Inspiratory flows through dry powder inhaler in chronic obstructive pulmonary disease: age and gender rather than severity matters.

Abstract:

BACKGROUND:Dry powder inhalers (DPIs) are inspiratory flow driven and hence flow dependent. Most patients with chronic obstructive pulmonary disease (COPD) are elderly and have poor lung function. The factors affecting their inspiratory flows through inhalers are unclear. OBJECTIVE:To study peak inspiratory flows (PIFs) and their determinants through a DPI in COPD patients of varying age and severity. METHODS:Flow-volume spirometry was performed in 93 COPD patients. Maximum PIF rates were recorded through an empty Easyhaler (PIF(EH); Orion Corporation, Espoo, Finland), a DPI that provides consistent dose delivery at inhalation rates through the inhaler of 28 L/min or higher. RESULTS:The mean PIF(EH) was 54 L/min (range 26-95 L/min) with a coefficient of variation of 7%. All but two patients were able to generate a flow of > or = 28 L/min. In a general linear model, the independent determinants for PIF(EH) were age (P = 0.02) and gender (P = 0.01), and forced expiratory volume in 1 s (FEV(1)) expressed as percent predicted was not a significant factor. The regression model accounted only for 18% of the variation in PIF(EH). CONCLUSION:In patients with COPD, age and gender are more important determinants of inspiratory flow through DPIs than the degree of expiratory airway obstruction. Most COPD patients with varying age and severity are able to generate inspiratory flows through the test inhaler that is sufficient for optimal drug delivery to the lower airways.

authors

Malmberg LP,Rytilä P,Happonen P,Haahtela T

doi

10.2147/copd.s11474

subject

Has Abstract

pub_date

2010-08-09 00:00:00

pages

257-62

eissn

1176-9106

issn

1178-2005

journal_volume

5

pub_type

杂志文章
  • Long-term effects of gastrectomy in patients with spirometry-defined COPD and patients at risk of COPD: a case-control study.

    abstract:OBJECTIVE:Comorbidities are characteristic of COPD. However, little is known about the secondary manifestations of COPD in the gastrointestinal tract. Therefore, we aimed to explore the long-term effects of gastrectomy in patients with spirometry-defined COPD or those at risk of COPD. PARTICIPANTS:Subjects included 87...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S87135

    authors: Saito H,Nomura K,Abe S,Motegi T,Ishii T,Hattori K,Kusunoki Y,Gemma A,Kida K

    更新日期:2015-10-29 00:00:00

  • Alterations of the default mode network and cognitive impairments in patients with chronic obstructive pulmonary disease.

    abstract:Background and objectives:Cognitive impairment is a common extrapulmonary comorbidity in COPD patients. The default mode network (DMN) plays a critical role in maintaining the normal activities of humans, and its function can be evaluated by resting state functional magnetic resonance imaging. The aim of this study was...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S146870

    authors: Hu X,Wang H,Tu Y,Fei M,Yin M,Fei G,Yu Y

    更新日期:2018-02-07 00:00:00

  • Inhaled corticosteroid use in patients with chronic obstructive pulmonary disease and the risk of pneumonia: a retrospective claims data analysis.

    abstract:BACKGROUND:The use of inhaled corticosteroids in patients with chronic obstructive pulmonary disease (COPD) has been associated with an increased risk of pneumonia in controlled clinical trials and case-control analyses. OBJECTIVE:Using claims databases as a research model of real-world diagnosis and treatment, to det...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S42366

    authors: Yawn BP,Li Y,Tian H,Zhang J,Arcona S,Kahler KH

    更新日期:2013-01-01 00:00:00

  • Health effects in COPD smokers who switch to electronic cigarettes: a retrospective-prospective 3-year follow-up.

    abstract:Background:Health effects of electronic cigarette (EC) use in patients with chronic obstructive pulmonary disease (COPD) are largely unexplored. Aim:We present findings from a long-term prospective assessment of respiratory parameters in a cohort of COPD patients who ceased or substantially reduced conventional cigare...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S161138

    authors: Polosa R,Morjaria JB,Prosperini U,Russo C,Pennisi A,Puleo R,Caruso M,Caponnetto P

    更新日期:2018-08-22 00:00:00

  • COPD classification models and mortality prediction capacity.

    abstract:Objective:Our aim was to assess the impact of comorbidities on existing COPD prognosis scores. Patients and methods:A total of 543 patients with COPD (FEV1 <80% and FEV1/FVC <70%) were included between January 2003 and January 2004. Patients were stable for at least 6 weeks before inclusion and were followed for 5 yea...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S184695

    authors: Aramburu A,Arostegui I,Moraza J,Barrio I,Aburto M,García-Loizaga A,Uranga A,Zabala T,Quintana JM,Esteban C

