Budesonide/formoterol combination in COPD: a US perspective.

abstract：Background:Airway inflammation may drive the progression of chronic obstructive pulmonary disease (COPD) associated with alpha-1 antitrypsin deficiency (AATD), but the relationship between airway microbiota and inflammation has not been investigated. Methods:We studied 21 non-treated AATD (AATD-noT) patients, 20 AATD-...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Balbi B,Sangiorgi C,Gnemmi I,Ferrarotti I,Vallese D,Paracchini E,Delle Donne L,Corda L,Baderna P,Corsico A,Carone M,Brun P,Cappello F,Ricciardolo FL,Ruggeri P,Mumby S,Adcock IM,Caramori G,Di Stefano A

更新日期：2019-08-21 00:00:00

abstract：Purpose:COPD is a multisystem disease and there is a need for clinical serum markers that can assess the decline in lung and muscle function in COPD. The goal of this study was to evaluate the potential association of serum club-cell protein 16 (CC16), α-1 acid glycoprotein (AGP) and total sialic acid (TSA) with spirom...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Qaisar R,Karim A,Muhammad T

更新日期：2020-02-11 00:00:00

abstract：PURPOSE:A low body mass index has been associated with high mortalities in patients with chronic obstructive pulmonary disease (COPD), and studies reveal that obesity aggravates the clinical effects of COPD. We investigated the impact of obesity on patients newly identified with COPD. PATIENTS AND METHODS:This populat...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Park JH,Lee JK,Heo EY,Kim DK,Chung HS

更新日期：2017-02-24 00:00:00

abstract：Background:COPD is characterized by a persistent inflammatory response, especially against cigarette smoke. COPD patients may develop varying degrees of emphysematous destruction of the lungs. A pathophysiological role for miRNAs in COPD has been suggested in several studies. We examined changes in microRNAs expression...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Cazorla-Rivero S,Mura-Escorche G,Gonzalvo-Hernández F,Mayato D,Córdoba-Lanús E,Casanova C

更新日期：2020-10-29 00:00:00

abstract：BACKGROUND:The purpose of this study was to describe the prevalence of renal and hepatic disease, related laboratory abnormalities, and potentially hepatotoxic and nephrotoxic medication use in a population-based cohort of persons with chronic obstructive pulmonary disease (COPD). METHODS:This was a retrospective case...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Mapel DW,Marton JP

更新日期：2013-01-01 00:00:00

abstract：Purpose:Depression is reported in association with chronic obstructive pulmonary disease (COPD). However, to date, no multidimensional indices have taken depression into consideration to predict COPD patients' prognosis. This study aimed to determine whether a new multidimensional index named CODEXS, based on comorbidi...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Deng D,Zhou A,Chen P,Shuang Q

更新日期：2020-02-03 00:00:00

abstract：Purpose:miR-190a-5p expression alters dynamically in response to hypoxia. However, the role of miR-190a-5p expression in hypoxia-induced pulmonary hypertension (PH) remains unclear. We sought to correlate the miR-190a-5p expression levels with the severity, diagnosis, and prognosis of PH in relation to chronic obstruct...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Jiang J,Xia Y,Liang Y,Yang M,Zeng W,Zeng X

更新日期：2018-11-20 00:00:00

abstract：Background:In COPD disturbed sleep is related to exacerbation frequency, poor quality of life, and early mortality. We developed the Manchester Respiratory-related Sleep Symptoms scale (MaRSS) to assess sleep-time symptoms in COPD. Methods:Focus groups including COPD and age-matched controls were used to develop an it...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Khan N,Vestbo J,Garrow A,Karur P,Kolsum U,Tyson S,Singh D,Yorke J

更新日期：2018-11-29 00:00:00

abstract：OBJECTIVE:Comorbidities are characteristic of COPD. However, little is known about the secondary manifestations of COPD in the gastrointestinal tract. Therefore, we aimed to explore the long-term effects of gastrectomy in patients with spirometry-defined COPD or those at risk of COPD. PARTICIPANTS:Subjects included 87...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Saito H,Nomura K,Abe S,Motegi T,Ishii T,Hattori K,Kusunoki Y,Gemma A,Kida K

