Treatment Pattern Analysis and Health-care Resource Consumption on Patients with Psoriatic Arthritis or Ankylosing Spondylitis Treated with Biological Drugs in a Northern Italian Region.

Abstract:

Purpose:To analyze the treatment patterns of psoriatic arthritis (PSA) or ankylosing spondylitis (AS) patients under biological therapies and to evaluate in this population the health-care resource consumption and related costs. Patients and Methods:A retrospective analysis was performed on administrative databases of the Veneto region. Patients ≥18 years with at least one prescription of biological drugs and a diagnosis at any level for PSA or AS from January 1, 2011 to December 31, 2016 (inclusion period) were included. Index date (ID) was defined as date of first biological drug prescription during inclusion period. Patients were characterized the year before ID and followed-up for one year after ID. The drug utilization profile in terms of adherence, persistence and therapeutic regimen changes, and the health-care resource consumption was analyzed during follow-up. Results:A total of 2602 patients were included: 1857 with PSA and 745 with AS. In the PSA cohort, 40.3% of patients were prescribed adalimumab, 35.6% etanercept, 8.0% golimumab, 7.5% infliximab, 5.6% ustekinumab and 3.0% certolizumab. Percentage of PSA patients adherent to treatment was higher among ustekinumab patients (91.3%) and lower among etanercept users (54.3%). Persistence ranged from 53.2% (infliximab) to 70.3% (etanercept). Regarding AS cohort, 45.5% of patients were prescribed adalimumab, 26% etanercept, 17.3% infliximab, 9.7% golimumab and 1.5% certolizumab. Adherence ranged from 46.9% (etanercept) to 90.9% (certolizumab) and persistence from 62.8% (adalimumab) to 81.8% (certolizumab). Mean annual health-care costs (including costs for drug treatment, diagnostic services, specialist visits and hospital admissions) ranged from €9727 (certolizumab) to €14,994 (ustekinumab) among PSA patients and from €9875 (infliximab) to €12,991 (golimumab) among AS patients. Conclusion:This study in Veneto region gave a picture of biological treatment patterns among PSA and AS patients in a real-world setting. Our findings showed the high degree of variability concerning utilization of each biological drug and provided insight on the economic burden of both diseases.

journal_name

Ther Clin Risk Manag

authors

Perrone V,Giacomini E,Sangiorgi D,Andretta M,Menti AM,Naclerio M,Ritrovato D,Degli Esposti L

doi

10.2147/TCRM.S248390

subject

Has Abstract

pub_date

2020-06-09 00:00:00

pages

509-521

eissn

1176-6336

issn

1178-203X

pii

248390

journal_volume

16

pub_type

杂志文章
  • Comparison of anterior decompression and fusion versus laminoplasty in the treatment of multilevel cervical ossification of the posterior longitudinal ligament: a systematic review and meta-analysis.

    abstract:PURPOSE:A meta-analysis was conducted to evaluate the clinical outcomes, complications, reoperation rates, and late neurological deterioration between anterior decompression and fusion (ADF) and laminoplasty (LAMP) in the treatment of multilevel cervical ossification of the posterior longitudinal ligament (OPLL). METH...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S100046

    authors: Liu W,Hu L,Chou PH,Liu M,Kan W,Wang J

    更新日期:2016-04-26 00:00:00

  • Hydroxychloroquine and risk of development of cancers: a nationwide population-based cohort study.

    abstract:Background:Hydroxychloroquine (HCQ), one of the disease-modifying antirheumatic drugs, may lead to an inhibition of autophagy. Autophagy, an intracellular self-defense mechanism for the lysosomal degradation of cytoplasmic components such as damaged organelles, plays a role in protecting against neoplasm growth but is ...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S175581

    authors: Mao IC,Lin CY,Wu CL,Kor CT,Chang CC

    更新日期:2018-08-20 00:00:00

  • Effects of recombinant growth hormone (GH) replacement and psychomotor and cognitive stimulation in the neurodevelopment of GH-deficient (GHD) children with cerebral palsy: a pilot study.

