Neutrophil-Lymphocyte Ratio (NLR) for Predicting Clinical Outcomes in Patients with Coronary Artery Disease and Type 2 Diabetes Mellitus: A Propensity Score Matching Analysis.

Abstract:

Background:Cardiovascular diseases (CVD) combined with Type 2 diabetes mellitus (T2DM) frequently occurred. In this study, we aimed at exploring the prognostic significance of blood neutrophil-lymphocyte ratio (NLR) in these types of patients. Patients and Methods:Between June 30, 2010 and August 30, 2017, 1454 patients with CVD were enrolled in this study. Kaplan and Meier methodology was used for survival analysis. We also used propensity score matching (PSM) to further compare survival in patients with or without T2DM. Results:Among all patients, we applied ROC curve analysis to stratify all patients into two different groups including NLR >2.5 (n=432) and NLR≤ 2.5 (n=1022) groups. After that, we further performed survival analysis between different groups. We found that patients with NLR ≤2.5 had significantly favorable OS compared with the overall survival in patients with NLR >2.5. We further built the PSM using 242 pairs of patients who have CVD and with or without T2DM. After adjusting for competing risk factors, we performed Cox proportional hazards models to identify the independent prognostic factors in multivariable adjustment. We found that NLR ≤2.5 (HR: 2.576, 95% CI: 1.241-4.583, P =0.001) and extent of coronary artery disease (HR: 2.432, 95% CI: 1.189-4.392, P =0.005) remained independent predictors of OS. Conclusion:In conclusion, we have established an PSM model and found that a high NLR value was an independent prognostic factor for survival, predicting in patients with both CAD and T2DM. The NLR value would be a valuable biomarker to evaluate the outcomes of patients and give them opportunities for choosing alternative therapies.

journal_name

Ther Clin Risk Manag

authors

Qiao S,Gao W,Guo S

doi

10.2147/TCRM.S244623

subject

Has Abstract

pub_date

2020-05-19 00:00:00

pages

437-443

eissn

1176-6336

issn

1178-203X

pii

244623

journal_volume

16

pub_type

杂志文章
  • The short-term effects of intravitreal aflibercept injections and dexamethasone implant on ocular hemodynamics in retinal vein occlusions.

    abstract:Purpose:To determine the early effects of intravitreal anti-VEGF and dexamethasone application on blood flow velocities in patients with retinal vein occlusions. Methods:The ophthalmic (OA) and the central retinal arteries (CRAs) of the affected and unaffected eyes of 21 patients with central retinal vein occlusion (C...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S200658

    authors: Ciloglu E,Yıldırım Celikdemir A

    更新日期:2019-07-04 00:00:00

  • Anthracycline extravasation injuries: management with dexrazoxane.

    abstract::The application of anthracyclines in anticancer therapy may result in accidental extravasation injury and can be a serious complication of their use. Tissue necrosis with skin ulceration is a possible outcome in the inadvertent extravasation of anthracyclines during intravenous administration. Until recently, there ha...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/tcrm.s3694

    authors: Jordan K,Behlendorf T,Mueller F,Schmoll HJ

    更新日期:2009-04-01 00:00:00

  • Serum sodium disorders in patients with traumatic brain injury.

    abstract::Sodium disorders are the most common and most poorly understood electrolyte disorders in neurological patients. The aim of this study was to determine the incidence of sodium disorders and its association with different traumatic brain injuries. This prospective study was conducted in 80 patients diagnosed with modera...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S17692

    authors: Paiva WS,Bezerra DA,Amorim RL,Figueiredo EG,Tavares WM,De Andrade AF,Teixeira MJ

    更新日期:2011-01-01 00:00:00

  • Subsection Laminectomy with Pedicle Screw Fixation to Treat Thoracic Ossification of Ligamentum Flavum: A Comparative Analysis with Lamina Osteotomy and the Replantation Technique.

    abstract:Background:There are many surgical procedures that can be used to relieve compression caused by thoracic ossification of the ligamentum flavum (TOLF). The present study aims to retrospectively observe the differences in subsection laminectomy with pedicle screw fixation (SLPF) and lamina osteotomy and replantation with...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S235868

    authors: Zhang JT,Lei T,Yang L,Lin YS,Wang ZH,Cao JM

    更新日期:2020-04-17 00:00:00

  • Erratum: Cone-beam computed tomography study of the root and canal morphology of mandibular permanent anterior teeth in a Chongqing population [Corrigendum].

    abstract::[This corrects the article on p. 19 in vol. 12, PMID: 26730198.]. ...

    journal_title:Therapeutics and clinical risk management

    pub_type: 已发布勘误

    doi:10.2147/TCRM.S105169

    authors:

