Fractal correlation property of heart rate variability in chronic obstructive pulmonary disease.

Abstract:

BACKGROUND:It was reported that autonomic nervous system function is altered in subjects with chronic obstructive pulmonary disease (COPD). We evaluated short- and long-term fractal exponents of heart rate variability (HRV) in COPD subjects. PATIENTS AND METHODS:We analyzed data from 30 volunteers, who were divided into two groups according to spirometric values: COPD (n = 15) and control (n = 15). For analysis of HRV indices, HRV was recorded beat by beat with the volunteers in the supine position for 30 minutes. We analyzed the linear indices in the time (SDNN [standard deviation of normal to normal] and RMSSD [root-mean square of differences]) and frequency domains (low frequency [LF], high frequency [HF], and LF/HF), and the short- and long-term fractal exponents were obtained by detrended fluctuation analysis. We considered P < 0.05 to be a significant difference. RESULTS:COPD patients presented reduced levels of all linear exponents and decreased short-term fractal exponent (alpha-1: 0.899 ± 0.18 versus 1.025 ± 0.09, P = 0.026). There was no significant difference between COPD and control groups in alpha-2 and alpha-1/alpha-2 ratio. CONCLUSION:COPD subjects present reduced short-term fractal correlation properties of HRV, which indicates that this index can be used for risk stratification, assessment of systemic disease manifestations, and therapeutic procedures to monitor those patients.

authors

Carvalho TD,Pastre CM,de Godoy MF,Fereira C,Pitta FO,de Abreu LC,Ramos EM,Valenti VE,Vanderlei LC

doi

10.2147/COPD.S15099

subject

Has Abstract

pub_date

2011-01-06 00:00:00

pages

23-8

eissn

1176-9106

issn

1178-2005

journal_volume

6

pub_type

杂志文章
  • Management of COPD in the UK primary-care setting: an analysis of real-life prescribing patterns.

    abstract:BACKGROUND:Despite the availability of national and international guidelines, evidence suggests that chronic obstructive pulmonary disease (COPD) treatment is not always prescribed according to recommendations. This study evaluated the current management of patients with COPD using a large UK primary-care database. ME...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S62750

    authors: Price D,West D,Brusselle G,Gruffydd-Jones K,Jones R,Miravitlles M,Rossi A,Hutton C,Ashton VL,Stewart R,Bichel K

    更新日期:2014-08-27 00:00:00

  • Long-term effects of gastrectomy in patients with spirometry-defined COPD and patients at risk of COPD: a case-control study.

    abstract:OBJECTIVE:Comorbidities are characteristic of COPD. However, little is known about the secondary manifestations of COPD in the gastrointestinal tract. Therefore, we aimed to explore the long-term effects of gastrectomy in patients with spirometry-defined COPD or those at risk of COPD. PARTICIPANTS:Subjects included 87...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S87135

    authors: Saito H,Nomura K,Abe S,Motegi T,Ishii T,Hattori K,Kusunoki Y,Gemma A,Kida K

    更新日期:2015-10-29 00:00:00

  • Erratum: Tiotropium/olodaterol versus tiotropium in Japanese patients with COPD: results from the DYNAGITO study [Corrigendum].

    abstract::[This corrects the article on p. 2147 in vol. 13, PMID: 30034230.]. ...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,已发布勘误

    doi:10.2147/COPD.S191099

    authors:

    更新日期:2018-10-30 00:00:00

  • Impact of selective and nonselective beta-blockers on the risk of severe exacerbations in patients with COPD.

    abstract:BACKGROUND:There is conflicting information regarding the effects of selective and nonselective beta-blocker treatment in patients with COPD. PARTICIPANTS AND METHODS:This nested case-control study used the Taiwan National Health Insurance Research Database. We included COPD patients who used inhalation steroid and be...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S145913

    authors: Huang YL,Lai CC,Wang YH,Wang CY,Wang JY,Wang HC,Yu CJ,Chen L

    更新日期:2017-10-11 00:00:00

  • Differences in health care outcomes between postdischarge COPD patients treated with inhaled corticosteroid/long-acting β2-agonist via dry-powder inhalers and pressurized metered-dose inhalers.

