Secukinumab for ankylosing spondylitis and psoriatic arthritis.

abstract：:Use of non-vitamin K antagonist oral anticoagulants is spreading in the real world. Despite that, a strong need for antidotes/reversal agents is still reported by several physicians. Idarucizumab is a humanized monoclonal antibody fragment that binds specifically to dabigatran. Idarucizumab was approved in 2015 by the...

journal_title：Therapeutics and clinical risk management

authors： Proietti M,Boriani G

更新日期：2018-08-22 00:00:00

abstract：:The topoisomerase I inhibitor topotecan is the only single-agent therapy approved for the treatment of recurrent small cell lung cancer (SCLC). Many patients with recurrent SCLC may be predisposed to treatment-related adverse events because of the presence of comorbidities such as advanced age, renal impairment, or ex...

journal_title：Therapeutics and clinical risk management

authors： Garst J

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the knowledge, attitude and barriers of pharmacy technicians and pharmacists toward pharmacovigilance, adverse drug reactions (ADRs) and ADR reporting in community pharmacies in Yemen. METHODS:This cross-sectional survey was conducted among community pharmacists and pharm...

journal_title：Therapeutics and clinical risk management

authors： Al-Worafi YM,Kassab YW,Alseragi WM,Almutairi MS,Ahmed A,Ming LC,Alkhoshaiban AS,Hadi MA

更新日期：2017-09-07 00:00:00

abstract：BACKGROUND:Traditional Chinese medicine (TCM) and Western medicine are both popular in Taiwan. Approximately 14.1% of Taiwanese residents use Western drugs and Chinese herbs concurrently; therefore, drug-herb interaction is critical to patient safety. This paper presents a new procedure for reducing the risk of drug in...

journal_title：Therapeutics and clinical risk management

authors： Lin SS,Tsai CL,Tu CY,Hsieh CL

更新日期：2015-02-16 00:00:00

abstract：Introduction:Severe hand, foot, and mouth disease (HFMD) may lead to serious complications, which cause child mortality during outbreaks. The aim of this study was to determine whether neutrophil-to-lymphocyte ratio (NLR) can predict death risk in severe HFMD. Methods:Medical records for 664 severe HFMD patients were ...

journal_title：Therapeutics and clinical risk management

authors： Li Y,Wang M,Wang W,Feng D,Deng H,Zhang Y,Dang S,Zhai S

更新日期：2020-10-23 00:00:00

abstract：:Hepatitis C virus (HCV) management in the transplant setting is still an open issue. The therapeutic strategies being addressed include: (a) pre-transplant prophylaxis (to prevent the infection of the transplanted organ); (b) post-transplant prophylaxis (to reduce the possibility of developing acute hepatitis); (c) ma...

journal_title：Therapeutics and clinical risk management

authors： Picciotto A

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:This study aims to investigate differences between continuous epidural infusion (CEI) and programmed intermittent epidural bolus (IEB) analgesia for the Chinese parturients undergoing spontaneous delivery and to approach their safety to parturients and neonates. METHODS:Two hundred healthy American Society ...

journal_title：Therapeutics and clinical risk management

authors： Lin Y,Li Q,Liu J,Yang R,Liu J

更新日期：2016-07-14 00:00:00

abstract：BACKGROUND:Adverse drug reactions are important determinants of inpatient and outpatient morbidity. Thiocolchicoside is a semisynthetic derivate of naturally occurring colchicoside, which is largely used in humans as a centrally acting muscle relaxant. Epileptic seizures after thiocolchicoside intake have been reported...

journal_title：Therapeutics and clinical risk management

authors： Giavina-Bianchi P,Giavina-Bianchi M,Tanno LK,Ensina LF,Motta AA,Kalil J

更新日期：2009-06-01 00:00:00

abstract：Purpose:We conducted this meta-analysis to evaluate the efficacy of hybrid grafts in anterior cruciate ligament reconstruction (ACLR). Methods:We performed an electronic search of the Cochrane Library, PubMed, Embase, and ScienceDirect from the inception of these databases to February 2018, based on the terms "anterio...

journal_title：Therapeutics and clinical risk management

authors： Wang L,Cao JG,Liu J

更新日期：2019-03-14 00:00:00

abstract：:Antimicrobial agents are the most valuable means available for treating bacterial infections. However, the administration of therapeutic doses of antimicrobial agents to patients is a leading cause of disturbance of the normal gastrointestinal microflora. This disturbance results in diminishing the natural defense mec...

