Defect of alveolar regeneration in pulmonary emphysema: role of lung fibroblasts.

abstract：:The landmark study of Fletcher and Peto on the natural history of tobacco smoke-related chronic airflow obstruction suggested that decline in the forced expiratory volume in the first second (FEV(1)) in chronic obstructive pulmonary disease (COPD) is slow at the beginning, becoming faster with more advanced disease. T...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Tantucci C,Modina D

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:It has been scientifically proven that pulmonary rehabilitation improves exercise tolerance and facilitates the carrying out of daily physical activities. To optimize the physical and physiological benefits, it is necessary to individualize the training intensity for each patient. The aim of this study is to...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Fabre C,Chehere B,Bart F,Mucci P,Wallaert B,Grosbois JM

更新日期：2017-05-16 00:00:00

abstract：BACKGROUND:There is conflicting information regarding the effects of selective and nonselective beta-blocker treatment in patients with COPD. PARTICIPANTS AND METHODS:This nested case-control study used the Taiwan National Health Insurance Research Database. We included COPD patients who used inhalation steroid and be...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Huang YL,Lai CC,Wang YH,Wang CY,Wang JY,Wang HC,Yu CJ,Chen L

更新日期：2017-10-11 00:00:00

abstract：Background:COPD is characterized by a persistent inflammatory response, especially against cigarette smoke. COPD patients may develop varying degrees of emphysematous destruction of the lungs. A pathophysiological role for miRNAs in COPD has been suggested in several studies. We examined changes in microRNAs expression...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Cazorla-Rivero S,Mura-Escorche G,Gonzalvo-Hernández F,Mayato D,Córdoba-Lanús E,Casanova C

更新日期：2020-10-29 00:00:00

abstract：BACKGROUND:indacaterol is a novel, inhaled once-daily ultra-long-acting β(2)-agonist for the treatment of chronic obstructive pulmonary disease (COPD). OBJECTIVES:this study compared the onset of action of single doses of indacaterol 150 and 300 μg with salbutamol 200 μg, salmeterol-fluticasone 50/500 μg, and placebo ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Balint B,Watz H,Amos C,Owen R,Higgins M,Kramer B,INSURE Study Investigators.

更新日期：2010-09-07 00:00:00

abstract：Introduction:COPD is an inflammatory airway pathology associated with recurrent infection by nontypeable Haemophilus influenzae (NTHi) that is not effectively managed by macrolide antibiotic therapy. We hypothesised that NTHi is able to reside intracellularly within COPD-derived airway epithelial cells (AEC), and that ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Poh WP,Kicic A,Lester SE,Nguyen PT,Bakaletz LO,Reynolds PN,Hodge S,Roscioli E

更新日期：2020-06-04 00:00:00

abstract：BACKGROUND:The chronic obstructive pulmonary disease (COPD) assessment test (CAT) is a short questionnaire that has facilitated health status measurements in subjects with COPD. However, it remains controversial as to whether the CAT can be used as a suitable substitute for the St George's Respiratory Questionnaire (SG...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Morishita-Katsu M,Nishimura K,Taniguchi H,Kimura T,Kondoh Y,Kataoka K,Ogawa T,Watanabe F,Arizono S,Nishiyama O,Nakayasu K,Imaizumi K,Hasegawa Y

更新日期：2016-07-07 00:00:00

abstract：Purpose:We hypothesized that increased level of serum β2-microglobulin (β2M) is an independent factor associated with higher mortality in hospitalized patients with exacerbated chronic obstructive pulmonary disease (COPD). Patients and Methods:We retrospectively analyzed 488 hospitalized patients with exacerbated COPD...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Mao W,Wang J,Zhang L,Wang Y,Wang W,Zeng N,Zhang J,Li Q,Jiao F,Li J,Cui N,Mi S,Xue Y,Wang Z,Ying S,Huang K

更新日期：2020-04-07 00:00:00

abstract：Background:Health effects of electronic cigarette (EC) use in patients with chronic obstructive pulmonary disease (COPD) are largely unexplored. Aim:We present findings from a long-term prospective assessment of respiratory parameters in a cohort of COPD patients who ceased or substantially reduced conventional cigare...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Polosa R,Morjaria JB,Prosperini U,Russo C,Pennisi A,Puleo R,Caruso M,Caponnetto P