    abstract:Purpose:The aim of this study was to examine real-world differences in health care resource use (HRU) and costs among COPD patients in the USA treated with a dry powder inhaler (DPI) or pressurized metered-dose inhaler (pMDI) following a COPD-related hospitalization. Methods:This retrospective analysis used the Truven...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S177213

    authors: Wittbrodt ET,Millette LA,Evans KA,Bonafede M,Tkacz J,Ferguson GT

    更新日期:2018-12-24 00:00:00

  • Metabolic Syndrome in Early Chronic Obstructive Pulmonary Disease: Gender Differences and Impact on Exacerbation and Medical Costs.

    abstract:Background:Metabolic syndrome (MetS) is a well-known comorbidity of chronic obstructive pulmonary disease (COPD). However, their interrelationship, particularly in early COPD, remains unclear. Therefore, we aimed to assess the prevalence and clinical characteristics of MetS in patients with early COPD, and to explore t...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S228497

    authors: Choi HS,Rhee CK,Park YB,Yoo KH,Lim SY

    更新日期:2019-12-10 00:00:00

  • Comprehensive analysis of gene-expression profile in chronic obstructive pulmonary disease.

    abstract:OBJECTIVE:To investigate the gene-expression profile of chronic obstructive pulmonary disease (COPD) patients and explore the possible therapeutic targets. METHODS:The microarray raw dataset GSE29133, including three COPD samples and three normal samples, was obtained from Gene Expression Omnibus. After data preproces...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S68570

    authors: Wei L,Xu D,Qian Y,Huang G,Ma W,Liu F,Shen Y,Wang Z,Li L,Zhang S,Chen Y

    更新日期:2015-06-10 00:00:00

  • Erratum: What is the impact of GOLD 2017 recommendations in primary care? - a descriptive study of patient classifications, treatment burden and costs [Erratum].

    abstract::[This corrects the article on p. 3485 in vol. 13, PMID: 30498338.]. ...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,已发布勘误

    doi:10.2147/COPD.S194746

    authors:

    更新日期:2018-12-05 00:00:00

  • Monitoring and analysis of lung sounds remotely.

    abstract::Visual and auditory analysis of respiratory sound signals promises improved detection of certain types of lung diseases. LabVIEW software was used to design a system that monitors the respiratory activity of the patient. The program developed calculates the respiratory rate, displays the time expanded waveform of the ...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S20067

    authors: Sahgal N

    更新日期:2011-01-01 00:00:00

  • Relationships between heart rate target determined in different exercise testing in COPD patients to prescribed with individualized exercise training.

    abstract:BACKGROUND:It has been scientifically proven that pulmonary rehabilitation improves exercise tolerance and facilitates the carrying out of daily physical activities. To optimize the physical and physiological benefits, it is necessary to individualize the training intensity for each patient. The aim of this study is to...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S129889

    authors: Fabre C,Chehere B,Bart F,Mucci P,Wallaert B,Grosbois JM

    更新日期:2017-05-16 00:00:00

  • Prevalence and risk factors for COPD in greenhouse farmers: a large, cross-sectional survey of 5,880 farmers from northeast China.

    abstract:BACKGROUND:COPD is one of the most common chronic diseases, and more and more farmers who were frequently exposed to greenhouse environments were diagnosed with COPD. However, little information is available on the prevalence of COPD among the greenhouse farmers. This study was conducted to assess the prevalence of COP...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S79264

    authors: Liu S,Ren Y,Wen D,Chen Y,Chen D,Li L,Zhang X,Zhang Y,Fu S,Li Z,Xia S,Wang D,Chen H,Zhao J,Wang X