journal_title：Therapeutics and clinical risk management

authors： Rafii F,Sutherland JB,Cerniglia CE

更新日期：2008-12-01 00:00:00

abstract：Purpose:To determine the early effects of intravitreal anti-VEGF and dexamethasone application on blood flow velocities in patients with retinal vein occlusions. Methods:The ophthalmic (OA) and the central retinal arteries (CRAs) of the affected and unaffected eyes of 21 patients with central retinal vein occlusion (C...

journal_title：Therapeutics and clinical risk management

authors： Ciloglu E,Yıldırım Celikdemir A

更新日期：2019-07-04 00:00:00

abstract：:Paclitaxel is an anticancer agent effective for the treatment of breast, ovarian, lung, and head and neck cancer. Because of water insolubility, paclitaxel is formulated with the micelle-forming vehicle Cremophor EL to enhance drug solubility. However, the addition of Cremophor EL results in hypersensitivity reactions...

journal_title：Therapeutics and clinical risk management

authors： Scripture CD,Figg WD,Sparreboom A

更新日期：2005-06-01 00:00:00

abstract：:Cariprazine is a recently developed antipsychotic drug with a partial agonism for the D2 and D3 receptors. It shows a tenfold greater affinity for the D3 receptor. In clinical trials, its therapeutic effect has been tested in patients with an acute exacerbation of schizophrenia and in patients with acute mania in bipo...

journal_title：Therapeutics and clinical risk management

authors： Werner FM,Coveñas R

更新日期：2015-11-02 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is highly endemic in certain regions including the People's Republic of China and Southeast Asia. Its etiology is unique and multifactorial, involving genetic background, epigenetic, and environment factors, including Epstein-Barr virus (EBV) infection. The presence of EBV in all tumor c...

journal_title：Therapeutics and clinical risk management

authors： Hutajulu SH,Kurnianda J,Tan IB,Middeldorp JM

更新日期：2014-09-05 00:00:00

abstract：:Cetuximab is a monoclonal antibody able to inhibit and to degrade the transmembrane receptor Her-1, also known as epidermal growth factor receptor (EGFR). The inhibition of EGFR is of major importance since the receptor influences many important tumor cell activities including tumor growth, neo-angiogenesis, inhibitio...

journal_title：Therapeutics and clinical risk management

authors： Merlano M,Occelli M

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Hypertension is a highly prevalent risk factor for cardiovascular disease in patients with type 1 diabetes mellitus. Elevated blood pressure (BP) promotes the development and progression of microvascular complications, eg, nephropathy and retinopathy. The purpose of this study was to identify and detect earl...

journal_title：Therapeutics and clinical risk management

authors： Shalaby NM,Shalaby NM

更新日期：2015-10-05 00:00:00

abstract：PURPOSE:To report two cases of chronic postoperative cystoid macular edema, resistant to topical therapy, treated with consecutive intravitreal injections of ketorolac tromethamine. METHODS:Four daily intravitreal injections of 500 μg/0.05 mL of ketorolac were given to each patient. Complete clinical examination and O...

journal_title：Therapeutics and clinical risk management

authors： Tsilimbaris MK,Tsika C,Kymionis GD

更新日期：2016-02-12 00:00:00

abstract：:Psoriasis is a common, chronic, inflammatory skin disease that can have a significant impact on the quality of life of those who are afflicted. Recent advances in the understanding of the pathophysiology of psoriasis have led to the development of new, genetically engineered, targeted therapies for this disease. Among...

journal_title：Therapeutics and clinical risk management

authors： Alwawi EA,Mehlis SL,Gordon KB

更新日期：2008-04-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) and Candidal prosthetic joint infections (PJIs) are very rare, and the optimal management for these patients is still unknown. A 54-year-old man with traumatic arthritis due to previous electric injury successfully retained the implant despite the successive infection...

journal_title：Therapeutics and clinical risk management

authors： Xiang Y,Xuan YY,Li G

更新日期：2018-06-20 00:00:00

abstract：:Denosumab is a breakthrough biological drug approved by the Food and Drug Administration and European Medicines Agency for the treatment of osteoporosis in 2010. It is a fully human monoclonal antireceptor activator of nuclear factor kappa-B ligand antibody, which inhibits the activity of osteoclasts, resulting in an ...

journal_title：Therapeutics and clinical risk management

authors： Cavalli L,Brandi ML

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Controversy remains regarding the optimal treatment method and postoperative rehabilitation of acute Achilles tendon ruptures. In this study, pedobarographic assessments of surgical and conservative treatments were compared. MATERIAL AND METHODS:A prospective assessment was made of 16 patients (eight surg...

