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The association between combined non-cystic fibrosis bronchiectasis and lung cancer in patients with chronic obstructive lung disease.

Abstract：

BACKGROUND:Whereas the epidemiological association between lung cancer and chronic obstructive pulmonary disease (COPD), a chronic inflammatory respiratory disease, is well known, limited studies have examined the association between lung cancer and non-cystic fibrosis bronchiectasis, a representative chronic airway inflammatory disease. This study evaluated the association between bronchiectasis and lung cancer in patients with COPD. METHODS:A matched case-control study was conducted in a referral hospital in South Korea. Among COPD patients with moderate to very severe airflow limitation (forced expiratory volume in one second/forced vital capacity <0.7 and forced expiratory volume in one second ≤70% [% predicted]) who underwent chest computed tomography (CT) between January 1, 2010 and May 30, 2013, patients with lung cancer and controls matched for age, sex, and smoking history were selected. The risk of lung cancer was assessed according to the presence of underlying bronchiectasis confirmed by chest CT. RESULTS:The study enrolled 99 cases and 198 controls. Combined bronchiectasis on chest CT was inversely associated with the risk of lung cancer compared with controls (odds ratio [OR] 0.25, 95% confidence interval [CI] 0.12-0.52, P<0.001). Significant associations were found in patients with squamous cell carcinoma (OR 0.11, 95% CI 0.03-0.49, P=0.001) and history of smoking (OR 0.27, 95% CI 0.12-0.57, P<0.001). However, the severity and location of bronchiectasis were not associated with the risk of lung cancer. CONCLUSION:Interestingly, the concomitant presence of bronchiectasis in COPD patients was associated with a lower risk of lung cancer.

journal_name

Int J Chron Obstruct Pulmon Dis

journal_title

International journal of chronic obstructive pulmonary disease

authors

Kim YW,Jin KN,Heo EY,Park SS,Chung HS,Kim DK

doi

10.2147/COPD.S80439

subject

Has Abstract

pub_date

2015-05-04 00:00:00

pages

873-9

eissn

1176-9106

issn

1178-2005

pii

copd-10-873

journal_volume

pub_type

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The association between combined non-cystic fibrosis bronchiectasis and lung cancer in patients with chronic obstructive lung disease.