Pazopanib in the management of advanced soft tissue sarcomas.

abstract：:Antimicrobial resistant bacteria are an increasing concern due to the resulting increase in morbidity, mortality, and health-care costs associated with the administration of inadequate or delayed antimicrobial therapy. The implications of inadequate antimicrobial therapy in complicated skin and skin structure infectio...

journal_title：Therapeutics and clinical risk management

authors： Barbour A,Derendorf H

更新日期：2010-10-05 00:00:00

abstract：Purpose:We aimed to present our experience with total hip arthroplasty in patients with previous hip arthrodesis. Patients and methods:This was a retrospective study, in which clinical and radiological outcomes of total hip arthroplasty performed in 17 patients (mean age 54.2±8.5 years; age range 33-68 years; female t...

journal_title：Therapeutics and clinical risk management

authors： Çalbıyık M

更新日期：2018-04-11 00:00:00

abstract：:We present two typical cases of severe complications (sepsis and hemorrhage) after negative pressure wound therapy (NPWT) in burned patients. Necrotic tissues in some deep burn wounds are difficult to judge correctly and remove thoroughly. An electrically burned blood vessel looks "intact" but can easily break. Necrot...

journal_title：Therapeutics and clinical risk management

authors： Ren H,Li Y

更新日期：2014-07-01 00:00:00

abstract：:Experimental data indicate that several pharmacological agents that have long been used for the management of various diseases unrelated to cancer exhibit profound in vitro and in vivo anticancer activity. This is of major clinical importance, since it would possibly aid in reassessing the therapeutic use of currently...

journal_title：Therapeutics and clinical risk management

authors： Papanagnou P,Baltopoulos P,Tsironi M

更新日期：2015-05-18 00:00:00

abstract：:Ongoing neuronal death in Parkinson's disease (PD) causes an altered neurotransmission of various biogenic amines, particularly dopamine. As these changes do not follow a distinct pattern, they vary individually, and are differently pronounced. As a result, a heterogeneous onset of motor and nonmotor features occurs i...

journal_title：Therapeutics and clinical risk management

authors： Müller T

更新日期：2016-08-02 00:00:00

abstract：Background:Liver cirrhosis is an uncommon but not rare side effect of amiodarone-induced hepatotoxicity. Patients with hepatitis B virus and hepatitis C virus infections are at a high risk for developing liver cirrhosis. However, the relationship between this treatment and risk of liver cirrhosis in high-risk chronic h...

journal_title：Therapeutics and clinical risk management

authors： Huang CH,Lai YY,Kuo YJ,Yang SC,Chang YJ,Chang KK,Chen WK

更新日期：2019-01-10 00:00:00

abstract：Background:Cardiovascular diseases (CVD) combined with Type 2 diabetes mellitus (T2DM) frequently occurred. In this study, we aimed at exploring the prognostic significance of blood neutrophil-lymphocyte ratio (NLR) in these types of patients. Patients and Methods:Between June 30, 2010 and August 30, 2017, 1454 pati...

journal_title：Therapeutics and clinical risk management

authors： Qiao S,Gao W,Guo S

更新日期：2020-05-19 00:00:00

abstract：INTRODUCTION:We carried out an economic analysis to assess the cost-effectiveness of highly active antiretroviral therapy (HAART) regimens in Italy for the management of human immunodeficiency virus (HIV)-infected patients according to clinical practice in the Infectious Diseases Department of "L. Sacco" Hospital, Mila...

journal_title：Therapeutics and clinical risk management

authors： Rizzardini G,Bonfanti P,Carenzi L,Coen M,Orlando G,Di Matteo S,Colombo GL

更新日期：2012-01-01 00:00:00

abstract：:Vorapaxar (ZONTIVITY™, formerly known as SCH 530348) is a specific, orally active antagonist of the protease-activated receptor-1 (PAR-1) on platelets. It inhibits thrombin-induced platelet activation by binding to the ectodomain of PAR-1. After animal studies and Phase II studies showed that vorapaxar sufficiently in...

journal_title：Therapeutics and clinical risk management

authors： Diehl P,Bode C,Duerschmied D

更新日期：2015-08-03 00:00:00

abstract：Background:The effect of continuous positive airway pressure (CPAP) on nasal symptoms in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) remains controversial. In addition, possible mechanism(s) remains unclear. Objective:To examine whether CPAP contributes to the onset and exacerbation of allergic rhi...

