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Proactive palliative care for patients with COPD (PROLONG): a pragmatic cluster controlled trial.

Abstract：

BACKGROUND AND AIM:Patients with advanced chronic obstructive pulmonary disease (COPD) have poor quality of life. The aim of this study was to assess the effects of proactive palliative care on the well-being of these patients. TRIAL REGISTRATION:This trial is registered with the Netherlands Trial Register, NTR4037. PATIENTS AND METHODS:A pragmatic cluster controlled trial (quasi-experimental design) was performed with hospitals as cluster (three intervention and three control) and a pretrial assessment was performed. Hospitals were selected for the intervention group based on the presence of a specialized palliative care team (SPCT). To control for confounders, a pretrial assessment was performed in which hospitals were compared on baseline characteristics. Patients with COPD with poor prognosis were recruited during hospitalization for acute exacerbation. All patients received usual care while patients in the intervention group received additional proactive palliative care in monthly meetings with an SPCT. Our primary outcome was change in quality of life score after 3 months, which was measured using the St George Respiratory Questionnaire (SGRQ). Secondary outcomes were, among others, quality of life at 6, 9 and 12 months; readmissions: survival; and having made advance care planning (ACP) choices. All analyses were performed following the principle of intention to treat. RESULTS:During the year 2014, 228 patients (90 intervention and 138 control) were recruited and at 3 months, 163 patients (67 intervention and 96 control) completed the SGRQ. There was no significant difference in change scores of the SGRQ total at 3 months between groups (-0.79 [95% CI, -4.61 to 3.34], p=0.70). However, patients who received proactive palliative care experienced less impact of their COPD (SGRQ impact subscale) at 6 months (-6.22 [-11.73 to -0.71], p=0.04) and had more often made ACP choices (adjusted odds ratio 3.26 [1.49-7.14], p=0.003). Other secondary outcomes were not significantly different. CONCLUSION:Proactive palliative care did not improve the overall quality of life of patients with COPD. However, patients more often made ACP choices which may lead to better quality of care toward the end of life.

journal_name

Int J Chron Obstruct Pulmon Dis

journal_title

International journal of chronic obstructive pulmonary disease

authors

Duenk RG,Verhagen C,Bronkhorst EM,van Mierlo P,Broeders M,Collard SM,Dekhuijzen P,Vissers K,Heijdra Y,Engels Y

doi

10.2147/COPD.S141974

subject

Has Abstract

pub_date

2017-09-28 00:00:00

pages

2795-2806

eissn

1176-9106

issn

1178-2005

pii

copd-12-2795

journal_volume

pub_type

杂志文章,多中心研究,随机对照试验

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Proactive palliative care for patients with COPD (PROLONG): a pragmatic cluster controlled trial.