Abstract:
Purpose:To determine the early effects of intravitreal anti-VEGF and dexamethasone application on blood flow velocities in patients with retinal vein occlusions. Methods:The ophthalmic (OA) and the central retinal arteries (CRAs) of the affected and unaffected eyes of 21 patients with central retinal vein occlusion (CRVO), and 26 patients with branch retinal vein occlusion (BRVO) were investigated by Color Doppler imaging (CDI). Peak systolic volume (PSV), end diastolic volume (EDV), and average blood velocity (Vmean) of the CRA and OA were measured and resistive indexes (RI) were calculated at pre-injection and the 1st week and 1st month post-injection. Results:There was no statistically significant difference between the OA values for affected and unaffected eyes in the CRVO group before treatment. The CRA, EDV, and Vmean values were significantly lower in affected eyes. Blood flow velocities of both CRA and OA were not significantly different than in the fellow unaffected eyes in the BRVO group. The differences between PSV, EDV, and Vmean measurements of OA and CRA at different times pre- and post-injection in response to anti-VEGF and dexamethasone treatment in the CRVO group were significant; but there was no difference in RI value. OA blood flow velocity measurements were not statistically different post-injection in the BRVO group; however, the values of PSV and EDV of CRA decreased post-injection. Conclusion:Intravitreal anti-VEGF and dexamethasone implant may induce retinal arteriolar vasoconstriction in patients with retinal vein occlusion.
journal_name
Ther Clin Risk Managjournal_title
Therapeutics and clinical risk managementauthors
Ciloglu E,Yıldırım Celikdemir Adoi
10.2147/TCRM.S200658subject
Has Abstractpub_date
2019-07-04 00:00:00pages
823-830eissn
1176-6336issn
1178-203Xpii
200658journal_volume
15pub_type
杂志文章abstract:Background:Liver cirrhosis is an uncommon but not rare side effect of amiodarone-induced hepatotoxicity. Patients with hepatitis B virus and hepatitis C virus infections are at a high risk for developing liver cirrhosis. However, the relationship between this treatment and risk of liver cirrhosis in high-risk chronic h...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S174868
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abstract:BACKGROUND:Artemether-lumefantrine (AL) has been used as a first-line treatment for uncomplicated Plasmodium falciparum malaria in Ethiopia since 2004. Antimalarial drug resistance is one of the major obstacles for malaria control and curtails the lifespan of several drugs. Thus, continued monitoring of the efficacy of...
journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章,评审
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更新日期:2018-08-24 00:00:00
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
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更新日期:2007-08-01 00:00:00
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journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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更新日期:2019-01-18 00:00:00
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更新日期:2017-10-06 00:00:00
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