更新日期：2015-10-29 00:00:00

abstract：Background:Telerehabilitation (TR) aimed at patients with COPD has shown promising effects on symptoms, physical function, and quality of life, but little research has been conducted to understand the impact of implementation on frontline health professionals. Therefore, the aim of this study was to examine the barrier...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Damhus CS,Emme C,Hansen H

更新日期：2018-08-17 00:00:00

abstract：:COPD is a major cause of chronic morbidity and mortality throughout the world. Although tumor necrosis factor-α (TNF-α) has a critical role in the development of COPD, the role of different TNF receptors (TNFRs) in pulmonary emphysema has not been resolved. We aimed to clarify the role of TNFRs in the development of p...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Fujita M,Ouchi H,Ikegame S,Harada E,Matsumoto T,Uchino J,Nakanishi Y,Watanabe K

更新日期：2016-07-28 00:00:00

abstract：Rationale:Emphysema and osteoporosis are tobacco-related diseases. Many studies have shown that emphysema is a strong and independent predictor of low bone mineral density (BMD) in smokers; however, none of them explored its association with different emphysema subtypes. Objective:To explore the association between th...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Gonzalez J,Rivera-Ortega P,Rodríguez-Fraile M,Restituto P,Colina I,Calleja MLD,Alcaide AB,Campo A,Bertó J,Seijo L,Pérez-Warnisher MT,Zulueta JJ,Varo N,de-Torres JP

更新日期：2020-07-27 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The overprescription of inhaled corticosteroids (ICS) in the current Global Initiative for Chronic Obstructive Lung Disease (GOLD) group A and B patients with chronic obstructive pulmonary disease (COPD) is not uncommon in clinical practice. The aim of this study was to explore the factors asso...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Wei YF,Kuo PH,Tsai YH,Tao CW,Cheng SL,Lee CH,Wu YK,Chen NH,Hsu WH,Hsu JY,Lin MS,Wang CC

更新日期：2015-09-14 00:00:00

abstract：INTRODUCTION:According to guidelines, the diagnosis of COPD should be confirmed by post-bronchodilator (post-BD) airway obstruction on spirometry; however, in clinical practice, this is not always performed. The aim of this population-based study was to compare clinical characteristics and prognosis, assessed as mortal...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Sawalha S,Hedman L,Rönmark E,Lundbäck B,Lindberg A

更新日期：2017-04-24 00:00:00

abstract：BACKGROUND:Dry powder inhalers (DPIs) are inspiratory flow driven and hence flow dependent. Most patients with chronic obstructive pulmonary disease (COPD) are elderly and have poor lung function. The factors affecting their inspiratory flows through inhalers are unclear. OBJECTIVE:To study peak inspiratory flows (PIF...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Malmberg LP,Rytilä P,Happonen P,Haahtela T

更新日期：2010-08-09 00:00:00

abstract：Background:Previous studies have suggested that β2-adrenergic receptor (ADRB2) is associated with COPD. However, the role of genetic polymorphisms in ADRB2 on COPD has not been evaluated yet. Methods:In this study, SNaPshot genotyping, luciferase assay, chromatin immunoprecipitation and real-time polymerase chain reac...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Li JX,Fu WP,Zhang J,Zhang XH,Sun C,Dai LM,Zhong L,Yu L,Zhang YP

更新日期：2018-03-16 00:00:00

abstract：:Though the guidelines for the optimal management of chronic obstructive pulmonary disease (COPD) following an acute exacerbation (AE) are well established, issues associated with poor adherence to nonpharmacological interventions such as self-management advice and pulmonary rehabilitation will impact on hospital readm...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Harrison SL,Goldstein R,Desveaux L,Tulloch V,Brooks D

更新日期：2014-10-29 00:00:00

abstract：:We hypothesized that bronchodilator treatment not only improves hyperinflation and endurance capacity but also muscular efficiency in stable chronic obstructive pulmonary disease (COPD). We aimed to demonstrate that tiotropium and salmeterol improve muscular efficiency compared with placebo. Twenty-five COPD patients ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： van der Vaart H,Postma DS,Grevink R,Roemer W,ten Hacken N

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The combination of umeclidinium (UMEC), a long-acting muscarinic receptor antagonist, and vilanterol (VI), a selective long-acting β₂ agonist, is in development for the treatment of chronic obstructive pulmonary disease (COPD). This study evaluated the pharmacokinetics, safety and tolerability, and pharmacod...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Mehta R,Kelleher D,Preece A,Hughes S,Crater G

