Case-control study of childhood leukaemia and cancer in Scotland: findings for neonatal intramuscular vitamin K.

Abstract:

OBJECTIVE:To test the hypothesis of an association between neonatal intramuscular vitamin K and childhood leukaemia and other cancers. DESIGN:Population based case-control study with data abstracted from hospital records. SETTING:Scotland. SUBJECTS:Children aged 0-14 years resident in Scotland from 1991-4 and diagnosed with leukaemia (150), lymphomas (46), central nervous system tumours (79), a range of other solid tumours (142), and a subset of acute lymphoblastic leukaemia (129). Controls were 777 children matched for age and sex, providing 417 matched sets (360 triplets and 57 pairs) for analysis. MAIN OUTCOME MEASURE:Odds ratios for the risk of childhood leukaemia and cancer and intramuscular vitamin K versus a combined group of oral doses, none, and no record. Results are given for information recorded in medical notes and data supplemented by hospital policy. RESULTS:Odds ratios based on medical record abstractions showed no significant positive association for leukaemias (odds ratio 1.30; 95% confidence interval 0.83 to 2.03), acute lymphoblastic leukaemia (1.21; 0.74 to 1.97), lymphomas (1.06; 0.46 to 2.42), central nervous system tumours (0.74; 0.40 to 1.34), and other solid tumours (0.59; 0.37 to 0.96). There was no association with acute lymphoblastic leukaemia in children aged 1 to 6 years. Imputation of exposure from hospital policy gave similar results. Adjustment for deprivation and type of delivery moved risk estimates closer to unity for all major diagnostic groups. CONCLUSIONS:The observation of an increased risk of childhood leukaemia and cancer associated with intramuscular vitamin K is not confirmed by this independent population based study.

journal_name

BMJ

authors

McKinney PA,Juszczak E,Findlay E,Smith K

doi

10.1136/bmj.316.7126.173

subject

Has Abstract

pub_date

1998-01-17 00:00:00

pages

173-7

issue

7126

eissn

0959-8138

issn

1756-1833

journal_volume

316

pub_type

杂志文章
  • Written informed consent and selection bias in observational studies using medical records: systematic review.

    abstract:OBJECTIVES:To determine whether informed consent introduces selection bias in prospective observational studies using data from medical records, and consent rates for such studies. DESIGN:Systematic review. DATA SOURCES:Embase, Medline, and the Cochrane Library up to March 2008, reference lists from pertinent article...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.b866

    authors: Kho ME,Duffett M,Willison DJ,Cook DJ,Brouwers MC

    更新日期:2009-03-12 00:00:00

  • Readmission after hysterectomy and prophylactic low molecular weight heparin: retrospective case-control study.

    abstract:OBJECTIVE:To determine whether use of tinzaparin, a low molecular weight heparin introduced for prophylactic management of deep vein thrombosis, increases the risk of serious postoperative bleeding leading to a higher than expected 28 day readmission rate after discharge for hysterectomy. DESIGN:Retrospective case-con...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.38783.624444.55

    authors: Cook G,Depares J,Singh M,McElduff P

    更新日期:2006-04-08 00:00:00

  • Performance evaluation of a new rapid urine test for chlamydia in men: prospective cohort study.

    abstract:OBJECTIVE:To evaluate the performance of a rapid test for chlamydia with first void male urine samples as a potential tool for diagnosis and screening of chlamydial infection in men. DESIGN:Evaluation of test performance in prospective cohort study. Settings A young people's sexual health centre (site 1) and a genitou...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.b2655

    authors: Nadala EC,Goh BT,Magbanua JP,Barber P,Swain A,Alexander S,Laitila V,Michel CE,Mahilum-Tapay L,Ushiro-Lumb I,Ison C,Lee HH

    更新日期:2009-07-28 00:00:00

  • Systematic review of day hospital care for elderly people. The Day Hospital Group.

    abstract:OBJECTIVE:To examine the effectiveness of day hospital attendance in prolonging independent living for elderly people. DESIGN:Systematic review of 12 controlled clinical trials (available by January 1997) comparing day hospital care with comprehensive care (five trials), domiciliary care (four trials), or no comprehen...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析

    doi:10.1136/bmj.318.7187.837

    authors: Forster A,Young J,Langhorne P

    更新日期:1999-03-27 00:00:00

  • Long term trends in prevalence of neural tube defects in Europe: population based study.

    abstract:STUDY QUESTION:What are the long term trends in the total (live births, fetal deaths, and terminations of pregnancy for fetal anomaly) and live birth prevalence of neural tube defects (NTD) in Europe, where many countries have issued recommendations for folic acid supplementation but a policy for mandatory folic acid f...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.h5949

    authors: Khoshnood B,Loane M,de Walle H,Arriola L,Addor MC,Barisic I,Beres J,Bianchi F,Dias C,Draper E,Garne E,Gatt M,Haeusler M,Klungsoyr K,Latos-Bielenska A,Lynch C,McDonnell B,Nelen V,Neville AJ,O'Mahony MT,Queisser-Luf

