Serum levels of trace minerals and heavy metals in severe COPD patients with and without pulmonary hypertension.

abstract：Background:In contrast to cigarette smoking, the association between water pipe smoking and airway hyperresponsiveness remains widely unexplored. Methods:A bronchoprovocation challenge with mannitol was performed in young adults recruited at the University of Basel, Switzerland. Subjects were categorized as acute wate...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Scherr A,Schmidlin J,Albisser S,Tamm M,Stolz D

更新日期：2018-01-03 00:00:00

abstract：PURPOSE:To explore the decision-making of general practitioners (GPs) concerning treatment with antibiotics and/or oral corticosteroids and hospitalization for COPD patients with exacerbations. METHODS:Thematic analysis of seven focus groups with 53 GPs from urban and rural areas in Norway, Germany, Wales, Poland, Rus...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Laue J,Melbye H,Halvorsen PA,Andreeva EA,Godycki-Cwirko M,Wollny A,Francis NA,Spigt M,Kung K,Risør MB

更新日期：2016-12-08 00:00:00

abstract：Introduction:Understanding the breadth of patients' support needs is important for the delivery of person-centered care, particularly in progressive long-term conditions such as chronic obstructive pulmonary disease (COPD). Existing reviews identify important aspects of managing life with COPD with which patients may n...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Gardener AC,Ewing G,Kuhn I,Farquhar M

更新日期：2018-03-26 00:00:00

abstract：Purpose:Peripheral blood eosinophilic counts are susceptible to many factors and have variability over time. There are limited studies on association of blood eosinophilia with long-term mortality of chronic obstructive pulmonary disease (COPD) patients and these results remain controversial. Our aims were to explore t...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Zhang Y,Liang LR,Zhang S,Lu Y,Chen YY,Shi HZ,Lin YX

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:The combination of umeclidinium (UMEC), a long-acting muscarinic receptor antagonist, and vilanterol (VI), a selective long-acting β₂ agonist, is in development for the treatment of chronic obstructive pulmonary disease (COPD). This study evaluated the pharmacokinetics, safety and tolerability, and pharmacod...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Mehta R,Kelleher D,Preece A,Hughes S,Crater G

更新日期：2013-01-01 00:00:00

abstract：Purpose:Acute exacerbation of COPD (AECOPD) is among the most frequent causes for hospital admission, causing morbidity and mortality. Infection is the most frequent cause, and studies on pollution have shown higher hospital admission and mortality with inconsistent results. The objective was to identify if there is a ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Morantes-Caballero JA,Fajardo Rodriguez HA

更新日期：2019-07-11 00:00:00

abstract：BACKGROUND:To estimate the potential cost savings by following the current Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline recommendations in patients being treated for chronic obstructive pulmonary disease (COPD) with the combination of long-acting β(2)-agonist (LABA), long-acting muscarinic an...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Asche CV,Leader S,Plauschinat C,Raparla S,Yan M,Ye X,Young D

更新日期：2012-01-01 00:00:00

abstract：Introduction:COPD is an inflammatory airway pathology associated with recurrent infection by nontypeable Haemophilus influenzae (NTHi) that is not effectively managed by macrolide antibiotic therapy. We hypothesised that NTHi is able to reside intracellularly within COPD-derived airway epithelial cells (AEC), and that ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Poh WP,Kicic A,Lester SE,Nguyen PT,Bakaletz LO,Reynolds PN,Hodge S,Roscioli E

更新日期：2020-06-04 00:00:00

abstract：INTRODUCTION:Randomized interventional trials generally recruit highly selected patients. In contrast, long-term, noninterventional studies can reflect standard of care of real-life populations. DACCORD (Die ambulante Versorgung mit langwirksamen Bronchodilatatoren: COPD-Register in Deutschland [Outpatient Care With Lo...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Buhl R,Criée CP,Kardos P,Vogelmeier C,Lossi N,Mailänder C,Worth H

更新日期：2016-07-20 00:00:00

abstract：Purpose:The unpredictable trajectory of COPD can present challenges for patients when faced with a decision regarding a do-not-resuscitate (DNR) directive. The current retrospective analysis was conducted to investigate factors associated with an early DNR decision (prior to last hospital admission) and differences in ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Fu PK,Tung YC,Wang CY,Hwang SF,Lin SP,Hsu CY,Chen DR

