acute myocardial infarction. In this study, we sought to evaluate the performance of different machine learning models in predicting the 1-year mortality rate of anter...

journal_title：Therapeutics and clinical risk management

authors： Li YM,Jiang LC,He JJ,Jia KY,Peng Y,Chen M

更新日期：2020-01-09 00:00:00

abstract：OBJECTIVES:The objective of this study is to mathematically evaluate the influence of multiple factors on implant stability quotient values in clinical practice. PATIENTS AND METHODS:Resonance frequency analysis was performed at T1 (measured immediately at the time of implant placement) and at T2 (measured before dent...

journal_title：Therapeutics and clinical risk management

authors： Huang H,Wismeijer D,Shao X,Wu G

更新日期：2016-10-11 00:00:00

abstract：Background:Treatment-related problems (TRPs) may pose risks for patients if unaddressed. With the increased complexity of health care, it is important to target pharmacists' efforts to patients that are at high risk for TRPs. Objectives:The present study aimed to identify medications most commonly associated with TRPs...

journal_title：Therapeutics and clinical risk management

authors： Al-Taani GM,Al-Azzam SI,Alzoubi KH,Aldeyab MA

更新日期：2018-11-16 00:00:00

abstract：BACKGROUND:This study aims to investigate differences between continuous epidural infusion (CEI) and programmed intermittent epidural bolus (IEB) analgesia for the Chinese parturients undergoing spontaneous delivery and to approach their safety to parturients and neonates. METHODS:Two hundred healthy American Society ...

journal_title：Therapeutics and clinical risk management

authors： Lin Y,Li Q,Liu J,Yang R,Liu J

更新日期：2016-07-14 00:00:00

abstract：AIM:To compare the long-term survival outcomes of radiofrequency ablation and liver resection for single very early/early stage hepatocellular carcinoma (HCC). METHODS:The Cochrane Library (Issue 3, 2015), Embase (1974 to March 15, 2015), PubMed (1950 to March 15, 2015), Web of Science (1900 to March 15, 2015), and Ch...

journal_title：Therapeutics and clinical risk management

authors： He ZX,Xiang P,Gong JP,Cheng NS,Zhang W

更新日期：2016-02-23 00:00:00

abstract：:The introduction of TNFα blockers has revolutionized the treatment of ankylosing spondylitis (AS). The objectives of this review are to summarize the most up-to-date data on long-term efficacy and safety of infliximab in AS, with special emphasis on axial and extra-articular disease, predictors of response, and radiol...

journal_title：Therapeutics and clinical risk management

authors： Elalouf O,Elkayam O

更新日期：2015-11-19 00:00:00

abstract：:Preterm birth is the major cause of perinatal morbidity and mortality in the developed world, and spontaneous preterm labor is the commonest cause of preterm birth. Interventions to treat women in spontaneous preterm labor have not reduced the incidence of preterm births but this may be due to increased risk factors, ...

journal_title：Therapeutics and clinical risk management

authors： Sanu O,Lamont RF

更新日期：2010-04-26 00:00:00

abstract：:A utilization study was performed in a 2200-bed tertiary care teaching hospital. Data mining was performed on all nasogastric medication prescriptions for patients hospitalized in 2011. Nurses were interviewed by questionnaire. A PDCA (Plan-Do-Check-Act) cycle was used for continuous quality improvement. The proportio...

journal_title：Therapeutics and clinical risk management

authors： Zhu LL,Xu LC,Wang HQ,Jin JF,Wang HF,Zhou Q

更新日期：2012-01-01 00:00:00

abstract：:Procarbazine HCl is a 'nonclassical' oral alkylating anticancer agent that was first synthesized in the late 1950s. It has been used in the treatment of many cancers, but its main use is in the treatment of Hodgkin's lymphoma and brain tumors and, to a lesser extent, Non-Hodgkin's lymphoma and primary central nervous ...