    更新日期:2015-11-24 00:00:00

  • Impact of late diagnosis and treatment on life expectancy in people with HIV-1: UK Collaborative HIV Cohort (UK CHIC) Study.

    abstract:OBJECTIVES:To estimate life expectancy for people with HIV undergoing treatment compared with life expectancy in the general population and to assess the impact on life expectancy of late treatment, defined as CD4 count <200 cells/mm(3) at start of antiretroviral therapy. DESIGN:Cohort study. SETTING:Outpatient HIV c...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.d6016

    authors: May M,Gompels M,Delpech V,Porter K,Post F,Johnson M,Dunn D,Palfreeman A,Gilson R,Gazzard B,Hill T,Walsh J,Fisher M,Orkin C,Ainsworth J,Bansi L,Phillips A,Leen C,Nelson M,Anderson J,Sabin C

    更新日期:2011-10-11 00:00:00

  • Baby food industry lobbies WHO on breast feeding advice.

    abstract::In the existing WHO guidelines, complementary feeding at 4-6 months is advocated. However, many nutrition specialists believe that these guidelines lead to complementary foods being offered from the age of 3 months, or even earlier, subsequently suggesting that the WHO should change its recommendations to about 6 mon...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 新闻

    doi:

    authors: Yamey G

    更新日期:2000-09-09 00:00:00

  • Different strategies for screening and prevention of type 2 diabetes in adults: cost effectiveness analysis.

    abstract:OBJECTIVE:To compare four potential screening strategies, and subsequent interventions, for the prevention and treatment of type 2 diabetes: (a) screening for type 2 diabetes to enable early detection and treatment, (b) screening for type 2 diabetes and impaired glucose tolerance, intervening with lifestyle interventio...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.39545.585289.25

    authors: Gillies CL,Lambert PC,Abrams KR,Sutton AJ,Cooper NJ,Hsu RT,Davies MJ,Khunti K

    更新日期:2008-05-24 00:00:00

  • Widening access to UK medical education for under-represented socioeconomic groups: modelling the impact of the UKCAT in the 2009 cohort.

    abstract:OBJECTIVE:To determine whether the use of the UK clinical aptitude test (UKCAT) in the medical schools admissions process reduces the relative disadvantage encountered by certain sociodemographic groups. DESIGN:Prospective cohort study. SETTING:Applicants to 22 UK medical schools in 2009 that were members of the cons...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.e1805

    authors: Tiffin PA,Dowell JS,McLachlan JC

    更新日期:2012-04-17 00:00:00

  • Estimates of burden and consequences of infants born small for gestational age in low and middle income countries with INTERGROWTH-21st standard: analysis of CHERG datasets.

    abstract::Objectives To estimate small for gestational age birth prevalence and attributable neonatal mortality in low and middle income countries with the INTERGROWTH-21st birth weight standard.Design Secondary analysis of data from the Child Health Epidemiology Reference Group (CHERG), including 14 birth cohorts with gestatio...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.j3677

    authors: Lee AC,Kozuki N,Cousens S,Stevens GA,Blencowe H,Silveira MF,Sania A,Rosen HE,Schmiegelow C,Adair LS,Baqui AH,Barros FC,Bhutta ZA,Caulfield LE,Christian P,Clarke SE,Fawzi W,Gonzalez R,Humphrey J,Huybregts L,Kariuki

    更新日期:2017-08-17 00:00:00

  • Admissions processes for five year medical courses at English schools: review.

    abstract:OBJECTIVE:To describe the current methods used by English medical schools to identify prospective medical students for admission to the five year degree course. DESIGN:Review study including documentary analysis and interviews with admissions tutors. SETTING:All schools (n = 22) participating in the national expansio...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.38768.590174.55

    authors: Parry J,Mathers J,Stevens A,Parsons A,Lilford R,Spurgeon P,Thomas H

    更新日期:2006-04-29 00:00:00

  • Continuing medical education: experience and opinions of consultants.

    abstract::The right of consultants to study leave and expenses is not binding on trusts and has been eroded in directly managed units. Complaints led to a survey of consultants in North West Thames region. This showed that most consultants use their own time and money to maintain their knowledge by buying and consulting journal...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.306.6889.1398

    authors: Kerr DN,Jones SA,Easmon CS

    更新日期:1993-05-22 00:00:00

  • Effectiveness of dementia follow-up care by memory clinics or general practitioners: randomised controlled trial.

