Hyperuricemia is a biomarker of early mortality in patients with chronic obstructive pulmonary disease.

abstract：:Pulmonary emphysema is usually the result of chronic exposure to cigarette smoke in at risk individuals. To investigate the hypothesis that lung damage in emphysema results from coincident weakening in the structural properties of the tissue and increased mechanical forces--as one explanation of the continued developm...

journal_title：International journal of chronic obstructive pulmonary disease

authors： de Ryk J,Thiesse J,Namati E,McLennan G

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Endobronchial valve (EBV) therapy is increasingly being seen as a therapeutic option for advanced emphysema, but its clinical utility in Asian populations, who may have different phenotypes to other ethnic populations, has not been assessed. PATIENTS AND METHODS:This prospective open-label single-arm clinical ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Park TS,Hong Y,Lee JS,Oh SY,Lee SM,Kim N,Seo JB,Oh YM,Lee SD,Lee SW

更新日期：2015-07-29 00:00:00

abstract：:Abstract: Static lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease (COPD). Given that most of these patients have respiratory and peripheral muscle weakness, dyspnea and functional exercise capacity may improve as a result of inspiratory muscle training (IMT...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Shahin B,Germain M,Kazem A,Annat G

更新日期：2008-01-01 00:00:00

abstract：Background:The risk of dying of lung cancer is up to eightfold higher in patients with COPD than in age- and gender-matched controls. The aim of this study was to investigate the factors associated with lung cancer in a large cohort of COPD patients from primary care centers. Methods:To analyze whether age, gender, so...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Sandelin M,Mindus S,Thuresson M,Lisspers K,Ställberg B,Johansson G,Larsson K,Janson C

更新日期：2018-06-06 00:00:00

abstract：BACKGROUND:Noncommunicable diseases have become a public heath problem in India concomitant with economic development, leading to increases in tobacco consumption, obesity, and changes in diet and lifestyle. Although observation suggests that tobacco consumption is a major risk factor for deaths due to circulatory, pul...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Singh RB,Singh S,Chattopadhya P,Singh K,Singhz V,Kulshrestha SK,Tomar RS,Kumar R,Singh G,Mechirova V,Pella D

更新日期：2007-01-01 00:00:00

abstract：:Cigarette smoking is an established cause of lung cancer. However, pulmonary fibrosis is also an independent risk factor for the development of lung cancer. Smoking-related interstitial fibrosis (SRIF) has recently been reported. We hypothesized that adenocarcinomas in lungs with SRIF might show distinct molecular cha...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Primiani A,Dias-Santagata D,Iafrate AJ,Kradin RL

更新日期：2014-05-24 00:00:00

abstract：INTRODUCTION:COPD exacerbation negatively impacts the patient's quality of life and lung function, increases mortality, and increases socioeconomic costs. In a real-world setting, the majority of patients with COPD have mild-to-moderate airflow limitation. Therefore, it is important to evaluate COPD exacerbation in pat...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Kim JK,Lee SH,Lee BH,Lee CY,Kim do J,Min KH,Kim SK,Yoo KH,Jung KS,Hwang YI

更新日期：2016-06-16 00:00:00

abstract：:COPD is a common complex disease characterized by progressive airflow limitation. Several genome-wide association studies (GWASs) have discovered genes that are associated with COPD. Recently, candidate genes for COPD identified by GWASs include CHRNA3/5 (cholinergic nicotine receptor alpha 3/5), IREB2 (iron regulator...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Kim WJ,Lee SD

更新日期：2015-10-19 00:00:00

abstract：:Etiological evidence demonstrates that there is a significant association between cigarette smoking and chronic airway inflammatory disease. Abnormal expression of placental growth factor (PlGF) has been reported in COPD, and its downstream signaling molecules have been reported to contribute to the pathogenesis of ai...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Wu D,Yuan Y,Lin Z,Lai T,Chen M,Li W,Lv Q,Yuan B,Li D,Wu B

更新日期：2016-12-02 00:00:00

abstract：Background:Health effects of electronic cigarette (EC) use in patients with chronic obstructive pulmonary disease (COPD) are largely unexplored. Aim:We present findings from a long-term prospective assessment of respiratory parameters in a cohort of COPD patients who ceased or substantially reduced conventional cigare...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Polosa R,Morjaria JB,Prosperini U,Russo C,Pennisi A,Puleo R,Caruso M,Caponnetto P