    更新日期:2019-03-07 00:00:00

  • The pathophysiology of bronchiectasis.

    abstract::Bronchiectasis is defined by permanent and abnormal widening of the bronchi. This process occurs in the context of chronic airway infection and inflammation. It is usually diagnosed using computed tomography scanning to visualize the larger bronchi. Bronchiectasis is also characterized by mild to moderate airflow obst...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,评审

    doi:10.2147/copd.s6133

    authors: King PT

    更新日期:2009-01-01 00:00:00

  • Barriers and enablers of COPD telerehabilitation - a frontline staff perspective.

    abstract:Background:Telerehabilitation (TR) aimed at patients with COPD has shown promising effects on symptoms, physical function, and quality of life, but little research has been conducted to understand the impact of implementation on frontline health professionals. Therefore, the aim of this study was to examine the barrier...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S167501

    authors: Damhus CS,Emme C,Hansen H

    更新日期:2018-08-17 00:00:00

  • Upper-extremity function prospectively predicts adverse discharge and all-cause COPD readmissions: a pilot study.

    abstract:Background:Frailty can inform management approaches for individuals with COPD. However, inpatient measures of frailty are seldom employed because they are time-consuming or inapplicable for bed-bound patients. We investigated the feasibility and potential of an innovative sensor-based upper-extremity function (UEF) tes...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S182802

    authors: Ehsani H,Mohler MJ,Golden T,Toosizadeh N

    更新日期:2018-12-18 00:00:00

  • Low back pain and gastroesophageal reflux in patients with COPD: the disease in the breath.

    abstract::COPD is a worsening condition that leads to a pathologic degeneration of the respiratory system. It represents one of the most important causes of mortality and morbidity in the world, and it is characterized by the presence of associated comorbidity. This article analyzes gastroesophageal reflux disease (GERD) and lo...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S150401

    authors: Bordoni B,Marelli F,Morabito B,Sacconi B,Caiazzo P,Castagna R

    更新日期:2018-01-17 00:00:00

  • Efficacy and safety of once-daily glycopyrronium in predominantly Chinese patients with moderate-to-severe chronic obstructive pulmonary disease: the GLOW7 study.

    abstract:BACKGROUND:Glycopyrronium is a once-daily (od) long-acting muscarinic antagonist for the maintenance treatment of chronic obstructive pulmonary disease (COPD). The GLOW7 study evaluated the efficacy and safety of od glycopyrronium 50 μg in predominantly Chinese patients with moderate-to-severe COPD. METHODS:In this 26...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2147/COPD.S72650

    authors: Wang C,Sun T,Huang Y,Humphries M,Bai L,Li L,Wang Q,Kho P,Firth R,D'Andrea P

    更新日期:2015-01-05 00:00:00

  • Adherence to current guidelines for chronic obstructive pulmonary disease (COPD) among patients treated with combination of long-acting bronchodilators or inhaled corticosteroids.

    abstract:BACKGROUND:To estimate the potential cost savings by following the current Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline recommendations in patients being treated for chronic obstructive pulmonary disease (COPD) with the combination of long-acting β(2)-agonist (LABA), long-acting muscarinic an...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S25805

    authors: Asche CV,Leader S,Plauschinat C,Raparla S,Yan M,Ye X,Young D

    更新日期:2012-01-01 00:00:00

  • Defect of alveolar regeneration in pulmonary emphysema: role of lung fibroblasts.

    abstract::Pulmonary emphysema is characterized by the irreversible loss of pulmonary alveoli. Despite recent advances in the understanding this disease, its treatment remains palliative. In this review, we will successively review the data suggesting (1) that alveolar regeneration systems are functional in the mammalian lung an...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,评审

    doi:

    authors: Plantier L,Boczkowski J,Crestani B

    更新日期:2007-01-01 00:00:00

  • Phenotyping COPD exacerbations using imaging and blood-based biomarkers.

    abstract:Rationale:Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are caused by a variety of different etiologic agents. Our aim was to phenotype COPD exacerbations using imaging (chest X-ray [CXR] and computed tomography [CT]) and to determine the possible role of the blood tests (C-reactive protein [CRP...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S152484

    authors: Alotaibi NM,Chen V,Hollander Z,Hague CJ,Murphy DT,Leipsic JA,DeMarco ML,FitzGerald JM,McManus BM,Ng RT,Sin DD

    更新日期:2018-01-08 00:00:00

  • COPD in patients with stable heart failure in the primary care setting.

