Review of the combined contraceptive vaginal ring, NuvaRing.

abstract：INTRODUCTION:The seven-year experience of elective abdominal aortic aneurysm (AAA) repair of a vascular surgical unit in a teaching hospital was reviewed to determine the factors associated with in-hospital mortality. METHODS:All patients who underwent elective open repair of an AAA between July 1, 1991, and June 30, ...

journal_title：Therapeutics and clinical risk management

authors： Mackenzie S,Swan JR,D'Este C,Spigelman AD

更新日期：2005-03-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is highly endemic in certain regions including the People's Republic of China and Southeast Asia. Its etiology is unique and multifactorial, involving genetic background, epigenetic, and environment factors, including Epstein-Barr virus (EBV) infection. The presence of EBV in all tumor c...

journal_title：Therapeutics and clinical risk management

authors： Hutajulu SH,Kurnianda J,Tan IB,Middeldorp JM

更新日期：2014-09-05 00:00:00

abstract：:Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS). Pharmacologic options studied for treating severe PMS and PMDD may include selective serotonin reuptake inhibitors, anxiolytic agents, gonadotropin-releasing hormone agonists and the diuretic spironolactone. However, the use of com...

journal_title：Therapeutics and clinical risk management

authors： De Berardis D,Serroni N,Salerno RM,Ferro FM

更新日期：2007-08-01 00:00:00

abstract：:Eslicarbazepine is a new dibenzazepine antiepileptic agent. It is a high affinity antagonist of the voltage-gated sodium channel. It is closely related to both carbamazepine and oxcarbazepine. Eslicarbazepine has similar affinity to inactivated sodium channels (channels in just activated neurons) as carbamazepine, and...

journal_title：Therapeutics and clinical risk management

authors： Brown ME,El-Mallakh RS

更新日期：2010-04-15 00:00:00

abstract：:In January 2012, glucarpidase (Voraxaze(®)) received approval from the US Food and Drug Administration for intravenous treatment of toxic plasma methotrexate concentrations due to impaired renal clearance. Methotrexate, an antifolate agent, has been used for over 60 years in the treatment of various cancers. High-dose...

journal_title：Therapeutics and clinical risk management

authors： Green JM

更新日期：2012-01-01 00:00:00

abstract：:A 9-year-old girl was severely injured in a car accident in Afghanistan, in which both her lower legs were badly damaged. She was treated at the Hospital of Ingolstadt (Klinikum Ingolstadt) after she had undergone initial surgery at an Indian hospital. Various bacterial species were isolated from multiple wounds, and ...

journal_title：Therapeutics and clinical risk management

authors： Borgmann S,Rieß B,von Wernitz-Keibel T,Bühler M,Layer F,Strommenger B

更新日期：2016-05-11 00:00:00

abstract：AIM:To compare the long-term survival outcomes of radiofrequency ablation and liver resection for single very early/early stage hepatocellular carcinoma (HCC). METHODS:The Cochrane Library (Issue 3, 2015), Embase (1974 to March 15, 2015), PubMed (1950 to March 15, 2015), Web of Science (1900 to March 15, 2015), and Ch...

journal_title：Therapeutics and clinical risk management

authors： He ZX,Xiang P,Gong JP,Cheng NS,Zhang W

更新日期：2016-02-23 00:00:00

abstract：Purpose:To compare running suture (RS) and interrupted suture (IS) of vesicourethral anastomosis (VUA) during open retropubic radical prostatectomy (RRP) on early urinary continence and extravasation. Patients and Methods:Single center analysis of 211 patients who underwent RRP performed by a single surgeon during 200...

journal_title：Therapeutics and clinical risk management

authors： Köhler N,El-Bandar N,Maxeiner A,Ralla B,Miller K,Busch J,Friedersdorff F

更新日期：2020-12-23 00:00:00

abstract：:Regular blood transfusions as supportive care for patients with chronic anemia inevitably lead to iron overload as humans cannot actively remove excess iron. The cumulative effects of iron overload cause significant morbidity and mortality if not effectively treated with chelation therapy. Based on a comprehensive cli...

journal_title：Therapeutics and clinical risk management

authors： Taher A,Cappellini MD

更新日期：2009-01-01 00:00:00

abstract：:The most frequent causes of leg ulcers are chronic venous disease (CVD) related mainly to venous hypertension and peripheral arterial disease (PAD) related to disseminated atheromatous lesions in lower limb arteries. In 15%-21% of patients, ulcers of mixed venous-arterial etiology occur, which are usually more resista...

