A review of topotecan in combination chemotherapy for advanced cervical cancer.

abstract：:Angioid streaks are visible irregular crack-like dehiscences in Bruch's membrane that are associated with atrophic degeneration of the overlying retinal pigmented epithelium. Angioid streaks may be associated with pseudoxanthoma elasticum, Paget's disease, sickle-cell anemia, acromegaly, Ehlers-Danlos syndrome, and di...

journal_title：Therapeutics and clinical risk management

authors： Georgalas I,Papaconstantinou D,Koutsandrea C,Kalantzis G,Karagiannis D,Georgopoulos G,Ladas I

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To investigate the reactivation of the hepatitis B virus (HBV) following transarterial chemoembolization (TACE) in Chinese hepatocellular carcinoma (HCC) patients with low serum HBV DNA level, and to analyze the factors related to HBV reactivation in HCC patients with low serum HBV DNA level. METHODS:From No...

journal_title：Therapeutics and clinical risk management

authors： Shao W,Zhang F,Cong N,Li J,Song J

更新日期：2015-09-07 00:00:00

abstract：AIM:To compare the long-term survival outcomes of radiofrequency ablation and liver resection for single very early/early stage hepatocellular carcinoma (HCC). METHODS:The Cochrane Library (Issue 3, 2015), Embase (1974 to March 15, 2015), PubMed (1950 to March 15, 2015), Web of Science (1900 to March 15, 2015), and Ch...

journal_title：Therapeutics and clinical risk management

authors： He ZX,Xiang P,Gong JP,Cheng NS,Zhang W

更新日期：2016-02-23 00:00:00

abstract：BACKGROUND:Traditional Chinese medicine (TCM) and Western medicine are both popular in Taiwan. Approximately 14.1% of Taiwanese residents use Western drugs and Chinese herbs concurrently; therefore, drug-herb interaction is critical to patient safety. This paper presents a new procedure for reducing the risk of drug in...

journal_title：Therapeutics and clinical risk management

authors： Lin SS,Tsai CL,Tu CY,Hsieh CL

更新日期：2015-02-16 00:00:00

abstract：BACKGROUND:The irradiation of head and neck cancer (HNC) often causes damage to the salivary glands. The resulting salivary gland hypofunction and xerostomia seriously reduce the patient's quality of life. PURPOSE:To analyze the literature of actual management strategies for radiation-induced hypofunction and xerostom...

journal_title：Therapeutics and clinical risk management

authors： Pinna R,Campus G,Cumbo E,Mura I,Milia E

更新日期：2015-02-04 00:00:00

abstract：BACKGROUND:Hypertension is a highly prevalent risk factor for cardiovascular disease in patients with type 1 diabetes mellitus. Elevated blood pressure (BP) promotes the development and progression of microvascular complications, eg, nephropathy and retinopathy. The purpose of this study was to identify and detect earl...

journal_title：Therapeutics and clinical risk management

authors： Shalaby NM,Shalaby NM

更新日期：2015-10-05 00:00:00

abstract：BACKGROUND:This retrospective cohort study evaluated whether manual lymphatic drainage (MLD) therapy increases the risk of recurrence of breast cancer. METHODS:We analyzed 1,106 women who were diagnosed with stage 0-3 breast cancer between 2007 and 2011 and experienced remission after surgery and adjuvant therapy. The...

journal_title：Therapeutics and clinical risk management

authors： Hsiao PC,Liu JT,Lin CL,Chou W,Lu SR

更新日期：2015-02-27 00:00:00

abstract：:Lobomycosis is a subcutaneous mycosis of chronic evolution caused by the Lacazia loboi fungus. Its distribution is almost exclusive in the Americas, and it has a particularly high prevalence in the Amazon basin. Cases of lobomycosis have been reported only in dolphins and humans. Its prevalence is higher among men who...

journal_title：Therapeutics and clinical risk management

authors： Francesconi VA,Klein AP,Santos AP,Ramasawmy R,Francesconi F

更新日期：2014-10-09 00:00:00

abstract：Introduction:Severe hand, foot, and mouth disease (HFMD) may lead to serious complications, which cause child mortality during outbreaks. The aim of this study was to determine whether neutrophil-to-lymphocyte ratio (NLR) can predict death risk in severe HFMD. Methods:Medical records for 664 severe HFMD patients were ...

journal_title：Therapeutics and clinical risk management

authors： Li Y,Wang M,Wang W,Feng D,Deng H,Zhang Y,Dang S,Zhai S

更新日期：2020-10-23 00:00:00

abstract：:Trichosporon asahii is an emerging opportunistic pathogen that is life-threatening particularly for immunosuppressed patients. Only a few studies have described Trichosporon infection in kidney transplant recipients. This study reports a 67-year-old male kidney transplant recipient who developed fatal fungemia and pne...

