Stress distribution in a three dimensional, geometric alveolar sac under normal and emphysematous conditions.

abstract：:Measurement of inspiratory capacity (IC) as a marker of dynamic lung hyperinflation has been shown to correlate with dyspnea and exercise performance in stable COPD, and is therefore of potential utility in the management of this condition. We have examined whether similar relationships exist during acute exacerbation...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Pretto JJ,McMahon MA,Rochford PD,Berlowitz DJ,Jones SM,Brazzale DJ,McDonald CF

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The combination of umeclidinium (UMEC), a long-acting muscarinic receptor antagonist, and vilanterol (VI), a selective long-acting β₂ agonist, is in development for the treatment of chronic obstructive pulmonary disease (COPD). This study evaluated the pharmacokinetics, safety and tolerability, and pharmacod...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Mehta R,Kelleher D,Preece A,Hughes S,Crater G

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Early palliative care is not a common practice for patients with COPD. Important barriers are the identification of patients for palliative care and the organization of such care in this patient group. OBJECTIVE:Pulmonologists have a central role in providing good quality palliative care for patients with...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Duenk RG,Verhagen C,Dekhuijzen P,Vissers K,Engels Y,Heijdra Y

更新日期：2017-01-17 00:00:00

abstract：:Influenza viruses cause respiratory tract infections that in patients with underlying lung diseases such as chronic obstructive pulmonary disease (COPD) are associated with exacerbations and excess morbidity and mortality. Typically, influenza B is associated with relatively mild, local outbreaks, whereas influenza A ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Wesseling G

更新日期：2007-01-01 00:00:00

abstract：Background:Domiciliary noninvasive ventilation (NIV) use in stable hypercarbic COPD is becoming increasingly widespread. However, treatment compliance criteria and factors related to compliance remain to be defined. Methods:This research was designed as a prospective, cross-sectional, multicenter real-life study. Chro...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Yazar EE,Özlü T,Sarıaydın M,Taylan M,Ekici A,Aydın D,Coşgun İG,Durmuş Koçak N

更新日期：2018-08-10 00:00:00

abstract：BACKGROUND:In recent decades, morbidity and mortality have been found to be significantly increased in patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary tuberculosis (PTB). Platelet-lymphocyte ratio (PLR) is an indicator for inflammatory diseases. This study aims to investigate wheth...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Chen G,Wu C,Luo Z,Teng Y,Mao S

更新日期：2016-11-03 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory condition, and progresses with acute exacerbations. (AE). During AE, levels of acute phase reactants such as C-reactive protein (CRP) and inflammatory cells in the circulation increase. Soluble urokinase-type plasminogen activator recepto...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Gumus A,Altintas N,Cinarka H,Kirbas A,Hazıroglu M,Karatas M,Sahin U

更新日期：2015-02-13 00:00:00

abstract：Background:Exacerbations explain much of the cost of COPD. Higher blood eosinophil cell counts at admission for acute exacerbation of COPD increase the risk of subsequent exacerbations and hospitalizations. However, there is no literature on the economic burden of patients with this inflammatory profile. The objective ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Poder TG,Carrier N,Bélanger M,Couillard S,Courteau J,Larivée P,Vanasse A

更新日期：2018-10-08 00:00:00

abstract：Background:COPD may lead to cognitive impairment or even dementia. However, the current conclusions are inconsistent with little evidence from prospective, large-sample studies. This study was designed to explore the association of COPD with mild cognitive impairment (MCI) and dementia risk based on a cohort study. Pa...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Xie F,Xie L

更新日期：2019-02-13 00:00:00

abstract：BACKGROUND:Whereas the epidemiological association between lung cancer and chronic obstructive pulmonary disease (COPD), a chronic inflammatory respiratory disease, is well known, limited studies have examined the association between lung cancer and non-cystic fibrosis bronchiectasis, a representative chronic airway in...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Kim YW,Jin KN,Heo EY,Park SS,Chung HS,Kim DK

更新日期：2015-05-04 00:00:00

abstract：INTRODUCTION:Randomized interventional trials generally recruit highly selected patients. In contrast, long-term, noninterventional studies can reflect standard of care of real-life populations. DACCORD (Die ambulante Versorgung mit langwirksamen Bronchodilatatoren: COPD-Register in Deutschland [Outpatient Care With Lo...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Buhl R,Criée CP,Kardos P,Vogelmeier C,Lossi N,Mailänder C,Worth H