journal_title：Therapeutics and clinical risk management

authors： Armand JP,Ribrag V,Harrousseau JL,Abrey L

更新日期：2007-06-01 00:00:00

abstract：:Hepatitis C virus (HCV) management in the transplant setting is still an open issue. The therapeutic strategies being addressed include: (a) pre-transplant prophylaxis (to prevent the infection of the transplanted organ); (b) post-transplant prophylaxis (to reduce the possibility of developing acute hepatitis); (c) ma...

journal_title：Therapeutics and clinical risk management

authors： Picciotto A

更新日期：2006-03-01 00:00:00

abstract：Background:The effect of continuous positive airway pressure (CPAP) on nasal symptoms in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) remains controversial. In addition, possible mechanism(s) remains unclear. Objective:To examine whether CPAP contributes to the onset and exacerbation of allergic rhi...

journal_title：Therapeutics and clinical risk management

authors： Yang Q,Li H,Wu W,Huang X,Tu B,Ma Y,Deng H,Li M,He H,Li C,Yang Y

更新日期：2018-08-24 00:00:00

abstract：Purpose:Postoperative urinary retention (POUR) is one of the most common complications following spinal anesthesia. Spinal anesthesia may influence urinary bladder function due to interruption of the micturition reflex. Urinary catheterization is the standard treatment of POUR. Urinary catheter insertion is an invasive...

journal_title：Therapeutics and clinical risk management

authors： Senapathi TGA,Wiryana M,Subagiartha IM,Suarjaya IPP,Widnyana IMG,Sutawan IBKJ,Jaya AAGPS,Thewidya A

更新日期：2018-09-11 00:00:00

abstract：:Ongoing neuronal death in Parkinson's disease (PD) causes an altered neurotransmission of various biogenic amines, particularly dopamine. As these changes do not follow a distinct pattern, they vary individually, and are differently pronounced. As a result, a heterogeneous onset of motor and nonmotor features occurs i...

journal_title：Therapeutics and clinical risk management

authors： Müller T

更新日期：2016-08-02 00:00:00

abstract：Background:Cardiovascular diseases (CVDs) are the main complication leading to morbidity and mortality among patients with type 2 diabetes mellitus (T2DM). There is a large amount of evidence to support the use of lipid-lowering therapy (LLT) for the prevention of CVD. This study aimed to assess the effectiveness and p...

journal_title：Therapeutics and clinical risk management

authors： Elnaem MH,Mohamed MHN,Huri HZ,Shah ASM

更新日期：2019-01-18 00:00:00

abstract：Purpose:Videolaryngoscopy in nasotracheal intubation has been reported to be better than direct laryngoscopy. The most suitable type of videolaryngoscope remains unknown. This study aimed to compare two videolaryngoscopes (McGrath MAC and Pentax AWS) with a Macintosh laryngoscope during nasotracheal intubation. Method...

journal_title：Therapeutics and clinical risk management

authors： Chae YJ,Kim DH,Park EJ,Oh J,Yi IK

更新日期：2019-09-18 00:00:00

abstract：Purpose:To compare running suture (RS) and interrupted suture (IS) of vesicourethral anastomosis (VUA) during open retropubic radical prostatectomy (RRP) on early urinary continence and extravasation. Patients and Methods:Single center analysis of 211 patients who underwent RRP performed by a single surgeon during 200...

journal_title：Therapeutics and clinical risk management

authors： Köhler N,El-Bandar N,Maxeiner A,Ralla B,Miller K,Busch J,Friedersdorff F

更新日期：2020-12-23 00:00:00

abstract：:Prostacyclin is an endogenous eicosanoid produced by endothelial cells; through actions on vascular smooth-muscle cells, it promotes vasodilation. Pulmonary arterial hypertension (PAH) is characterized by elevated mean pulmonary artery pressure due to a high pulmonary vascular resistance state. A relative decrease in ...

journal_title：Therapeutics and clinical risk management

authors： LeVarge BL

更新日期：2015-03-31 00:00:00