当前位置： SCI文献检索 > International Journal of Chronic Obstructive Pulmonary Disease期刊下所有文献 > Bronchodilation improves endurance but not muscular efficiency in chronic obstructive pulmonary disease.

Bronchodilation improves endurance but not muscular efficiency in chronic obstructive pulmonary disease.

Abstract：

:We hypothesized that bronchodilator treatment not only improves hyperinflation and endurance capacity but also muscular efficiency in stable chronic obstructive pulmonary disease (COPD). We aimed to demonstrate that tiotropium and salmeterol improve muscular efficiency compared with placebo. Twenty-five COPD patients were studied, including 20 males of mean (standard deviation) age 62 years (7 years) with baseline forced expiratory volume in 1 second of 41% (10%) predicted, and maximal workload of 101 Watt (36 Watt). Subjects were randomized for 6-week treatment with tiotropium 18 μg once daily, salmeterol 50 μg twice daily, or placebo using a double-blind, crossover design. Muscular efficiency and endurance time were measured during cycling at 50% of maximal work load. Resting energy expenditure was measured using a ventilated hood. Muscular efficiency after tiotropium, salmeterol, and placebo treatment was 14.6%, 14.4%, and 14.4%, respectively (P > 0.05), and resting energy expenditure was 1485 kcal/24 hours, 1709 kcal/24 hours, and 1472 kcal/24 hours (P > 0.05), respectively. Endurance time after tiotropium treatment was significantly higher than that after placebo (27.0 minutes versus 19.3 minutes [P = 0.02]), whereas endurance time after salmeterol treatment was not higher than that after placebo (23.3 minutes [P = 0.22]). In this small study, we were not able to demonstrate that bronchodilator therapy improved muscular efficiency. Apparently, reduced costs of breathing relative to total energy expenditure were too small to be detected.

journal_name

Int J Chron Obstruct Pulmon Dis

journal_title

International journal of chronic obstructive pulmonary disease

authors

van der Vaart H,Postma DS,Grevink R,Roemer W,ten Hacken N

doi

10.2147/COPD.S17482

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

229-35

eissn

1176-9106

issn

1178-2005

pii

copd-6-229

journal_volume

6

pub_type

杂志文章,随机对照试验

相关文献

International Journal of Chronic Obstructive Pulmonary Disease文献大全
  • Prevalence of Chronic Obstructive Pulmonary Disease and its Associated Factors in Nepal: Findings from a Community-based Household Survey.

    abstract：Background:Despite chronic obstructive pulmonary disease (COPD) being the commonest non-communicable disease in Nepal, there is limited research evidence estimating the spirometry-based burden of COPD. This study aims to estimate the prevalence of COPD and its correlates through a community-based survey in Pokhara Metr...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S268110

    authors： Adhikari TB,Acharya P,Högman M,Neupane D,Karki A,Drews A,Cooper BG,Sigsgaard T,Kallestrup P

    更新日期：2020-09-29 00:00:00

  • Eosinophil counts in first COPD hospitalizations: a 1-year cost analysis in Quebec, Canada.

    abstract：Background:Exacerbations explain much of the cost of COPD. Higher blood eosinophil cell counts at admission for acute exacerbation of COPD increase the risk of subsequent exacerbations and hospitalizations. However, there is no literature on the economic burden of patients with this inflammatory profile. The objective ...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S170747

    authors： Poder TG,Carrier N,Bélanger M,Couillard S,Courteau J,Larivée P,Vanasse A

    更新日期：2018-10-08 00:00:00

  • Differences in health care outcomes between postdischarge COPD patients treated with inhaled corticosteroid/long-acting β2-agonist via dry-powder inhalers and pressurized metered-dose inhalers.

    abstract：Purpose:The aim of this study was to examine real-world differences in health care resource use (HRU) and costs among COPD patients in the USA treated with a dry powder inhaler (DPI) or pressurized metered-dose inhaler (pMDI) following a COPD-related hospitalization. Methods:This retrospective analysis used the Truven...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S177213

    authors： Wittbrodt ET,Millette LA,Evans KA,Bonafede M,Tkacz J,Ferguson GT

    更新日期：2018-12-24 00:00:00

  • Agreement between a simple dyspnea-guided treatment algorithm for stable COPD and the GOLD guidelines: a pilot study.