    abstract:BACKGROUND:Presence of chronic obstructive pulmonary disease (COPD) in heart failure (HF) has prognostic and therapeutic implications. Exact prevalence estimates are lacking because most previous studies estimated the prevalence of COPD among HF patients while unstable and in the presence of pulmonary congestion. METH...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S77085

    authors: Valk MJ,Broekhuizen BD,Mosterd A,Zuithoff NP,Hoes AW,Rutten FH

    更新日期:2015-06-26 00:00:00

  • Long QT and death in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease is not related to electrolyte disorders.

    abstract::Objectives: COPD is the fourth-leading cause of mortality worldwide. Prolonged QTc has been found to be a long-term negative prognostic factor in ambulatory COPD patients. The aim of this study was to evaluate the extent of prolonged-QTc syndrome in COPD patients upon admission to an internal medicine department, its ...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S196428

    authors: Zilberman-Itskovich S,Rahamim E,Tsiporin-Havatinsky F,Ziv-Baran T,Golik A,Zaidenstein R

    更新日期:2019-05-20 00:00:00

  • New developments in the assessment of COPD: early diagnosis is key.

    abstract::Chronic obstructive pulmonary disease (COPD) is the most common chronic lung disease in the world, and its associated health burdens and costs are mounting. Until recently, it was generally accepted that targeting the diagnosis of COPD early in its course was a relatively fruitless effort, since treatments other than ...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,评审

    doi:10.2147/COPD.S46198

    authors: Csikesz NG,Gartman EJ

    更新日期:2014-02-27 00:00:00

  • Periodontal Status and Microbiologic Pathogens in Patients with Chronic Obstructive Pulmonary Disease and Periodontitis: A Case-Control Study.

    abstract:Purpose:To evaluate clinical periodontal status and microbiologic pathogens in patients with chronic obstructive pulmonary disease (COPD) and periodontitis. Patients and Methods:We conducted a case-control study of 60 periodontitis patients with COPD (case group) and 60 periodontitis patients with normal pulmonary fun...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S266612

    authors: Zhou X,Wang J,Liu W,Huang X,Song Y,Wang Z,Jia X

    更新日期:2020-09-03 00:00:00

  • The association of renin-angiotensin system blockades and pneumonia requiring admission in patients with COPD.

    abstract:BACKGROUND:The hallmark of COPD is chronic airway inflammation, which may be mediated by renin-angiotensin system. The renin-angiotensin system blockers such as angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARBs) have exhibited anti-inflammatory and immunomodulatory effects in pa...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S104097

    authors: Kim J,Lee JK,Heo EY,Chung HS,Kim DK

    更新日期:2016-09-09 00:00:00

  • Do frequent moderate exacerbations contribute to progression of chronic obstructive pulmonary disease in patients who are ex-smokers?

    abstract:BACKGROUND:In addition to smoking, acute exacerbations are considered to be a contributing factor to progression of chronic obstructive pulmonary disease (COPD). However, these findings come from studies including active smokers, while results in ex-smokers are scarce and contradictory. The purpose of this study was to...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S76475

    authors: Dreyse J,Díaz O,Repetto PB,Morales A,Saldías F,Lisboa C

    更新日期:2015-03-10 00:00:00

  • COPD affects worker productivity and health care costs.

    abstract:Purpose:This study aimed to measure the true burden of COPD by calculating incremental direct and indirect costs. Direct medical resource use, productivity metrics, and COPD-specific resource use and costs were also evaluated. Patients and methods:This was a retrospective, observational, matched cohort study using adm...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S163795

    authors: Patel JG,Coutinho AD,Lunacsek OE,Dalal AA

    更新日期:2018-07-30 00:00:00

  • Efficacy and safety of ipratropium bromide/salbutamol sulphate administered in a hydrofluoroalkane metered-dose inhaler for the treatment of COPD.

    abstract:BACKGROUND:The use of chlorofluorocarbons (CFCs) has contributed to the depletion of the stratospheric ozone layer resulting in serious health concerns. Ipratropium bromide/salbutamol sulphate CFC-pressurized metered-dose inhalers (IB/SAL-CFC pMDI) have been in widespread use for many years without any apparent ill con...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2147/COPD.S89923

    authors: Bhattacharya A,Bhargava S,Singh V,Talwar D,Whig J,Rebello J,Purandare S,Gogtay J

    更新日期:2016-06-30 00:00:00

  • Disrupted resting-state spontaneous neural activity in stable COPD.

