The Effects of Aronia melanocarpa Extract on Testosterone-Induced Benign Prostatic Hyperplasia in Rats, and Quantitative Analysis of Major Constituents Depending on Extract Conditions.

Abstract:

:This study aimed to investigate the beneficial effects of A. melanocarpa on testosterone propionate (TP)-induced benign prostatic hyperplasia (BPH) in Wistar rats. Moreover, the bioactive constituents in the extract were determined using LC/MS and HPLC analyses. The dried fruits of A. melanocarpa were extracted using accelerated solvent extraction (ASE) under different extract conditions (temperature, 30 C or 100 C; extract solvent, 60% or 100% ethanol) to yield four extracts (T1~T4). Of the four A. melanocarpa extracts, T1 extracted under the condition of 100% ethanol/low temperature (30 C) exhibited the greatest inhibitory activity on TP-induced prostatic hyperplasia in rats. The administration of T1 (100 mg/kg body weight, p.o.) for six weeks attenuated TP-induced prostate enlargement and reduced the levels of dihydrotestosterone (DHT) and 5α-reductase in both serum and prostate tissue. The suppression of PCNA mRNA expression in prostate tissue was remarkable in T1-treated rats. In LC/MS analysis, the levels of main anthocyanins and phenolics were significantly higher in T1 than in the other extracts. Furthermore, the quantitative study showed that the contents of cyanidin-3-glucose and cyanidin-3-xylose in T1 exhibited 1.27~1.67 and 1.10~1.26 folds higher compared to those in the other extracts. These findings demonstrated that A. melanocarpa extract containing anthocyanins as bioactive constituents attenuated the development of testosterone-induced prostatic hyperplasia, and suggested that this extract has therapeutic potential to treat prostate enlargement and BPH.

journal_name

Nutrients

journal_title

Nutrients

authors

Kim NH,Jegal J,Kim YN,Heo JD,Rho JR,Yang MH,Jeong EJ

doi

10.3390/nu12061575

subject

Has Abstract

pub_date

2020-05-28 00:00:00

issue

6

issn

2072-6643

pii

nu12061575

journal_volume

12

pub_type

杂志文章
  • Vitamin A intake, serum vitamin D and bone mineral density: analysis of the Korea National Health and Nutrition Examination Survey (KNHANES, 2008-2011).

    abstract::The association of high vitamin A intake and low bone mineral density (BMD) is still controversial. To determine the association of dietary vitamin A intake and serum 25-hydroxyvitamin D (25(OH)D) concentration with BMD, a total of 6481 subjects (2907 men and 3574 women) aged ≥50 years from the Korean National Health ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu7031716

    authors: Joo NS,Yang SW,Song BC,Yeum KJ

    更新日期:2015-03-10 00:00:00

  • β-hydroxybutyrate Impedes the Progression of Alzheimer's Disease and Atherosclerosis in ApoE-Deficient Mice.

    abstract::β-hydroxybutyrate (β-OHB) has been shown to exert an anti-inflammatory activity. Apolipoprotein-E (ApoE) is strongly associated with atherosclerosis and Alzheimer's disease (AD). This study aimed to explore the therapeutic effect of β-OHB in the brain and the aorta of high-fat diet (HFD)-fed ApoE-deficient mice. We fo...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12020471

    authors: Krishnan M,Hwang JS,Kim M,Kim YJ,Seo JH,Jung J,Ha E

    更新日期:2020-02-13 00:00:00

  • Fructose-Induced Intestinal Microbiota Shift Following Two Types of Short-Term High-Fructose Dietary Phases.

    abstract::High consumption of fructose and high-fructose corn syrup is related to the development of obesity-associated metabolic diseases, which have become the most relevant diet-induced diseases. However, the influences of a high-fructose diet on gut microbiota are still largely unknown. We therefore examined the effect of s...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12113444

    authors: Beisner J,Gonzalez-Granda A,Basrai M,Damms-Machado A,Bischoff SC

    更新日期:2020-11-10 00:00:00

  • Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection?