    abstract：INTRODUCTION:Guidelines recommendations for the treatment of COPD are poorly followed. This could be related to the complexity of classification and treatment algorithms. The purpose of this study was to validate a simpler dyspnea-based treatment algorithm for inhaled pharmacotherapy in stable COPD, comparing its conco...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章,多中心研究

    doi：10.2147/COPD.S100853

    authors： Cabrera C,Casanova C,Martín Y,Mirabal V,Sánchez Mdel C,Álvarez F,Juliá G,Cabrera-Navarro P,García-Bello MÁ,Marín JM,de-Torres JP,Divo M,Celli B

    更新日期：2016-06-08 00:00:00

  • Treatment of patients with COPD and recurrent exacerbations: the role of infection and inflammation.

    abstract：:Exacerbations of COPD represent an important medical and health care problem. Certain susceptible patients suffer recurrent exacerbations and as a consequence have a poorer prognosis. The effects of bronchial infection, either acute or chronic, and of the inflammation characteristic of the disease itself raise the que...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章,评审

    doi：10.2147/COPD.S98333

    authors： Santos S,Marin A,Serra-Batlles J,de la Rosa D,Solanes I,Pomares X,López-Sánchez M,Muñoz-Esquerre M,Miravitlles M

    更新日期：2016-03-11 00:00:00

  • Clinical and Economic Consequences of Inhaled Corticosteroid Doses and Particle Size in Triple Inhalation Therapy for COPD: Real-Life Study.

    abstract：Objective:To determine the clinical and economic consequences of inhaled corticosteroid doses and particle size in patients on triple-inhalation therapy for COPD. Methods:Patients aged ≥40 years who initiated treatment with multi-inhaler triple-inhaled therapy between 1 January 2015 and 31 March were included and foll...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S281333

    authors： Sicras-Mainar A,de Abajo FJ,Izquierdo-Alonso JL

    更新日期：2020-12-09 00:00:00

  • Network meta-analysis of success rate and safety in antibiotic treatments of bronchitis.

    abstract：:The purpose of this study was to compare the relative efficacy and safety of different antibiotic drugs and recommend superior regimens in the treatment of bronchitis. With respect to the antibiotic comparisons against quinolones in terms of intention-to-treat patients, we concluded that quinolones had advantages over...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章,meta分析,评审

    doi：10.2147/COPD.S139521

    authors： Wang J,Xu H,Liu P,Li M

    更新日期：2017-08-09 00:00:00

  • Health status in patients with coexistent COPD and heart failure: a validation and comparison between the Clinical COPD Questionnaire and the Minnesota Living with Heart Failure Questionnaire.

    abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) and heart failure (HF) are both common diseases that coexist frequently. Patients with both diseases have worse stable state health status when compared with patients with one of these diseases. In many outpatient clinics, health status is monitored routinely in C...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S66028

    authors： Berkhof FF,Metzemaekers L,Uil SM,Kerstjens HA,van den Berg JW

    更新日期：2014-09-22 00:00:00

  • COPD-Related Modification to the Airway Epithelium Permits Intracellular Residence of Nontypeable Haemophilus influenzae and May Be Potentiated by Macrolide Arrest of Autophagy.

    abstract：Introduction:COPD is an inflammatory airway pathology associated with recurrent infection by nontypeable Haemophilus influenzae (NTHi) that is not effectively managed by macrolide antibiotic therapy. We hypothesised that NTHi is able to reside intracellularly within COPD-derived airway epithelial cells (AEC), and that ...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S245819

    authors： Poh WP,Kicic A,Lester SE,Nguyen PT,Bakaletz LO,Reynolds PN,Hodge S,Roscioli E

    更新日期：2020-06-04 00:00:00

  • Erratum: What is the impact of GOLD 2017 recommendations in primary care? - a descriptive study of patient classifications, treatment burden and costs [Erratum].

