Use of idarucizumab in reversing dabigatran anticoagulant effect: a critical appraisal.

Abstract:

:Use of non-vitamin K antagonist oral anticoagulants is spreading in the real world. Despite that, a strong need for antidotes/reversal agents is still reported by several physicians. Idarucizumab is a humanized monoclonal antibody fragment that binds specifically to dabigatran. Idarucizumab was approved in 2015 by the US Food and Drugs Administration and European Medicines Agency for reversal of anticoagulation activity in dabigatrantreated patients. This review briefly summarizes the experimental evidence about effectiveness and safety of idarucizumab. Furthermore, we review the current recommendations and experts' point of view about the use of antidotes/reversal agents in patients reporting a major bleeding event.

journal_name

Ther Clin Risk Manag

authors

Proietti M,Boriani G

doi

10.2147/TCRM.S140377

subject

Has Abstract

pub_date

2018-08-22 00:00:00

pages

1483-1488

eissn

1176-6336

issn

1178-203X

pii

tcrm-14-1483

journal_volume

14

pub_type

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