journal_title：Therapeutics and clinical risk management

authors： Karaaslan F,Mermerkaya MU,Çıraklı A,Karaoğlu S,Duygulu F

更新日期：2016-08-29 00:00:00

abstract：Objective:Retrospective studies and a meta-analysis were performed to evaluate the safety and effectiveness of the perioperative administration of recombinant human brain natriuretic peptide (rhBNP) during cardiac surgery under extracorporeal circulation. Methods:Computerized literature searches were performed in Medl...

journal_title：Therapeutics and clinical risk management

authors： Hua P,Liu J,Tao J,Lin X,Zou R,Zhang D,Yang S

更新日期：2018-02-20 00:00:00

abstract：Background:Despite the considerable experience gained thus far using endoscopic technologies, the role of total endoscopic thyroidectomy (ET) for papillary thyroid cancer (PTC) remains controversial. We conducted a systematic review and meta-analysis to investigate the safety and effectiveness of total ET compared with...

journal_title：Therapeutics and clinical risk management

authors： Chen C,Huang S,Huang A,Jia Y,Wang J,Mao M,Zhou J,Wang L

更新日期：2018-12-05 00:00:00

abstract：:Glucocorticoids are commonly used in various fields within medicine. One of their most common and clinically significant side effects is glucocorticoid-induced osteoporosis (GIOP). GIOP is a disease leading to progressive decreases in bone mineral density, decreased bone strength, and increased risk of skeletal fractu...

journal_title：Therapeutics and clinical risk management

authors： Lau AN,Adachi JD

更新日期：2010-10-21 00:00:00

abstract：:Behçet's disease is an autoinflammatory vasculitis of unknown origin characterized by recurrent oral and genital ulcers, uveitis, arthritis and skin lesions. Additionally, involvement of the gastrointestinal tract, central nervous system and large vessels may occur. The disease is prevalent in countries along the anci...

journal_title：Therapeutics and clinical risk management

authors： van Daele PL,Kappen JH,van Hagen PM,van Laar JA

更新日期：2009-04-01 00:00:00

abstract：Background:Hydroxychloroquine (HCQ), one of the disease-modifying antirheumatic drugs, may lead to an inhibition of autophagy. Autophagy, an intracellular self-defense mechanism for the lysosomal degradation of cytoplasmic components such as damaged organelles, plays a role in protecting against neoplasm growth but is ...

journal_title：Therapeutics and clinical risk management

authors： Mao IC,Lin CY,Wu CL,Kor CT,Chang CC

更新日期：2018-08-20 00:00:00

abstract：BACKGROUND:The irradiation of head and neck cancer (HNC) often causes damage to the salivary glands. The resulting salivary gland hypofunction and xerostomia seriously reduce the patient's quality of life. PURPOSE:To analyze the literature of actual management strategies for radiation-induced hypofunction and xerostom...

journal_title：Therapeutics and clinical risk management

authors： Pinna R,Campus G,Cumbo E,Mura I,Milia E

更新日期：2015-02-04 00:00:00

abstract：Background:Cardiovascular diseases (CVDs) are the main complication leading to morbidity and mortality among patients with type 2 diabetes mellitus (T2DM). There is a large amount of evidence to support the use of lipid-lowering therapy (LLT) for the prevention of CVD. This study aimed to assess the effectiveness and p...

journal_title：Therapeutics and clinical risk management

authors： Elnaem MH,Mohamed MHN,Huri HZ,Shah ASM

更新日期：2019-01-18 00:00:00

abstract：:The C-MAC videolaryngoscope was evaluated for intubation in patients with predicted extremely difficult airway. The presented cases are patients with neoplasm tumors in larynx. In all cases, awake intubation using C-MAC videolaryngoscope was performed in patients breathing spontaneously, under local anaesthesia, with ...

journal_title：Therapeutics and clinical risk management

authors： Gaszyński T

更新日期：2018-03-14 00:00:00

abstract：Background:Our aim was to investigate the postoperative analgesic effect of ultrasound (US)-guided bilateral transversus abdominis plane (TAP) blocks combined with rectus sheath blocks (RSBs) in laparoscopic hepatectomy. Patients and Methods:A total of 126 patients were allocated into two groups for analysis. Group 1 ...

journal_title：Therapeutics and clinical risk management

authors： Lu X,Yu P,Ou C,Wang J,Zhou Z,Lai R

更新日期：2020-09-18 00:00:00