    更新日期:2015-10-01 00:00:00

  • Pharmacoeconomics in COPD: lessons for the future.

    abstract::COPD exerts a substantial burden on health and health care systems globally and will continue to do so for the foreseeable future. Treatment however can be costly and health care providers are interested in both whether treatments can offer improvements in disease burden and whether they represent value for money. Eco...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,评审

    doi:

    authors: Starkie HJ,Briggs AH,Chambers MG

    更新日期:2008-01-01 00:00:00

  • Clinical implications of blood eosinophil count in patients with non-asthma-COPD overlap syndrome COPD.

    abstract:BACKGROUND:Recent studies that assessed the relevance of the blood eosinophil count as a biomarker in patients with COPD may have overestimated it because they included patients with asthma-COPD overlap syndrome (ACOS). We investigated the clinical implications of the blood eosinophil count in patients with non-ACOS CO...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,多中心研究

    doi:10.2147/COPD.S129321

    authors: Song JH,Lee CH,Kim JW,Lee WY,Jung JY,Park JH,Jung KS,Yoo KH,Park YB,Kim DK

    更新日期:2017-08-17 00:00:00

  • Prevalence of Asthma Characteristics in COPD Patients in a Dutch Well-Established Asthma/COPD Service for Primary Care.

    abstract:Purpose:Primary care COPD guidelines indicate that COPD patients with asthma characteristics should be treated as having asthma. This study aims to describe the prevalence of asthma characteristics in patients with a pulmonologist-confirmed working diagnosis of COPD or ACO. Patients and Methods:This retrospective cros...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S247819

    authors: Baron AJ,Flokstra-de Blok BMJ,van Heijst E,Riemersma RA,Sonnenschein-van der Voort AMM,Metting EI,Kocks JWH

    更新日期:2020-07-06 00:00:00

  • The mediating role of cytokine IL-6 on the relationship of FEV₁ upon 6-minute walk distance in chronic obstructive pulmonary disease.

    abstract:OBJECTIVES:To explore the mediating role of protein interleukin-6 (IL-6) on the relationship between forced expiratory volume in 1 second (FEV1) and 6-minute walk distance (6MWD) and, further, to determine whether status variables (such as age, sex, and body mass index [BMI]) operate as moderators of this mediation rel...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S57845

    authors: Baldi S,Jose PE,Bruschi C,Pinna GD,Maestri R,Rezzani A,Bellinzona E,Fracchia C,Dacosto E,Crotti P,Montemartini S

    更新日期:2014-10-07 00:00:00

  • Prospective cross-sectional multicenter study on domiciliary noninvasive ventilation in stable hypercapnic COPD patients.

    abstract:Background:Domiciliary noninvasive ventilation (NIV) use in stable hypercarbic COPD is becoming increasingly widespread. However, treatment compliance criteria and factors related to compliance remain to be defined. Methods:This research was designed as a prospective, cross-sectional, multicenter real-life study. Chro...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,多中心研究

    doi:10.2147/COPD.S164384

    authors: Yazar EE,Özlü T,Sarıaydın M,Taylan M,Ekici A,Aydın D,Coşgun İG,Durmuş Koçak N

    更新日期:2018-08-10 00:00:00

  • Impact of symptom variability on clinical outcomes in COPD: analysis of a longitudinal cohort.

    abstract:Purpose:We compared clinical characteristics of COPD patients according to symptom variability and evaluated the effect of symptom variability during the first year of enrollment on clinical outcomes of COPD. Methods:We analyzed COPD patients' data from the Korean Obstructive Lung Disease (KOLD) cohort. Symptom variab...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,多中心研究

    doi:10.2147/COPD.S203715

    authors: Kim MA,Suh MK,Park J,Kim JH,Kim TH,Kim EK,Oh YM,Lee SD,Lee JH

    更新日期:2019-09-20 00:00:00

  • Onset of action of indacaterol in patients with COPD: comparison with salbutamol and salmeterol-fluticasone.

    abstract:BACKGROUND:indacaterol is a novel, inhaled once-daily ultra-long-acting β(2)-agonist for the treatment of chronic obstructive pulmonary disease (COPD). OBJECTIVES:this study compared the onset of action of single doses of indacaterol 150 and 300 μg with salbutamol 200 μg, salmeterol-fluticasone 50/500 μg, and placebo ...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2147/copd.s12120

    authors: Balint B,Watz H,Amos C,Owen R,Higgins M,Kramer B,INSURE Study Investigators.