更新日期：2018-08-22 00:00:00

abstract：Background and objective:The distance of 6-minute walk test (D6MWT) has been widely used in the assessment of functional status in patients with COPD, while very little attention has been paid to the role of steps of 6-minute walk test (S6MWT). The purpose of this study was to investigate the relationship between S6MWT...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Zeng GS,Chen LC,Fan HZ,Wu LL,Wu XP,Fang ZK,He X,Yu HP

更新日期：2018-12-28 00:00:00

abstract：Background and objectives:Cognitive impairment is a common extrapulmonary comorbidity in COPD patients. The default mode network (DMN) plays a critical role in maintaining the normal activities of humans, and its function can be evaluated by resting state functional magnetic resonance imaging. The aim of this study was...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Hu X,Wang H,Tu Y,Fei M,Yin M,Fei G,Yu Y

更新日期：2018-02-07 00:00:00

abstract：:Health status questionnaires provide standardized measures of patients' perceptions of the impact of disease on their daily life and well-being. Factors associated with health status were examined in a sample of 58 outpatients with chronic obstructive pulmonary disease (COPD) and co-morbid anxiety and/or depression. A...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Hynninen MJ,Pallesen S,Nordhus IH

更新日期：2007-01-01 00:00:00

abstract：:The landmark study of Fletcher and Peto on the natural history of tobacco smoke-related chronic airflow obstruction suggested that decline in the forced expiratory volume in the first second (FEV(1)) in chronic obstructive pulmonary disease (COPD) is slow at the beginning, becoming faster with more advanced disease. T...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Tantucci C,Modina D

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The hallmark of COPD is chronic airway inflammation, which may be mediated by renin-angiotensin system. The renin-angiotensin system blockers such as angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARBs) have exhibited anti-inflammatory and immunomodulatory effects in pa...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Kim J,Lee JK,Heo EY,Chung HS,Kim DK

更新日期：2016-09-09 00:00:00

abstract：BACKGROUND:To estimate the potential cost savings by following the current Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline recommendations in patients being treated for chronic obstructive pulmonary disease (COPD) with the combination of long-acting β(2)-agonist (LABA), long-acting muscarinic an...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Asche CV,Leader S,Plauschinat C,Raparla S,Yan M,Ye X,Young D

更新日期：2012-01-01 00:00:00

abstract：:Bronchoconstriction has been reported in asthma and chronic obstructive pulmonary disease (COPD) patients after administration of some aqueous inhalation solutions. We investigated the incidence of this event during long-term clinical trials of tiotropium delivered via Respimat(®) Soft Mist™ Inhaler (SMI). We retrospe...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Hodder R,Pavia D,Lee A,Bateman E

更新日期：2011-01-01 00:00:00

abstract：Background:COPD is considered an independent risk factor for lung cancer. COPD and lung cancer are both very heterogeneous diseases, and the study herein investigates the link between COPD phenotypes and specific histological subtypes of lung cancer. Methods:This case-control study comprised 2,283 patients with newly ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Wang W,Xie M,Dou S,Cui L,Zheng C,Xiao W

更新日期：2018-04-13 00:00:00

abstract：:Noninvasive ventilation (NIV) has been one of the major advances in respiratory medicine in the last decade. NIV improves quality of life, prolongs survival, and improves gas exchange and sleep quality in restrictive patients, but evidence available now does not allow us to establish clear criteria for prescribing NIV...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Díaz-Lobato S,Alises SM,Rodríguez EP

更新日期：2006-01-01 00:00:00

abstract：:[This corrects the article on p. 2147 in vol. 13, PMID: 30034230.]. ...

journal_title：International journal of chronic obstructive pulmonary disease

authors：

更新日期：2018-10-30 00:00:00

abstract：:Objectives: COPD is the fourth-leading cause of mortality worldwide. Prolonged QTc has been found to be a long-term negative prognostic factor in ambulatory COPD patients. The aim of this study was to evaluate the extent of prolonged-QTc syndrome in COPD patients upon admission to an internal medicine department, its ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Zilberman-Itskovich S,Rahamim E,Tsiporin-Havatinsky F,Ziv-Baran T,Golik A,Zaidenstein R