    更新日期:2016-03-10 00:00:00

  • Surgical versus conservative treatment following acute rupture of the Achilles tendon: is there a pedobarographic difference?

    abstract:INTRODUCTION:Controversy remains regarding the optimal treatment method and postoperative rehabilitation of acute Achilles tendon ruptures. In this study, pedobarographic assessments of surgical and conservative treatments were compared. MATERIAL AND METHODS:A prospective assessment was made of 16 patients (eight surg...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S116385

    authors: Karaaslan F,Mermerkaya MU,Çıraklı A,Karaoğlu S,Duygulu F

    更新日期:2016-08-29 00:00:00

  • Managing Behçet's disease: An update on current and emerging treatment options.

    abstract::Behçet's disease is an autoinflammatory vasculitis of unknown origin characterized by recurrent oral and genital ulcers, uveitis, arthritis and skin lesions. Additionally, involvement of the gastrointestinal tract, central nervous system and large vessels may occur. The disease is prevalent in countries along the anci...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/tcrm.s4446

    authors: van Daele PL,Kappen JH,van Hagen PM,van Laar JA

    更新日期:2009-04-01 00:00:00

  • Mycophenolate therapy in interstitial pneumonia with autoimmune features: a cohort study.

    abstract:Objectives:International experts recently characterized interstitial pneumonia with autoimmune features (IPAF) as a provisional diagnosis for patients with interstitial lung disease who have characteristics of autoimmune disease but do not meet criteria for a specific autoimmune disease. We describe clinical characteri...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S173154

    authors: McCoy SS,Mukadam Z,Meyer KC,Kanne JP,Meyer CA,Martin MD,Sampene E,Aesif SW,Rice LN,Bartels CM

    更新日期:2018-11-01 00:00:00

  • Phosphate binding therapy in dialysis patients: focus on lanthanum carbonate.

    abstract::Hyperphosphatemia is an inevitable consequence of end stage chronic kidney disease and is present in the majority of dialysis patients. Recent observational data has associated hyperphosphatemia with increased cardiovascular mortality among dialysis patients. Dietary restriction of phosphate and current dialysis presc...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/tcrm.s1555

    authors: Mohammed IA,Hutchison AJ

    更新日期:2008-10-01 00:00:00

  • Comparison of the clinical features and outcomes of infective endocarditis between hemodialysis and non-hemodialysis patients.

    abstract::Hemodialysis (HD) patients are more susceptible to infective endocarditis (IE) due to the increased risk of bacterial invasion through intravascular access. However, it remains unclear whether the causative organisms and outcomes of IE in HD patients differ from those in non-HD patients. This study clarified the diffe...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S135262

    authors: Hsiao CC,Weng CH,Li YJ,Wu HH,Chen YC,Chen YM,Hsu HH,Tian YC

    更新日期:2017-05-24 00:00:00

  • Ceftaroline fosamil for the treatment of community-acquired bacterial pneumonia in the intensive care unit.

    abstract::The Clinical Assessment Program and Teflaro(®) Utilization Registry (CAPTURE) is a multicenter study evaluating the clinical use of ceftaroline fosamil in patients with community-acquired bacterial pneumonia (CABP) or acute bacterial skin and skin structure infection. Data were collected between August 2011 and Februa...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S75191

    authors: Maggiore C,Vazquez JA,Guervil DJ,Ramani A,Jandourek A,Cole P,Friedland HD

    更新日期:2015-04-02 00:00:00

  • Decompressive craniectomy for severe traumatic brain injury patients with fixed dilated pupils.

    abstract:OBJECTIVE:The outcome of decompressive craniectomy (DC) for severe traumatic brain injury (sTBI) patients with fixed dilated pupils (FDPs) is not clear. The objective of this study was to validate the outcome of DC in sTBI patients with FDPs. PATIENTS:We retrospectively collected data from 207 sTBI patients with FDPs ...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S89820

    authors: Mao X,Miao G,Hao S,Tao X,Hou Z,Li H,Tian R,Zhang H,Lu T,Ma J,Zhang X,Cheng H,Liu B

    更新日期:2015-10-22 00:00:00

  • In vivo efficacy of artemether-lumefantrine against uncomplicated Plasmodium falciparum malaria in Dembia District, northwest Ethiopia.

    abstract:BACKGROUND:Artemether-lumefantrine (AL) has been used as a first-line treatment for uncomplicated Plasmodium falciparum malaria in Ethiopia since 2004. Antimalarial drug resistance is one of the major obstacles for malaria control and curtails the lifespan of several drugs. Thus, continued monitoring of the efficacy of...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S127571

    authors: Deressa T,Seid ME,Birhan W,Aleka Y,Tebeje BM

    更新日期:2017-02-16 00:00:00

  • Management of children's acute diarrhea by community pharmacies in five towns of Ethiopia: simulated client case study.