    abstract：:[This corrects the article on p. 3485 in vol. 13, PMID: 30498338.]. ...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章,已发布勘误

    doi：10.2147/COPD.S194746

    authors：

    更新日期：2018-12-05 00:00:00

  • Cigarette smoke extract induces placental growth factor release from human bronchial epithelial cells via ROS/MAPK (ERK-1/2)/Egr-1 axis.

    abstract：:Etiological evidence demonstrates that there is a significant association between cigarette smoking and chronic airway inflammatory disease. Abnormal expression of placental growth factor (PlGF) has been reported in COPD, and its downstream signaling molecules have been reported to contribute to the pathogenesis of ai...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S120849

    authors： Wu D,Yuan Y,Lin Z,Lai T,Chen M,Li W,Lv Q,Yuan B,Li D,Wu B

    更新日期：2016-12-02 00:00:00

  • Symptoms and impact of symptoms on function and health in patients with chronic obstructive pulmonary disease and chronic heart failure in primary health care.

    abstract：BACKGROUND:Patients with chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) seem to have several symptoms in common that impact health. However, methodological differences make this difficult to compare. AIM:Comparisons of symptoms, impact of symptoms on function and health between patients w...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S62563

    authors： Theander K,Hasselgren M,Luhr K,Eckerblad J,Unosson M,Karlsson I

    更新日期：2014-07-18 00:00:00

  • Adherence to current guidelines for chronic obstructive pulmonary disease (COPD) among patients treated with combination of long-acting bronchodilators or inhaled corticosteroids.

    abstract：BACKGROUND:To estimate the potential cost savings by following the current Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline recommendations in patients being treated for chronic obstructive pulmonary disease (COPD) with the combination of long-acting β(2)-agonist (LABA), long-acting muscarinic an...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S25805

    authors： Asche CV,Leader S,Plauschinat C,Raparla S,Yan M,Ye X,Young D

    更新日期：2012-01-01 00:00:00

  • Onset of action of indacaterol in patients with COPD: comparison with salbutamol and salmeterol-fluticasone.

    abstract：BACKGROUND:indacaterol is a novel, inhaled once-daily ultra-long-acting β(2)-agonist for the treatment of chronic obstructive pulmonary disease (COPD). OBJECTIVES:this study compared the onset of action of single doses of indacaterol 150 and 300 μg with salbutamol 200 μg, salmeterol-fluticasone 50/500 μg, and placebo ...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.2147/copd.s12120

    authors： Balint B,Watz H,Amos C,Owen R,Higgins M,Kramer B,INSURE Study Investigators.

    更新日期：2010-09-07 00:00:00

  • Social economic costs of COPD in Extremadura (Spain): an observational study.

    abstract：Purpose:COPD has been associated with a high number of comorbidities and a relatively high level of health care resource utilization. This study aimed to estimate the social economic impact of COPD in the autonomous community of Extremadura (Spain) in 2015. Patients and methods:This is a retrospective observational st...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S167357

    authors： Merino M,Villoro R,Hidalgo-Vega Á,Carmona C

    更新日期：2018-08-21 00:00:00

  • A new functional method to choose the target lobe for lung volume reduction in emphysema - comparison with the conventional densitometric method.

    abstract：BACKGROUND:Lung volume reduction (LVR) improves breathing mechanics by reducing hyperinflation. Lobar selection usually focuses on choosing the most destroyed emphysematous lobes as seen on an inspiratory CT scan. However, it has never been shown to what extent these densitometric CT parameters predict the least deflat...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S139304

    authors： Hetzel J,Boeckeler M,Horger M,Ehab A,Kloth C,Wagner R,Freitag L,Slebos DJ,Lewis RA,Haentschel M

    更新日期：2017-08-30 00:00:00

  • Pilot study of a cell phone-based exercise persistence intervention post-rehabilitation for COPD.

    abstract：OBJECTIVE:To determine the feasibility and efficacy of a six-month, cell phone-based exercise persistence intervention for patients with chronic obstructive pulmonary disease (COPD) following pulmonary rehabilitation. METHODS:Participants who completed a two-week run-in were randomly assigned to either MOBILE-Coached ...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章,随机对照试验

    doi：10.2147/copd.s6643

    authors： Nguyen HQ,Gill DP,Wolpin S,Steele BG,Benditt JO

    更新日期：2009-01-01 00:00:00

  • The COPD assessment test and St George's Respiratory Questionnaire: are they equivalent in subjects with COPD?