journal_title：Therapeutics and clinical risk management

authors： Yang Q,Li H,Wu W,Huang X,Tu B,Ma Y,Deng H,Li M,He H,Li C,Yang Y

更新日期：2018-08-24 00:00:00

abstract：BACKGROUND:Adherence to antiretroviral treatment (ART) is important to achieve treatment success in human immunodeficiency virus (HIV)-infected patients. Most HIV clinics apply the patient self-report (PSR) method. However, the reliability of this method in experienced HIV patients remains questionable. PURPOSE:To val...

journal_title：Therapeutics and clinical risk management

authors： Minzi O,Mugoyela V,Gustafsson L

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:To report two cases of chronic postoperative cystoid macular edema, resistant to topical therapy, treated with consecutive intravitreal injections of ketorolac tromethamine. METHODS:Four daily intravitreal injections of 500 μg/0.05 mL of ketorolac were given to each patient. Complete clinical examination and O...

journal_title：Therapeutics and clinical risk management

authors： Tsilimbaris MK,Tsika C,Kymionis GD

更新日期：2016-02-12 00:00:00

abstract：AIM:To compare the long-term survival outcomes of radiofrequency ablation and liver resection for single very early/early stage hepatocellular carcinoma (HCC). METHODS:The Cochrane Library (Issue 3, 2015), Embase (1974 to March 15, 2015), PubMed (1950 to March 15, 2015), Web of Science (1900 to March 15, 2015), and Ch...

journal_title：Therapeutics and clinical risk management

authors： He ZX,Xiang P,Gong JP,Cheng NS,Zhang W

更新日期：2016-02-23 00:00:00

abstract：:The advent of exponential growth of novel agents tested and approved for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) has brought about a need for understanding of the mechanism of action, side-effects, and clinical efficacy of these drugs as they relate to these patients. Thi...

journal_title：Therapeutics and clinical risk management

authors： Patel NK,Finianos A,Whitaker KD,Aragon-Ching JB

更新日期：2014-08-16 00:00:00

abstract：INTRODUCTION:Renal cell carcinoma (RCC) represents 2%-3% of all cancers in adults, and its pathogenesis is mainly related to altered cellular response to hypoxia. Lenvatinib, a novel multitarget tyrosine kinase inhibitor (TKI), represents a therapeutic option, in combination with mammalian target of rapamycin (mTOR) in...

journal_title：Therapeutics and clinical risk management

authors： Leonetti A,Leonardi F,Bersanelli M,Buti S

更新日期：2017-06-30 00:00:00

abstract：AIM:To evaluate the efficacy of glycopyrrolate oral solution (1 mg/5 mL) in managing problem drooling associated with cerebral palsy and other neurologic conditions. METHOD:Thirty-eight patients aged 3-23 years weighing at least 27 lb (12.2 kg) with severe drooling (clothing damp 5-7 days/week) were randomized to glyc...

journal_title：Therapeutics and clinical risk management

authors： Zeller RS,Lee HM,Cavanaugh PF,Davidson J

更新日期：2012-01-01 00:00:00

abstract：:Behçet's disease is an autoinflammatory vasculitis of unknown origin characterized by recurrent oral and genital ulcers, uveitis, arthritis and skin lesions. Additionally, involvement of the gastrointestinal tract, central nervous system and large vessels may occur. The disease is prevalent in countries along the anci...

journal_title：Therapeutics and clinical risk management

authors： van Daele PL,Kappen JH,van Hagen PM,van Laar JA

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:The irradiation of head and neck cancer (HNC) often causes damage to the salivary glands. The resulting salivary gland hypofunction and xerostomia seriously reduce the patient's quality of life. PURPOSE:To analyze the literature of actual management strategies for radiation-induced hypofunction and xerostom...

journal_title：Therapeutics and clinical risk management

authors： Pinna R,Campus G,Cumbo E,Mura I,Milia E

更新日期：2015-02-04 00:00:00

abstract：:Cariprazine is a recently developed antipsychotic drug with a partial agonism for the D2 and D3 receptors. It shows a tenfold greater affinity for the D3 receptor. In clinical trials, its therapeutic effect has been tested in patients with an acute exacerbation of schizophrenia and in patients with acute mania in bipo...

journal_title：Therapeutics and clinical risk management

authors： Werner FM,Coveñas R

更新日期：2015-11-02 00:00:00

abstract：:Hepatoid adenocarcinoma of the stomach (HAS) is a rare subgroup of gastric cancer (GC). Morphologically, this tumor exhibits both adenocarcinomatous and hepatocellular differentiation, and most tumors show immunohistochemical staining for alpha-fetoprotein (AFP) or elevated AFP serum levels. The diagnosis of HAS is fr...