    abstract:BACKGROUND:Acute diarrhea is the major cause of child morbidity and mortality in low-income nations. It is the second most common cause of death among children <5 years of age globally. The indispensable role of community pharmacists is clearly observed in the prevention and treatment of diarrhea. However, there is a p...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S98474

    authors: Abegaz TM,Belachew SA,Abebe TB,Gebresilassie BM,Teni FS,Woldie HG

    更新日期:2016-04-05 00:00:00

  • Treatment of premenstrual dysphoric disorder (PMDD) with a novel formulation of drospirenone and ethinyl estradiol.

    abstract::Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS). Pharmacologic options studied for treating severe PMS and PMDD may include selective serotonin reuptake inhibitors, anxiolytic agents, gonadotropin-releasing hormone agonists and the diuretic spironolactone. However, the use of com...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:

    authors: De Berardis D,Serroni N,Salerno RM,Ferro FM

    更新日期:2007-08-01 00:00:00

  • Cancer treatment-induced mucositis pain: strategies for assessment and management.

    abstract::Mucositis pain is a major clinical problem associated with cancer treatment. Mucosal tissue injury is a dose-limiting side effect and also limits nutritional intake and oral function, resulting in weight loss and nutritional deficits for many patients. The pathophysiology of mucositis is thought to be a complex array ...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/tcrm.2006.2.3.251

    authors: Harris DJ

    更新日期:2006-09-01 00:00:00

  • Advanced prostate cancer - patient survival and potential impact of enzalutamide and other emerging therapies.

    abstract::The advent of exponential growth of novel agents tested and approved for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) has brought about a need for understanding of the mechanism of action, side-effects, and clinical efficacy of these drugs as they relate to these patients. Thi...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章,评审

    doi:10.2147/TCRM.S57509

    authors: Patel NK,Finianos A,Whitaker KD,Aragon-Ching JB

    更新日期:2014-08-16 00:00:00

  • Relationship between low-density lipoprotein cholesterol and severe acute pancreatitis ("the lipid paradox").

    abstract:Background and aim:The aim of this study was to investigate the association between low-density lipoprotein cholesterol (LDL-C) and the development of severe acute pancreatitis (SAP). Patients and methods:A total of 674 patients with acute pancreatitis were enrolled. Non-linearity in the relationship between LDL-C and...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S159387

    authors: Hong W,Zimmer V,Stock S,Zippi M,Omoshoro-Jones JA,Zhou M

    更新日期:2018-05-30 00:00:00

  • Atrial fibrillation is a predictor of in-hospital mortality in ischemic stroke patients.

    abstract:BACKGROUND/PURPOSE:In-hospital mortality rate of acute ischemic stroke patients remains between 3% and 18%. For improving the quality of stroke care, we investigated the factors that contribute to the risk of in-hospital mortality in acute ischemic stroke patients. MATERIALS AND METHODS:Between January 1, 2007, and De...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S105703

    authors: Ong CT,Wong YS,Wu CS,Su YH

    更新日期:2016-06-29 00:00:00

  • Seven years' experience with etidronate in a woman with anorexia nervosa and vertebral fractures.

    abstract::We report the case of a 30-year-old Japanese woman with anorexia nervosa and vertebral fractures who was treated with etidronate. She had a history of anorexia nervosa, chronic back pain, osteoporosis, and multiple vertebral fractures (morphometric fractures) that responded poorly to treatment with alfacalcidol (1 μg ...

    journal_title:Therapeutics and clinical risk management

    pub_type:

    doi:10.2147/TCRM.S21357

    authors: Iwamoto J,Sato Y,Uzawa M,Takeda T,Matsumoto H

    更新日期:2011-01-01 00:00:00

  • Erratum: A restrictive dose of crystalloids in patients during laparoscopic cholecystectomy is safe and cost-effective: prospective, two-arm parallel, randomized controlled trial [Corrigendum].

    abstract::[This corrects the article on p. 741 in vol. 14, PMID: 29719401.]. ...

    journal_title:Therapeutics and clinical risk management

    pub_type: 已发布勘误

    doi:10.2147/TCRM.S177217

    authors:

    更新日期:2018-06-26 00:00:00

  • Effects of short-term combined treatment with alendronate and elcatonin on bone mineral density and bone turnover in postmenopausal women with osteoporosis.