    更新日期:2010-09-07 00:00:00

  • Lack of paradoxical bronchoconstriction after administration of tiotropium via Respimat® Soft Mist™ Inhaler in COPD.

    abstract::Bronchoconstriction has been reported in asthma and chronic obstructive pulmonary disease (COPD) patients after administration of some aqueous inhalation solutions. We investigated the incidence of this event during long-term clinical trials of tiotropium delivered via Respimat(®) Soft Mist™ Inhaler (SMI). We retrospe...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S16094

    authors: Hodder R,Pavia D,Lee A,Bateman E

    更新日期:2011-01-01 00:00:00

  • Efficacy and safety characteristics of mometasone furoate/formoterol fumarate fixed-dose combination in subjects with moderate to very severe COPD: findings from pooled analysis of two randomized, 52-week placebo-controlled trials.

    abstract:BACKGROUND:The clinical efficacy and safety of a mometasone furoate/formoterol fumarate (MF/F) fixed-dose combination formulation administered via a metered-dose inhaler was investigated in patients with moderate to very severe chronic obstructive pulmonary disease (COPD). METHODS:Two 52-week, multicenter, double-blin...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2147/COPD.S29444

    authors: Tashkin DP,Doherty DE,Kerwin E,Matiz-Bueno CE,Knorr B,Shekar T,Gates D,Staudinger H

    更新日期:2012-01-01 00:00:00

  • Enlightening chronic obstructive pulmonary disease through patients' and caregivers' narratives.

    abstract:Purpose:The primary aim of this research was to raise awareness for COPD through real narratives of patients, caregivers, and pulmonologists. The second objective includes providing clinicians new means of caring for and treating patients with COPD. Methods:Using narrative medicine, testimonies from patients, their ca...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S172214

    authors: Gatti V,Banfi P,Centanni S,D'Antonio S,Giustini S,Piraino A,Zibellini M,Marini MG

    更新日期:2018-10-05 00:00:00

  • Pulmonary function impairment in patients with combined pulmonary fibrosis and emphysema with and without airflow obstruction.

    abstract:BACKGROUND:The syndrome of combined pulmonary fibrosis and emphysema (CPFE) is a recently described entity associating upper-lobe emphysema and lower-lobe fibrosis. We sought to evaluate differences in pulmonary function between CPFE patients with and without airflow obstruction. SUBJECTS AND METHODS:Thirty-one CPFE p...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S65621

    authors: Kitaguchi Y,Fujimoto K,Hanaoka M,Honda T,Hotta J,Hirayama J

    更新日期:2014-07-29 00:00:00

  • Identification and Validation of Autophagy-Related Genes in Chronic Obstructive Pulmonary Disease.

    abstract:Purpose:Autophagy plays essential roles in the development of COPD. We aim to identify and validate the potential autophagy-related genes of COPD through bioinformatics analysis and experiment validation. Methods:The mRNA expression profile dataset GSE38974 was obtained from GEO database. The potential differentially ...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S288428

    authors: Sun S,Shen Y,Wang J,Li J,Cao J,Zhang J

    更新日期:2021-01-12 00:00:00

  • Lung function decline in COPD.

    abstract::The landmark study of Fletcher and Peto on the natural history of tobacco smoke-related chronic airflow obstruction suggested that decline in the forced expiratory volume in the first second (FEV(1)) in chronic obstructive pulmonary disease (COPD) is slow at the beginning, becoming faster with more advanced disease. T...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,评审

    doi:10.2147/COPD.S27480

    authors: Tantucci C,Modina D

    更新日期:2012-01-01 00:00:00

  • Budgetary impact analysis on funding smoking-cessation drugs in patients with COPD in Spain.

