Abstract:
:Polyamines (including putrescine, spermidine, and spermine) are small, cationic molecules that are necessary for cell proliferation and differentiation. Few studies have examined the association of dietary polyamines intake with colorectal cancer risk. The aim of this study was to evaluate total polyamines, putrescine, spermidine, and spermine intake in relation to colorectal cancer risk in China. In total, 2502 colorectal cancer cases and 2538 age-(5-year interval) and sex-matched controls were recruited from July 2010 to April 2019. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated by multivariable unconditional logistic regression after adjustment for various potential confounding factors. Higher intake of total polyamine, putrescine and spermidine was significantly associated with reduced risk of colorectal cancer. The adjusted ORs for the highest compared with the lowest quartile of intake were 0.60 (95% CI 0.50, 0.72; Ptrend < 0.001) for total polyamines, 0.35 (95% CI 0.29, 0.43; Ptrend < 0.001) for putrescine and 0.79 (95% CI 0.66, 0.95; Ptrend = 0.001) for spermidine, respectively. However, higher intake of spermine was associated with increased risk of colorectal cancer, with an adjusted OR of 1.58 (95% CI 1.29, 1.93; Ptrend < 0.001). This data indicate that higher intake of total polyamines, putrescine and spermidine, as well as lower intake of spermine, is associated with a decreased risk of colorectal cancer.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Huang CY,Fang YJ,Abulimiti A,Yang X,Li L,Liu KY,Zhang X,Feng XL,Chen YM,Zhang CXdoi
10.3390/nu12113575subject
Has Abstractpub_date
2020-11-22 00:00:00issue
11issn
2072-6643pii
nu12113575journal_volume
12pub_type
杂志文章相关文献
Nutrients文献大全abstract::Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(-/-) mice and perinatal defic...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu6093818
更新日期:2014-09-19 00:00:00
abstract::We performed an external cross-validation study of 10 equations to estimate resting energy expenditure (REE) in 2037 children with and 389 without obesity. Inclusion criteria were Caucasian ethnicity, age ≤ 18 years, and availability of REE. REE was measured using indirect calorimetry. The correct classification fract...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12051421
更新日期:2020-05-14 00:00:00
abstract::The most common tools used to screen for abdominal obesity are waist circumference (WC) and waist-to-height ratio (WHtR); the latter may represent a more suitable tool for the general non-professional population. The objective of this study was to evaluate the association of WHtR, WC, and body mass index with lipidic ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10121850
更新日期:2018-12-01 00:00:00
abstract::Abstract: Background: Dietary protein intake is important for health. Eggs, as a protein-rich food with characteristics that appeal to older adults, may provide opportunities for increasing protein intake. Interventions that focus on the challenges or facilitators that affect a large proportion of the population will ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10101409
更新日期:2018-10-02 00:00:00
abstract::Several preventive strategies to reduce dyslipidemia have been suggested, of which dietary modification features as an important one. Dyslipidemia is a major risk factor for coronary heart disease and strategies to manage dyslipidemia have been shown to reduce the incidence of cardiovascular disease (CVD). Although th...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10040468
更新日期:2018-04-11 00:00:00
abstract::Syndecans are transmembrane proteoglycans that, like integrins, bind to components of the extracellular matrix. Previously, we showed significant associations of genetic variants in the Syndecan-4 (SDC4) gene with intra-abdominal fat, fasting plasma glucose levels, and insulin sensitivity index in children, and with f...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11112810
更新日期:2019-11-18 00:00:00
abstract::Osteoporosis and associated low energy fractures are a significant clinical problem, especially in the elderly population. The occurrence of a hip fracture is associated with significant mortality and a high risk of disability. For this, apart from the treatment of osteoporosis, effective prevention of both the develo...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12082394
更新日期:2020-08-10 00:00:00
abstract::Despite the life stage of menopause being identified as a high risk for weight gain, there are few obesity prevention interventions for this target group, and no evidence on maintenance of intervention effects after intervention support is withdrawn. In the 40-Something Randomized Controlled Trial (RCT) (ACTRN12611000...