更新日期：2013-01-01 00:00:00

abstract：:[This corrects the article on p. 3485 in vol. 13, PMID: 30498338.]. ...

journal_title：International journal of chronic obstructive pulmonary disease

authors：

更新日期：2018-12-05 00:00:00

abstract：:Smoking-related interstitial lung disease (ILD) consists of a heterogeneous group of disorders that are considered a distinct entity. The 2013 American Thoracic Society and European Respiratory Society recommendations classified respiratory bronchiolitis (RB)/RB-ILD and desquamative interstitial pneumonia (DIP) as smo...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Bak SH,Lee HY

更新日期：2017-11-01 00:00:00

abstract：:The course of COPD is punctuated by acute exacerbations that are associated with an increase in the morbidity and mortality related to this chronic disease and may contribute to its rate of progression. Therefore, preventing and treating exacerbations are major goals of COPD management. The role of tiotropium in the p...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Tashkin DP

更新日期：2010-02-18 00:00:00

abstract：:Regenerative or stem cell therapy is an emerging field of treatment based on stimulation of endogenous resident stem cells or administration of exogenous stem cells to treat diseases or injury and to replace malfunctioning or damaged tissues. Current evidence suggests that in the lung, these cells may participate in t...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Lipsi R,Rogliani P,Calzetta L,Segreti A,Cazzola M

更新日期：2014-12-12 00:00:00

abstract：OBJECTIVE:To determine the characteristics of undiagnosed chronic obstructive pulmonary disease (COPD) in a senior community center. METHODS:We performed a cross-sectional, observational study with the following procedures: questionnaire to record demographic and health status data, anthropometry, questionnaire about ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Santos SR,Lizzi ES,Vianna EO

更新日期：2014-10-15 00:00:00

abstract：Background:Patients with diseases linked with smoking, such as COPD, report a health-related stigma on their smoking behavior, which is related to a poorer quality of life and psychological distress. According to patients with COPD, health-care professionals sometimes reinforce the sense of stigma. However, little is k...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Mooren K,van der Linden G,Pool K,Engels Y

更新日期：2019-11-29 00:00:00

abstract：BACKGROUND:COPD is a major cause of death and morbidity worldwide, and is characterized by persistent airflow obstruction. The evaluation of obstruction is critically dependent on sensitive methods for lung-function testing. A wide body of knowledge has been accumulated in recent years showing that these methods have b...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Lopes AJ,de Melo PL

更新日期：2016-07-11 00:00:00

abstract：Objectives:To describe the trends in pharmacologic treatment for patients newly diagnosed with chronic obstructive pulmonary disease (COPD) in Alberta, Canada. Methods:We linked Alberta health databases to identify patients aged ≥35 years with incident COPD between April 2010 and March 2017. Incident cases were define...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Tran DT,Akpinar I,Mayers I,Makhinova T,Jacobs P

更新日期：2019-09-26 00:00:00

abstract：:Clinical trials of a combination therapy of an inhaled corticosteroid, fluticasone propionate (FP), with a long-acting beta2-agonist, salmeterol (Sal), have demonstrated a greater improvement in lung function and in quality of life measures after the combination compared with either component of alone. In a subanalysi...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Chung KF

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to determine whether long-term intermittent azithromycin therapy reduces the frequency of exacerbation in severe chronic obstructive pulmonary disease (COPD). METHODS:We retrospectively investigated the clinical benefits of long-term azithromycin (500 mg orally three times per week...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Pomares X,Montón C,Espasa M,Casabon J,Monsó E,Gallego M

更新日期：2011-01-01 00:00:00

abstract：Introduction:Biomass smoke exposure (BSE) is a recognized cause of COPD particularly in rural areas. However, little research has been focused on BSE in suburban areas. Objective:The aim of this study was to determine the prevalence of COPD, respiratory symptoms (RS) and BSE in women living in a suburban area of Mexic...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Ramírez-Venegas A,Velázquez-Uncal M,Pérez-Hernández R,Guzmán-Bouilloud NE,Falfán-Valencia R,Mayar-Maya ME,Aranda-Chávez A,Sansores RH

更新日期：2018-05-25 00:00:00