    abstract::Cerebral palsy (CP) is the main cause of physical disability in childhood and is an important health issue that has a strong socioeconomic impact. There is no effective treatment for CP and therapeutic approaches report only partial benefits for affected people. In this study we assessed the effects of growth hormone ...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S21403

    authors: Devesa J,Alonso B,Casteleiro N,Couto P,Castañón B,Zas E,Reimunde P

    更新日期:2011-01-01 00:00:00

  • Treating psoriasis with adalimumab.

    abstract::Psoriasis is a common, chronic, inflammatory skin disease that can have a significant impact on the quality of life of those who are afflicted. Recent advances in the understanding of the pathophysiology of psoriasis have led to the development of new, genetically engineered, targeted therapies for this disease. Among...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/tcrm.s1265

    authors: Alwawi EA,Mehlis SL,Gordon KB

    更新日期:2008-04-01 00:00:00

  • Radiofrequency ablation versus resection for Barcelona clinic liver cancer very early/early stage hepatocellular carcinoma: a systematic review.

    abstract:AIM:To compare the long-term survival outcomes of radiofrequency ablation and liver resection for single very early/early stage hepatocellular carcinoma (HCC). METHODS:The Cochrane Library (Issue 3, 2015), Embase (1974 to March 15, 2015), PubMed (1950 to March 15, 2015), Web of Science (1900 to March 15, 2015), and Ch...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章,评审

    doi:10.2147/TCRM.S96760

    authors: He ZX,Xiang P,Gong JP,Cheng NS,Zhang W

    更新日期:2016-02-23 00:00:00

  • Relationship between low-density lipoprotein cholesterol and severe acute pancreatitis ("the lipid paradox").

    abstract:Background and aim:The aim of this study was to investigate the association between low-density lipoprotein cholesterol (LDL-C) and the development of severe acute pancreatitis (SAP). Patients and methods:A total of 674 patients with acute pancreatitis were enrolled. Non-linearity in the relationship between LDL-C and...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S159387

    authors: Hong W,Zimmer V,Stock S,Zippi M,Omoshoro-Jones JA,Zhou M

    更新日期:2018-05-30 00:00:00

  • New orally active anticoagulant agents for the prevention and treatment of venous thromboembolism in cancer patients.

    abstract::Patients with cancer have a 6-7-fold higher risk of venous thromboembolism (VTE) as compared with non-cancer patients. Effective and safe anticoagulation for the prevention and treatment of VTE is the cornerstone of the management of patients with cancer, aiming to decrease morbidity and mortality and to improve quali...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章,评审

    doi:10.2147/TCRM.S49063

    authors: Gerotziafas GT,Mahé I,Elalamy I

    更新日期:2014-06-13 00:00:00

  • Epidemiology of Japanese encephalitis: past, present, and future prospects.

    abstract::Japanese encephalitis (JE) is one of severe viral encephalitis that affects individuals in Asia, western Pacific countries, and northern Australia. Although 67,900 JE cases have been estimated among 24 JE epidemic countries annually, only 10,426 have been reported in 2011. With the establishment of JE surveillance and...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章,评审

    doi:10.2147/TCRM.S51168

    authors: Wang H,Liang G

    更新日期:2015-03-19 00:00:00

  • Endoscopic treatment of biliary complications in left lobe living donor liver transplantation.

    abstract:Purpose:Almost all of the publications regarding the treatment of biliary complications after liver transplantation are related to biliary complications after right lobe living donor liver transplantation (LDLT) and cadaveric liver transplantation (LT). The number of publications regarding endoscopic treatment of bilia...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S175215

    authors: Erdogan MA,Harputluoglu MM

    更新日期:2018-10-17 00:00:00

  • New developments in the management of schizophrenia and bipolar disorder: potential use of cariprazine.

