Abstract：
:Obesity is a global public health problem and a risk factor for several metabolic disorders as well as cancer. In this study, we investigated the effects of L-fucose on lipid metabolism through chronic and acute in vivo experiments in mice. In the chronic test, mice were fed a high-calorie diet (HCD) containing 0.0001%, 0.001%, 0.01%, and 0.1% L-fucose for one month. The L-fucose supplementation inhibited body weight and visceral fat mass gain in HCD-fed mice. The results of the acute test showed that L-fucose increased the ratio of serum high molecular weight adiponectin and enhanced glucose and lipid catabolism. Furthermore, L-fucose also decreased the expression of adipogenic genes (peroxisome proliferator-activated receptor γ and cluster of differentiation 36). In conclusion, this study provides a new approach to combat obesity and the related diseases.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Yuan X,Nakao T,Satone H,Ohara K,Kominami Y,Ito M,Aizawa T,Ueno T,Ushio Hdoi
10.3390/nu12123798subject
Has Abstractpub_date
2020-12-11 00:00:00issue
12issn
2072-6643pii
nu12123798journal_volume
12pub_type
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