更新日期：2016-07-20 00:00:00

abstract：:[This corrects the article on p. 2749 in vol. 11, PMID: 27853362.]. ...

journal_title：International journal of chronic obstructive pulmonary disease

authors：

更新日期：2017-01-10 00:00:00

abstract：Introduction:With increasing availability of different treatments for chronic obstructive pulmonary disease (COPD), we sought to understand patient preferences for COPD treatment in the UK, USA, and Germany using a discrete choice experiment (DCE). Methods:Qualitative research identified six attributes associated with...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Lewis HB,Schroeder M,Gunsoy NB,Janssen EM,Llewellyn S,Doll HA,Jones PW,Ismaila AS

更新日期：2020-03-18 00:00:00

abstract：Purpose:Chronic obstructive pulmonary disease (COPD) is a major cause of chronic diseases causing considerable social and economic burden globally. Despite substantial evidence on temperature-COPD association, few studies have investigated the acute effect of temperature variability (TV), a potential trigger of exacerb...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Zhan ZY,Tian Q,Chen TT,Ye Y,Lin Q,Han D,Ou CQ

更新日期：2020-09-22 00:00:00

abstract：BACKGROUND:The clinical efficacy and safety of a mometasone furoate/formoterol fumarate (MF/F) fixed-dose combination formulation administered via a metered-dose inhaler was investigated in patients with moderate to very severe chronic obstructive pulmonary disease (COPD). METHODS:Two 52-week, multicenter, double-blin...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Tashkin DP,Doherty DE,Kerwin E,Matiz-Bueno CE,Knorr B,Shekar T,Gates D,Staudinger H

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The diagnosis and assessment of COPD rely mainly on the use of spirometry, which is an effort-dependent test and requires good patient cooperation. Impulse oscillometry (IOS) is a non-volitional method that requires less effort and cooperation and presents advantages for geriatric patients. However, the clin...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Liu Z,Lin L,Liu X

更新日期：2017-03-15 00:00:00

abstract：BACKGROUND:We investigated whether a relationship between small airways dysfunction and bronchodilator responsiveness exists in patients with chronic obstructive pulmonary disease (COPD). METHODS:We studied 100 (20 female; mean age: 68±10 years) patients with COPD (forced expiratory volume in 1 second [FEV1]: 55% pred...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Pisi R,Aiello M,Zanini A,Tzani P,Paleari D,Marangio E,Spanevello A,Nicolini G,Chetta A

更新日期：2015-06-19 00:00:00

abstract：Introduction:Understanding the breadth of patients' support needs is important for the delivery of person-centered care, particularly in progressive long-term conditions such as chronic obstructive pulmonary disease (COPD). Existing reviews identify important aspects of managing life with COPD with which patients may n...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Gardener AC,Ewing G,Kuhn I,Farquhar M

更新日期：2018-03-26 00:00:00

abstract：Background:Since most internal medicine nurses work with chronic obstructive pulmonary disease (COPD) patients daily, their ability to meet the needs of COPD patients is an important issue. Our study aimed to assess COPD-related knowledge in internal medicine nurses. Methods:A descriptive cross-sectional study includi...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Ma Y,Peng Y,Chen P,Nie N,Chen Y

更新日期：2019-12-17 00:00:00

abstract：Purpose:COPD is a multisystem disease and there is a need for clinical serum markers that can assess the decline in lung and muscle function in COPD. The goal of this study was to evaluate the potential association of serum club-cell protein 16 (CC16), α-1 acid glycoprotein (AGP) and total sialic acid (TSA) with spirom...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Qaisar R,Karim A,Muhammad T

更新日期：2020-02-11 00:00:00

abstract：Purpose:The primary aim of this research was to raise awareness for COPD through real narratives of patients, caregivers, and pulmonologists. The second objective includes providing clinicians new means of caring for and treating patients with COPD. Methods:Using narrative medicine, testimonies from patients, their ca...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Gatti V,Banfi P,Centanni S,D'Antonio S,Giustini S,Piraino A,Zibellini M,Marini MG