更新日期：2018-08-22 00:00:00

abstract：BACKGROUND:Pneumonia poses a significant risk in patients with moderate to severe chronic obstructive pulmonary disease but data are limited on the disease phenotypes most susceptible to pneumonia. METHODS:Cluster analysis using a data-driven recursive partitioning algorithm was employed using baseline data from two p...

journal_title：International journal of chronic obstructive pulmonary disease

authors： DiSantostefano RL,Li H,Hinds D,Galkin DV,Rubin DB

更新日期：2014-05-07 00:00:00

abstract：OBJECTIVE:To investigate the gene-expression profile of chronic obstructive pulmonary disease (COPD) patients and explore the possible therapeutic targets. METHODS:The microarray raw dataset GSE29133, including three COPD samples and three normal samples, was obtained from Gene Expression Omnibus. After data preproces...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Wei L,Xu D,Qian Y,Huang G,Ma W,Liu F,Shen Y,Wang Z,Li L,Zhang S,Chen Y

更新日期：2015-06-10 00:00:00

abstract：Purpose:To evaluate clinical periodontal status and microbiologic pathogens in patients with chronic obstructive pulmonary disease (COPD) and periodontitis. Patients and Methods:We conducted a case-control study of 60 periodontitis patients with COPD (case group) and 60 periodontitis patients with normal pulmonary fun...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Zhou X,Wang J,Liu W,Huang X,Song Y,Wang Z,Jia X

更新日期：2020-09-03 00:00:00

abstract：PURPOSE:COPD is characterized by an accelerated and progressive decline in forced expiratory volume in 1 second (FEV1) and lung hyperinflation. Although lung hyperinflation is the hallmark of COPD, data on the longitudinal changes in lung hyperinflation and any association with the decline in FEV1 are lacking. The aim ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Park J,Lee CH,Lee YJ,Park JS,Cho YJ,Lee JH,Lee CT,Yoon HI

更新日期：2017-02-03 00:00:00

abstract：BACKGROUND:In addition to smoking, acute exacerbations are considered to be a contributing factor to progression of chronic obstructive pulmonary disease (COPD). However, these findings come from studies including active smokers, while results in ex-smokers are scarce and contradictory. The purpose of this study was to...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Dreyse J,Díaz O,Repetto PB,Morales A,Saldías F,Lisboa C

更新日期：2015-03-10 00:00:00

abstract：Background:In COPD disturbed sleep is related to exacerbation frequency, poor quality of life, and early mortality. We developed the Manchester Respiratory-related Sleep Symptoms scale (MaRSS) to assess sleep-time symptoms in COPD. Methods:Focus groups including COPD and age-matched controls were used to develop an it...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Khan N,Vestbo J,Garrow A,Karur P,Kolsum U,Tyson S,Singh D,Yorke J

更新日期：2018-11-29 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD), a respiratory disease characterized by a progressive decline in lung function, is considered to be a leading cause of morbidity and mortality. Long-acting inhaled bronchodilators, such as long-acting β2 agonists (LABAs) or long-acting muscarinic antagonists (LAMAs), are th...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Ramadan WH,Kabbara WK,El Khoury GM,Al Assir SA

更新日期：2015-10-30 00:00:00

abstract：INTRODUCTION:End-stage lung disease (ESLD) (predominantly caused by chronic obstructive pulmonary disease and restrictive lung disease) is a significant cause of death. Little is known about community care for people with ESLD especially in the period leading to death. This paper describes demographic characteristics o...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Currow DC,Ward A,Clark K,Burns CM,Abernethy AP

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:To estimate the potential cost savings by following the current Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline recommendations in patients being treated for chronic obstructive pulmonary disease (COPD) with the combination of long-acting β(2)-agonist (LABA), long-acting muscarinic an...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Asche CV,Leader S,Plauschinat C,Raparla S,Yan M,Ye X,Young D

更新日期：2012-01-01 00:00:00

abstract：Purpose:Primary care COPD guidelines indicate that COPD patients with asthma characteristics should be treated as having asthma. This study aims to describe the prevalence of asthma characteristics in patients with a pulmonologist-confirmed working diagnosis of COPD or ACO. Patients and Methods:This retrospective cros...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Baron AJ,Flokstra-de Blok BMJ,van Heijst E,Riemersma RA,Sonnenschein-van der Voort AMM,Metting EI,Kocks JWH