    abstract:Introduction and aim:Abnormal brain structure and function in COPD has been reported on MRI. However, the deficit in local synchronization of spontaneous activity in patients with stable COPD remains unknown. The main aim of the present study was to explore spontaneous brain activity in patients with COPD compared with...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S190671

    authors: Xin H,Li H,Yu H,Yu J,Zhang J,Wang W,Peng D

    更新日期:2019-02-27 00:00:00

  • Prevalence of smoking in a psychiatric hospital and its relationship with respiratory symptoms and the prevalence of COPD.

    abstract:Purpose:Psychiatric patients present an elevated rate of smoking, and the smoking habit is related to a high morbidity and mortality in this collective. The aim of this study was to determine the prevalence of smoking in patients admitted for psychiatric disorders and its relationship with respiratory disease, the prev...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S165880

    authors: Lores L,Monje A,Bergada M,Arellano E,Rodríguez-Larrea J,Miravitlles M

    更新日期:2018-09-07 00:00:00

  • Overlaps and uncertainties of smoking-related idiopathic interstitial pneumonias.

    abstract::Smoking-related interstitial lung disease (ILD) consists of a heterogeneous group of disorders that are considered a distinct entity. The 2013 American Thoracic Society and European Respiratory Society recommendations classified respiratory bronchiolitis (RB)/RB-ILD and desquamative interstitial pneumonia (DIP) as smo...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,评审

    doi:10.2147/COPD.S146899

    authors: Bak SH,Lee HY

    更新日期:2017-11-01 00:00:00

  • Onset of action of indacaterol in patients with COPD: comparison with salbutamol and salmeterol-fluticasone.

    abstract:BACKGROUND:indacaterol is a novel, inhaled once-daily ultra-long-acting β(2)-agonist for the treatment of chronic obstructive pulmonary disease (COPD). OBJECTIVES:this study compared the onset of action of single doses of indacaterol 150 and 300 μg with salbutamol 200 μg, salmeterol-fluticasone 50/500 μg, and placebo ...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2147/copd.s12120

    authors: Balint B,Watz H,Amos C,Owen R,Higgins M,Kramer B,INSURE Study Investigators.

    更新日期:2010-09-07 00:00:00

  • Prevalence of Chronic Obstructive Pulmonary Disease and its Associated Factors in Nepal: Findings from a Community-based Household Survey.

    abstract:Background:Despite chronic obstructive pulmonary disease (COPD) being the commonest non-communicable disease in Nepal, there is limited research evidence estimating the spirometry-based burden of COPD. This study aims to estimate the prevalence of COPD and its correlates through a community-based survey in Pokhara Metr...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S268110

    authors: Adhikari TB,Acharya P,Högman M,Neupane D,Karki A,Drews A,Cooper BG,Sigsgaard T,Kallestrup P

    更新日期:2020-09-29 00:00:00

  • Health care utilization history, GOLD guidelines, and respiratory medication prescriptions in patients with COPD.

    abstract:BACKGROUND:The relationship between prior health care utilization and respiratory medication prescriptions in an unselected population of patients with COPD is not known. METHODS:We determined the prescribed respiratory medications and respiratory and nonrespiratory health care encounters in 523 Veterans with COPD at ...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/copd.s8822

    authors: Seaman J,Leonard AC,Panos RJ

    更新日期:2010-04-07 00:00:00

  • Impact of selective and nonselective beta-blockers on the risk of severe exacerbations in patients with COPD.

    abstract:BACKGROUND:There is conflicting information regarding the effects of selective and nonselective beta-blocker treatment in patients with COPD. PARTICIPANTS AND METHODS:This nested case-control study used the Taiwan National Health Insurance Research Database. We included COPD patients who used inhalation steroid and be...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S145913

    authors: Huang YL,Lai CC,Wang YH,Wang CY,Wang JY,Wang HC,Yu CJ,Chen L

    更新日期:2017-10-11 00:00:00

  • Risk of pneumonia with inhaled corticosteroid/long-acting β2 agonist therapy in chronic obstructive pulmonary disease: a cluster analysis.

    abstract:BACKGROUND:Pneumonia poses a significant risk in patients with moderate to severe chronic obstructive pulmonary disease but data are limited on the disease phenotypes most susceptible to pneumonia. METHODS:Cluster analysis using a data-driven recursive partitioning algorithm was employed using baseline data from two p...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2147/COPD.S60498

    authors: DiSantostefano RL,Li H,Hinds D,Galkin DV,Rubin DB

    更新日期:2014-05-07 00:00:00

  • Erratum: Bronchiectasis in COPD patients: more than a comorbidity? [Corrigendum].

    abstract::[This corrects the article on p. 1401 in vol. 12, PMID: 28546748.]. ...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,已发布勘误

    doi:10.2147/COPD.S194432

    authors:

    更新日期:2019-01-18 00:00:00