更新日期：2018-10-05 00:00:00

abstract：:Bronchodilators represent the hallmark of symptomatic treatment of Chronic Obstructive Pulmonary Disease (COPD). There are four categories of bronchodilators: anticholinergics, methylxanthines, short-acting beta2-agonists, and long-acting beta2-agonists such as formoterol. Significant research has been performed to in...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Steiropoulos P,Tzouvelekis A,Bouros D

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Assessment of dyspnea in COPD patients relies in clinical practice on the modified Medical Research Council (mMRC) scale, whereas the Baseline Dyspnea Index (BDI) is mainly used in clinical trials. Little is known on the correspondence between the two methods. METHODS:Cross-sectional analysis was carried ou...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Perez T,Burgel PR,Paillasseur JL,Caillaud D,Deslée G,Chanez P,Roche N,INITIATIVES BPCO Scientific Committee.

更新日期：2015-08-18 00:00:00

abstract：Background:Patients with chronic obstructive pulmonary disease (COPD) and cardiovascular comorbidities may have an increased risk of medication-related cardiac arrhythmias. We therefore performed an analysis of Holter electrocardiogram (ECG) data from two large, long-term, controlled clinical COPD trials to investigate...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Andreas S,Bothner U,de la Hoz A,Kloer I,Trampisch M,Alter P

更新日期：2020-08-10 00:00:00

abstract：BACKGROUND:Exacerbations of chronic obstructive pulmonary disease (COPD) lead to significant increases in resource utilization and cost to the health care system. COPD patients with chronic bronchitis and a history of exacerbations pose an additional burden to the system. This study examined health care utilization and...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Pasquale MK,Sun SX,Song F,Hartnett HJ,Stemkowski SA

更新日期：2012-01-01 00:00:00

abstract：Background:Previous studies suggest that gender differences exist in COPD diagnosis and symptoms; these differences may be more pronounced in younger adults. Our objective was to explore age-associated gender differences across a range of COPD severities. Materials and methods:A total of 4,484 current and former smoke...

journal_title：International journal of chronic obstructive pulmonary disease

authors： DeMeo DL,Ramagopalan S,Kavati A,Vegesna A,Han MK,Yadao A,Wilcox TK,Make BJ,COPDGene Investigators.

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:In addition to lung involvement, several other diseases and syndromes coexist in patients with chronic obstructive pulmonary disease (COPD). Our purpose was to investigate the prevalence of idiopathic arterial hypertension (IAH), ischemic heart disease, heart failure, peripheral vascular disease (PVD), diabe...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Camiciottoli G,Bigazzi F,Magni C,Bonti V,Diciotti S,Bartolucci M,Mascalchi M,Pistolesi M

更新日期：2016-09-14 00:00:00

abstract：Purpose:Epigenetic modification is one of most important mechanisms underlying the pathogenesis of chronic obstructive pulmonary disease (COPD). The purpose of this study was to determine whether histone acetyltransferase binding to ORC1 (HBO1) can protect against cigarette smoke (CS)-induced cell apoptosis and sustain...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Chen L,Luo L,Kang N,He X,Li T,Chen Y

更新日期：2020-01-06 00:00:00

abstract：Background:Comorbidities including cardiovascular diseases are very common in chronic obstructive pulmonary disease (COPD) secondary to tobacco smoking and contribute to the overall severity of the disease. In non-smoking COPD, which accounts for about 25% of COPD cases worldwide, current knowledge on the frequency and...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Soumagne T,Guillien A,Roche N,Annesi-Maesano I,Andujar P,Laurent L,Jouneau S,Botebol M,Laplante JJ,Dalphin JC,Degano B

更新日期：2020-07-01 00:00:00

abstract：Background:In COPD disturbed sleep is related to exacerbation frequency, poor quality of life, and early mortality. We developed the Manchester Respiratory-related Sleep Symptoms scale (MaRSS) to assess sleep-time symptoms in COPD. Methods:Focus groups including COPD and age-matched controls were used to develop an it...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Khan N,Vestbo J,Garrow A,Karur P,Kolsum U,Tyson S,Singh D,Yorke J

更新日期：2018-11-29 00:00:00