Effect of verapamil on systemic exposure and safety of umeclidinium and vilanterol: a randomized and open-label study.

abstract：:Chronic obstructive pulmonary disease (COPD) is a progressive chronic disease where treatment decisions should be based on disease severity and also should be equally distributed across age, gender, and social situation. The aim of this study was to determine to what extent patients with COPD are offered evidence-base...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Henoch I,Strang S,Löfdahl CG,Ekberg-Jansson A

更新日期：2016-10-26 00:00:00

abstract：:The course of COPD is punctuated by acute exacerbations that are associated with an increase in the morbidity and mortality related to this chronic disease and may contribute to its rate of progression. Therefore, preventing and treating exacerbations are major goals of COPD management. The role of tiotropium in the p...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Tashkin DP

更新日期：2010-02-18 00:00:00

abstract：Background:Despite wide use of the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) 2011, little is known about between-stage transitions and what factors predict worsening transitions in patients with chronic obstructive pulmonary disease (COPD). Objective:To investigate the transition frequency bet...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Bernabeu-Mora R,Sánchez-Martínez MP,Montilla-Herrador J,Oliveira-Sousa SL,Gacto-Sánchez M,Medina-Mirapeix F

更新日期：2020-06-30 00:00:00

abstract：Background:Comorbidities including cardiovascular diseases are very common in chronic obstructive pulmonary disease (COPD) secondary to tobacco smoking and contribute to the overall severity of the disease. In non-smoking COPD, which accounts for about 25% of COPD cases worldwide, current knowledge on the frequency and...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Soumagne T,Guillien A,Roche N,Annesi-Maesano I,Andujar P,Laurent L,Jouneau S,Botebol M,Laplante JJ,Dalphin JC,Degano B

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess the relationship of smoking duration with respiratory symptoms and history of chronic obstructive pulmonary disease (COPD) in the South Carolina Behavioral Risk Factor Surveillance System survey in 2012. METHODS:Data from 4,135 adults aged ≥45 years with a smoking his...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Liu Y,Pleasants RA,Croft JB,Wheaton AG,Heidari K,Malarcher AM,Ohar JA,Kraft M,Mannino DM,Strange C

更新日期：2015-07-21 00:00:00

abstract：Objective:The presence of both emphysema and airway wall thickening determined via volumetric computed tomography (CT) is defined as mixed phenotype. The long-term clinical course of this phenotype has not been studied in depth. This study compared the mixed phenotype to other phenotypes of chronic obstructive pulmonar...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Lim JU,Kim EK,Lim SY,Lee JH,Lee JS,Lee SD,Oh YM,Rhee CK,KOLD Study Group.

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:Cardiac autonomic modulation (CAM) is impaired in patients with stable COPD. Exacerbation aggravates the patients' health status and functional capacity. While the clinical and functional effects of exacerbation are known, no studies investigated CAM during exacerbation and whether there is a relationship be...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Kabbach EZ,Mazzuco A,Borghi-Silva A,Cabiddu R,Agnoleto AG,Barbosa JF,de Carvalho Junior LCS,Mendes RG

更新日期：2017-07-28 00:00:00

abstract：BACKGROUND:Patients with chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) seem to have several symptoms in common that impact health. However, methodological differences make this difficult to compare. AIM:Comparisons of symptoms, impact of symptoms on function and health between patients w...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Theander K,Hasselgren M,Luhr K,Eckerblad J,Unosson M,Karlsson I

更新日期：2014-07-18 00:00:00

abstract：:Patients with chronic obstructive pulmonary disease (COPD) are often at high risk of early death. Identification of prognostic biomarkers for COPD may aid in improving their survival by providing early strengthened therapy for high-risk patients. In the present study, we investigated the prognostic role of hyperuricem...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Zhang X,Liu L,Liang R,Jin S

更新日期：2015-11-26 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is the most common chronic lung disease in the world, and its associated health burdens and costs are mounting. Until recently, it was generally accepted that targeting the diagnosis of COPD early in its course was a relatively fruitless effort, since treatments other than ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Csikesz NG,Gartman EJ