journal_title:Nutrients
pub_type: 临床试验,杂志文章
doi:10.3390/nu11051100
更新日期:2019-05-17 00:00:00
abstract:BACKGROUND:Observationally, sugar-sweetened beverage (SSB) consumption is associated with adiposity in Western children but could be confounded. We examined the association of SSB frequency with adiposity in the non-Western setting of Hong Kong. METHODS:We examined the associations of SSB consumption frequency at 11 a...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12041015
更新日期:2020-04-07 00:00:00
abstract::The 5'-3' structure-specific endonuclease ERCC1/XPF (Excision Repair Cross-Complementation Group 1/Xeroderma Pigmentosum group F) plays critical roles in the repair of cisplatin-induced DNA damage. As such, it has been identified as a potential pharmacological target for enhancing clinical response to platinum-based c...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10111644
更新日期:2018-11-03 00:00:00
abstract::Vitamin D is a steroid hormone with a broad range of biological effects ranging from the classical role as a mediator of calcium and phosphate balance to cellular differentiation and immune modulation. These effects impact normal and dysfunctional hematopoietic and immune function, which may allow an avenue for improv...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu5062206
更新日期:2013-06-18 00:00:00
abstract::A cross-over study was conducted in 16 healthy adult volunteers to describe the urinary excretion of polyphenols from date seeds and investigate the antioxidant effect after consumption of different doses of date seeds powder (DSP), bread (DSB) and extract (DSE). After 12 h of fasting, one of the six treatments (0.25 ...
journal_title:Nutrients
pub_type: 临床试验,杂志文章
doi:10.3390/nu11102489
更新日期:2019-10-16 00:00:00
abstract:BACKGROUND:Dyslipidemias are a heterogeneous group of metabolic disorders mainly characterized by an increased risk of atherosclerotic cardiovascular disease (ASCVD) or other conditions, such as acute pancreatitis in hypertriglyceridemia. The aim of this study was to evaluate the effect of diet treatment and nutraceuti...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12072056
更新日期:2020-07-10 00:00:00
abstract::High sodium intake is estimated to cause approximately 3 million deaths per year worldwide. The estimated average sodium intake of 3.95 g/day far exceeds the recommended intake. Population sodium reduction should be a global priority, while simultaneously ensuring universal salt iodization. This article identifies hig...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12092543
更新日期:2020-08-22 00:00:00
abstract::Caffeine's ergogenic effects on exercise performance are generally explained by its ability to bind to adenosine receptors. ADORA2A is the gene that encodes A2A subtypes of adenosine receptors. It has been suggested that ADORA2A gene polymorphisms may be responsible for the inter-individual variations in the effects o...
journal_title:Nutrients
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3390/nu12030741
更新日期:2020-03-11 00:00:00
abstract:BACKGROUND:Elevated ferritin, which is often used to represent iron storage, is known to increase the risk of metabolic syndrome (MetS) or its components, but its increase is affected by many factors. Therefore, it is necessary to analyze the relationship between other indicators of iron storage, and MetS and its compo...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12051486
更新日期:2020-05-20 00:00:00
abstract::Succinate is a metabolic intermediate of the tricarboxylic acid (TCA) cycle within host cells. Succinate is also produced in large amounts during bacterial fermentation of dietary fiber. Elevated succinate levels within the gut lumen have been reported in association with microbiome disturbances (dysbiosis), as well a...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11010025
更新日期:2018-12-22 00:00:00
abstract::In functional food advertising, messages are not always easily understandable for the target audience. Current European legislation, enforced through Regulation 1924/2006, specifies that such messages should be clear and precise so as not to mislead the consumer. The objective of this study was to observe consumers' u...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12113312
更新日期:2020-10-29 00:00:00
abstract::A dietary prebiotic is defined as 'a substrate that is selectively utilized by host microorganisms conferring a health benefit'. Although this definition evolved concomitantly with the knowledge and technological developments that accrued in the last twenty years, what qualifies as prebiotic continues to be a matter o...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9121376
更新日期:2017-12-20 00:00:00
abstract::Some infants experience excessive weight gain (EWG) during exclusive breastfeeding, but causes and consequences are unknown. The objective was to identify factors associated with early EWG. Infants with EWG (HW-group) were examined at 5, 9 and 18 mo and compared to a breastfed group with normal weight gain (NW-group)....