journal_title：Therapeutics and clinical risk management

authors： Yang MF,Gao HN,Li LJ

更新日期：2014-09-30 00:00:00

abstract：:In January 2012, glucarpidase (Voraxaze(®)) received approval from the US Food and Drug Administration for intravenous treatment of toxic plasma methotrexate concentrations due to impaired renal clearance. Methotrexate, an antifolate agent, has been used for over 60 years in the treatment of various cancers. High-dose...

journal_title：Therapeutics and clinical risk management

authors： Green JM

更新日期：2012-01-01 00:00:00

abstract：Purpose:Anastomotic leakage is a major surgical complication following esophagectomy and gastric pull-up. Specific risk factors such as celiac trunk (TC) stenosis and high calcification score of the aorta have been identified, but no data are available on their relative prognostic values. This retrospective study aimed...

journal_title：Therapeutics and clinical risk management

authors： Chang DH,Brinkmann S,Smith L,Becker I,Schroeder W,Hoelscher AH,Haneder S,Maintz D,Spiro JE

更新日期：2018-04-17 00:00:00

abstract：BACKGROUND:Adverse drug reactions are important determinants of inpatient and outpatient morbidity. Thiocolchicoside is a semisynthetic derivate of naturally occurring colchicoside, which is largely used in humans as a centrally acting muscle relaxant. Epileptic seizures after thiocolchicoside intake have been reported...

journal_title：Therapeutics and clinical risk management

authors： Giavina-Bianchi P,Giavina-Bianchi M,Tanno LK,Ensina LF,Motta AA,Kalil J

更新日期：2009-06-01 00:00:00

abstract：Purpose:To investigate the influence and possible pathophysiological mechanism of pulsatile cardiopulmonary bypass (CPB) in various frequencies in pediatric patients undergoing congenital cardiac surgery. Patients and methods:Clinical data and hemodynamic parameters were collected in 80 patients who underwent congenit...

journal_title：Therapeutics and clinical risk management

authors： Li G,Jiang W,Zhang Y,Zhang X,Chen J,Zhuang J,Zhou C

更新日期：2018-09-03 00:00:00

abstract：:This study examined the associations of diabetes-related distress (DRD), depressive symptoms, health-related quality of life (HRQoL), and medication adherence with glycemia, blood pressure (BP), and lipid biomarkers in adults with type 2 diabetes mellitus (T2D). This cross-sectional study was conducted in three Malays...

journal_title：Therapeutics and clinical risk management

authors： Chew BH,Sherina MS,Hassan NH

更新日期：2015-04-29 00:00:00

abstract：Objective:Retrospective studies and a meta-analysis were performed to evaluate the safety and effectiveness of the perioperative administration of recombinant human brain natriuretic peptide (rhBNP) during cardiac surgery under extracorporeal circulation. Methods:Computerized literature searches were performed in Medl...

journal_title：Therapeutics and clinical risk management

authors： Hua P,Liu J,Tao J,Lin X,Zou R,Zhang D,Yang S

更新日期：2018-02-20 00:00:00

abstract：:Treatment of HIV-1 infection has produced dramatic success for many patients. Nevertheless, viral resistance continues to limit the efficacy of currently available agents in many patients. The CCR5 antagonists are a new class of antiretroviral agents that target a necessary coreceptor for viral entry of many strains o...

journal_title：Therapeutics and clinical risk management

authors： Schlecht HP,Schellhorn S,Dezube BJ,Jacobson JM

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Acute heart failure (AHF) is a serious condition that is associated with increased mortality in critically ill patients. Previous studies indicated that environmental exposure to cadmium increases mortality of general populations. However, the relationship of cadmium exposure and mortality is unclear for AHF...

journal_title：Therapeutics and clinical risk management

authors： Hsu CW,Weng CH,Lee CC,Lin-Tan DT,Chu PH,Chen KH,Yen TH,Huang WH

更新日期：2017-03-27 00:00:00

abstract：:The Clinical Assessment Program and Teflaro(®) Utilization Registry (CAPTURE) is a multicenter study evaluating the clinical use of ceftaroline fosamil in patients with community-acquired bacterial pneumonia (CABP) or acute bacterial skin and skin structure infection. Data were collected between August 2011 and Februa...

journal_title：Therapeutics and clinical risk management

authors： Maggiore C,Vazquez JA,Guervil DJ,Ramani A,Jandourek A,Cole P,Friedland HD

更新日期：2015-04-02 00:00:00

abstract：OBJECTIVE:To determine the influence of various patient-specific factors, use of concomitant medications, and weekly vitamin K intake on total weekly warfarin maintenance dose (TWD). METHODS:Information collected, via retrospective chart review, included TWD, general demographics, vitamin K consumption, target INR ran...