更新日期：2014-02-27 00:00:00

abstract：Rationale:Individual socioeconomic status has been shown to influence the outcomes of patients with chronic obstructive pulmonary disease (COPD). However, contextual factors may also play a role. The objective of this study is to evaluate the association between neighborhood socioeconomic disadvantage measured by the a...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Galiatsatos P,Woo H,Paulin LM,Kind A,Putcha N,Gassett AJ,Cooper CB,Dransfield MT,Parekh TM,Oates GR,Barr RG,Comellas AP,Han MK,Peters SP,Krishnan JA,Labaki WW,McCormack MC,Kaufman JD,Hansel NN

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:Whereas the epidemiological association between lung cancer and chronic obstructive pulmonary disease (COPD), a chronic inflammatory respiratory disease, is well known, limited studies have examined the association between lung cancer and non-cystic fibrosis bronchiectasis, a representative chronic airway in...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Kim YW,Jin KN,Heo EY,Park SS,Chung HS,Kim DK

更新日期：2015-05-04 00:00:00

abstract：Purpose:Primary care COPD guidelines indicate that COPD patients with asthma characteristics should be treated as having asthma. This study aims to describe the prevalence of asthma characteristics in patients with a pulmonologist-confirmed working diagnosis of COPD or ACO. Patients and Methods:This retrospective cros...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Baron AJ,Flokstra-de Blok BMJ,van Heijst E,Riemersma RA,Sonnenschein-van der Voort AMM,Metting EI,Kocks JWH

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:In patients with acute hypercapnic respiratory failure (AHRF) during exacerbations of COPD, mortality can be high despite noninvasive ventilation (NIV). For some, AHRF is terminal and NIV is inappropriate. However there is no definitive method of identifying patients who are unlikely to survive. The aim of t...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Haja Mydin H,Murphy S,Clague H,Sridharan K,Taylor IK

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The use of inhaled corticosteroids in patients with chronic obstructive pulmonary disease (COPD) has been associated with an increased risk of pneumonia in controlled clinical trials and case-control analyses. OBJECTIVE:Using claims databases as a research model of real-world diagnosis and treatment, to det...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Yawn BP,Li Y,Tian H,Zhang J,Arcona S,Kahler KH

更新日期：2013-01-01 00:00:00

abstract：Background and purpose:While the efficacy and safety of combined tiotropium and olodaterol in patients with COPD was established in a large clinical trial program, it is important to assess whether clinical data can be applied to geographic patient groups, particularly for East Asian patients who may have a different p...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Bai C,Ichinose M,Lee SH,Lee KH,Jöns O,Bothner U,Zhao Y,Buhl R

更新日期：2017-11-20 00:00:00

abstract：Background:The risk of dying of lung cancer is up to eightfold higher in patients with COPD than in age- and gender-matched controls. The aim of this study was to investigate the factors associated with lung cancer in a large cohort of COPD patients from primary care centers. Methods:To analyze whether age, gender, so...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Sandelin M,Mindus S,Thuresson M,Lisspers K,Ställberg B,Johansson G,Larsson K,Janson C

更新日期：2018-06-06 00:00:00

abstract：BACKGROUND:Glycopyrronium is a once-daily (od) long-acting muscarinic antagonist for the maintenance treatment of chronic obstructive pulmonary disease (COPD). The GLOW7 study evaluated the efficacy and safety of od glycopyrronium 50 μg in predominantly Chinese patients with moderate-to-severe COPD. METHODS:In this 26...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Wang C,Sun T,Huang Y,Humphries M,Bai L,Li L,Wang Q,Kho P,Firth R,D'Andrea P

更新日期：2015-01-05 00:00:00

abstract：Purpose:This study investigated the effect of dual bronchodilation with the long-acting β-receptor agonist/long-acting muscarinic antagonist combination, indacaterol/glycopyrronium (IND/GLY), on nighttime oxygenation, lung function, sleep quality, and symptoms in patients with moderate-to-severe COPD. Patients and met...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Lehmann S,Ringbæk T,Løkke A,Grote L,Hedner J,Lindberg E

更新日期：2019-01-09 00:00:00

abstract：Introduction:Long-term oxygen therapy (LTOT) improves survival and may reduce hospital admissions in patients with chronic obstructive pulmonary disease (COPD) and severe hypoxemia, but the impact of daily duration of LTOT on hospitalization rate is unknown. We aimed to estimate the association between the daily durati...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Sundh J,Ahmadi Z,Ekström M

