Abstract:
BACKGROUND:It was reported that autonomic nervous system function is altered in subjects with chronic obstructive pulmonary disease (COPD). We evaluated short- and long-term fractal exponents of heart rate variability (HRV) in COPD subjects. PATIENTS AND METHODS:We analyzed data from 30 volunteers, who were divided into two groups according to spirometric values: COPD (n = 15) and control (n = 15). For analysis of HRV indices, HRV was recorded beat by beat with the volunteers in the supine position for 30 minutes. We analyzed the linear indices in the time (SDNN [standard deviation of normal to normal] and RMSSD [root-mean square of differences]) and frequency domains (low frequency [LF], high frequency [HF], and LF/HF), and the short- and long-term fractal exponents were obtained by detrended fluctuation analysis. We considered P < 0.05 to be a significant difference. RESULTS:COPD patients presented reduced levels of all linear exponents and decreased short-term fractal exponent (alpha-1: 0.899 ± 0.18 versus 1.025 ± 0.09, P = 0.026). There was no significant difference between COPD and control groups in alpha-2 and alpha-1/alpha-2 ratio. CONCLUSION:COPD subjects present reduced short-term fractal correlation properties of HRV, which indicates that this index can be used for risk stratification, assessment of systemic disease manifestations, and therapeutic procedures to monitor those patients.
journal_name
Int J Chron Obstruct Pulmon Disauthors
Carvalho TD,Pastre CM,de Godoy MF,Fereira C,Pitta FO,de Abreu LC,Ramos EM,Valenti VE,Vanderlei LCdoi
10.2147/COPD.S15099subject
Has Abstractpub_date
2011-01-06 00:00:00pages
23-8eissn
1176-9106issn
1178-2005journal_volume
6pub_type
杂志文章abstract:BACKGROUND:Despite the availability of national and international guidelines, evidence suggests that chronic obstructive pulmonary disease (COPD) treatment is not always prescribed according to recommendations. This study evaluated the current management of patients with COPD using a large UK primary-care database. ME...
journal_title:International journal of chronic obstructive pulmonary disease
pub_type: 杂志文章
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abstract::[This corrects the article on p. 2147 in vol. 13, PMID: 30034230.]. ...
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pub_type: 杂志文章,已发布勘误
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doi:
更新日期:2008-01-01 00:00:00
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更新日期:2010-09-07 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2021-01-12 00:00:00
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