journal_title：Therapeutics and clinical risk management

authors： Whitley HP,Fermo JD,Chumney EC,Brzezinski WA

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND AND AIMS:The aims of this study were to explore the correlation between chronic hepatitis B virus (HBV) drug-resistant mutation profiles and the efficacy of nucleoside analog rescue therapy in patients with initial antiviral treatment failure. PATIENTS AND METHODS:Patients with initial antiviral therapy fai...

journal_title：Therapeutics and clinical risk management

authors： Liang LB,Chen LL,Chen EQ,Liao J,Tang H

更新日期：2015-03-12 00:00:00

abstract：:Adoptive T-cell immunotherapy is a rapidly growing field and is shifting the paradigm of clinical cancer treatment. Axicabtagene ciloleucel (axi-cel) is an anti-CD19 chimeric antigen receptor T-cell therapy that was initially developed at the National Cancer Institute and has recently been commercially approved by the...

journal_title：Therapeutics and clinical risk management

authors： Jain MD,Bachmeier CA,Phuoc VH,Chavez JC

更新日期：2018-05-31 00:00:00

abstract：Introduction:Preservation of endodontically treated teeth (ETT) depends upon several patient-related and operator-related factors. The objectives of this study were to assess the effects of different types of coronal restoration and delayed placement on ETT survival. Methods:Data on dates of root canal treatment (RCT)...

journal_title：Therapeutics and clinical risk management

authors： Sadaf D

更新日期：2020-02-21 00:00:00

abstract：Background:Wells and Geneva scores are widely used in the assessment of pretest probability of pulmonary embolism (PE). Objective:The objective of this study was to examine the hypothesis that mean platelet volume (MPV) may better predict PE than the clinical prediction rules. Methods:A study was performed among pati...

journal_title：Therapeutics and clinical risk management

authors： Lipinska A,Ledakowicz-Polak A,Krauza G,Przybylak K,Zielinska M

更新日期：2018-11-09 00:00:00

abstract：:Ongoing neuronal death in Parkinson's disease (PD) causes an altered neurotransmission of various biogenic amines, particularly dopamine. As these changes do not follow a distinct pattern, they vary individually, and are differently pronounced. As a result, a heterogeneous onset of motor and nonmotor features occurs i...

journal_title：Therapeutics and clinical risk management

authors： Müller T

更新日期：2016-08-02 00:00:00

abstract：:Purpose: This study aimed to assess the effect of intravenous dexmedetomidine (DEX) on sevoflurane EC50 for supraglottic airway device (SAD) insertion in spontaneously breathing morbidly obese patients. Patients and methods: Thirty-eight morbidly obese patients with a body mass index 40-57 kg/m2 who were scheduled for...

journal_title：Therapeutics and clinical risk management

authors： Wan L,Shao LJ,Liu Y,Wang HX,Xue FS,Tian M

更新日期：2019-05-03 00:00:00

abstract：Purpose:We conducted this meta-analysis to evaluate the efficacy of hybrid grafts in anterior cruciate ligament reconstruction (ACLR). Methods:We performed an electronic search of the Cochrane Library, PubMed, Embase, and ScienceDirect from the inception of these databases to February 2018, based on the terms "anterio...

journal_title：Therapeutics and clinical risk management

authors： Wang L,Cao JG,Liu J

更新日期：2019-03-14 00:00:00

abstract：:Opioid analgesics are essential in the treatment of moderate to severe cancer-related pain. Opioids are also recognized as important in the management of other severe, persistent refractory painful conditions, such as sickle cell disease and arthritis. In the clinical practice of pain management, stable opioid dosing ...

journal_title：Therapeutics and clinical risk management

authors： Weinstein SM

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:International travelers from non-endemic areas are at high risk of contracting malaria due to their lack of immunity. Prevention is therefore of outmost importance and is achieved through effective and safe chemoprophylaxis, which reduces the risk of fatal disease. Among the various antimalarial drugs availab...

journal_title：Therapeutics and clinical risk management

authors： Nicosia V,Colombo G,Consentino M,Di Matteo S,Mika F,De Sanctis S,Ratti S,Vinci M

更新日期：2008-10-01 00:00:00

abstract：:The topoisomerase I inhibitor topotecan is the only single-agent therapy approved for the treatment of recurrent small cell lung cancer (SCLC). Many patients with recurrent SCLC may be predisposed to treatment-related adverse events because of the presence of comorbidities such as advanced age, renal impairment, or ex...

journal_title：Therapeutics and clinical risk management

authors： Garst J

更新日期：2007-12-01 00:00:00