更新日期：2018-08-28 00:00:00

abstract：Background:Health effects of electronic cigarette (EC) use in patients with chronic obstructive pulmonary disease (COPD) are largely unexplored. Aim:We present findings from a long-term prospective assessment of respiratory parameters in a cohort of COPD patients who ceased or substantially reduced conventional cigare...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Polosa R,Morjaria JB,Prosperini U,Russo C,Pennisi A,Puleo R,Caruso M,Caponnetto P

更新日期：2018-08-22 00:00:00

abstract：BACKGROUND:Pulmonary rehabilitation (PR) is recommended after a severe COPD exacerbation, but its short- and long-term effects on health care utilization have not been fully established. AIMS:The aims of this study were to evaluate patient compliance with a chronic disease management (CDM) program incorporating home-b...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Lalmolda C,Coll-Fernández R,Martínez N,Baré M,Teixidó Colet M,Epelde F,Monsó E

更新日期：2017-08-23 00:00:00

abstract：Purpose:The aim of this study was to examine real-world differences in health care resource use (HRU) and costs among COPD patients in the USA treated with a dry powder inhaler (DPI) or pressurized metered-dose inhaler (pMDI) following a COPD-related hospitalization. Methods:This retrospective analysis used the Truven...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Wittbrodt ET,Millette LA,Evans KA,Bonafede M,Tkacz J,Ferguson GT

更新日期：2018-12-24 00:00:00

abstract：:Impaired physical performance is common in chronic obstructive pulmonary disease (COPD), but its assessment can be difficult in routine clinical practice. We compared the timed up and go (TUG) test and other easily applied assessments of physical performance with the 6-minute walk distance (6MWD). In a longitudinal st...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Albarrati AM,Gale NS,Enright S,Munnery MM,Cockcroft JR,Shale DJ

更新日期：2016-08-02 00:00:00

abstract：:Cigarette smoking is an established cause of lung cancer. However, pulmonary fibrosis is also an independent risk factor for the development of lung cancer. Smoking-related interstitial fibrosis (SRIF) has recently been reported. We hypothesized that adenocarcinomas in lungs with SRIF might show distinct molecular cha...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Primiani A,Dias-Santagata D,Iafrate AJ,Kradin RL

更新日期：2014-05-24 00:00:00

abstract：Purpose:COPD has been associated with a high number of comorbidities and a relatively high level of health care resource utilization. This study aimed to estimate the social economic impact of COPD in the autonomous community of Extremadura (Spain) in 2015. Patients and methods:This is a retrospective observational st...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Merino M,Villoro R,Hidalgo-Vega Á,Carmona C

更新日期：2018-08-21 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is one of the top five major causes of morbidity and mortality worldwide. Despite worldwide health care efforts, costs, and medical research, COPD figures demonstrate a continuously increasing tendency in mortality. This is contrary to other top causes of death, such as neo...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Hillas G,Perlikos F,Tzanakis N

更新日期：2016-07-13 00:00:00

abstract：BACKGROUND:Although chronic obstructive pulmonary disease (COPD) is closely associated with gastroesophageal reflux disease (GERD), the clinical significance of laryngopharyngeal reflux (LPR) is not fully understood in COPD. METHODS:Prospective cohorts were established among 118 patients with COPD from March 2013 to J...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Jung YH,Lee DY,Kim DW,Park SS,Heo EY,Chung HS,Kim DK

更新日期：2015-07-15 00:00:00

abstract：Introduction:Inhaled corticosteroids (ICSs) are recommended for patients with frequent exacerbation of chronic obstructive pulmonary disease (COPD). However, accumulating evidence has indicated the risk of pneumonia from the use of ICS. This study aimed to investigate the association between ICS and pneumonia in the re...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Lee JH,Park YH,Kang DR,Lee SJ,Lee MK,Kim SH,Yong SJ,Lee WY

更新日期：2020-12-29 00:00:00

abstract：BACKGROUND:It was reported that autonomic nervous system function is altered in subjects with chronic obstructive pulmonary disease (COPD). We evaluated short- and long-term fractal exponents of heart rate variability (HRV) in COPD subjects. PATIENTS AND METHODS:We analyzed data from 30 volunteers, who were divided in...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Carvalho TD,Pastre CM,de Godoy MF,Fereira C,Pitta FO,de Abreu LC,Ramos EM,Valenti VE,Vanderlei LC

更新日期：2011-01-06 00:00:00