Updated Evaluation of Dupilumab in the Treatment of Asthma: Patient Selection and Reported Outcomes.

abstract：:Psoriasis is a common, chronic, inflammatory skin disease that can have a significant impact on the quality of life of those who are afflicted. Recent advances in the understanding of the pathophysiology of psoriasis have led to the development of new, genetically engineered, targeted therapies for this disease. Among...

journal_title：Therapeutics and clinical risk management

authors： Alwawi EA,Mehlis SL,Gordon KB

更新日期：2008-04-01 00:00:00

abstract：Purpose:Anastomotic leakage is a major surgical complication following esophagectomy and gastric pull-up. Specific risk factors such as celiac trunk (TC) stenosis and high calcification score of the aorta have been identified, but no data are available on their relative prognostic values. This retrospective study aimed...

journal_title：Therapeutics and clinical risk management

authors： Chang DH,Brinkmann S,Smith L,Becker I,Schroeder W,Hoelscher AH,Haneder S,Maintz D,Spiro JE

更新日期：2018-04-17 00:00:00

abstract：:The management of acute episodes in schizophrenia is frequently initiated in the psychiatric emergency department and requires rapid intervention to relieve distress and psychiatric symptoms. Both non-pharmacological and pharmacological interventions are needed to calm the patient and prevent potential harm to the pat...

journal_title：Therapeutics and clinical risk management

authors： Nuss P,Hummer M,Tessier C

更新日期：2007-03-01 00:00:00

abstract：:Hemodialysis (HD) patients are more susceptible to infective endocarditis (IE) due to the increased risk of bacterial invasion through intravascular access. However, it remains unclear whether the causative organisms and outcomes of IE in HD patients differ from those in non-HD patients. This study clarified the diffe...

journal_title：Therapeutics and clinical risk management

authors： Hsiao CC,Weng CH,Li YJ,Wu HH,Chen YC,Chen YM,Hsu HH,Tian YC

更新日期：2017-05-24 00:00:00

abstract：:Vorapaxar (ZONTIVITY™, formerly known as SCH 530348) is a specific, orally active antagonist of the protease-activated receptor-1 (PAR-1) on platelets. It inhibits thrombin-induced platelet activation by binding to the ectodomain of PAR-1. After animal studies and Phase II studies showed that vorapaxar sufficiently in...

journal_title：Therapeutics and clinical risk management

authors： Diehl P,Bode C,Duerschmied D

更新日期：2015-08-03 00:00:00

abstract：INTRODUCTION:Controversy remains regarding the optimal treatment method and postoperative rehabilitation of acute Achilles tendon ruptures. In this study, pedobarographic assessments of surgical and conservative treatments were compared. MATERIAL AND METHODS:A prospective assessment was made of 16 patients (eight surg...

journal_title：Therapeutics and clinical risk management

authors： Karaaslan F,Mermerkaya MU,Çıraklı A,Karaoğlu S,Duygulu F

更新日期：2016-08-29 00:00:00

abstract：BACKGROUND:Influenza A H1N1 and H3N2 are two influenza waves that have been identified in past years. METHODS:Data from 77 inpatients from three tertiary hospitals were included and statistical analysis was performed in three different clusters. RESULTS:Thirty-four patients (44.2%) had respiratory distress upon admis...

journal_title：Therapeutics and clinical risk management

authors： Petridis D,Zarogoulidis P,Kallianos A,Kioumis I,Trakada G,Spyratos D,Papaiwannou A,Porpodis K,Huang H,Rapti A,Hohenforst-Schmidt W,Zarogoulidis K

更新日期：2014-02-07 00:00:00

abstract：AIM:To evaluate the efficacy of glycopyrrolate oral solution (1 mg/5 mL) in managing problem drooling associated with cerebral palsy and other neurologic conditions. METHOD:Thirty-eight patients aged 3-23 years weighing at least 27 lb (12.2 kg) with severe drooling (clothing damp 5-7 days/week) were randomized to glyc...

journal_title：Therapeutics and clinical risk management

authors： Zeller RS,Lee HM,Cavanaugh PF,Davidson J

更新日期：2012-01-01 00:00:00

abstract：:Therapy of soft tissue sarcomas represents an area of significant unmet need in oncology. Angiogenesis has been explored as a potential target both preclinically and clinically, with suggestions of activity. Pazopanib is a multitargeted tyrosine kinase inhibitor with prominent antiangiogenic effects. In a Phase II stu...

journal_title：Therapeutics and clinical risk management

authors： Cranmer LD,Loggers ET,Pollack SM

更新日期：2016-06-09 00:00:00

abstract：Background:Cardiovascular diseases (CVD) combined with Type 2 diabetes mellitus (T2DM) frequently occurred. In this study, we aimed at exploring the prognostic significance of blood neutrophil-lymphocyte ratio (NLR) in these types of patients. Patients and Methods:Between June 30, 2010 and August 30, 2017, 1454 pati...

