The clinical use of regenerative therapy in COPD.

abstract：Background:Health effects of electronic cigarette (EC) use in patients with chronic obstructive pulmonary disease (COPD) are largely unexplored. Aim:We present findings from a long-term prospective assessment of respiratory parameters in a cohort of COPD patients who ceased or substantially reduced conventional cigare...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Polosa R,Morjaria JB,Prosperini U,Russo C,Pennisi A,Puleo R,Caruso M,Caponnetto P

更新日期：2018-08-22 00:00:00

abstract：PURPOSE:This study was conducted to determine COPD severity at the time of diagnosis as confirmed by spirometry in patients treated in a US managed care setting. PATIENTS AND METHODS:All patients with one or more inpatient stays, one or more emergency department visits, or two or more outpatient visits with diagnosis ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Mapel DW,Dalal AA,Blanchette CM,Petersen H,Ferguson GT

更新日期：2011-01-01 00:00:00

abstract：Background:Comorbidities including cardiovascular diseases are very common in chronic obstructive pulmonary disease (COPD) secondary to tobacco smoking and contribute to the overall severity of the disease. In non-smoking COPD, which accounts for about 25% of COPD cases worldwide, current knowledge on the frequency and...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Soumagne T,Guillien A,Roche N,Annesi-Maesano I,Andujar P,Laurent L,Jouneau S,Botebol M,Laplante JJ,Dalphin JC,Degano B

更新日期：2020-07-01 00:00:00

abstract：:Pulmonary hypertension (PH) is the hemodynamic manifestation of various pathological processes that result in elevated pulmonary artery pressures (PAP). The National Institutes of Health Registry defined pulmonary arterial hypertension as the mean PAP of more than 25 mm Hg with a pulmonary capillary wedge pressure or ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Jyothula S,Safdar Z

更新日期：2009-01-01 00:00:00

abstract：Introduction:Inhaled corticosteroids (ICSs) are recommended for patients with frequent exacerbation of chronic obstructive pulmonary disease (COPD). However, accumulating evidence has indicated the risk of pneumonia from the use of ICS. This study aimed to investigate the association between ICS and pneumonia in the re...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Lee JH,Park YH,Kang DR,Lee SJ,Lee MK,Kim SH,Yong SJ,Lee WY

更新日期：2020-12-29 00:00:00

abstract：INTRODUCTION:Pulmonary emphysema causes several electrocardiogram changes, and one of the most common and well known is on the frontal P-wave axis. P-axis verticalization (P-axis > 60°) serves as a quasidiagnostic indicator of emphysema. The correlation of P-axis verticalization with the radiological severity of emphys...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Chhabra L,Chaubey VK,Kothagundla C,Bajaj R,Kaul S,Spodick DH

更新日期：2013-01-01 00:00:00

abstract：:Cigarette smoking results in the accumulation of iron both systemically and locally, in the lung thereby causing imbalance in iron homeostasis. This disruption in iron homeostasis can be associated with oxidative stress and consequent tissue injury. Therefore, in this study, we tested the association between iron home...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Ghio AJ,Hilborn ED

更新日期：2017-07-18 00:00:00

abstract：Rationale:COPD has been perceived as being a disease of older men. However, >7 million women are estimated to live with COPD in the USA alone. Despite a growing body of literature suggesting an increasing burden of COPD in women, the evidence is limited. Objectives:To assess and synthesize the available evidence among...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Ntritsos G,Franek J,Belbasis L,Christou MA,Markozannes G,Altman P,Fogel R,Sayre T,Ntzani EE,Evangelou E

更新日期：2018-05-10 00:00:00

abstract：Purpose:This study investigated the effect of dual bronchodilation with the long-acting β-receptor agonist/long-acting muscarinic antagonist combination, indacaterol/glycopyrronium (IND/GLY), on nighttime oxygenation, lung function, sleep quality, and symptoms in patients with moderate-to-severe COPD. Patients and met...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Lehmann S,Ringbæk T,Løkke A,Grote L,Hedner J,Lindberg E

更新日期：2019-01-09 00:00:00

abstract：Purpose:We compared clinical characteristics of COPD patients according to symptom variability and evaluated the effect of symptom variability during the first year of enrollment on clinical outcomes of COPD. Methods:We analyzed COPD patients' data from the Korean Obstructive Lung Disease (KOLD) cohort. Symptom variab...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Kim MA,Suh MK,Park J,Kim JH,Kim TH,Kim EK,Oh YM,Lee SD,Lee JH

