Abstract:
:Coronary and cerebrovascular atherothrombosis are the leading cause of mortality and morbidity worldwide. Novel antiplatelet agents have been established for the management of patients with clinically evident coronary atherothrombosis and are increasingly used in these patients. These agents, however, have shown limited efficacy in the prevention of cerebrovascular events and potential harm in patients with history of stroke or transient ischemic attack. Herein, the efficacy and safety of two established antiplatelet agents in patients with stroke - aspirin and clopidogrel - are reviewed with a focus on the use and challenges related to novel antiplatelet agents - prasugrel, ticagrelor, and vorapaxar - in patients at risk for and with a history of stroke or transient ischemic attack.
journal_name
Ther Clin Risk Managjournal_title
Therapeutics and clinical risk managementauthors
Iannopollo G,Camporotondo R,De Ferrari GM,Leonardi Sdoi
10.2147/TCRM.S39216subject
Has Abstractpub_date
2014-05-02 00:00:00pages
321-9eissn
1176-6336issn
1178-203Xpii
tcrm-10-321journal_volume
10pub_type
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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doi:10.2147/tcrm.2007.3.2.319
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journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章
doi:10.2147/TCRM.S127571
更新日期:2017-02-16 00:00:00
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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journal_title:Therapeutics and clinical risk management
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更新日期:2008-06-01 00:00:00
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journal_title:Therapeutics and clinical risk management
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更新日期:2017-02-21 00:00:00
abstract::Chordomas are rare, locally aggressive skull base neoplasms known for local recurrence and not-infrequent treatment failure. Current evidence supports the role of maximal safe surgical resection. In addition to open skull-base approaches, the endoscopic endonasal approach to clival chordomas has been reported with fav...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章,评审
doi:10.2147/TCRM.S50526
更新日期:2015-05-26 00:00:00
abstract::Ongoing neuronal death in Parkinson's disease (PD) causes an altered neurotransmission of various biogenic amines, particularly dopamine. As these changes do not follow a distinct pattern, they vary individually, and are differently pronounced. As a result, a heterogeneous onset of motor and nonmotor features occurs i...
journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章,评审
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更新日期:2016-08-02 00:00:00
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journal_title:Therapeutics and clinical risk management
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更新日期:2008-10-01 00:00:00
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journal_title:Therapeutics and clinical risk management
pub_type: 杂志文章,评审
doi:10.2147/TCRM.S84789
更新日期:2016-01-13 00:00:00