Abstract：
BACKGROUND:The new HIV treatment guidelines in China recommend antiretroviral therapy (ART) for all people living with HIV, but significant gaps in implementation still exist. Pre-exposure prophylaxis (PrEP) can effectively reduce the risk of HIV transmission among men who have sex with men (MSM). This study assessed the epidemiological impact and cost effectiveness of PrEP, enhanced biomedical interventions and their combination among MSM in China. METHODS:A deterministic mathematical model was developed and projected over 20 years to assess the impact of the PrEP, biomedical interventions and their combinations. Incidence and prevalence of HIV were measured, and cost-effectiveness was assessed using incremental cost (international dollars, Int.$) per quality-adjusted life year (QALY) gained. RESULTS:A total of 0.78 million new HIV infections were estimated to occur over the next 20 years if no additional interventions are implemented among MSM. The PrEP-only strategy covering 25-75% of HIV-negative high-risk MSM can prevent 0.09-0.20 million (12.1-25.7%) new infections, at a cost of 17,277-18,452 Int.$/QALY. The optimal cost-effectiveness path is from test-and-treat to the combination strategy of test-and-treat and PrEP. Some strategies could almost eliminate new HIV infections over the next 20 years. CONCLUSIONS:PrEP, test-and-treat, and their combinations among MSM are effective and cost-effective relative to current policy. PrEP is an important and cost-effective addition to current policy in China.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Li J,Peng L,Gilmour S,Gu J,Ruan Y,Zou H,Hao C,Hao Y,Lau JTdoi
10.1186/s12879-018-3516-8subject
Has Abstractpub_date
2018-11-28 00:00:00pages
600issue
1issn
1471-2334pii
10.1186/s12879-018-3516-8journal_volume
18pub_type
杂志文章abstract：BACKGROUND:The emerging resistance to the extended-spectrum cephalosporins (ESCs) in Neisseria gonorrhoeae together with increasing incidence of gonorrhoea cases in many countries have been global public health concerns. However, in recent years the levels of ESC resistance have decreased in several regions worldwide. ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-015-1013-x
更新日期：2015-08-11 00:00:00
abstract：BACKGROUND:Chemokines have been reported to play an important role in granulomatous inflammation during Schistosoma mansoni infection. However there is less information on their role in Schistosoma haematobium infection, or on the effect of concurrent HIV-1 infection, as a potential modifying influence. METHODS:To det...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-9-174
更新日期：2009-10-23 00:00:00
abstract：BACKGROUND:Hepatitis B virus (HBV) infection is a major public health burden in China although it has steadily declined over the last two decades. A valid updated prevalence of HBV infection in China relies on a large sample size. Hence this study aimed to estimate HBV seroprevalence using a large inpatient population ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-019-4091-3
更新日期：2019-05-20 00:00:00
abstract：BACKGROUND:Improved treatment options of HIV have resulted in regular physical activities of many HIV-infected patients. However, data on effects of sports in HIV-patients are scarce. METHODS:21 HIV-infected persons were monitored prospectively while preparing for a marathon run. Multiple parameters with regard to imm...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-017-2651-y
更新日期：2017-08-08 00:00:00
abstract：BACKGROUND:Vibrio spp. are aquatic bacteria that are ubiquitous in warm estuarine and marine environments, of which 12 species are currently known to cause infections in humans. So far, only five human infections with V. harveyi have been reported. CASE PRESENTATION:A 26-year old patient was transferred to our center ...
journal_title：BMC infectious diseases
pub_type： 杂志文章,评审
doi：10.1186/s12879-020-4789-2
更新日期：2020-02-04 00:00:00
abstract：BACKGROUND:Hantavirus infection is worldwide epidemic and can cause life-threatening consequences. With more and more cases reported in countries with atypical morbidity, it is necessarily urgent to know some atypical symptoms and signs of Hantavirus infection. CASE PRESENTATION:Here we report the case of a 44-year ol...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-020-4775-8
更新日期：2020-01-13 00:00:00
abstract：BACKGROUND:The importance of multidrug-resistant organisms (MDRO) in Chinese hospitals is not clearly delineated. Thus we sought to assess the prevalence of MDRO in Chinese intensive care units (ICUs). METHODS:Prospective study of inpatients admitted consecutively to eight ICUs in four Chinese cities in 2009-10. Admis...