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:The causal association between depression, anxiety, and health-related quality of life (HRQoL) in chronic obstructive pulmonary disease (COPD) is unclear. We therefore conducted a systematic review of prospective cohort studies that measured depression, anxiety, and HRQoL in COPD. METHODS:Electronic databas...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Blakemore A,Dickens C,Guthrie E,Bower P,Kontopantelis E,Afzal C,Coventry PA

更新日期：2014-05-20 00:00:00

abstract：INTRODUCTION:Guidelines recommendations for the treatment of COPD are poorly followed. This could be related to the complexity of classification and treatment algorithms. The purpose of this study was to validate a simpler dyspnea-based treatment algorithm for inhaled pharmacotherapy in stable COPD, comparing its conco...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Cabrera C,Casanova C,Martín Y,Mirabal V,Sánchez Mdel C,Álvarez F,Juliá G,Cabrera-Navarro P,García-Bello MÁ,Marín JM,de-Torres JP,Divo M,Celli B

更新日期：2016-06-08 00:00:00

abstract：BACKGROUND:Forced expiratory volume in 1 second (FEV1)/forced expiratory volume in 6 seconds (FEV6) has been proposed as an alternative to FEV1/forced vital capacity (FVC) for detecting airway obstruction. A fixed cut-off value for FEV1/FEV6 in a Korean population is lacking. We investigated a fixed cut-off for FEV1/FE...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Chung KS,Jung JY,Park MS,Kim YS,Kim SK,Chang J,Song JH

更新日期：2016-08-19 00:00:00

abstract：:Smoking-related interstitial lung disease (ILD) consists of a heterogeneous group of disorders that are considered a distinct entity. The 2013 American Thoracic Society and European Respiratory Society recommendations classified respiratory bronchiolitis (RB)/RB-ILD and desquamative interstitial pneumonia (DIP) as smo...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Bak SH,Lee HY

更新日期：2017-11-01 00:00:00

abstract：Objective:Chronic obstructive pulmonary disease (COPD) is associated with atherosclerosis. Previous studies including limited sample sizes have shown the prevalence of peripheral arterial occlusive disease (PAOD) among COPD patients. We sought to investigate the incidence of PAOD among COPD patients in Taiwan using a n...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Liao KM,Kuo LT,Lu HY

更新日期：2019-07-04 00:00:00

abstract：:[This corrects the article on p. 2749 in vol. 11, PMID: 27853362.]. ...

journal_title：International journal of chronic obstructive pulmonary disease

authors：

更新日期：2017-01-10 00:00:00

abstract：:Bronchiectasis is defined by permanent and abnormal widening of the bronchi. This process occurs in the context of chronic airway infection and inflammation. It is usually diagnosed using computed tomography scanning to visualize the larger bronchi. Bronchiectasis is also characterized by mild to moderate airflow obst...

journal_title：International journal of chronic obstructive pulmonary disease

authors： King PT

更新日期：2009-01-01 00:00:00

abstract：Introduction and aim:Abnormal brain structure and function in COPD has been reported on MRI. However, the deficit in local synchronization of spontaneous activity in patients with stable COPD remains unknown. The main aim of the present study was to explore spontaneous brain activity in patients with COPD compared with...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Xin H,Li H,Yu H,Yu J,Zhang J,Wang W,Peng D

更新日期：2019-02-27 00:00:00

abstract：:Clinical trials of a combination therapy of an inhaled corticosteroid, fluticasone propionate (FP), with a long-acting beta2-agonist, salmeterol (Sal), have demonstrated a greater improvement in lung function and in quality of life measures after the combination compared with either component of alone. In a subanalysi...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Chung KF

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Comorbidities are characteristic of COPD. However, little is known about the secondary manifestations of COPD in the gastrointestinal tract. Therefore, we aimed to explore the long-term effects of gastrectomy in patients with spirometry-defined COPD or those at risk of COPD. PARTICIPANTS:Subjects included 87...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Saito H,Nomura K,Abe S,Motegi T,Ishii T,Hattori K,Kusunoki Y,Gemma A,Kida K

更新日期：2015-10-29 00:00:00

abstract：Purpose:This research examines the emerging role of respiratory oscillometry associated with integer (InOr) and fractional order (FrOr) respiratory models in the context of groups of patients with increasing severity. The contributions to our understanding of the respiratory abnormalities along the course of increasing...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Ribeiro CO,Lopes AJ,de Melo PL

更新日期：2020-12-08 00:00:00