New developments in the assessment of COPD: early diagnosis is key.

Abstract:

:Chronic obstructive pulmonary disease (COPD) is the most common chronic lung disease in the world, and its associated health burdens and costs are mounting. Until recently, it was generally accepted that targeting the diagnosis of COPD early in its course was a relatively fruitless effort, since treatments other than already ubiquitous smoking-cessation efforts were unlikely to alter its course. However, there is strong evidence to suggest that the majority of patients with objective COPD are not aware of their condition, and this leads to a significant delay in diagnosis, more aggressive smoking-cessation intervention, and potential treatment. Novel methods of diagnostic testing, community health programs, and primary-care provider recommendations hold promise to expand the recognition of COPD in its incipient stages - where recent evidence suggests a rapid decline in lung function occurs and may be prevented if acted upon. This review explores the evidence to support the efforts to justify programs aimed at early diagnosis, alternative diagnostic strategies that may augment traditional spirometry, therapeutic modalities that could potentially be used in the future to alter early lung-function decline, and emphasizes the necessary cooperative role that physicians, patients, communities, and governments need to play to realize the significant health impact that stands to be gained.

authors

Csikesz NG,Gartman EJ

doi

10.2147/COPD.S46198

subject

Has Abstract

pub_date

2014-02-27 00:00:00

pages

277-86

eissn

1176-9106

issn

1178-2005

pii

copd-9-277

journal_volume

9

pub_type

杂志文章,评审
  • "You Leave There Feeling Part of Something": A Qualitative Study of Hospitalized COPD Patients' Perceptions of Pulmonary Rehabilitation.

    abstract:Rationale:Current guidelines recommend that patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease (COPD) initiate pulmonary rehabilitation (PR) shortly after discharge from the hospital. However, fewer than 2 percent of Medicare beneficiaries do so. Few studies have examined hospitalize...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S234833

    authors: Spitzer KA,Stefan MS,Drake AA,Pack QR,Lagu T,Mazor KM,Pinto-Plata V,Lindenauer PK

    更新日期:2020-03-17 00:00:00

  • Decreased serum club cell secretory protein in asthma and chronic obstructive pulmonary disease overlap: a pilot study.

    abstract:Purpose:Improvement in the diagnosis of asthma and chronic obstructive pulmonary disease (COPD) overlap (ACO), and identification of biomarkers for phenotype recognition will encourage good patient care by providing optimal therapy. We investigated club cell secretory protein (CC-16), a protective and anti-inflammatory...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,多中心研究

    doi:10.2147/COPD.S174545

    authors: Oh JY,Lee YS,Min KH,Hur GY,Lee SY,Kang KH,Rhee CK,Park SJ,Shim JJ

    更新日期:2018-10-18 00:00:00

  • Evaluation of isokinetic muscle strength of upper limb and the relationship with pulmonary function and respiratory muscle strength in stable COPD patients.

    abstract:Background:Upper limb muscle strength plays an important role in respiratory and pulmonary function, and limited research focuses on the role of strength and endurance of the elbow extensor and flexor. This study was conducted to accurately assess upper limb muscle function and quantified associations with pulmonary fu...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S214737

    authors: Liu X,Li P,Wang Z,Lu Y,Li N,Xiao L,Duan H,Wang Z,Li J,Shan C,Wu W

    更新日期:2019-09-05 00:00:00

  • Inhaled corticosteroid use in patients with chronic obstructive pulmonary disease and the risk of pneumonia: a retrospective claims data analysis.

    abstract:BACKGROUND:The use of inhaled corticosteroids in patients with chronic obstructive pulmonary disease (COPD) has been associated with an increased risk of pneumonia in controlled clinical trials and case-control analyses. OBJECTIVE:Using claims databases as a research model of real-world diagnosis and treatment, to det...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S42366

    authors: Yawn BP,Li Y,Tian H,Zhang J,Arcona S,Kahler KH

    更新日期:2013-01-01 00:00:00

  • Efficacy and safety characteristics of mometasone furoate/formoterol fumarate fixed-dose combination in subjects with moderate to very severe COPD: findings from pooled analysis of two randomized, 52-week placebo-controlled trials.

    abstract:BACKGROUND:The clinical efficacy and safety of a mometasone furoate/formoterol fumarate (MF/F) fixed-dose combination formulation administered via a metered-dose inhaler was investigated in patients with moderate to very severe chronic obstructive pulmonary disease (COPD). METHODS:Two 52-week, multicenter, double-blin...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2147/COPD.S29444

    authors: Tashkin DP,Doherty DE,Kerwin E,Matiz-Bueno CE,Knorr B,Shekar T,Gates D,Staudinger H

    更新日期:2012-01-01 00:00:00

  • Increased brachial intima-media thickness is associated with circulating levels of asymmetric dimethylarginine in patients with COPD.

