Abstract:
Introduction:Severe hand, foot, and mouth disease (HFMD) may lead to serious complications, which cause child mortality during outbreaks. The aim of this study was to determine whether neutrophil-to-lymphocyte ratio (NLR) can predict death risk in severe HFMD. Methods:Medical records for 664 severe HFMD patients were retrospectively examined, and NLR was calculated from blood counts. Youden's index was calculated to determine the optimal NLR cutoff. Uni- and multivariate logistic regression were used to determine death risk factors associated with severe HFMD. Results:An NLR cutoff value of 2.01 and 2.50 respectively predicted mortality among all 664 severe HFMD and 137 critical HFMD. Among all 664 patients, the multivariate model identified the following as independently associated with death risk: high fever (OR 3.342, 95% CI 1.736-6.432), EV71 infection (OR 3.200, 95% CI 1.529-6.698), fasting glucose (OR 37.343, 95% CI 18.616-74.909), and NLR (>2.01) (OR 2.142, 95% CI 1.125-4.079). Among 137 critical HFMD, EV71 infection (OR 3.441, 95% CI 1.132-10.462), fasting glucose (OR 14.173, 95% CI 4.920-40.827), and NLR (>2.50) (OR 4.166, 95% CI 1.570-11.051) were associated with death risk. Conclusion:In conclusion, NLR (>2.01) in severe HFMD and NLR (>2.50) in critical HFMD patients may be associated with increased death risk.
journal_name
Ther Clin Risk Managjournal_title
Therapeutics and clinical risk managementauthors
Li Y,Wang M,Wang W,Feng D,Deng H,Zhang Y,Dang S,Zhai Sdoi
10.2147/TCRM.S268130subject
Has Abstractpub_date
2020-10-23 00:00:00pages
1023-1029eissn
1176-6336issn
1178-203Xpii
268130journal_volume
16pub_type
杂志文章abstract::The advent of exponential growth of novel agents tested and approved for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) has brought about a need for understanding of the mechanism of action, side-effects, and clinical efficacy of these drugs as they relate to these patients. Thi...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章,评审
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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doi:10.2147/tcrm.2007.3.2.319
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/tcrm.2006.2.3.251
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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abstract::A 9-year-old girl was severely injured in a car accident in Afghanistan, in which both her lower legs were badly damaged. She was treated at the Hospital of Ingolstadt (Klinikum Ingolstadt) after she had undergone initial surgery at an Indian hospital. Various bacterial species were isolated from multiple wounds, and ...
journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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