更新日期：2019-09-20 00:00:00

abstract：BACKGROUND:Exercise intolerance is a major issue affecting many people with COPD. Six-minute walking distance (6MWD) is a widely used indicator of exercise capacity in patients with COPD. The process is strenuous and time-consuming, especially for patients who have muscle wasting. Anthropometric indicators that reflect...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Ho SC,Hsu MF,Kuo HP,Wang JY,Chen LF,Lee KY,Chuang HC

更新日期：2015-09-08 00:00:00

abstract：:The course of COPD is punctuated by acute exacerbations that are associated with an increase in the morbidity and mortality related to this chronic disease and may contribute to its rate of progression. Therefore, preventing and treating exacerbations are major goals of COPD management. The role of tiotropium in the p...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Tashkin DP

更新日期：2010-02-18 00:00:00

abstract：BACKGROUND:In addition to smoking, acute exacerbations are considered to be a contributing factor to progression of chronic obstructive pulmonary disease (COPD). However, these findings come from studies including active smokers, while results in ex-smokers are scarce and contradictory. The purpose of this study was to...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Dreyse J,Díaz O,Repetto PB,Morales A,Saldías F,Lisboa C

更新日期：2015-03-10 00:00:00

abstract：:Chronic bronchitis is a relatively common entity among patients with underlying chronic obstructive lung disease. Typical treatment includes pulmonary hygiene, bronchodilators, and antimicrobial therapy. In recent years, the duration of antimicrobial therapy in acute exacerbations of COPD has become shorter and shorte...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Milstone AP

更新日期：2008-01-01 00:00:00

abstract：Background:The risk of dying of lung cancer is up to eightfold higher in patients with COPD than in age- and gender-matched controls. The aim of this study was to investigate the factors associated with lung cancer in a large cohort of COPD patients from primary care centers. Methods:To analyze whether age, gender, so...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Sandelin M,Mindus S,Thuresson M,Lisspers K,Ställberg B,Johansson G,Larsson K,Janson C

更新日期：2018-06-06 00:00:00

abstract：Background:Frailty can inform management approaches for individuals with COPD. However, inpatient measures of frailty are seldom employed because they are time-consuming or inapplicable for bed-bound patients. We investigated the feasibility and potential of an innovative sensor-based upper-extremity function (UEF) tes...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Ehsani H,Mohler MJ,Golden T,Toosizadeh N

更新日期：2018-12-18 00:00:00

abstract：:Frailty is a state of increased risk of unfavorable outcomes when exposed to stressors, and COPD is one of the several chronic illnesses associated with the condition. However, few studies have been conducted regarding the prevalence of COPD and its related factors in Southeast Asia. The objectives of this study were ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Limpawattana P,Putraveephong S,Inthasuwan P,Boonsawat W,Theerakulpisut D,Chindaprasirt J

更新日期：2017-04-18 00:00:00

abstract：Purpose:There is currently no measure to predict a treatability of long-acting β-2 agonist (LABA) or long-acting muscarinic antagonist (LAMA) in patients with chronic obstructive pulmonary disease (COPD). We aimed to build prediction models for the treatment response to these bronchodilators, in order to determine the ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Kang J,Kim KT,Lee JH,Kim EK,Kim TH,Yoo KH,Lee JS,Kim WJ,Kim JH,Oh YM

更新日期：2017-12-12 00:00:00

abstract：Introduction:Training in correct inhaler use, ideally in person or by video demonstration, can minimize errors but is rarely provided in clinics. This open-label, low-intervention study evaluated critical error rates with dry-powder inhalers (DPIs), before and after training, in patients with chronic obstructive pulmon...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Collier DJ,Wielders P,van der Palen J,Heyes L,Midwinter D,Collison K,Preece A,Barnes N,Sharma R

更新日期：2020-06-09 00:00:00

abstract：OBJECTIVES:COPD is an abnormal inflammatory response characterized by decreased expression of TLR2 in patients, which is suggested to induce invasive pulmonary aspergillosis (IPA). MicroRNAs (miRNAs) have been shown to play important roles in the pathogenesis of human respiratory system disorders. Therefore, the aim of...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Xu H,Wu Y,Li L,Yuan W,Zhang D,Yan Q,Guo Z,Huang W