    abstract::Obesity and iron deficiency (ID) are two of the most common nutritional disorders in the world. In children both conditions deserve particular attention. Several studies revealed an association between obesity and iron deficiency in children and, in some cases, a reduced response to oral supplementation. The connectin...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu7115458

    authors: Grandone A,Marzuillo P,Perrone L,Del Giudice EM

    更新日期:2015-11-06 00:00:00

  • Vitamin D Receptor (VDR) Gene Polymorphism in Patients Diagnosed with Colorectal Cancer.

    abstract::Colorectal cancer (CRC) is one of the most commonly occurring neoplasias in humans. The prevalence of CRC rates is still rising. Although the exact background of the disease still remains unknown, it is believed that CRC may not only be a result of environmental factors, but also genetic ones. One of the mechanisms un...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu13010200

    authors: Latacz M,Rozmus D,Fiedorowicz E,Snarska J,Jarmołowska B,Kordulewska N,Savelkoul H,Cieślińska A

    更新日期:2021-01-11 00:00:00

  • Does Incorporating Gender Differences into Quantifying a Food Frequency Questionnaire Influence the Association of Total Energy Intake with All-Cause and Cause-Specific Mortality?

    abstract::This study aims to evaluate whether incorporating gender differences in portion sizes as part of quantifying a food frequency questionnaire influences the association of total energy intake with mortality. The analysis included 156,434 participants (70,142 men and 86,292 women) in the Multiethnic Cohort Study, aged 45...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12102914

    authors: Kang M,Park SY,Boushey CJ,Wilkens LR,Le Marchand L,Hankin JH,Paik HY

    更新日期:2020-09-23 00:00:00

  • Hospital Malnutrition, Nutritional Risk Factors, and Elements of Nutritional Care in Europe: Comparison of Polish Results with All European Countries Participating in the nDay Survey.

    abstract::NutritionDay (nDay) is a project established by the Medical University of Vienna and the European Society for Clinical Nutrition and Metabolism (ESPEN) to audit the nutritional status of hospitalized patients and nursing home residents. This study aimed to evaluate nDay data describing the prevalence of hospital malnu...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu13010263

    authors: Ostrowska J,Sulz I,Tarantino S,Hiesmayr M,Szostak-Węgierek D

    更新日期:2021-01-18 00:00:00

  • Mediterranean Diet and Cardiovascular Disease: A Critical Evaluation of A Priori Dietary Indexes.

    abstract::The aim of this paper is to analyze the a priori dietary indexes used in the studies that have evaluated the role of the Mediterranean Diet in influencing the risk of developing cardiovascular disease. All the studies show that this dietary pattern protects against cardiovascular disease, but studies show quite differ...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu7095367

    authors: D'Alessandro A,De Pergola G

    更新日期:2015-09-16 00:00:00

  • Maternal Diet Influences the Reinstatement of Cocaine-Seeking Behavior and the Expression of Melanocortin-4 Receptors in Female Offspring of Rats.

    abstract::Recent studies have emphasized the role of the maternal diet in the development of mental disorders in offspring. Substance use disorder is a major global health and economic burden. Therefore, the search for predisposing factors for the development of this disease can contribute to reducing the health and social dama...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12051462

    authors: Gawliński D,Gawlińska K,Frankowska M,Filip M

    更新日期:2020-05-19 00:00:00

  • The Impact of Dietary Fucosylated Oligosaccharides and Glycoproteins of Human Milk on Infant Well-Being.

    abstract::Apart from optimal nutritional value, human milk is the feeding strategy to support the immature immunological system of developing newborns and infants. The most beneficial dietary carbohydrate components of breast milk are human milk oligosaccharides (HMOs) and glycoproteins (HMGs), involved in both specific and non...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12041105

    authors: Orczyk-Pawiłowicz M,Lis-Kuberka J

    更新日期:2020-04-16 00:00:00

  • Carotenoid Content in Breastmilk in the 3rd and 6th Month of Lactation and Its Associations with Maternal Dietary Intake and Anthropometric Characteristics.