journal_title：Therapeutics and clinical risk management

authors： Qiao S,Gao W,Guo S

更新日期：2020-05-19 00:00:00

abstract：PURPOSE:A meta-analysis was conducted to evaluate the clinical outcomes, complications, reoperation rates, and late neurological deterioration between anterior decompression and fusion (ADF) and laminoplasty (LAMP) in the treatment of multilevel cervical ossification of the posterior longitudinal ligament (OPLL). METH...

journal_title：Therapeutics and clinical risk management

authors： Liu W,Hu L,Chou PH,Liu M,Kan W,Wang J

更新日期：2016-04-26 00:00:00

abstract：Background:The effect of continuous positive airway pressure (CPAP) on nasal symptoms in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) remains controversial. In addition, possible mechanism(s) remains unclear. Objective:To examine whether CPAP contributes to the onset and exacerbation of allergic rhi...

journal_title：Therapeutics and clinical risk management

authors： Yang Q,Li H,Wu W,Huang X,Tu B,Ma Y,Deng H,Li M,He H,Li C,Yang Y

更新日期：2018-08-24 00:00:00

abstract：:Selectins mediate tethering and rolling of leukocytes to the vascular endothelium, the first adhesive step in the recruitment of immune cells to inflamed tissues. Thus, selectins play a key role in the pathogenesis of common inflammatory skin disorders such as atopic dermatitis or psoriasis. As a consequence of their ...

journal_title：Therapeutics and clinical risk management

authors： Schön MP

更新日期：2005-09-01 00:00:00

abstract：:Erectile dysfunction (ED) is often perceived by both patients and sexual partners as a serious problem that can jeopardize quality of life, psychosocial or emotional well-being, and the partnership in the long term. Since their introduction, oral phosphodiesterase type 5 inhibitors (PDE5Is) have been found to be highl...

journal_title：Therapeutics and clinical risk management

authors： Cho MC,Paick JS

更新日期：2014-05-14 00:00:00

abstract：OBJECTIVE:To investigate the reactivation of the hepatitis B virus (HBV) following transarterial chemoembolization (TACE) in Chinese hepatocellular carcinoma (HCC) patients with low serum HBV DNA level, and to analyze the factors related to HBV reactivation in HCC patients with low serum HBV DNA level. METHODS:From No...

journal_title：Therapeutics and clinical risk management

authors： Shao W,Zhang F,Cong N,Li J,Song J

更新日期：2015-09-07 00:00:00

abstract：:Background: Avian AIV-H7N9 influenza progresses rapidly and has a high fatality rate. However, it lacks an early effective biomarker to predict disease severity and fatal outcomes successfully. Our study aimed to explore whether the neutrophil-to-lymphocyte ratio (NLR) taken within 24 h after admission can predict dis...

journal_title：Therapeutics and clinical risk management

authors： Zhang Y,Zou P,Gao H,Yang M,Yi P,Gan J,Shen Y,Wang W,Zhang W,Li J,Liu P,Li L

更新日期：2019-07-24 00:00:00

abstract：AIM:To compare the long-term survival outcomes of radiofrequency ablation and liver resection for single very early/early stage hepatocellular carcinoma (HCC). METHODS:The Cochrane Library (Issue 3, 2015), Embase (1974 to March 15, 2015), PubMed (1950 to March 15, 2015), Web of Science (1900 to March 15, 2015), and Ch...

journal_title：Therapeutics and clinical risk management

authors： He ZX,Xiang P,Gong JP,Cheng NS,Zhang W

更新日期：2016-02-23 00:00:00

abstract：:[This corrects the article on p. 19 in vol. 12, PMID: 26730198.]. ...

journal_title：Therapeutics and clinical risk management

authors：

更新日期：2016-03-10 00:00:00

abstract：:The purpose of this review was to test contraceptive efficacy, cycle control, tolerability, and acceptability as found in the non-comparative studies with NuvaRing((R)) by those found in the randomized trials comparing NuvaRing and combined oral contraceptives (COCs). All large non-comparative studies and all relevant...

journal_title：Therapeutics and clinical risk management

authors： Roumen FJ

更新日期：2008-04-01 00:00:00

abstract：:The most frequent causes of leg ulcers are chronic venous disease (CVD) related mainly to venous hypertension and peripheral arterial disease (PAD) related to disseminated atheromatous lesions in lower limb arteries. In 15%-21% of patients, ulcers of mixed venous-arterial etiology occur, which are usually more resista...