    abstract：BACKGROUND:The chronic obstructive pulmonary disease (COPD) assessment test (CAT) is a short questionnaire that has facilitated health status measurements in subjects with COPD. However, it remains controversial as to whether the CAT can be used as a suitable substitute for the St George's Respiratory Questionnaire (SG...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S104947

    authors： Morishita-Katsu M,Nishimura K,Taniguchi H,Kimura T,Kondoh Y,Kataoka K,Ogawa T,Watanabe F,Arizono S,Nishiyama O,Nakayasu K,Imaizumi K,Hasegawa Y

    更新日期：2016-07-07 00:00:00

  • Metabolic Syndrome in Early Chronic Obstructive Pulmonary Disease: Gender Differences and Impact on Exacerbation and Medical Costs.

    abstract：Background:Metabolic syndrome (MetS) is a well-known comorbidity of chronic obstructive pulmonary disease (COPD). However, their interrelationship, particularly in early COPD, remains unclear. Therefore, we aimed to assess the prevalence and clinical characteristics of MetS in patients with early COPD, and to explore t...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S228497

    authors： Choi HS,Rhee CK,Park YB,Yoo KH,Lim SY

    更新日期：2019-12-10 00:00:00

  • The Protective Effect of HBO1 on Cigarette Smoke Extract-Induced Apoptosis in Airway Epithelial Cells.

    abstract：Purpose:Epigenetic modification is one of most important mechanisms underlying the pathogenesis of chronic obstructive pulmonary disease (COPD). The purpose of this study was to determine whether histone acetyltransferase binding to ORC1 (HBO1) can protect against cigarette smoke (CS)-induced cell apoptosis and sustain...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S234634

    authors： Chen L,Luo L,Kang N,He X,Li T,Chen Y

    更新日期：2020-01-06 00:00:00

  • Relationships between heart rate target determined in different exercise testing in COPD patients to prescribed with individualized exercise training.

    abstract：BACKGROUND:It has been scientifically proven that pulmonary rehabilitation improves exercise tolerance and facilitates the carrying out of daily physical activities. To optimize the physical and physiological benefits, it is necessary to individualize the training intensity for each patient. The aim of this study is to...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S129889

    authors： Fabre C,Chehere B,Bart F,Mucci P,Wallaert B,Grosbois JM

    更新日期：2017-05-16 00:00:00

  • Distinct pain profiles in patients with chronic obstructive pulmonary disease.

    abstract：Background:Few studies have examined changes in the pain experience of patients with COPD and predictors of pain in these patients. Objectives:The objectives of the study were to examine whether distinct groups of COPD patients could be identified based on changes in the occurrence and severity of pain over 12 months ...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章,多中心研究

    doi：10.2147/COPD.S150114

    authors： Bentsen SB,Miaskowski C,Cooper BA,Christensen VL,Henriksen AH,Holm AM,Rustøen T

    更新日期：2018-03-06 00:00:00

  • A TASMAN Expedition: Development of a Questionnaire to Assess Specific Self-Management Abilities.

    abstract：Introduction:Self-management (SM) is a core component of well-being and perceived health for patients with chronic obstructive pulmonary disease (COPD). Most theories on SM share that self-efficacy, illness-perception and coping are determinants of SM behavior. Optimal support to improve SM should be tailored to the in...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S224943

    authors： Voorhaar M,Tiemensma J,Asijee GM,Slok AHM,Muris JWM,Kaptein AA

    更新日期：2020-06-19 00:00:00

  • Efficacy and safety of ipratropium bromide/salbutamol sulphate administered in a hydrofluoroalkane metered-dose inhaler for the treatment of COPD.