    abstract::Carotenoids are diet-dependent milk components that are important for the visual and cognitive development of an infant. This study determined β-carotene, lycopene and lutein + zeaxanthin in breastmilk and its associations with dietary intake from healthy Polish mothers in the first six months of lactation. Concentrat...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11010193

    authors: Zielinska MA,Hamulka J,Wesolowska A

    更新日期:2019-01-18 00:00:00

  • Drink Choice is Important: Beverages Make a Substantial Contribution to Energy, Sugar, Calcium and Vitamin C Intake among Australians.

    abstract::It is important to understand the role of beverages in population dietary intake in order to give relevant advice. Population estimates were derived from one-day food recall dietary data from 12,153 participants in the 2011-2012 Australian National Nutrition and Physical Activity Survey. Almost all Australians (99.9%)...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11061389

    authors: Riley MD,Hendrie GA,Baird DL

    更新日期:2019-06-20 00:00:00

  • Association between Dietary Inflammatory Index, C-Reactive Protein and Metabolic Syndrome: A Cross-Sectional Study.

    abstract::Increased prevalence of metabolic syndrome (MetS) has become a global major public health problem. Chronic low-grade inflammation associated with diet was found to play an import role in the development of MetS, although further studies are needed. The main purpose of this study was to explore the association between ...

    journal_title:Nutrients

    pub_type: 杂志文章,多中心研究

    doi:10.3390/nu10070831

    authors: Ren Z,Zhao A,Wang Y,Meng L,Szeto IM,Li T,Gong H,Tian Z,Zhang Y,Wang P

    更新日期:2018-06-27 00:00:00

  • Bariatric Surgery and Precision Nutrition.

    abstract::This review provides a literature overview of new findings relating nutritional genomics and bariatric surgery. It also describes the importance of nutritional genomics concepts in personalized bariatric management. It includes a discussion of the potential role bariatric surgery plays in altering the three pillars of...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu9090974

    authors: Nicoletti CF,Cortes-Oliveira C,Pinhel MAS,Nonino CB

    更新日期:2017-09-06 00:00:00

  • Intake of Lutein-Rich Vegetables Is Associated with Higher Levels of Physical Activity.

    abstract::Levels of physical inactivity, a major contributor to burden of disease, are high in many countries. Some preliminary research suggests that circulating lutein concentrations are associated with high levels of physical activity (PA). We aimed to assess whether the intake of lutein-containing foods, including vegetable...

    journal_title:Nutrients

    pub_type: 杂志文章,多中心研究

    doi:10.3390/nu7095378

    authors: Crichton G,Elias M,Alkerwi A,Buckley J

    更新日期:2015-09-18 00:00:00

  • Stabilization of Vitamin D in Pea Protein Isolate Nanoemulsions Increases Its Bioefficacy in Rats.

    abstract::Micronutrient delivery formulations based on nanoemulsions can enhance the absorption of nutrients and bioactives, and thus, are of great potential for food fortification and supplementation strategies. The aim was to evaluate the bioefficacy of vitamin D (VitD) encapsulated in nanoemulsions developed by sonication an...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11010075

    authors: Almajwal AM,Abulmeaty MMA,Feng H,Alruwaili NW,Dominguez-Uscanga A,Andrade JE,Razak S,ElSadek MF

    更新日期:2019-01-02 00:00:00

  • Understanding the Elements of Maternal Protection from Systemic Bacterial Infections during Early Life.

    abstract::Late-onset sepsis (LOS) and other systemic bloodstream infections are notable causes of neonatal mortality, particularly in prematurely born very low birth weight infants. Breastfeeding in early life has numerous health benefits, impacting the health of the newborn in both the short-term and in the long-term. Though t...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12041045

    authors: Kleist SA,Knoop KA

    更新日期:2020-04-10 00:00:00

  • A Multifunctional Bread Rich in Beta Glucans and Low in Starch Improves Metabolic Control in Type 2 Diabetes: A Controlled Trial.