    abstract::The aim of the study was to assess the budgetary impact of funding smoking-cessation drugs in COPD patients in Spain. A hybrid model (cohort and Markov) was developed for a 5-year time horizon. Only approved cessation drugs (varenicline, bupropion, and nicotine replacement therapy) were considered. Irrespective of the...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S87597

    authors: Jiménez-Ruiz CA,Solano-Reina S,Signes-Costa J,de Higes-Martinez E,Granda-Orive JI,Lorza-Blasco JJ,Riesco-Miranda JA,Altet-Gomez N,Barrueco M,Oyagüez I,Rejas J,SESEPARAR’s Integrated Tobacco Research Program.

    更新日期:2015-09-24 00:00:00

  • Normal lung attenuation distribution and lung volume on computed tomography in a Chinese population.

    abstract::Backgroud and objectives: Although lung attenuation distribution and lung volume on computed tomography (CT) have been widely used in evaluating COPD and interstitial lung disease, there are only a few studies regarding the normal range of these indices, especially in Chinese subjects. We aimed to describe the normal ...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S187596

    authors: Cheng T,Li Y,Pang S,Wan H,Shi G,Cheng Q,Li Q,Pan Z,Huang S

    更新日期:2019-07-24 00:00:00

  • The association between combined non-cystic fibrosis bronchiectasis and lung cancer in patients with chronic obstructive lung disease.

    abstract:BACKGROUND:Whereas the epidemiological association between lung cancer and chronic obstructive pulmonary disease (COPD), a chronic inflammatory respiratory disease, is well known, limited studies have examined the association between lung cancer and non-cystic fibrosis bronchiectasis, a representative chronic airway in...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S80439

    authors: Kim YW,Jin KN,Heo EY,Park SS,Chung HS,Kim DK

    更新日期:2015-05-04 00:00:00

  • Airway reactivity to mannitol is similarly increased in chronic cigarette and water pipe smokers.

    abstract:Background:In contrast to cigarette smoking, the association between water pipe smoking and airway hyperresponsiveness remains widely unexplored. Methods:A bronchoprovocation challenge with mannitol was performed in young adults recruited at the University of Basel, Switzerland. Subjects were categorized as acute wate...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S152085

    authors: Scherr A,Schmidlin J,Albisser S,Tamm M,Stolz D

    更新日期:2018-01-03 00:00:00

  • Mean platelet volume as a predictor of pulmonary hypertension in patients with stable COPD.

    abstract::Background: Pulmonary hypertension (PH) is one of the most common complications developed during the course of chronic obstructive pulmonary disease (COPD). Platelet activation plays an important role in its pathophysiology, and mean platelet volume (MPV) is considered a respectable index of platelet activation. The a...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章,多中心研究

    doi:10.2147/COPD.S176413

    authors: Mohamed MF,Ali A,Abbas A,Awad MS,Gouda M,Sediq AM

    更新日期:2019-05-23 00:00:00

  • A comparison of three multidimensional indices of COPD severity as predictors of future exacerbations.

    abstract:BACKGROUND:Prediction of future exacerbations of chronic obstructive pulmonary disease (COPD) is a major concern for long-term management of this disease. AIM:To determine which of three multidimensional assessment systems (the body mass index, obstruction, dyspnea, and exercise capacity [BODE] index; dyspnea, obstruc...

    journal_title:International journal of chronic obstructive pulmonary disease

    pub_type: 杂志文章

    doi:10.2147/COPD.S42769

    authors: Motegi T,Jones RC,Ishii T,Hattori K,Kusunoki Y,Furutate R,Yamada K,Gemma A,Kida K

    更新日期:2013-01-01 00:00:00