更新日期：2017-02-14 00:00:00

abstract：Purpose:Waterpipe (WP) use has become a global trend in young populations. However, there are few well-controlled studies focusing specifically on the chronic effects of exclusive WP use on young adults' respiratory health. We sought to compare in young adults the burden of respiratory symptoms in regular WP smokers (W...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Hawari FI,Obeidat NA,Abu Alhalawa M,Al-Busaidi Z,Amara B,Baddar S,Elhabiby M,Elkholy H

更新日期：2019-08-13 00:00:00

abstract：:Cigarette smoking is an established cause of lung cancer. However, pulmonary fibrosis is also an independent risk factor for the development of lung cancer. Smoking-related interstitial fibrosis (SRIF) has recently been reported. We hypothesized that adenocarcinomas in lungs with SRIF might show distinct molecular cha...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Primiani A,Dias-Santagata D,Iafrate AJ,Kradin RL

更新日期：2014-05-24 00:00:00

abstract：BACKGROUND:A year-long pan-Canadian quality improvement collaborative (QIC) led by the Canadian Foundation for Healthcare Improvement (CFHI) supported the spread of the successful Halifax, Nova Scotia-based INSPIRED COPD Outreach Program™ to 19 teams in the 10 Canadian provinces. We describe QIC results, addressing two...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Rocker GM,Amar C,Laframboise WL,Burns J,Verma JY

更新日期：2017-07-26 00:00:00

abstract：BACKGROUND:Whereas the epidemiological association between lung cancer and chronic obstructive pulmonary disease (COPD), a chronic inflammatory respiratory disease, is well known, limited studies have examined the association between lung cancer and non-cystic fibrosis bronchiectasis, a representative chronic airway in...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Kim YW,Jin KN,Heo EY,Park SS,Chung HS,Kim DK

更新日期：2015-05-04 00:00:00

abstract：Aim:Six-minute walking test distance (6MWD) and body mass index, obstruction, dyspnea and exercise (BODE) index are measures of functional status in COPD patients, but require space, time and patient's compliance. Exhaled volatile organic compounds (VOCs) analysis via electronic nose is a quick and easy method that has...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Finamore P,Pedone C,Scarlata S,Di Paolo A,Grasso S,Santonico M,Pennazza G,Antonelli Incalzi R

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:Plasminogen activator inhibitor-1 (PAI-1), a major inhibitor of fibrinolysis, is associated with thrombosis, obesity, insulin resistance, dyslipidemia, and premature aging, which all are coexisting conditions of chronic obstructive pulmonary disease (COPD). The role of PAI-1 in COPD with respect to metabol...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Waschki B,Watz H,Holz O,Magnussen H,Olejnicka B,Welte T,Rabe KF,Janciauskiene S

更新日期：2017-03-22 00:00:00

abstract：:In this review we consider the therapeutic potential of targeting Akt for the treatment of COPD. Akt is a serine/threonine protein kinase that functions as a signaling intermediate linked to multiple signaling programs involved in survival, inflammation, and growth. Akt is closely associated with key membrane-bound re...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Bozinovski S,Vlahos R,Hansen M,Liu K,Anderson GP

更新日期：2006-01-01 00:00:00

abstract：:Pulmonary emphysema is usually the result of chronic exposure to cigarette smoke in at risk individuals. To investigate the hypothesis that lung damage in emphysema results from coincident weakening in the structural properties of the tissue and increased mechanical forces--as one explanation of the continued developm...

journal_title：International journal of chronic obstructive pulmonary disease

authors： de Ryk J,Thiesse J,Namati E,McLennan G

更新日期：2007-01-01 00:00:00

abstract：Background:This study examines the effects of the COPD-specific health promoting self-management intervention "Better living with COPD" on different self-management-related domains, self-efficacy, and sense of coherence (SOC). Methods:In a randomized controlled design, 182 people with COPD were allocated to either an ...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Bringsvor HB,Langeland E,Oftedal BF,Skaug K,Assmus J,Bentsen SB

更新日期：2018-11-08 00:00:00

abstract：BACKGROUND:Pulmonary rehabilitation (PR) is recommended after a severe COPD exacerbation, but its short- and long-term effects on health care utilization have not been fully established. AIMS:The aims of this study were to evaluate patient compliance with a chronic disease management (CDM) program incorporating home-b...

journal_title：International journal of chronic obstructive pulmonary disease

authors： Lalmolda C,Coll-Fernández R,Martínez N,Baré M,Teixidó Colet M,Epelde F,Monsó E

更新日期：2017-08-23 00:00:00