    abstract:DESIGN:Functional foods may be useful for people with diabetes. The soluble fibers beta glucans can modify starch digestion and improve postprandial glucose response. We analyzed the metabolic effects of a specifically designed 'functional' bread, low in starch, rich in fibers (7 g/100 g), with a beta glucan/starch rat...

    journal_title:Nutrients

    pub_type: 杂志文章,随机对照试验

    doi:10.3390/nu9030297

    authors: Tessari P,Lante A

    更新日期:2017-03-17 00:00:00

  • Results of a Mass Media Campaign in South Africa to Promote a Sugary Drinks Tax.

    abstract:BACKGROUND:In South Africa, the increased consumption of sugary drinks has been associated with increased obesity rates. Mass media campaigns can play a crucial role in improving knowledge, shifting attitudes, and building support for government action on reducing sugary drink consumption. No study to date has evaluate...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12061878

    authors: Murukutla N,Cotter T,Wang S,Cullinan K,Gaston F,Kotov A,Maharjan M,Mullin S

    更新日期:2020-06-23 00:00:00

  • Fructose Beverage Consumption Induces a Metabolic Syndrome Phenotype in the Rat: A Systematic Review and Meta-Analysis.

    abstract::A high intake of refined carbohydrates, particularly the monosaccharide fructose, has been attributed to the growing epidemics of obesity and type-2 diabetes. Animal studies have helped elucidate the metabolic effects of dietary fructose, however, variations in study design make it difficult to draw conclusions. The a...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu8090577

    authors: Toop CR,Gentili S

    更新日期:2016-09-20 00:00:00

  • The Origins of Salivary Vitamin A, Vitamin B12 and Vitamin D-Binding Proteins.

    abstract::Vitamin A- (retinol), vitamin B12- (haptocorrin) and vitamin D-binding proteins are the major circulatory transporters of their respective ligands; they are also constituents of the salivary proteome, the origins of which, remain unclear. The aim of this study was to explore how these proteins enter saliva and their r...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12123838

    authors: Blakeley M,Sobczyńska-Malefora A,Carpenter G

    更新日期:2020-12-16 00:00:00

  • Oleuropein Decreases Cyclooxygenase-2 and Interleukin-17 Expression and Attenuates Inflammatory Damage in Colonic Samples from Ulcerative Colitis Patients.

    abstract::Oleuropein (OLE) is the major phenolic secoiridoid of olive tree leaves, and its antioxidant and anti-inflammatory activities have been demonstrated in in vitro and in vivo animal models. The aim of this study was to investigate the activity of OLE in the colonic mucosa from patients with ulcerative colitis (UC). Biop...

    journal_title:Nutrients

    pub_type: 临床试验,杂志文章

    doi:10.3390/nu9040391

    authors: Larussa T,Oliverio M,Suraci E,Greco M,Placida R,Gervasi S,Marasco R,Imeneo M,Paolino D,Tucci L,Gulletta E,Fresta M,Procopio A,Luzza F

    更新日期:2017-04-15 00:00:00

  • Anti-Atherogenic Activity of Polyphenol-Rich Extract from Bee Pollen.

    abstract::The aim of this study was to determine the effect of polyphenol-rich ethanol extract of bee pollen (EEP) on atherosclerosis induced by a high-fat diet in ApoE-knockout mice. EEP was given with feed in two doses of 0.1 and 1 g/kg body mass (BM). The studies have been conducted in a period of 16 weeks. The following fac...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu9121369

    authors: Rzepecka-Stojko A,Stojko J,Jasik K,Buszman E

    更新日期:2017-12-18 00:00:00

  • Older Adults' Awareness and Knowledge of Beans in Relation to Their Nutrient Content and Role in Chronic Disease Risk.