journal_title：BMC infectious diseases
pub_type： 杂志文章,多中心研究
doi：10.1186/s12879-015-1105-7
更新日期：2015-08-21 00:00:00
abstract：BACKGROUND:Hepatitis B (HBV) and C (HCV) infections are a serious global and national public health problem. Earlier studies have reported increasing rates of hepatitis infection in Pakistan, particularly in rural areas. Pakistan has no active surveillance program to monitor trends of these infections. The objective of...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-8-43
更新日期：2008-04-10 00:00:00
abstract：BACKGROUND:Chlamydia trachomatis is a common sexually transmitted infection in Australia. This report aims to measure the burden of chlamydia infection by systematically reviewing reports on prevalence in Australian populations. METHODS:Electronic databases and conference websites were searched from 1997-2011 using th...
journal_title：BMC infectious diseases
pub_type： 杂志文章,meta分析,评审
doi：10.1186/1471-2334-12-113
更新日期：2012-05-14 00:00:00
abstract：BACKGROUND:Malaria remains a major tropical vector-borne disease of immense public health concern owing to its debilitating effects in sub-Saharan Africa. Over the past 30 years, the high altitude areas in Eastern Africa have been reported to experience increased cases of malaria. Governments including that of the Repu...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-020-05158-5
更新日期：2020-06-17 00:00:00
abstract：BACKGROUND:The widespread antimicrobial resistance of Neisseria gonorrhoeae is a serious problem for the treatment and control of gonorrhoea. Many of the previously effective therapeutic agents are no longer viable. Because N. gonorrhoeae infections are not reportable in Germany, only limited data on disease epidemiolo...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-018-2944-9
更新日期：2018-01-17 00:00:00
abstract：BACKGROUND:There have been no reports regarding clinical features and molecular characteristics of childhood methicillin-susceptible Staphylococcus aureus (MSSA) infections in Taiwan. METHODS:We prospectively collected clinical S. aureus isolates from patients aged < 18 years in a university-affiliated hospital in 201...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-019-4033-0
更新日期：2019-05-10 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate the epidemiology and resistance of methicillin-resistant Staphylococcus aureus (MRSA) isolates from long-term care facilities (LTCF) residents and to analyze the potential risk factors for MRSA occurrence, defined as MRSA colonization and/or infection. METHODS:Point ...
journal_title：BMC infectious diseases
pub_type： 杂志文章,多中心研究
doi：10.1186/1471-2334-14-271
更新日期：2014-05-18 00:00:00
abstract：BACKGROUND:The effects of helminth co-infection on malaria in humans remain uncertain. This study aimed to evaluate the nature of association of intestinal helminths with prevalence and clinical outcomes of Plasmodium infection. METHODS:A cross-sectional study involving 1,065 malaria suspected febrile patients was con...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-12-291
更新日期：2012-11-09 00:00:00
abstract：BACKGROUND:Routine culture-based diagnosis of Pseudomonas aeruginosa lung infection in Cystic Fibrosis (CF) patients can be hampered by the phenotypic variability of the microorganism, including its transition to a Viable But Non-Culturable (VBNC) state. The aim of this study was to validate an ecfX-targeting qPCR prot...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-018-3612-9
更新日期：2018-12-27 00:00:00
abstract：BACKGROUND:Cupriavidus gilardii is an aerobic, Gram-negative, glucose-nonfermenting rod that was first identified in 1999. Because of the difficulty in accurate species identification of C. gilardii, there are few case reports of infection caused by this organism. In previous reports, C. gilardii has been characterized...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-016-1838-y
更新日期：2016-09-19 00:00:00
abstract：BACKGROUND:Community-acquired pneumonia (CAP) is a serious cause of morbidity among children in developed countries. The real impact of 7-valent pneumococcal conjugate vaccine (PCV7) on pneumococcal pneumonia is difficult to assess accurately. METHODS:Children aged ≤16 years with clinical and radiological pneumonia we...
journal_title：BMC infectious diseases
pub_type： 杂志文章,多中心研究
doi：10.1186/1471-2334-13-357
更新日期：2013-07-31 00:00:00
abstract：BACKGROUND:Understanding the types of strains and lineages of Mycobacterium tuberculosis (M. tuberculosis) circulating in a country is of paramount importance for tuberculosis (TB) control program of that country. The main aim of this study was to review and compile the results of studies conducted on strains and linea...
