Abstract:
BACKGROUND:Listeria monocytogenes (L. monocytogenes) is a facultative intracellular bacterial pathogen which can invade different mammalian cells and reach to the central nervous system (CNS), leading to meningoencephalitis and brain abscesses. In the diagnosis of L. monocytogenes meningoencephalitis (LMM), the traditional test often reports negative owing to the antibiotic treatment or a low number of bacteria in the cerebrospinal fluid. To date, timely diagnosis and accurate treatment remains a challenge for patients with listeria infections. CASE PRESENTATION:We present the case of a 66-year-old woman whose clinical manifestations were suspected as tuberculous meningoencephalitis, but the case was finally properly diagnosed as LMM by next-generation sequencing (NGS). The patient was successfully treated using a combined antibacterial therapy, comprising ampicillin and trimethoprim-sulfamethoxazole. CONCLUSION:To improve the sensitivity of LMM diagnosis, we used NGS for the detection of L. monocytogenes. Hence, the clinical utility of this approach can be very helpful since it provides quickly and trust results.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Lan ZW,Xiao MJ,Guan YL,Zhan YJ,Tang XQdoi
10.1186/s12879-020-05447-zsubject
Has Abstractpub_date
2020-10-01 00:00:00pages
721issue
1issn
1471-2334pii
10.1186/s12879-020-05447-zjournal_volume
20pub_type
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