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is associated with an increased cardiovascular risk. However, the mechanisms for this association are yet unclear. The aim of this study was to investigate the relationship between brachial intima-media thickness (B-IMT), an independent predictor of cardiovascular...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S118596

    authors: Urban MH,Eickhoff P,Funk GC,Burghuber OC,Wolzt M,Valipour A

    更新日期:2017-01-04 00:00:00

  • Impact of selective and nonselective beta-blockers on the risk of severe exacerbations in patients with COPD.

    abstract:BACKGROUND:There is conflicting information regarding the effects of selective and nonselective beta-blocker treatment in patients with COPD. PARTICIPANTS AND METHODS:This nested case-control study used the Taiwan National Health Insurance Research Database. We included COPD patients who used inhalation steroid and be...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S145913

    authors: Huang YL,Lai CC,Wang YH,Wang CY,Wang JY,Wang HC,Yu CJ,Chen L

    更新日期:2017-10-11 00:00:00

  • Relationship between airway obstruction and incidence of metabolic syndrome in Korea: a community-based cohort study.

    abstract:Background:Although studies have examined the relationship between metabolic syndrome (MetS) and COPD, the incidence of MetS in individuals with COPD has not specifically been investigated. This study aimed to evaluate the incidence of MetS in subjects with airway obstruction using data from a community-based cohort. ...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S157453

    authors: Kim CY,Park Y,Leem AY,Chung KS,Jung JY,Park MS,Kim YS

    更新日期:2018-06-28 00:00:00

  • The evaluation of β-adrenoceptor blocking agents in patients with COPD and congestive heart failure: a nationwide study.

    abstract:OBJECTIVE:β-Blockers are safe and improve survival in patients with both congestive heart failure (CHF) and COPD. However, the superiority of different types of β-blockers is still unclear among patients with CHF and COPD. The association between β-blockers and CHF exacerbation as well as COPD exacerbation remains uncl...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S141694

    authors: Liao KM,Lin TY,Huang YB,Kuo CC,Chen CY

    更新日期:2017-08-26 00:00:00

  • Clinical application value of impulse oscillometry in geriatric patients with COPD.

    abstract:BACKGROUND:The diagnosis and assessment of COPD rely mainly on the use of spirometry, which is an effort-dependent test and requires good patient cooperation. Impulse oscillometry (IOS) is a non-volitional method that requires less effort and cooperation and presents advantages for geriatric patients. However, the clin...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S129974

    authors: Liu Z,Lin L,Liu X

    更新日期:2017-03-15 00:00:00

  • The association between combined non-cystic fibrosis bronchiectasis and lung cancer in patients with chronic obstructive lung disease.

    abstract:BACKGROUND:Whereas the epidemiological association between lung cancer and chronic obstructive pulmonary disease (COPD), a chronic inflammatory respiratory disease, is well known, limited studies have examined the association between lung cancer and non-cystic fibrosis bronchiectasis, a representative chronic airway in...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S80439

    authors: Kim YW,Jin KN,Heo EY,Park SS,Chung HS,Kim DK

    更新日期:2015-05-04 00:00:00

  • Long-term effects of gastrectomy in patients with spirometry-defined COPD and patients at risk of COPD: a case-control study.

    abstract:OBJECTIVE:Comorbidities are characteristic of COPD. However, little is known about the secondary manifestations of COPD in the gastrointestinal tract. Therefore, we aimed to explore the long-term effects of gastrectomy in patients with spirometry-defined COPD or those at risk of COPD. PARTICIPANTS:Subjects included 87...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S87135

    authors: Saito H,Nomura K,Abe S,Motegi T,Ishii T,Hattori K,Kusunoki Y,Gemma A,Kida K

    更新日期:2015-10-29 00:00:00

  • Management of COPD, equal treatment across age, gender, and social situation? A register study.

    abstract::Chronic obstructive pulmonary disease (COPD) is a progressive chronic disease where treatment decisions should be based on disease severity and also should be equally distributed across age, gender, and social situation. The aim of this study was to determine to what extent patients with COPD are offered evidence-base...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S115238

    authors: Henoch I,Strang S,Löfdahl CG,Ekberg-Jansson A

    更新日期:2016-10-26 00:00:00

  • Virtual Reality Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial.