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10091290
更新日期:2018-09-12 00:00:00
abstract::This systematic review aims to evaluate the association of adiponectin (ADIPOQ) and leptin (LEP) gene variants with energy intake. Cross-sectional, cohort, and case⁻control studies that reported an association of leptin and/or adiponectin gene variants with energy intake were included in this review. Human studies wit...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11040750
更新日期:2019-03-30 00:00:00
abstract::Some flavonoids identified in beet stalks can help the antioxidant endogenous defenses during a chronic inflammation process. The current study investigates the effect of polyphenols present in beet stalks and leaves on liver oxidative damage in mice fed a high-fat diet (HF). The control (CT) or HF diet groups were su...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10070872
更新日期:2018-07-05 00:00:00
abstract::The intestinal microbiome plays an important role in maintaining health throughout life. The microbiota develops progressively after birth and is influenced by many factors, including the mode of delivery, antibiotics, and diet. Maternal milk is critically important to the development of the neonatal intestinal microb...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12030823
更新日期:2020-03-20 00:00:00
abstract::To clarify the anti-obesity effect of Allomyrina dichotoma larvae (ADL), we previously reported that ADL block adipocyte differentiation on 3T3-L1 cell lines through downregulation of transcription factors, such as peroxisome proliferator-activated receptor-γ (PPARG) and CCAAT/enhancer binding protein-α (CEBPA). In th...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7031978
更新日期:2015-03-17 00:00:00
abstract::Intestinal barrier function is suggested to decrease with aging and may be improved by pectin intake. The aim of this study was to investigate the effects of four weeks pectin supplementation on gastrointestinal barrier function in vivo and ex vivo in different age groups. In a randomized, double-blind, placebo-contro...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11071554
更新日期:2019-07-09 00:00:00
abstract::A low-carbohydrate, high-fat ketogenic diet (KD) is a nutritional approach ensuring that the body utilizes lipids. In our previous study, we found that an eight-week ketogenic high-fat, low-carbohydrate diet increased the capacity of endurance exercise in mice without aggravated muscle injury, despite the decrease of ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10101339
更新日期:2018-09-20 00:00:00
abstract::The effect of a raised body mass index (BMI) on the outcome of assisted reproduction technology (ART) still represents a controversial issue. Even less clear is whether BMI acts with a potential detrimental effect on IVF outcomes via a deleterious effect on innate quality of oocytes or on the environmental milieu with...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8030109
更新日期:2016-02-23 00:00:00
abstract::Little is known about iodine nutritional status in island countries in the Pacific Ocean. The primary objective of this study was to report for the first time the iodine nutritional status of people in Nauru. In addition, sources of iodine nutrition (i.e., water and salt) were investigated. A school-based cross-sectio...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8090520
更新日期:2016-08-23 00:00:00
abstract:BACKGROUND:a large number of studies have linked vitamin B6 to inflammation and cardiovascular disease in the general population. However, it remains uncertain whether vitamin B6 is associated with cardiovascular outcome independent of inflammation. METHODS:we measured plasma pyridoxal 5'-phosphate (PLP), as an indica...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12092711
更新日期:2020-09-04 00:00:00
abstract::Long term nut consumption is associated with reduced risk of coronary heart disease and better cognitive function. This study examined supplementing habitual diets with almonds or carbohydrate-rich snack foods (providing 15% energy) on biomarkers of cardiovascular and metabolic health, mood and cognitive performance. ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12041180
更新日期:2020-04-23 00:00:00