journal_title：Therapeutics and clinical risk management

authors： Søreide JA

更新日期：2019-12-23 00:00:00

abstract：BACKGROUND AND AIMS:The aims of this study were to explore the correlation between chronic hepatitis B virus (HBV) drug-resistant mutation profiles and the efficacy of nucleoside analog rescue therapy in patients with initial antiviral treatment failure. PATIENTS AND METHODS:Patients with initial antiviral therapy fai...

journal_title：Therapeutics and clinical risk management

authors： Liang LB,Chen LL,Chen EQ,Liao J,Tang H

更新日期：2015-03-12 00:00:00

abstract：:Japanese encephalitis (JE) is one of severe viral encephalitis that affects individuals in Asia, western Pacific countries, and northern Australia. Although 67,900 JE cases have been estimated among 24 JE epidemic countries annually, only 10,426 have been reported in 2011. With the establishment of JE surveillance and...

journal_title：Therapeutics and clinical risk management

authors： Wang H,Liang G

更新日期：2015-03-19 00:00:00

abstract：Background and aim:The aim of this study was to investigate the association between low-density lipoprotein cholesterol (LDL-C) and the development of severe acute pancreatitis (SAP). Patients and methods:A total of 674 patients with acute pancreatitis were enrolled. Non-linearity in the relationship between LDL-C and...

journal_title：Therapeutics and clinical risk management

authors： Hong W,Zimmer V,Stock S,Zippi M,Omoshoro-Jones JA,Zhou M

更新日期：2018-05-30 00:00:00

abstract：:Staphylococcus aureus bacteremia is a common disease with a high risk of mortality and complications. An increasing proportion of cases are methicillin-resistant S.aureus (MRSA), and methicillin-resistance is being observed from both community-acquired bacteremias and in healthcare-associated infections. The duration ...

journal_title：Therapeutics and clinical risk management

authors： Bamberger DM

更新日期：2007-08-01 00:00:00

abstract：Background:The aim of this study was to evaluate the efficacy of induction chemotherapy (IC) in nasopharyngeal carcinoma (NPC) patients with moderate-risk treated with intensity-modulated radiotherapy (IMRT). Methods:We retrospectively assessed 506 patients with T1-2N1M0 or T3-4N0-1M0 NPC (according to the 2010 UICC/A...

journal_title：Therapeutics and clinical risk management

authors： Su Z,Zou GR,Tang J,Li XY,Xie FY

更新日期：2020-03-26 00:00:00

abstract：:[This corrects the article on p. 19 in vol. 12, PMID: 26730198.]. ...

journal_title：Therapeutics and clinical risk management

authors：

更新日期：2016-03-10 00:00:00

abstract：Background:Anesthesia and surgery may deteriorate liver function in patients with elevated liver enzyme levels; therefore, in these patients, choosing anesthetics with less hepatotoxicity is important. Methods:This retrospective study investigated the effect of total intravenous anesthesia (TIVA) versus inhalation ane...

journal_title：Therapeutics and clinical risk management

authors： Oh SK,Lim BG,Kim YS,Kim SS

更新日期：2020-04-05 00:00:00

abstract：:Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS). Pharmacologic options studied for treating severe PMS and PMDD may include selective serotonin reuptake inhibitors, anxiolytic agents, gonadotropin-releasing hormone agonists and the diuretic spironolactone. However, the use of com...

journal_title：Therapeutics and clinical risk management

authors： De Berardis D,Serroni N,Salerno RM,Ferro FM

更新日期：2007-08-01 00:00:00

abstract：:Glucocorticoids are commonly used in various fields within medicine. One of their most common and clinically significant side effects is glucocorticoid-induced osteoporosis (GIOP). GIOP is a disease leading to progressive decreases in bone mineral density, decreased bone strength, and increased risk of skeletal fractu...

journal_title：Therapeutics and clinical risk management

authors： Lau AN,Adachi JD

更新日期：2010-10-21 00:00:00

abstract：Purpose:We aimed to build a model to qualitatively and quantitatively evaluate publications of research of spinal cord injury rehabilitation from 1997 to 2016. Methods:Data were obtained from the Web of Science Core Collection on October 6, 2017. We conducted a qualitative and quantitative analysis of publication outp...

journal_title：Therapeutics and clinical risk management

authors： Liu X,Liu N,Zhou M,Lu Y,Li F

更新日期：2018-12-17 00:00:00