journal_title：Therapeutics and clinical risk management

authors： Pasek J,Cieślar G,Sieroń A

更新日期：2018-10-08 00:00:00

abstract：BACKGROUND:Narcolepsy is a lifelong, rare neurological sleep disorder characterized by chronic, excessive attacks of daytime sleepiness. This disease is often extremely incapacitating, interfering with every aspect of life, in work and social settings. OBJECTIVE:The purpose of this study is to specify the treatment co...

journal_title：Therapeutics and clinical risk management

authors： Maresova P,Novotny M,Klímová B,Kuča K

更新日期：2016-11-18 00:00:00

abstract：:Purpose: This study aimed to assess the effect of intravenous dexmedetomidine (DEX) on sevoflurane EC50 for supraglottic airway device (SAD) insertion in spontaneously breathing morbidly obese patients. Patients and methods: Thirty-eight morbidly obese patients with a body mass index 40-57 kg/m2 who were scheduled for...

journal_title：Therapeutics and clinical risk management

authors： Wan L,Shao LJ,Liu Y,Wang HX,Xue FS,Tian M

更新日期：2019-05-03 00:00:00

abstract：:Cetuximab is a monoclonal antibody able to inhibit and to degrade the transmembrane receptor Her-1, also known as epidermal growth factor receptor (EGFR). The inhibition of EGFR is of major importance since the receptor influences many important tumor cell activities including tumor growth, neo-angiogenesis, inhibitio...

journal_title：Therapeutics and clinical risk management

authors： Merlano M,Occelli M

更新日期：2007-10-01 00:00:00

abstract：:Angiogenesis is an essential process in the development, growth, and metastasis of malignant tumors including lung cancer. Several angiogenesis inhibitors have been developed as potential therapies for non-small-cell lung cancer (NSCLC). Nintedanib is a small-molecule tyrosine kinase inhibitor that targets receptors f...

journal_title：Therapeutics and clinical risk management

authors： Takeda M,Okamoto I,Nakagawa K

更新日期：2015-11-16 00:00:00

abstract：:Selectins mediate tethering and rolling of leukocytes to the vascular endothelium, the first adhesive step in the recruitment of immune cells to inflamed tissues. Thus, selectins play a key role in the pathogenesis of common inflammatory skin disorders such as atopic dermatitis or psoriasis. As a consequence of their ...

journal_title：Therapeutics and clinical risk management

authors： Schön MP

更新日期：2005-09-01 00:00:00

abstract：:Use of non-vitamin K antagonist oral anticoagulants is spreading in the real world. Despite that, a strong need for antidotes/reversal agents is still reported by several physicians. Idarucizumab is a humanized monoclonal antibody fragment that binds specifically to dabigatran. Idarucizumab was approved in 2015 by the...

journal_title：Therapeutics and clinical risk management

authors： Proietti M,Boriani G

更新日期：2018-08-22 00:00:00

abstract：:Background: To report our experience with retroperitoneal robot-assisted laparoscopic upper pole heminephrectomy in adult patients with duplex kidneys. Methods: We retrospectively reviewed the medical records of 7 patients who underwent retroperitoneal robot-assisted laparoscopic upper pole heminephrectomy at our inst...

journal_title：Therapeutics and clinical risk management

authors： Qin J,Wang P,Jing T,Kong D,Ye S,Xia D,Wang S

更新日期：2019-06-11 00:00:00

abstract：:Chordomas are rare, locally aggressive skull base neoplasms known for local recurrence and not-infrequent treatment failure. Current evidence supports the role of maximal safe surgical resection. In addition to open skull-base approaches, the endoscopic endonasal approach to clival chordomas has been reported with fav...

journal_title：Therapeutics and clinical risk management

authors： Di Maio S,Yip S,Al Zhrani GA,Alotaibi FE,Al Turki A,Kong E,Rostomily RC

更新日期：2015-05-26 00:00:00

abstract：:The C-MAC videolaryngoscope was evaluated for intubation in patients with predicted extremely difficult airway. The presented cases are patients with neoplasm tumors in larynx. In all cases, awake intubation using C-MAC videolaryngoscope was performed in patients breathing spontaneously, under local anaesthesia, with ...

journal_title：Therapeutics and clinical risk management

authors： Gaszyński T

更新日期：2018-03-14 00:00:00

abstract：Background:Liver cirrhosis is an uncommon but not rare side effect of amiodarone-induced hepatotoxicity. Patients with hepatitis B virus and hepatitis C virus infections are at a high risk for developing liver cirrhosis. However, the relationship between this treatment and risk of liver cirrhosis in high-risk chronic h...