    abstract:OBJECTIVE:To examine the effectiveness of post-diagnosis dementia treatment and coordination of care by memory clinics compared with general practitioners. DESIGN:Multicentre randomised controlled trial. SETTING:Nine memory clinics and 159 general practitioners in the Netherlands. PARTICIPANTS:175 patients with a ne...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/bmj.e3086

    authors: Meeuwsen EJ,Melis RJ,Van Der Aa GC,Golüke-Willemse GA,De Leest BJ,Van Raak FH,Schölzel-Dorenbos CJ,Verheijen DC,Verhey FR,Visser MC,Wolfs CA,Adang EM,Olde Rikkert MG

    更新日期:2012-05-15 00:00:00

  • Trajectory of body shape in early and middle life and all cause and cause specific mortality: results from two prospective US cohort studies.

    abstract:OBJECTIVE:To assess body shape trajectories in early and middle life in relation to risk of mortality. DESIGN:Prospective cohort study. SETTING:Nurses' Health Study and Health Professionals Follow-up Study. POPULATION:80 266 women and 36 622 men who recalled their body shape at ages 5, 10, 20, 30, and 40 years and p...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 评论,杂志文章

    doi:10.1136/bmj.i2195

    authors: Song M,Hu FB,Wu K,Must A,Chan AT,Willett WC,Giovannucci EL

    更新日期:2016-05-04 00:00:00

  • Effect of homoeopathic medicines on daily burden of symptoms in children with recurrent upper respiratory tract infections.

    abstract:OBJECTIVE:To investigate the intrinsic effects of individually prescribed homoeopathic medicines. DESIGN:Randomised double blind placebo controlled study. SETTING:Paediatric outpatient department of university hospital. PATIENTS:175 children with frequently recurring upper respiratory tract infections. Of the 170 ch...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.309.6965.1329

    authors: de Lange de Klerk ES,Blommers J,Kuik DJ,Bezemer PD,Feenstra L

    更新日期:1994-11-19 00:00:00

  • Case-control study of self reported genitourinary infections and risk of gastroschisis: findings from the national birth defects prevention study, 1997-2003.

    abstract:OBJECTIVE:To assess the association between genitourinary infections in the month before conception to the end of the first trimesterand gastroschisis. DESIGN:Case-control study with self reported infections from a computer assisted telephone interview. SETTING:National birth defects prevention study, a multisite, po...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.39567.509074.25

    authors: Feldkamp ML,Reefhuis J,Kucik J,Krikov S,Wilson A,Moore CA,Carey JC,Botto LD

    更新日期:2008-06-21 00:00:00

  • Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement.

    abstract::Prediction models are developed to aid health care providers in estimating the probability or risk that a specific disease or condition is present (diagnostic models) or that a specific event will occur in the future (prognostic models), to inform their decision making. However, the overwhelming evidence shows that th...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.g7594

    authors: Collins GS,Reitsma JB,Altman DG,Moons KG

    更新日期:2015-01-07 00:00:00

  • Diet and cancer.

    abstract::Accumulating data indicate that modifications in diet may reduce the risk of cancer by as much as one third and possibly by as much as two thirds. On the basis of the existing evidence, however, it is not possible to be certain which cancers are causally related to diet and what proportion of them are due to specific ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.308.6944.1610

    authors: Austoker J

    更新日期:1994-06-18 00:00:00

  • Differences in mortality after fracture of hip: the east Anglian audit.

    abstract:OBJECTIVE:To investigate differences between hospitals in clinical management of patients admitted with fractured hip and to relate these to mortality at 90 days. DESIGN:A prospective audit of process and outcome of care based on interviews with patients, abstraction from records with standard proforma, and follow up ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.310.6984.904

    authors: Todd CJ,Freeman CJ,Camilleri-Ferrante C,Palmer CR,Hyder A,Laxton CE,Parker MJ,Payne BV,Rushton N

    更新日期:1995-04-08 00:00:00

  • Effect on weight gain of routinely giving albendazole to preschool children during child health days in Uganda: cluster randomised controlled trial.

    abstract:OBJECTIVE:To estimate the effectiveness of delivering an anthelmintic through a community child health programme on the weight gain of preschool children in Uganda. DESIGN:Cluster randomised controlled trial. SETTING:Eastern Uganda. PARTICIPANTS:48 parishes participating in a new programme for child health: 24 offer...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmj.38877.393530.7C

    authors: Alderman H,Konde-Lule J,Sebuliba I,Bundy D,Hall A

    更新日期:2006-07-15 00:00:00

  • The demand for neonatal intensive care.