journal_title：Therapeutics and clinical risk management

authors： Pasek J,Cieślar G,Sieroń A

更新日期：2018-10-08 00:00:00

abstract：BACKGROUND:Metabolic syndrome is a worldwide disorder and also the major risk factor of several systemic diseases. Evidence identifying the association between metabolic syndrome and nephrolithiasis is lacking, especially in Taiwan. AIM:The aim of this study was to investigate the association between nephrolithiasis a...

journal_title：Therapeutics and clinical risk management

authors： Liu YT,Yang PY,Yang YW,Sun HY,Lin IC

更新日期：2017-01-06 00:00:00

abstract：INTRODUCTION:Renal cell carcinoma (RCC) represents 2%-3% of all cancers in adults, and its pathogenesis is mainly related to altered cellular response to hypoxia. Lenvatinib, a novel multitarget tyrosine kinase inhibitor (TKI), represents a therapeutic option, in combination with mammalian target of rapamycin (mTOR) in...

journal_title：Therapeutics and clinical risk management

authors： Leonetti A,Leonardi F,Bersanelli M,Buti S

更新日期：2017-06-30 00:00:00

abstract：Purpose:To compare running suture (RS) and interrupted suture (IS) of vesicourethral anastomosis (VUA) during open retropubic radical prostatectomy (RRP) on early urinary continence and extravasation. Patients and Methods:Single center analysis of 211 patients who underwent RRP performed by a single surgeon during 200...

journal_title：Therapeutics and clinical risk management

authors： Köhler N,El-Bandar N,Maxeiner A,Ralla B,Miller K,Busch J,Friedersdorff F

更新日期：2020-12-23 00:00:00

abstract：BACKGROUND:Despite the well recognized protective effect of cruciferous vegetables against various cancers, including human colorectal cancers, little is known about how this effect is conferred. It is thought that some phytochemicals found only in these vegetables confer the protection. These compounds include the glu...

journal_title：Therapeutics and clinical risk management

authors： McGrath DR,Frydoonfar H,Hunt JJ,Dunkley CJ,Spigelman AD

更新日期：2010-05-25 00:00:00

abstract：:Use of non-vitamin K antagonist oral anticoagulants is spreading in the real world. Despite that, a strong need for antidotes/reversal agents is still reported by several physicians. Idarucizumab is a humanized monoclonal antibody fragment that binds specifically to dabigatran. Idarucizumab was approved in 2015 by the...

journal_title：Therapeutics and clinical risk management

authors： Proietti M,Boriani G

更新日期：2018-08-22 00:00:00

abstract：BACKGROUND:This study aims to investigate differences between continuous epidural infusion (CEI) and programmed intermittent epidural bolus (IEB) analgesia for the Chinese parturients undergoing spontaneous delivery and to approach their safety to parturients and neonates. METHODS:Two hundred healthy American Society ...

journal_title：Therapeutics and clinical risk management

authors： Lin Y,Li Q,Liu J,Yang R,Liu J

更新日期：2016-07-14 00:00:00

abstract：BACKGROUND:Multifactor cardiovascular disease is the leading cause of death; besides well-known cardiovascular risk factors, several emerging factors such as mental stress, diet type, and physical inactivity, have been associated to cardiovascular disease. To date, preventive strategies are based on the concept of abso...

journal_title：Therapeutics and clinical risk management

authors： Franchi D,Cini D,Iervasi G

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Acute heart failure (AHF) is a serious condition that is associated with increased mortality in critically ill patients. Previous studies indicated that environmental exposure to cadmium increases mortality of general populations. However, the relationship of cadmium exposure and mortality is unclear for AHF...

journal_title：Therapeutics and clinical risk management

authors： Hsu CW,Weng CH,Lee CC,Lin-Tan DT,Chu PH,Chen KH,Yen TH,Huang WH

更新日期：2017-03-27 00:00:00

abstract：:Some specific features of the 24 h blood pressure (BP) pattern are linked to the progressive injury of target tissues and the triggering of cardiac and cerebrovascular events. In particular, many studies show the extent of the nocturnal BP decline relative to the diurnal BP mean (the diurnal/nocturnal ratio, an index ...

journal_title：Therapeutics and clinical risk management

authors： Hermida RC,Ayala DE,Calvo C

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:The irradiation of head and neck cancer (HNC) often causes damage to the salivary glands. The resulting salivary gland hypofunction and xerostomia seriously reduce the patient's quality of life. PURPOSE:To analyze the literature of actual management strategies for radiation-induced hypofunction and xerostom...

journal_title：Therapeutics and clinical risk management

authors： Pinna R,Campus G,Cumbo E,Mura I,Milia E

更新日期：2015-02-04 00:00:00