journal_title：BMC infectious diseases
pub_type： 杂志文章,评审
doi：10.1186/s12879-018-3046-4
更新日期：2018-03-27 00:00:00
abstract：BACKGROUND:High-risk strains of human papillomavirus (HPV) cause cervical cancer. American Indian (AI) women in the Northern Plains of the U.S. have significantly higher incidence and mortality rates for cervical cancer than White women in the same geographical area. We compared HPV prevalence, patterns of HPV types, a...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-11-252
更新日期：2011-09-24 00:00:00
abstract：BACKGROUND:In Colombia, the dengue virus (DENV) has been endemic for decades, and with the recent entry of the chikungunya virus (CHIKV) (2014) and the Zika virus (ZIKV) (2015), health systems are overloaded because the diagnosis of these three diseases is based on clinical symptoms, and the three diseases share a symp...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-018-2976-1
更新日期：2018-01-30 00:00:00
abstract：BACKGROUND:To verify whether a daily service of Infectious Diseases consultation (ID-cons) is more effective than a weekly service in reducing antibiotic (ATB) consumption without worsening of clinical outcomes. METHODS:Two-year observational analysis of the ID-cons provided in a hospital setting in Milan, Italy. ID-c...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-020-05550-1
更新日期：2020-11-07 00:00:00
abstract：BACKGROUND:HIV-uninfected infants born to HIV-infected mothers (HIV-exposed uninfected, HEU) have been described to have immune alterations as compared to unexposed infants. This study sought to characterize T-cell populations after birth in HEU infants and unexposed infants living in a semirural area in southern Mozam...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-015-0766-6
更新日期：2015-02-03 00:00:00
abstract：BACKGROUND:In Creutzfeldt-Jakob disease (CJD) and other related transmissible spongiform encephalopathies it is critical to understand the various pathways by which the infectious agent spreads to different organs. METHODS:We injected a CJD agent into mice, either intracerebrally (ic) or intraperitoneally (ip) and mon...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-1-20
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:Due to limited therapeutic options, the spread of extended-spectrum beta-lactamases (ESBLs) have become a major public health concern. We conducted a prospective, randomized, open-label comparison of the therapeutic efficacy of piperacillin-tazobactam (PTZ), cefepime, and ertapenem in febrile nosocomial urin...
journal_title：BMC infectious diseases
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12879-017-2502-x
更新日期：2017-06-07 00:00:00
abstract：BACKGROUND:Microascus cirrosus, the teleomorph of Scopulariopsis spp., is a saprobic species with a worldwide distribution and rarely causes human infection. In the present paper, we present the first case of primary cutaneous M. cirrosus infection in a Chinese female. CASE PRESENTATION:A 17-year-old female presented ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-018-3535-5
更新日期：2018-12-03 00:00:00
abstract：BACKGROUND:The pandemic influenza A (H1N1) virus emerged during 2009 and has spread worldwide. This virus can cause injuries to the lungs, liver, and heart. However, data regarding whether this influenza virus can affect pancreatic islets are limited. We investigated the effects of influenza A (H1N1) pneumonia on fasti...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-11-104
更新日期：2011-04-21 00:00:00
abstract：BACKGROUND:Procalcitonin (PCT) has become a commonly used serum inflammatory marker. Our aim was to describe the kinetics and usefulness of serial post-operative PCT measurements to detect bacterial infection in a cohort of children immediately after pediatric liver transplantation (pLT). METHODS:We performed a retros...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-017-2234-y
更新日期：2017-02-15 00:00:00
abstract：BACKGROUND:Visceral disseminated varicella zoster virus (VDVZV) infection is a rare disease with a high mortality rate (55%) in immunocompromised patients, but it is not yet widely recognized in the field of nephrology. We report a case of VDVZV contracted during immunosuppressive therapy for membranous nephropathy. C...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-019-4193-y
更新日期：2019-07-15 00:00:00
abstract：BACKGROUND:ProvLab Alberta provides all laboratory testing for Bordetella pertussis including sporadic cases and outbreak investigations through collaborations with provincial public health partners. We describe B. pertussis activity in Alberta from July 2004 to December 2012. METHODS:Laboratory testing for pertussis ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/1471-2334-14-48
更新日期：2014-01-30 00:00:00
abstract：BACKGROUND:A healthy 25-year-old woman developed COVID-19 disease with clinical characteristics resembling Multisystem Inflammatory Syndrome in Children (MIS-C), a rare form of COVID-19 described primarily in children under 21 years of age. CASE PRESENTATION:The patient presented with 1 week of weakness, dyspnea, and ...
journal_title：BMC infectious diseases
pub_type： 杂志文章
doi：10.1186/s12879-020-05439-z
更新日期：2020-09-29 00:00:00