    abstract：BACKGROUND:The use of chlorofluorocarbons (CFCs) has contributed to the depletion of the stratospheric ozone layer resulting in serious health concerns. Ipratropium bromide/salbutamol sulphate CFC-pressurized metered-dose inhalers (IB/SAL-CFC pMDI) have been in widespread use for many years without any apparent ill con...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.2147/COPD.S89923

    authors： Bhattacharya A,Bhargava S,Singh V,Talwar D,Whig J,Rebello J,Purandare S,Gogtay J

    更新日期：2016-06-30 00:00:00

  • MiR-344b-1-3p targets TLR2 and negatively regulates TLR2 signaling pathway.

    abstract：OBJECTIVES:COPD is an abnormal inflammatory response characterized by decreased expression of TLR2 in patients, which is suggested to induce invasive pulmonary aspergillosis (IPA). MicroRNAs (miRNAs) have been shown to play important roles in the pathogenesis of human respiratory system disorders. Therefore, the aim of...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S120415

    authors： Xu H,Wu Y,Li L,Yuan W,Zhang D,Yan Q,Guo Z,Huang W

    更新日期：2017-02-14 00:00:00

  • Risk of Pneumonia Associated with Inhaled Corticosteroid in Patients with Chronic Obstructive Pulmonary Disease: A Korean Population-Based Study.

    abstract：Introduction:Inhaled corticosteroids (ICSs) are recommended for patients with frequent exacerbation of chronic obstructive pulmonary disease (COPD). However, accumulating evidence has indicated the risk of pneumonia from the use of ICS. This study aimed to investigate the association between ICS and pneumonia in the re...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S286149

    authors： Lee JH,Park YH,Kang DR,Lee SJ,Lee MK,Kim SH,Yong SJ,Lee WY

    更新日期：2020-12-29 00:00:00

  • Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis.

    abstract：:Cigarette smoking is an established cause of lung cancer. However, pulmonary fibrosis is also an independent risk factor for the development of lung cancer. Smoking-related interstitial fibrosis (SRIF) has recently been reported. We hypothesized that adenocarcinomas in lungs with SRIF might show distinct molecular cha...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S61932

    authors： Primiani A,Dias-Santagata D,Iafrate AJ,Kradin RL

    更新日期：2014-05-24 00:00:00

  • Safety and effectiveness of the high-frequency chest wall oscillation vs intrapulmonary percussive ventilation in patients with severe COPD.

    abstract：Purpose:Chest physiotherapy is an important tool in the treatment of COPD. Intrapulmonary percussive ventilation (IPV) and high-frequency chest wall oscillation (HFCWO) are techniques designed to create a global percussion of the lung which removes secretions and probably clears the peripheral bronchial tree. We tested...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章,随机对照试验

    doi：10.2147/COPD.S145440

    authors： Nicolini A,Grecchi B,Ferrari-Bravo M,Barlascini C

    更新日期：2018-02-16 00:00:00

  • Prevalence of airflow limitation in subjects undergoing comprehensive health examination in Japan: Survey of Chronic Obstructive pulmonary disease Patients Epidemiology in Japan.

    abstract：PURPOSE:There are still evidence gaps on the prevalence of airflow limitation in Japan. The purpose of this survey was to estimate the prevalence of airflow limitation among healthy subjects in Japan and to show what proportion of subjects with airflow limitation had been diagnosed with chronic obstructive pulmonary di...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章,多中心研究

    doi：10.2147/COPD.S99935

    authors： Omori H,Kaise T,Suzuki T,Hagan G

    更新日期：2016-04-22 00:00:00

  • A functional SNP upstream of the ADRB2 gene is associated with COPD.

    abstract：Background:Previous studies have suggested that β2-adrenergic receptor (ADRB2) is associated with COPD. However, the role of genetic polymorphisms in ADRB2 on COPD has not been evaluated yet. Methods:In this study, SNaPshot genotyping, luciferase assay, chromatin immunoprecipitation and real-time polymerase chain reac...

    journal_title：International journal of chronic obstructive pulmonary disease

    pub_type： 杂志文章

    doi：10.2147/COPD.S151153

    authors： Li JX,Fu WP,Zhang J,Zhang XH,Sun C,Dai LM,Zhong L,Yu L,Zhang YP

    更新日期：2018-03-16 00:00:00