更新日期：2018-08-14 00:00:00

abstract：BACKGROUND:Whereas the epidemiological association between lung cancer and chronic obstructive pulmonary disease (COPD), a chronic inflammatory respiratory disease, is well known, limited studies have examined the association between lung cancer and non-cystic fibrosis bronchiectasis, a representative chronic airway in...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Kim YW,Jin KN,Heo EY,Park SS,Chung HS,Kim DK

更新日期：2015-05-04 00:00:00

abstract：BACKGROUND:Homology is a mathematical concept that can be used to quantify degree of contact. Recently, image processing with the homology method has been proposed. In this study, we used the homology method and computed tomography images to quantify emphysema. METHODS:This study included 112 patients who had undergon...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Nishio M,Nakane K,Tanaka Y

更新日期：2016-09-06 00:00:00

abstract：Background:The risk of dying of lung cancer is up to eightfold higher in patients with COPD than in age- and gender-matched controls. The aim of this study was to investigate the factors associated with lung cancer in a large cohort of COPD patients from primary care centers. Methods:To analyze whether age, gender, so...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Sandelin M,Mindus S,Thuresson M,Lisspers K,Ställberg B,Johansson G,Larsson K,Janson C

更新日期：2018-06-06 00:00:00

abstract：OBJECTIVE:β-Blockers are safe and improve survival in patients with both congestive heart failure (CHF) and COPD. However, the superiority of different types of β-blockers is still unclear among patients with CHF and COPD. The association between β-blockers and CHF exacerbation as well as COPD exacerbation remains uncl...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Liao KM,Lin TY,Huang YB,Kuo CC,Chen CY

更新日期：2017-08-26 00:00:00

abstract：:COPD is a major cause of chronic morbidity and mortality throughout the world. Although tumor necrosis factor-α (TNF-α) has a critical role in the development of COPD, the role of different TNF receptors (TNFRs) in pulmonary emphysema has not been resolved. We aimed to clarify the role of TNFRs in the development of p...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Fujita M,Ouchi H,Ikegame S,Harada E,Matsumoto T,Uchino J,Nakanishi Y,Watanabe K

更新日期：2016-07-28 00:00:00

abstract：INTRODUCTION:While cross-national studies have documented rates of chronic obstructive pulmonary disease (COPD) misdiagnosis among patients in primary care, US studies are scarce. Studies investigating diagnosis among uninsured patients are lacking. OBJECTIVE:The purpose of this study is to identify patients who are o...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Ghattas C,Dai A,Gemmel DJ,Awad MH

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:Emphysema is one of the prognostic factors for rapid lung function decline in patients with COPD, but the impact of incidentally detected emphysema on population without spirometric abnormalities has not been evaluated. This study aimed to determine whether emphysema detected upon computed tomography (CT) sc...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Koo HK,Jin KN,Kim DK,Chung HS,Lee CH

更新日期：2016-01-29 00:00:00

abstract：:Bronchiectasis is defined by permanent and abnormal widening of the bronchi. This process occurs in the context of chronic airway infection and inflammation. It is usually diagnosed using computed tomography scanning to visualize the larger bronchi. Bronchiectasis is also characterized by mild to moderate airflow obst...

journal_title：International journal of chronic obstructive pulmonary disease

authors： King PT

更新日期：2009-01-01 00:00:00

abstract：:Bronchodilators represent the hallmark of symptomatic treatment of Chronic Obstructive Pulmonary Disease (COPD). There are four categories of bronchodilators: anticholinergics, methylxanthines, short-acting beta2-agonists, and long-acting beta2-agonists such as formoterol. Significant research has been performed to in...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Steiropoulos P,Tzouvelekis A,Bouros D

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess the relationship of smoking duration with respiratory symptoms and history of chronic obstructive pulmonary disease (COPD) in the South Carolina Behavioral Risk Factor Surveillance System survey in 2012. METHODS:Data from 4,135 adults aged ≥45 years with a smoking his...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Liu Y,Pleasants RA,Croft JB,Wheaton AG,Heidari K,Malarcher AM,Ohar JA,Kraft M,Mannino DM,Strange C

更新日期：2015-07-21 00:00:00

abstract：BACKGROUND:For patients with COPD, physical activity (PA) is recommended as the core component of pulmonary rehabilitation, but there is lack of a validated questionnaire for assessing the PA effectively. AIM:To evaluate the reliability and validity of the Chinese version of Physical Activity Scale for the Elderly (PA...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Tao YX,Wang L,Dong XY,Zheng H,Zheng YS,Tang XY,Zhao Y,Zhang Q