    abstract:Purpose:This study compared the effects of inpatient-based rehabilitation program of patients with chronic obstructive pulmonary disease (COPD) using non-immersive virtual reality (VR) training with a traditional pulmonary rehabilitation program. The aims of this study were to determine 1) whether rehabilitation featur...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S223592

    authors: Rutkowski S,Rutkowska A,Kiper P,Jastrzebski D,Racheniuk H,Turolla A,Szczegielniak J,Casaburi R

    更新日期:2020-01-13 00:00:00

  • Early and late do-not-resuscitate (DNR) decisions in patients with terminal COPD: a retrospective study in the last year of life.

    abstract:Purpose:The unpredictable trajectory of COPD can present challenges for patients when faced with a decision regarding a do-not-resuscitate (DNR) directive. The current retrospective analysis was conducted to investigate factors associated with an early DNR decision (prior to last hospital admission) and differences in ...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S168049

    authors: Fu PK,Tung YC,Wang CY,Hwang SF,Lin SP,Hsu CY,Chen DR

    更新日期:2018-08-14 00:00:00

  • Epidemiology of chronic obstructive pulmonary disease: a population-based study in Krasnoyarsk region, Russia.

    abstract:BACKGROUND:Krasnoyarsk region is a territory with the widespread risk factors for chronic obstructive pulmonary disease (COPD) such as tobacco smoke, air pollution, and occupational exposure. An assessment of COPD prevalence based on medical diagnosis statistics underestimates the true COPD prevalence. This study aims ...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S79601

    authors: Artyukhov IP,Arshukova IL,Dobretsova EA,Dugina TA,Shulmin AV,Demko IV

    更新日期:2015-09-02 00:00:00

  • Increased parasympathetic cardiac modulation in patients with acute exacerbation of COPD: how should we interpret it?

    abstract:BACKGROUND:Cardiac autonomic modulation (CAM) is impaired in patients with stable COPD. Exacerbation aggravates the patients' health status and functional capacity. While the clinical and functional effects of exacerbation are known, no studies investigated CAM during exacerbation and whether there is a relationship be...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S134498

    authors: Kabbach EZ,Mazzuco A,Borghi-Silva A,Cabiddu R,Agnoleto AG,Barbosa JF,de Carvalho Junior LCS,Mendes RG

    更新日期:2017-07-28 00:00:00

  • Tobacco consumption in relation to causes of death in an urban population of north India.

    abstract:BACKGROUND:Noncommunicable diseases have become a public heath problem in India concomitant with economic development, leading to increases in tobacco consumption, obesity, and changes in diet and lifestyle. Although observation suggests that tobacco consumption is a major risk factor for deaths due to circulatory, pul...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:

    authors: Singh RB,Singh S,Chattopadhya P,Singh K,Singhz V,Kulshrestha SK,Tomar RS,Kumar R,Singh G,Mechirova V,Pella D

    更新日期:2007-01-01 00:00:00

  • Application of the homology method for quantification of low-attenuation lung region inpatients with and without COPD.

    abstract:BACKGROUND:Homology is a mathematical concept that can be used to quantify degree of contact. Recently, image processing with the homology method has been proposed. In this study, we used the homology method and computed tomography images to quantify emphysema. METHODS:This study included 112 patients who had undergon...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S110504

    authors: Nishio M,Nakane K,Tanaka Y

    更新日期:2016-09-06 00:00:00

  • Different impacts of respiratory symptoms and comorbidities on COPD-specific health-related quality of life by COPD severity.

    abstract:Background:Patients with chronic obstructive pulmonary disease (COPD) often have poor health-related quality of life (HRQoL) that is disproportionate to their degree of airflow limitation. This study evaluated the association between St George's Respiratory Questionnaire for COPD (SGRQ-C) score and forced expiratory vo...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,多中心研究

    doi:10.2147/COPD.S145910

    authors: Lee H,Jhun BW,Cho J,Yoo KH,Lee JH,Kim DK,Lee JD,Jung KS,Lee JY,Park HY

    更新日期:2017-11-13 00:00:00

  • The Experience of COPD Patients in Lockdown Due to the COVID-19 Pandemic.

    abstract:Purpose:On March 16, 2020, the Spanish government declared a state of alarm due to the rapid spread of coronavirus disease 2019 (COVID-19). Patients with chronic obstructive pulmonary disease (COPD) were restricted to remain confined at home, and medical visits were cancelled for 3 months. The impact of this lockdown o...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S268421

    authors: Pleguezuelos E,Del Carmen A,Moreno E,Ortega P,Vila X,Ovejero L,Serra-Prat M,Palomera E,Garnacho-Castaño MV,Loeb E,Farago G,Miravitlles M