    abstract::Cariprazine is a recently developed antipsychotic drug with a partial agonism for the D2 and D3 receptors. It shows a tenfold greater affinity for the D3 receptor. In clinical trials, its therapeutic effect has been tested in patients with an acute exacerbation of schizophrenia and in patients with acute mania in bipo...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章,评审

    doi:10.2147/TCRM.S64915

    authors: Werner FM,Coveñas R

    更新日期:2015-11-02 00:00:00

  • Effect of continuous positive airway pressure on allergic rhinitis in patients with obstructive sleep apnea-hypopnea syndrome.

    abstract:Background:The effect of continuous positive airway pressure (CPAP) on nasal symptoms in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) remains controversial. In addition, possible mechanism(s) remains unclear. Objective:To examine whether CPAP contributes to the onset and exacerbation of allergic rhi...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S170548

    authors: Yang Q,Li H,Wu W,Huang X,Tu B,Ma Y,Deng H,Li M,He H,Li C,Yang Y

    更新日期:2018-08-24 00:00:00

  • The association of nephrolithiasis with metabolic syndrome and its components: a cross-sectional analysis.

    abstract:BACKGROUND:Metabolic syndrome is a worldwide disorder and also the major risk factor of several systemic diseases. Evidence identifying the association between metabolic syndrome and nephrolithiasis is lacking, especially in Taiwan. AIM:The aim of this study was to investigate the association between nephrolithiasis a...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S125480

    authors: Liu YT,Yang PY,Yang YW,Sun HY,Lin IC

    更新日期:2017-01-06 00:00:00

  • Angioid streaks, clinical course, complications, and current therapeutic management.

    abstract::Angioid streaks are visible irregular crack-like dehiscences in Bruch's membrane that are associated with atrophic degeneration of the overlying retinal pigmented epithelium. Angioid streaks may be associated with pseudoxanthoma elasticum, Paget's disease, sickle-cell anemia, acromegaly, Ehlers-Danlos syndrome, and di...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:

    authors: Georgalas I,Papaconstantinou D,Koutsandrea C,Kalantzis G,Karagiannis D,Georgopoulos G,Ladas I

    更新日期:2009-02-01 00:00:00

  • Which drugs cause treatment-related problems? Analysis of 10,672 problems within the outpatient setting.

    abstract:Background:Treatment-related problems (TRPs) may pose risks for patients if unaddressed. With the increased complexity of health care, it is important to target pharmacists' efforts to patients that are at high risk for TRPs. Objectives:The present study aimed to identify medications most commonly associated with TRPs...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S180747

    authors: Al-Taani GM,Al-Azzam SI,Alzoubi KH,Aldeyab MA

    更新日期:2018-11-16 00:00:00

  • Mycophenolate therapy in interstitial pneumonia with autoimmune features: a cohort study.

    abstract:Objectives:International experts recently characterized interstitial pneumonia with autoimmune features (IPAF) as a provisional diagnosis for patients with interstitial lung disease who have characteristics of autoimmune disease but do not meet criteria for a specific autoimmune disease. We describe clinical characteri...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S173154

    authors: McCoy SS,Mukadam Z,Meyer KC,Kanne JP,Meyer CA,Martin MD,Sampene E,Aesif SW,Rice LN,Bartels CM

    更新日期:2018-11-01 00:00:00

  • Effectiveness of intramuscular neostigmine to accelerate bladder emptying after spinal anesthesia.

    abstract:Purpose:Postoperative urinary retention (POUR) is one of the most common complications following spinal anesthesia. Spinal anesthesia may influence urinary bladder function due to interruption of the micturition reflex. Urinary catheterization is the standard treatment of POUR. Urinary catheter insertion is an invasive...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S176281

    authors: Senapathi TGA,Wiryana M,Subagiartha IM,Suarjaya IPP,Widnyana IMG,Sutawan IBKJ,Jaya AAGPS,Thewidya A