    abstract::The antiresorptive drug elcatonin (ECT) is known to relieve pain in postmenopausal women with osteoporosis. A prospective open-labeled trial was conducted to compare the effects of short-term combined treatment with alendronate (ALN) and ECT on bone mineral density (BMD) and bone turnover with those of single treatmen...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/tcrm.s5982

    authors: Iwamoto J,Uzawa M,Sato Y,Takeda T,Matsumoto H

    更新日期:2009-06-01 00:00:00

  • The value of trabectedin in the treatment of soft tissue sarcoma.

    abstract::Soft tissue sarcomas (STSs) are a group of rare tumors accounting for less than 1% of all adult malignant tumors, a heterogeneous group of more than 50 histological subtypes. Five percent to 30% of STS patients experience local recurrence and 10%-38% present with clinically detectable metastases. Doxorubicin either al...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章,评审

    doi:10.2147/TCRM.S84789

    authors: Nakamura T,Matsumine A,Sudo A

    更新日期:2016-01-13 00:00:00

  • A new Web-based medical tool for assessment and prevention of comprehensive cardiovascular risk.

    abstract:BACKGROUND:Multifactor cardiovascular disease is the leading cause of death; besides well-known cardiovascular risk factors, several emerging factors such as mental stress, diet type, and physical inactivity, have been associated to cardiovascular disease. To date, preventive strategies are based on the concept of abso...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S16523

    authors: Franchi D,Cini D,Iervasi G

    更新日期:2011-01-01 00:00:00

  • Management and outcomes of hyperparathyroidism: a case series from a single institution over two decades.

    abstract:Background:Hyperparathyroidism is a frequent endocrine disorder with variable clinical manifestations and outcomes. We aimed to evaluate clinical presentations, management and outcomes of hyperparathyroidism. Methods:A retrospective study was conducted to include all patients presented with hyperparathyroidism between...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S160896

    authors: Al-Thani H,El-Matbouly M,Al-Sulaiti M,Asim M,Majzoub A,Tabeb A,El-Menyar A

    更新日期:2018-07-31 00:00:00

  • Improved perioperative quality of life in endoscopic sinus surgery by application of enhanced recovery after surgery.

    abstract::Background: Endoscopic sinus surgery (ESS) has been the definitive treatment for chronic rhinosinusitis (CRS), but the complications caused perioperatively may affect patients' quality of life (QoL). This study aims to evaluate the effects of enhanced recovery after surgery (ERAS) on improving perioperative QoL in ESS...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S199630

    authors: Wu X,Kong W,Zhu Q,Wang W,Xu H,Zhou S,Yang Q

    更新日期:2019-06-04 00:00:00

  • Comparative study on drug safety surveillance between medical students of Malaysia and Nigeria.

    abstract:BACKGROUND:Internationally, there is a remarkable achievement in the areas of drug discovery, drug design, and clinical trials. New and efficient drug formulation techniques are widely available which have led to success in treatment of several diseases. Despite these achievements, large number of patients continue to ...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S85019

    authors: Abubakar AR,Ismail S,Rahman NI,Haque M

    更新日期:2015-06-30 00:00:00

  • Effects of treatment with antimicrobial agents on the human colonic microflora.

    abstract::Antimicrobial agents are the most valuable means available for treating bacterial infections. However, the administration of therapeutic doses of antimicrobial agents to patients is a leading cause of disturbance of the normal gastrointestinal microflora. This disturbance results in diminishing the natural defense mec...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/tcrm.s4328

    authors: Rafii F,Sutherland JB,Cerniglia CE

    更新日期:2008-12-01 00:00:00

  • Outcomes of Adding Induction Chemotherapy to Concurrent Chemotherapy for Nasopharyngeal Carcinoma Patients with Moderate-Risk in the Intensity-Modulated Radiotherapy Era.

    abstract:Background:The aim of this study was to evaluate the efficacy of induction chemotherapy (IC) in nasopharyngeal carcinoma (NPC) patients with moderate-risk treated with intensity-modulated radiotherapy (IMRT). Methods:We retrospectively assessed 506 patients with T1-2N1M0 or T3-4N0-1M0 NPC (according to the 2010 UICC/A...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S241216

    authors: Su Z,Zou GR,Tang J,Li XY,Xie FY

    更新日期:2020-03-26 00:00:00

  • A review of topotecan in combination chemotherapy for advanced cervical cancer.

    abstract::Treatment of advanced, recurrent or persistent cervical cancer includes radiotherapy and chemotherapy. Radiation has been the primary treatment modality for locoregionally advanced cervical cancer. Concomitant systemic cisplatin chemotherapy and radiation have shown high response rates with improvements in durable rem...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/tcrm.s1771

    authors: Robati M,Holtz D,Dunton CJ

    更新日期:2008-02-01 00:00:00