journal_title：Therapeutics and clinical risk management

authors： Huang CH,Lai YY,Kuo YJ,Yang SC,Chang YJ,Chang KK,Chen WK

更新日期：2019-01-10 00:00:00

abstract：:A number of drugs rely on the kidney for excretion and thus require their dose to be modified in any patients where there is renal impairment. Others are nephrotoxic and should be avoided completely in patients with renal disease. Traditionally clinicians have had to rely on serum creatinine to assess renal function b...

journal_title：Therapeutics and clinical risk management

authors： Harris K,Stribling B

更新日期：2007-10-01 00:00:00

abstract：:The treatment of ankylosing spondylitis (AS) and psoriatic arthritis (PsA) positively changed since the introduction of anti-TNFα drugs. These treatments were shown to reduce the symptoms and signs of the diseases and improve the quality of life. However, a variable percentage of patients do not respond to anti-TNFα o...

journal_title：Therapeutics and clinical risk management

authors： Lubrano E,Perrotta FM

更新日期：2016-10-21 00:00:00

abstract：:The myelodysplastic syndromes (MDS) are a heterogeneous group of disorders that manifest as bone marrow failure with the risk of life threatening infections and bleeding. A third of these patients may transform to acute leukemia. Age and co-morbidities have limited treatment in the majority to supportive care with a m...

journal_title：Therapeutics and clinical risk management

authors： Raj K,Mufti GJ

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:This retrospective cohort study evaluated whether manual lymphatic drainage (MLD) therapy increases the risk of recurrence of breast cancer. METHODS:We analyzed 1,106 women who were diagnosed with stage 0-3 breast cancer between 2007 and 2011 and experienced remission after surgery and adjuvant therapy. The...

journal_title：Therapeutics and clinical risk management

authors： Hsiao PC,Liu JT,Lin CL,Chou W,Lu SR

更新日期：2015-02-27 00:00:00

abstract：BACKGROUND:Influenza A H1N1 and H3N2 are two influenza waves that have been identified in past years. METHODS:Data from 77 inpatients from three tertiary hospitals were included and statistical analysis was performed in three different clusters. RESULTS:Thirty-four patients (44.2%) had respiratory distress upon admis...

journal_title：Therapeutics and clinical risk management

authors： Petridis D,Zarogoulidis P,Kallianos A,Kioumis I,Trakada G,Spyratos D,Papaiwannou A,Porpodis K,Huang H,Rapti A,Hohenforst-Schmidt W,Zarogoulidis K

更新日期：2014-02-07 00:00:00

abstract：OBJECTIVE:The outcome of decompressive craniectomy (DC) for severe traumatic brain injury (sTBI) patients with fixed dilated pupils (FDPs) is not clear. The objective of this study was to validate the outcome of DC in sTBI patients with FDPs. PATIENTS:We retrospectively collected data from 207 sTBI patients with FDPs ...

journal_title：Therapeutics and clinical risk management

authors： Mao X,Miao G,Hao S,Tao X,Hou Z,Li H,Tian R,Zhang H,Lu T,Ma J,Zhang X,Cheng H,Liu B

更新日期：2015-10-22 00:00:00

abstract：:Experimental data indicate that several pharmacological agents that have long been used for the management of various diseases unrelated to cancer exhibit profound in vitro and in vivo anticancer activity. This is of major clinical importance, since it would possibly aid in reassessing the therapeutic use of currently...

journal_title：Therapeutics and clinical risk management

authors： Papanagnou P,Baltopoulos P,Tsironi M

更新日期：2015-05-18 00:00:00

abstract：:[This corrects the article on p. 19 in vol. 12, PMID: 26730198.]. ...

journal_title：Therapeutics and clinical risk management

authors：

更新日期：2016-03-10 00:00:00

abstract：INTRODUCTION:Renal cell carcinoma (RCC) represents 2%-3% of all cancers in adults, and its pathogenesis is mainly related to altered cellular response to hypoxia. Lenvatinib, a novel multitarget tyrosine kinase inhibitor (TKI), represents a therapeutic option, in combination with mammalian target of rapamycin (mTOR) in...

journal_title：Therapeutics and clinical risk management

authors： Leonetti A,Leonardi F,Bersanelli M,Buti S

更新日期：2017-06-30 00:00:00

abstract：Purpose:We aimed to build a model to qualitatively and quantitatively evaluate publications of research of spinal cord injury rehabilitation from 1997 to 2016. Methods:Data were obtained from the Web of Science Core Collection on October 6, 2017. We conducted a qualitative and quantitative analysis of publication outp...

journal_title：Therapeutics and clinical risk management

authors： Liu X,Liu N,Zhou M,Lu Y,Li F

更新日期：2018-12-17 00:00:00