Abstract:
:Background: Pulmonary hypertension (PH) is one of the most common complications developed during the course of chronic obstructive pulmonary disease (COPD). Platelet activation plays an important role in its pathophysiology, and mean platelet volume (MPV) is considered a respectable index of platelet activation. The aim of this work is to assess the ability of MPV in predicting PH secondary to COPD as well as its severity. Methods: A cross-sectional study was conducted on 228 stable COPD patients. CBC, echocardiography, and pulmonary function tests were performed. Results: The prevalence of PH in stable COPD patients was high (63%), and the majority of patients had a mild degree (33%). There was no significant association between PH presence with different COPD grade, but, in very severe COPD, severe PH was significantly presented. MPV in COPD patients with PH was significantly higher than those without (9.02±1.14 vs 7.11±0.98, P<0.001). Moreover, a significant statistical rising of MPV with increased severity of PH. Multivariate regression analysis of predictors of PH demonstrated that; MPV is a real predictor of PH in such patients. The likelihood probability of PH increased up to 7-times with increasing one unit of MPV; (OR=6.7). A cut-off value of MPV >7.25 had 96% sensitivity and 76% specificity in predicting PH. Conclusion: MPV was higher in COPD patients with PH and positively correlated with PH severity. If the data are to be confirmed, MPV may be taken into consideration in decision-making and management of COPD patients.
journal_name
Int J Chron Obstruct Pulmon Disauthors
Mohamed MF,Ali A,Abbas A,Awad MS,Gouda M,Sediq AMdoi
10.2147/COPD.S176413subject
Has Abstractpub_date
2019-05-23 00:00:00pages
1099-1108eissn
1176-9106issn
1178-2005pii
176413journal_volume
14pub_type
杂志文章,多中心研究abstract:Purpose:The aim of this study was to examine real-world differences in health care resource use (HRU) and costs among COPD patients in the USA treated with a dry powder inhaler (DPI) or pressurized metered-dose inhaler (pMDI) following a COPD-related hospitalization. Methods:This retrospective analysis used the Truven...
journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章
doi:10.2147/COPD.S177213
更新日期:2018-12-24 00:00:00
abstract:BACKGROUND:In recent decades, morbidity and mortality have been found to be significantly increased in patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary tuberculosis (PTB). Platelet-lymphocyte ratio (PLR) is an indicator for inflammatory diseases. This study aims to investigate wheth...
journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章
doi:10.2147/COPD.S111254
更新日期:2016-11-03 00:00:00
abstract:BACKGROUND:The causal association between depression, anxiety, and health-related quality of life (HRQoL) in chronic obstructive pulmonary disease (COPD) is unclear. We therefore conducted a systematic review of prospective cohort studies that measured depression, anxiety, and HRQoL in COPD. METHODS:Electronic databas...
journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章,meta分析,评审
doi:10.2147/COPD.S58136
更新日期:2014-05-20 00:00:00
abstract:BACKGROUND:The purpose of this study was to describe the prevalence of renal and hepatic disease, related laboratory abnormalities, and potentially hepatotoxic and nephrotoxic medication use in a population-based cohort of persons with chronic obstructive pulmonary disease (COPD). METHODS:This was a retrospective case...
journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章
doi:10.2147/COPD.S40123
更新日期:2013-01-01 00:00:00
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doi:10.2147/COPD.S232055
更新日期:2019-12-17 00:00:00
abstract:PURPOSE:There are still evidence gaps on the prevalence of airflow limitation in Japan. The purpose of this survey was to estimate the prevalence of airflow limitation among healthy subjects in Japan and to show what proportion of subjects with airflow limitation had been diagnosed with chronic obstructive pulmonary di...
journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章,多中心研究
doi:10.2147/COPD.S99935
更新日期:2016-04-22 00:00:00
abstract::We used the Manitoba Health database to examine the relationship between use of inhaled respiratory drugs in people with chronic obstructive respiratory diseases and cardiovascular hospitalizations from 1996 through 2000. The drugs examined were beta agonists [BA], ipratropium bromide IB, and inhaled steroids (ICS). E...
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pub_type: 杂志文章
doi:10.2147/copd.s1516
更新日期:2008-01-01 00:00:00
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章
doi:10.2147/COPD.S194277
更新日期:2019-02-13 00:00:00
abstract:BACKGROUND:Management of chronic incurable diseases such as chronic obstructive pulmonary disease (COPD) and asthma is difficult. Incorporation of patient preferences is widely encouraged. PURPOSE:To summarize original research articles determining patient preference in moderate-to-severe disease. METHODS:Acceptable ...
journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究
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abstract:INTRODUCTION:According to guidelines, the diagnosis of COPD should be confirmed by post-bronchodilator (post-BD) airway obstruction on spirometry; however, in clinical practice, this is not always performed. The aim of this population-based study was to compare clinical characteristics and prognosis, assessed as mortal...
journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章
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更新日期:2017-04-24 00:00:00
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章
doi:10.2147/COPD.S150705
更新日期:2017-12-19 00:00:00
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章,评审
doi:10.2147/COPD.S54328
更新日期:2016-07-11 00:00:00
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pub_type: 杂志文章
doi:10.2147/COPD.S223592
更新日期:2020-01-13 00:00:00
abstract:BACKGROUND:Krasnoyarsk region is a territory with the widespread risk factors for chronic obstructive pulmonary disease (COPD) such as tobacco smoke, air pollution, and occupational exposure. An assessment of COPD prevalence based on medical diagnosis statistics underestimates the true COPD prevalence. This study aims ...
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更新日期:2015-09-02 00:00:00
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pub_type: 杂志文章
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更新日期:2020-07-06 00:00:00
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章
doi:10.2147/COPD.S88114
更新日期:2015-09-14 00:00:00
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章
doi:10.2147/COPD.S68570
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章
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更新日期:2014-09-22 00:00:00
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journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章,评审
doi:10.2147/COPD.S30664
更新日期:2012-01-01 00:00:00