更新日期：2016-12-22 00:00:00

abstract：BACKGROUND:Circulating markers of inflammation in chronic obstructive pulmonary disease (COPD) may correlate to disease progression and extrapulmonary complications such as malnourishment. However, surprisingly little is known about gender-related differences for circulating inflammatory markers in COPD. PURPOSE:To ch...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Larsson S,Nordenson A,Glader P,Yoshihara S,Lindén A,Slinde F

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:Endobronchial valve (EBV) therapy is increasingly being seen as a therapeutic option for advanced emphysema, but its clinical utility in Asian populations, who may have different phenotypes to other ethnic populations, has not been assessed. PATIENTS AND METHODS:This prospective open-label single-arm clinical ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Park TS,Hong Y,Lee JS,Oh SY,Lee SM,Kim N,Seo JB,Oh YM,Lee SD,Lee SW

更新日期：2015-07-29 00:00:00

abstract：Introduction:Training in correct inhaler use, ideally in person or by video demonstration, can minimize errors but is rarely provided in clinics. This open-label, low-intervention study evaluated critical error rates with dry-powder inhalers (DPIs), before and after training, in patients with chronic obstructive pulmon...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Collier DJ,Wielders P,van der Palen J,Heyes L,Midwinter D,Collison K,Preece A,Barnes N,Sharma R

更新日期：2020-06-09 00:00:00

abstract：BACKGROUND:The use of chlorofluorocarbons (CFCs) has contributed to the depletion of the stratospheric ozone layer resulting in serious health concerns. Ipratropium bromide/salbutamol sulphate CFC-pressurized metered-dose inhalers (IB/SAL-CFC pMDI) have been in widespread use for many years without any apparent ill con...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Bhattacharya A,Bhargava S,Singh V,Talwar D,Whig J,Rebello J,Purandare S,Gogtay J

更新日期：2016-06-30 00:00:00

abstract：Background and Objectives:Long non-coding RNAs (lncRNAs) play an important role in the pathogenesis of many diseases, including cancer, pulmonary fibrosis and chronic obstructive pulmonary disease (COPD). In this study, we intended to identify the differentially expressed lncRNAs and the role of HOXA cluster antisense ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Zhou AY,Zhao YY,Zhou ZJ,Duan JX,Zhu YZ,Cai S,Chen P

更新日期：2020-10-09 00:00:00

abstract：PURPOSE:A low body mass index has been associated with high mortalities in patients with chronic obstructive pulmonary disease (COPD), and studies reveal that obesity aggravates the clinical effects of COPD. We investigated the impact of obesity on patients newly identified with COPD. PATIENTS AND METHODS:This populat...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Park JH,Lee JK,Heo EY,Kim DK,Chung HS

更新日期：2017-02-24 00:00:00

abstract：BACKGROUND:With the growing burden of COPD and associated morbidity and mortality, a need for self-management has been identified. The Self-management Programme of Activity, Coping and Education for Chronic Obstructive Pulmonary Disease (SPACE for COPD) manual was developed to support self-management in COPD patients. ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Blackmore C,Johnson-Warrington VL,Williams JE,Apps LD,Young HM,Bourne C,Singh SJ

更新日期：2017-06-07 00:00:00

abstract：BACKGROUND:Although chronic obstructive pulmonary disease (COPD) is closely associated with gastroesophageal reflux disease (GERD), the clinical significance of laryngopharyngeal reflux (LPR) is not fully understood in COPD. METHODS:Prospective cohorts were established among 118 patients with COPD from March 2013 to J...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Jung YH,Lee DY,Kim DW,Park SS,Heo EY,Chung HS,Kim DK

更新日期：2015-07-15 00:00:00

abstract：Background:COPD is characterized by a persistent inflammatory response, especially against cigarette smoke. COPD patients may develop varying degrees of emphysematous destruction of the lungs. A pathophysiological role for miRNAs in COPD has been suggested in several studies. We examined changes in microRNAs expression...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Cazorla-Rivero S,Mura-Escorche G,Gonzalvo-Hernández F,Mayato D,Córdoba-Lanús E,Casanova C

更新日期：2020-10-29 00:00:00