更新日期：2019-05-20 00:00:00

abstract：BACKGROUND:The syndrome of combined pulmonary fibrosis and emphysema (CPFE) is a recently described entity associating upper-lobe emphysema and lower-lobe fibrosis. We sought to evaluate differences in pulmonary function between CPFE patients with and without airflow obstruction. SUBJECTS AND METHODS:Thirty-one CPFE p...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Kitaguchi Y,Fujimoto K,Hanaoka M,Honda T,Hotta J,Hirayama J

更新日期：2014-07-29 00:00:00

abstract：Background:Comorbidities including cardiovascular diseases are very common in chronic obstructive pulmonary disease (COPD) secondary to tobacco smoking and contribute to the overall severity of the disease. In non-smoking COPD, which accounts for about 25% of COPD cases worldwide, current knowledge on the frequency and...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Soumagne T,Guillien A,Roche N,Annesi-Maesano I,Andujar P,Laurent L,Jouneau S,Botebol M,Laplante JJ,Dalphin JC,Degano B

更新日期：2020-07-01 00:00:00

abstract：:Background: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) released an updated document in 2017 that excluded the spirometric parameter in the classification of patients. The validity of this new classification system in predicting mortality and respiratory hospitalization is still uncertain. Method...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Lee SJ,Yun SS,Ju S,You JW,Cho YJ,Jeong YY,Kim JY,Kim HC,Lee JD

更新日期：2019-04-29 00:00:00

abstract：:COPD is a chronic inflammatory disease of the lungs associated with an abnormal inflammatory response to noxious particles, the most prevalent of which is cigarette smoke. Studies have demonstrated that cigarette smoking is associated with activation of the bone marrow, and chronic smoking can lead to the inflammatory...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Carlson AA,Smith EA,Reid DJ

更新日期：2015-10-22 00:00:00

abstract：:Background: Qualitative research provides real-life information on patients' condition and facilitates informed design of future clinical studies. Objective: We used Online Communities as a qualitative research tool to evaluate the effect of cough and mucus on COPD patients. Methods: Two 2-week Online Communities were...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Cook N,Gey J,Oezel B,Mackay AJ,Kumari C,Kaur VP,Larkin N,Harte J,Vergara-Muro S,Gutzwiller FS

更新日期：2019-06-24 00:00:00

abstract：BACKGROUND:Management of chronic incurable diseases such as chronic obstructive pulmonary disease (COPD) and asthma is difficult. Incorporation of patient preferences is widely encouraged. PURPOSE:To summarize original research articles determining patient preference in moderate-to-severe disease. METHODS:Acceptable ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Bereza BG,Troelsgaard Nielsen A,Valgardsson S,Hemels ME,Einarson TR

更新日期：2015-04-08 00:00:00

abstract：Background and purpose:While the efficacy and safety of combined tiotropium and olodaterol in patients with COPD was established in a large clinical trial program, it is important to assess whether clinical data can be applied to geographic patient groups, particularly for East Asian patients who may have a different p...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Bai C,Ichinose M,Lee SH,Lee KH,Jöns O,Bothner U,Zhao Y,Buhl R

更新日期：2017-11-20 00:00:00

abstract：BACKGROUND:Smoking is a major risk factor for chronic obstructive pulmonary disease (COPD); however, the similarities and differences in clinical presentation between smokers and nonsmokers are not fully described in patients with COPD. This study was designed to address this issue in a general teaching hospital in the...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Zhang J,Lin XF,Bai CX

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:COPD is one of the most common chronic diseases, and more and more farmers who were frequently exposed to greenhouse environments were diagnosed with COPD. However, little information is available on the prevalence of COPD among the greenhouse farmers. This study was conducted to assess the prevalence of COP...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Liu S,Ren Y,Wen D,Chen Y,Chen D,Li L,Zhang X,Zhang Y,Fu S,Li Z,Xia S,Wang D,Chen H,Zhao J,Wang X

更新日期：2015-10-01 00:00:00