    更新日期:2018-09-11 00:00:00

  • Retroperitoneal robot-assisted laparoscopic upper pole heminephrectomy in adult patients with duplex kidneys.

    abstract::Background: To report our experience with retroperitoneal robot-assisted laparoscopic upper pole heminephrectomy in adult patients with duplex kidneys. Methods: We retrospectively reviewed the medical records of 7 patients who underwent retroperitoneal robot-assisted laparoscopic upper pole heminephrectomy at our inst...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S202454

    authors: Qin J,Wang P,Jing T,Kong D,Ye S,Xia D,Wang S

    更新日期:2019-06-11 00:00:00

  • Study of ambulatory blood pressure in diabetic children: prediction of early renal insult.

    abstract:BACKGROUND:Hypertension is a highly prevalent risk factor for cardiovascular disease in patients with type 1 diabetes mellitus. Elevated blood pressure (BP) promotes the development and progression of microvascular complications, eg, nephropathy and retinopathy. The purpose of this study was to identify and detect earl...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S87751

    authors: Shalaby NM,Shalaby NM

    更新日期:2015-10-05 00:00:00

  • Targeted approaches in the treatment of osteoporosis: differential mechanism of action of denosumab and clinical utility.

    abstract::Denosumab is a breakthrough biological drug approved by the Food and Drug Administration and European Medicines Agency for the treatment of osteoporosis in 2010. It is a fully human monoclonal antireceptor activator of nuclear factor kappa-B ligand antibody, which inhibits the activity of osteoclasts, resulting in an ...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S7688

    authors: Cavalli L,Brandi ML

    更新日期:2012-01-01 00:00:00

  • Emerging treatment options for the management of pemphigus vulgaris.

    abstract::Pemphigus vulgaris (PV) is a life-threatening disease belonging to the pemphigus group of autoimmune intra-epidermal bullous diseases of the skin and mucosae. The therapeutic management of PV remains challenging and, in some cases, conventional therapy is not adequate to induce clinical remission. The cornerstone of P...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章,评审

    doi:10.2147/TCRM.S142471

    authors: Kridin K

    更新日期:2018-04-27 00:00:00

  • Atrial fibrillation is a predictor of in-hospital mortality in ischemic stroke patients.

    abstract:BACKGROUND/PURPOSE:In-hospital mortality rate of acute ischemic stroke patients remains between 3% and 18%. For improving the quality of stroke care, we investigated the factors that contribute to the risk of in-hospital mortality in acute ischemic stroke patients. MATERIALS AND METHODS:Between January 1, 2007, and De...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S105703

    authors: Ong CT,Wong YS,Wu CS,Su YH

    更新日期:2016-06-29 00:00:00

  • Inferior vena cava filters in cancer patients: to filter or not to filter.

    abstract:PURPOSE:Cancer and its treatment are recognized risk factors for venous thromboembolism (VTE); active cancer accounts for almost 20% of all newly diagnosed VTE. Inferior vena cava (IVC) filters are utilized to provide mechanical thromboprophylaxis to prevent pulmonary embolism (PE) or to avoid bleeding from systemic an...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S17912

    authors: Abdel-Razeq H,Mansour A,Ismael Y,Abdulelah H

    更新日期:2011-01-01 00:00:00

  • Evaluation of pharmacokinetic, pharmacodynamic, efficacy, and safety data of low-dose ticagrelor versus standard dose in East Asians: a systematic review.

    abstract::East Asians are prone to higher systemic exposure and increased risk of bleeding compared to other races after administration of antiplatelet agent(s). The aim of this systematic review was to compare and evaluate the appropriateness of a lower dose versus standard dose of ticagrelor in East Asians. A systematic searc...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章,评审

    doi:10.2147/TCRM.S152276

    authors: Lee YJ,Kim H,Choi J,Lee BH,Lee SY

    更新日期:2018-01-08 00:00:00

  • Is hypertriglyceridemia a prognostic factor in sepsis?