    abstract::Awareness and knowledge of nutrient-dense foods are important for older adults to help them make dietary choices that support a food-first approach to healthy aging. This is especially important since age is a major risk factor for chronic disease and the proportion of older adults in North America is increasing. Bean...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11112680

    authors: Doma KM,Farrell EL,Leith-Bailey ER,Soucier VD,Duncan AM

    更新日期:2019-11-05 00:00:00

  • Protein Supplementation Does Not Further Increase Latissimus Dorsi Muscle Fiber Hypertrophy after Eight Weeks of Resistance Training in Novice Subjects, but Partially Counteracts the Fast-to-Slow Muscle Fiber Transition.

    abstract::The response to resistance training and protein supplementation in the latissimus dorsi muscle (LDM) has never been investigated. We investigated the effects of resistance training (RT) and protein supplementation on muscle mass, strength, and fiber characteristics of the LDM. Eighteen healthy young subjects were rand...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu8060331

    authors: Paoli A,Pacelli QF,Cancellara P,Toniolo L,Moro T,Canato M,Miotti D,Neri M,Morra A,Quadrelli M,Reggiani C

    更新日期:2016-06-01 00:00:00

  • Association of Low Serum l-Carnitine Levels with Peripheral Arterial Stiffness in Patients Who Undergo Kidney Transplantation.

    abstract::l-carnitine is an important co-factor in fatty-acid metabolism, and its deficiency is associated with insulin resistance, which is independently associated with arterial stiffness. This study evaluated the relationship between serum l-carnitine level and peripheral arterial stiffness (PAS) in kidney transplantation (K...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11092000

    authors: Lai YH,Lee MC,Ho GJ,Liu CH,Hsu BG

    更新日期:2019-08-24 00:00:00

  • Human Milk Casein and Whey Protein and Infant Body Composition over the First 12 Months of Lactation.

    abstract::Human milk (HM) influences infant feeding patterns and body composition (BC). This small proof-of concept longitudinal study investigated relationships between infant/maternal BC and HM casein, whey and total protein during the first 12 months of lactation. BC of breastfeeding dyads (n = 20) was measured at 2 (n = 15)...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu10091332

    authors: Gridneva Z,Tie WJ,Rea A,Lai CT,Ward LC,Murray K,Hartmann PE,Geddes DT

    更新日期:2018-09-19 00:00:00

  • Imbalanced Nutrient Intake in Cancer Survivors from the Examination from the Nationwide Health Examination Center-Based Cohort.

    abstract::This study was conducted to examine the nutrient intake status of cancer survivors. A total of 5224 cancer survivors, 19,926 non-cancer individuals without comorbidities (non-cancer I), and 20,622 non-cancer individuals with comorbidities, matched by age, gender, and recruitment center location were included in the an...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu10020212

    authors: Park B,Lee J,Kim J

    更新日期:2018-02-14 00:00:00

  • Dietary Assessment Methods in Military and Veteran Populations: A Scoping Review.

    abstract::Optimal dietary intake is important for the health and physical performance of military personnel. For military veterans, the complex nature of transition into civilian life and sub-optimal dietary intake is a leading contributor to the increased burden of disease. A scoping review was undertaken to determine what is ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12030769

    authors: Collins RA,Baker B,Coyle DH,Rollo ME,Burrows TL

    更新日期:2020-03-14 00:00:00

  • Iron Deficiency and Iron Homeostasis in Low Birth Weight Preterm Infants: A Systematic Review.

    abstract::Iron is an essential micronutrient that is involved in many functions in humans, as it plays a critical role in the growth and development of the central nervous system, among others. Premature and low birth weight infants have higher iron requirements due to increased postnatal growth compared to that of term infants...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11051090

    authors: Moreno-Fernandez J,Ochoa JJ,Latunde-Dada GO,Diaz-Castro J

    更新日期:2019-05-16 00:00:00