Abstract:
BACKGROUND:Circulating markers of inflammation in chronic obstructive pulmonary disease (COPD) may correlate to disease progression and extrapulmonary complications such as malnourishment. However, surprisingly little is known about gender-related differences for circulating inflammatory markers in COPD. PURPOSE:To characterize differences in circulating markers of inflammation in malnourished female and male patients with COPD. SUBJECTS:Thirty female and 11 male patients with a clinical diagnosis of COPD and malnourishment were examined. A group of control subjects without evidence of COPD was recruited for comparison of some variables. METHODS:Blood samples were drawn, and the following parameters were studied: leukocytes and differential counts, C-reactive protein (CRP), tumor necrosis factor-α, interleukin (IL)-6 and IL-8, myeloperoxidase (MPO), neutrophil elastase (NE), intracellular adhesion molecule-1, vascular endothelial adhesion molecule-1, and E-selectin. RESULTS:The mean neutrophil concentration was significantly (P = 0.019) higher in female (4.5 × 10(9)/L) than in male patients with COPD (3.5 × 10(9)/L) and significantly higher than in female control subjects (3.1 × 10(9)/L) (P < 0.01, n = 85). The mean CRP values were considerably higher in female (4.9 mg/mL) than in male patients with COPD (1.5 mg/mL), but the difference was not statistically significant (P = 0.20). The mean concentrations of IL-6 and IL-8 tended to be higher in female than in male patients with COPD, but these differences did not reach statistical significance either (P > 0.05). Confounding factors (smoking, medication) could not explain the gender differences noted. The concentrations of MPO and NE displayed a strong correlation (r = 0.89; P < 0.01, n = 41) but revealed no gender differences. The latter was true for concentrations of adhesion molecules as well. CONCLUSIONS:Our study puts forward evidence of a gender-related difference in systemic inflammation in malnourished patients with COPD in terms of circulating neutrophils being more abundant in female patients. Among these female patients, there was also a trend toward an increase in two neutrophil-mobilizing cytokines. New and better-powered studies are warranted to confirm and characterize this potentially important phenomenon in greater detail.
journal_name
Int J Chron Obstruct Pulmon Disauthors
Larsson S,Nordenson A,Glader P,Yoshihara S,Lindén A,Slinde Fdoi
10.2147/COPD.S15351subject
Has Abstractpub_date
2011-01-01 00:00:00pages
83-8eissn
1176-9106issn
1178-2005journal_volume
6pub_type
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