    abstract::In a one year prospective study within the Trent Regional Health Authority the demand for neonatal intensive care was estimated to be 1.1 cots per 1000 births. Intensive care level 1 (as defined by the British Paediatric Association and British Association for Perinatal Paediatrics) was determined by two separate tech...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.299.6711.1305

    authors: Field DJ,Hodges S,Mason E,Burton P,Yates J,Wale S

    更新日期:1989-11-25 00:00:00

  • Prevalence of diabetes in a predominantly Asian community: preliminary findings of the Coventry diabetes study.

    abstract::To assess the prevalence of both diagnosed and undiagnosed diabetes mellitus in an area of predominantly Asian population the Coventry diabetes study is carrying out house to house screening for diabetes in people aged 20 and over in Foleshill, Coventry. In the first five of 12 areas to be studied 2130 of 2283 Asian (...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.298.6665.18

    authors: Simmons D,Williams DR,Powell MJ

    更新日期:1989-01-07 00:00:00

  • Education, income inequality, and mortality: a multiple regression analysis.

    abstract:OBJECTIVE:To test whether the relation between income inequality and mortality found in US states is because of different levels of formal education. DESIGN:Cross sectional, multiple regression analysis. SETTING:All US states and the District of Columbia (n=51). DATA SOURCES:US census statistics and vital statistics...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.324.7328.23

    authors: Muller A

    更新日期:2002-01-05 00:00:00

  • Demographic shifts and medical training.

    abstract::The rapid aging of populations in developing countries as compared to those in the developed world has implications for medical training in these places. Moreover, the growing globalization of employment for many health professionals means that demographic shifts have implications for the training of health professio...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.319.7221.1358

    authors: Ebrahim S

    更新日期:1999-11-20 00:00:00

  • Science, medicine, and the future. Lung cancer.

    abstract::Lung cancer, the most prevalent cancer in the Western world, is mainly caused by smoking. Nevertheless, only 20% of smokers develop lung cancer and while prevention is important, environmental factors are expected to contribute to the predicted rise in the incidence of lung cancer in the next 25 years. Survival of lun...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.314.7081.652

    authors: Sethi T

    更新日期:1997-03-01 00:00:00

  • Change in social status and risk of low birth weight in Denmark: population based cohort study.

    abstract:OBJECTIVE:To estimate the risk of having a low birthweight infant associated with changes in social, environmental, and genetic factors. DESIGN:Population based, historical cohort study using the Danish medical birth registry and Statistic Denmark's fertility database. SUBJECTS:All women who had a low birthweight inf...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.315.7121.1498

    authors: Basso O,Olsen J,Johansen AM,Christensen K

    更新日期:1997-12-06 00:00:00

  • Association of soy and fermented soy product intake with total and cause specific mortality: prospective cohort study.

    abstract:OBJECTIVE:To investigate the association between several types of soy products and all cause and cause specific mortality. DESIGN:Population based cohort study. SETTING:Japan Public Health Centre-based Prospective Study, which includes 11 public health centre areas in Japan. PARTICIPANTS:92 915 participants (42 750 ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.m34

    authors: Katagiri R,Sawada N,Goto A,Yamaji T,Iwasaki M,Noda M,Iso H,Tsugane S,Japan Public Health Center-based Prospective Study Group.

    更新日期:2020-01-29 00:00:00

  • Abortion laws cause problems in Poland.

    abstract::A doctor who performed an abortion in Poland faces two years in prison and the loss of his medical license for up to 10 years if he is found guilty of violating the new abortion laws introduced in 1993 after a lengthy campaign by the Catholic church and the Christian Democratic Union party. The new laws permit aborti...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 新闻

    doi:10.1136/bmj.310.6994.1556a

    authors: Gajewski M

    更新日期:1995-06-17 00:00:00

  • Influence of environmental factors on mental health within prisons: focus group study.

    abstract:OBJECTIVE:To increase understanding of how the prison environment influences the mental health of prisoners and prison staff. DESIGN:Qualitative study with focus groups. SETTING:A local prison in southern England. PARTICIPANTS:Prisoners and prison staff. RESULTS:Prisoners reported that long periods of isolation wit...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.327.7413.480

    authors: Nurse J,Woodcock P,Ormsby J

    更新日期:2003-08-30 00:00:00

  • Improving generalist end of life care: national consultation with practitioners, commissioners, academics, and service user groups.

    abstract:OBJECTIVE:To identify major concerns of national and local importance in the provision, commissioning, research, and use of generalist end of life care. DESIGN:A national consultation and prioritising exercise using a modified form of the nominal group technique. PARTICIPANTS:Healthcare practitioners, commissioners, ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.a1720

    authors: Shipman C,Gysels M,White P,Worth A,Murray SA,Barclay S,Forrest S,Shepherd J,Dale J,Dewar S,Peters M,White S,Richardson A,Lorenz K,Koffman J,Higginson IJ

    更新日期:2008-10-01 00:00:00