    更新日期:2020-10-23 00:00:00

  • Benefits of short inspiratory muscle training on exercise capacity, dyspnea, and inspiratory fraction in COPD patients.

    abstract::Abstract: Static lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease (COPD). Given that most of these patients have respiratory and peripheral muscle weakness, dyspnea and functional exercise capacity may improve as a result of inspiratory muscle training (IMT...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/copd.s1822

    authors: Shahin B,Germain M,Kazem A,Annat G

    更新日期:2008-01-01 00:00:00

  • Airflow obstruction: is it asthma or is it COPD?

    abstract::Despite the availability of guideline recommendations, diagnostic confusion between COPD and asthma appears common, and often it is very difficult to decide whether the obstruction is caused by asthma or COPD in a patient with airway obstruction. However, there are well-defined features that help in differentiating as...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,评审

    doi:10.2147/COPD.S54927

    authors: Rogliani P,Ora J,Puxeddu E,Cazzola M

    更新日期:2016-11-30 00:00:00

  • Akt in the pathogenesis of COPD.

    abstract::In this review we consider the therapeutic potential of targeting Akt for the treatment of COPD. Akt is a serine/threonine protein kinase that functions as a signaling intermediate linked to multiple signaling programs involved in survival, inflammation, and growth. Akt is closely associated with key membrane-bound re...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,评审

    doi:10.2147/copd.2006.1.1.31

    authors: Bozinovski S,Vlahos R,Hansen M,Liu K,Anderson GP

    更新日期:2006-01-01 00:00:00

  • Caregivers for people with end-stage lung disease: characteristics and unmet needs in the whole population.

    abstract:INTRODUCTION:End-stage lung disease (ESLD) (predominantly caused by chronic obstructive pulmonary disease and restrictive lung disease) is a significant cause of death. Little is known about community care for people with ESLD especially in the period leading to death. This paper describes demographic characteristics o...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/copd.s3890

    authors: Currow DC,Ward A,Clark K,Burns CM,Abernethy AP

    更新日期:2008-01-01 00:00:00

  • Pre- and post-bronchodilator airway obstruction are associated with similar clinical characteristics but different prognosis - report from a population-based study.

    abstract:INTRODUCTION:According to guidelines, the diagnosis of COPD should be confirmed by post-bronchodilator (post-BD) airway obstruction on spirometry; however, in clinical practice, this is not always performed. The aim of this population-based study was to compare clinical characteristics and prognosis, assessed as mortal...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S127923

    authors: Sawalha S,Hedman L,Rönmark E,Lundbäck B,Lindberg A

    更新日期:2017-04-24 00:00:00

  • Defect of alveolar regeneration in pulmonary emphysema: role of lung fibroblasts.

    abstract::Pulmonary emphysema is characterized by the irreversible loss of pulmonary alveoli. Despite recent advances in the understanding this disease, its treatment remains palliative. In this review, we will successively review the data suggesting (1) that alveolar regeneration systems are functional in the mammalian lung an...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,评审

    doi:

    authors: Plantier L,Boczkowski J,Crestani B

    更新日期:2007-01-01 00:00:00

  • Monitoring and analysis of lung sounds remotely.

    abstract::Visual and auditory analysis of respiratory sound signals promises improved detection of certain types of lung diseases. LabVIEW software was used to design a system that monitors the respiratory activity of the patient. The program developed calculates the respiratory rate, displays the time expanded waveform of the ...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S20067

    authors: Sahgal N

    更新日期:2011-01-01 00:00:00

  • Impact of exacerbations on health care cost and resource utilization in chronic obstructive pulmonary disease patients with chronic bronchitis from a predominantly Medicare population.

    abstract:BACKGROUND:Exacerbations of chronic obstructive pulmonary disease (COPD) lead to significant increases in resource utilization and cost to the health care system. COPD patients with chronic bronchitis and a history of exacerbations pose an additional burden to the system. This study examined health care utilization and...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S36997

    authors: Pasquale MK,Sun SX,Song F,Hartnett HJ,Stemkowski SA

    更新日期:2012-01-01 00:00:00

  • Mean platelet volume as a predictor of pulmonary hypertension in patients with stable COPD.

    abstract::Background: Pulmonary hypertension (PH) is one of the most common complications developed during the course of chronic obstructive pulmonary disease (COPD). Platelet activation plays an important role in its pathophysiology, and mean platelet volume (MPV) is considered a respectable index of platelet activation. The a...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,多中心研究

    doi:10.2147/COPD.S176413

    authors: Mohamed MF,Ali A,Abbas A,Awad MS,Gouda M,Sediq AM

    更新日期:2019-05-23 00:00:00