    abstract:INTRODUCTION:Sepsis and septic shock are important causes of mortality in intensive care unit patients, hence early diagnosis and therapy are important in management of their treatment. The available information on sepsis patients is not enough to recommend or to discard the routine evaluation of triglyceride (TG) leve...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S57791

    authors: Cetinkaya A,Erden A,Avci D,Karagoz H,Karahan S,Basak M,Bulut K,Gencer V,Mutlu H

    更新日期:2014-02-27 00:00:00

  • Animal-derived surfactants for the treatment and prevention of neonatal respiratory distress syndrome: summary of clinical trials.

    abstract:INTRODUCTION:Available literature suggests that the advantage of animal-derived surfactants over first-generation synthetic agents derives from the presence of surface-active proteins and their phospholipid content. Here we summarize the results of clinical trials comparing animal-derived surfactant preparations with o...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/tcrm.s4029

    authors: Logan JW,Moya FR

    更新日期:2009-02-01 00:00:00

  • Erratum: A restrictive dose of crystalloids in patients during laparoscopic cholecystectomy is safe and cost-effective: prospective, two-arm parallel, randomized controlled trial [Corrigendum].

    abstract::[This corrects the article on p. 741 in vol. 14, PMID: 29719401.]. ...

    journal_title:Therapeutics and clinical risk management

    pub_type: 已发布勘误

    doi:10.2147/TCRM.S177217

    authors:

    更新日期:2018-06-26 00:00:00

  • Reducing drug-herb interaction risk with a computerized reminder system.

    abstract:BACKGROUND:Traditional Chinese medicine (TCM) and Western medicine are both popular in Taiwan. Approximately 14.1% of Taiwanese residents use Western drugs and Chinese herbs concurrently; therefore, drug-herb interaction is critical to patient safety. This paper presents a new procedure for reducing the risk of drug in...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S78124

    authors: Lin SS,Tsai CL,Tu CY,Hsieh CL

    更新日期:2015-02-16 00:00:00

  • Lobomycosis: epidemiology, clinical presentation, and management options.

    abstract::Lobomycosis is a subcutaneous mycosis of chronic evolution caused by the Lacazia loboi fungus. Its distribution is almost exclusive in the Americas, and it has a particularly high prevalence in the Amazon basin. Cases of lobomycosis have been reported only in dolphins and humans. Its prevalence is higher among men who...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章,评审

    doi:10.2147/TCRM.S46251

    authors: Francesconi VA,Klein AP,Santos AP,Ramasawmy R,Francesconi F

    更新日期:2014-10-09 00:00:00

  • Surgical versus conservative treatment following acute rupture of the Achilles tendon: is there a pedobarographic difference?

    abstract:INTRODUCTION:Controversy remains regarding the optimal treatment method and postoperative rehabilitation of acute Achilles tendon ruptures. In this study, pedobarographic assessments of surgical and conservative treatments were compared. MATERIAL AND METHODS:A prospective assessment was made of 16 patients (eight surg...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:10.2147/TCRM.S116385

    authors: Karaaslan F,Mermerkaya MU,Çıraklı A,Karaoğlu S,Duygulu F

    更新日期:2016-08-29 00:00:00

  • Bacteremia and endocarditis due to methicillin-resistant Staphylococcus aureus: the potential role of daptomycin.

    abstract::Staphylococcus aureus bacteremia is a common disease with a high risk of mortality and complications. An increasing proportion of cases are methicillin-resistant S.aureus (MRSA), and methicillin-resistance is being observed from both community-acquired bacteremias and in healthcare-associated infections. The duration ...

    journal_title:Therapeutics and clinical risk management

    pub_type: 杂志文章

    doi:

    authors: Bamberger DM

    更新日期:2007-08-01 00:00:00