Abstract:
INTRODUCTION:Diabetic foot ulcer represents a major health problem globally. Preliminary studies have indicated that systemic treatment of diabetic foot ulcer patients with hyperbaric oxygen therapy have beneficial effects on wound healing, risk of amputation, glycaemic control, atherosclerosis, inflammatory markers and other clinical and laboratory parameters. This protocol for a systematic review aims at identifying the beneficial and harmful effects of adding hyperbaric oxygen therapy to standard wound care for diabetic foot ulcers. METHODS AND ANALYSIS:This protocol was performed following the recommendations of the Cochrane Collaboration and the eight-step assessment procedure suggested by Jakobsen and colleagues. We plan to include all relevant randomised clinical trials assessing the effects of hyperbaric oxygen therapy in the treatment of diabetic foot ulcer versus any control group with any intervention defined as standard wound care or similar, together with sham interventions. Our primary outcome will be: all-cause mortality, serious adverse events and quality of life. Our secondary outcomes will be: healing of index wound, major amputation and wound infection. Any eligible trial will be assessed and classified as either high risk of bias or low risk of bias, and our conclusions will be based on trials with low risk of bias. The analyses of the extracted data will be performed using Review Manager 5 and Trial Sequential Analysis. For both our primary and secondary outcomes, we will create a 'Summary of Findings' table and use GRADE (Grading of Recommendations Assessment, Development and Evaluation) assessment to assess the quality of the evidence. ETHICS AND DISSEMINATION:We use publicly accessible documents as evidence, there is no participant involvement at an individual level and an institutional ethics approval is not required. The results of the review will be sought published in a peer-reviewed journals, also in the event of insignificant results or null results, and thereby it will be disseminated to clinicians and public available. PROSPERO REGISTRATION NUMBER:CRD42019139256.
journal_name
BMJ Openjournal_title
BMJ openauthors
Vinkel J,Holm NFR,Jakobsen JC,Hyldegaard Odoi
10.1136/bmjopen-2019-031708subject
Has Abstractpub_date
2020-06-29 00:00:00pages
e031708issue
6issn
2044-6055pii
bmjopen-2019-031708journal_volume
10pub_type
杂志文章相关文献
BMJ Open文献大全abstract:OBJECTIVE:Paediatric heart transplantation (PHTX) comprises 12% of all cardiac transplants and many of the children now survive into adulthood. Only a few studies have investigated the long-term psychosocial well-being of young adult patients after PHTX; no studies have investigated developmental tasks of emerging adul...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-022461
更新日期:2018-11-25 00:00:00
abstract:OBJECTIVE:In ST elevation myocardial infarction women received less evidence-based medicine and had worse outcome during the fibrinolytic era. With the shift to primary percutaneous coronary intervention (pPCI) as preferred reperfusion strategy, the authors aimed to investigate whether these gender differences has dimi...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000726
更新日期:2012-03-27 00:00:00
abstract:OBJECTIVES:The present study aimed to assess the level of knowledge on peripherally inserted central catheter (PICC) maintenance among nurses in China and to analyse the related factors influencing this variable. DESIGN:A cross-sectional survey. SETTING:Ninety-one hospitals at three different levels in Hunan Province...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033804
更新日期:2020-05-21 00:00:00
abstract:OBJECTIVE:To test the hypothesis that cancer mortality rates among the Moluccan-Dutch, the oldest non-Western migrant group to arrive in the Netherlands after the Second World War, are similar to those in the general Dutch population. DESIGN:Population-based retrospective study. SETTING:Data from the national cause o...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-029288
更新日期:2019-08-15 00:00:00
abstract:OBJECTIVES:To explore the prevalence, discomfort, and self-relief behaviours of painful diabetic neuropathy (PDN) among rural community residents with type 2 diabetes. DESIGN:A community-based, cross-sectional study. SETTING:This study was part of a longitudinal cohort study of a nurse-led health promotion programme ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011897
更新日期:2016-10-03 00:00:00
abstract:OBJECTIVES:To develop a better understanding of general practitioners' (GPs) views and experiences of the management of patients with headaches and use of direct-access MRI scans, and observe outcomes of an educational session offered by a GP with a special interest (GPwSI) to GPs. DESIGN:A qualitative study using sem...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-018169
更新日期:2017-11-09 00:00:00
abstract:OBJECTIVE:To investigate the gap between real-world data and clinical research initiated by doctors in China, explore the potential reasons for this gap and collect different stakeholders' suggestions. DESIGN:This qualitative study involved three types of hospital personnel based on three interview outlines. The data ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-038375
更新日期:2020-12-29 00:00:00
abstract:INTRODUCTION:Ageing--along with its associated physiological and pathological changes--places individuals at a higher risk of multimorbidity and treatment-related complications. Today, polypharmacy, a common and important problem related to drug use, occurs subsequent to this multimorbidity in the elderly in all popula...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-010989
更新日期:2016-03-24 00:00:00
abstract:INTRODUCTION:Type 2 diabetes mellitus is a major source of morbidity and mortality in South Africa, spurred by increased urbanisation and unhealthy lifestyle factors. Local epidemiological data are required to inform health planning and policy. The purpose of this systematic review is to identify, collate and synthesis...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-021029
更新日期:2018-07-11 00:00:00
abstract:OBJECTIVES:Taiwan succeeded in raising the proportion of peritoneal dialysis (PD) usage after the National Health Insurance (NHI) payment scheme introduced financial incentives in 2005. This study aims to compare the economic costs between automated PD (APD) and continuous ambulatory PD (CAPD) modalities from a societa...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-015067
更新日期:2017-03-21 00:00:00
abstract:INTRODUCTION:Amyotrophic lateral sclerosis (ALS) is a representative rare disease characterised by progressive, fatal motor neuron degeneration. Due to the unknown aetiology and variability of the phenotypes, there are no accurate reports concerning the epidemiology or clinical characteristics of the disease. The low p...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-042603
更新日期:2020-12-04 00:00:00
abstract:OBJECTIVE:Cholangiocarcinoma (CCA) is the most common malignancy in a Northeast Thai population. Smoking and alcohol drinking are associated with the production of free radical intermediates, which can cause several types of DNA lesions. Reduced repair of these DNA lesions would constitute an important risk factor for ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005447
更新日期:2014-10-21 00:00:00
abstract:OBJECTIVE:Persons with type 2 diabetes are often stigmatised for having what is considered a lifestyle-related disease. Accordingly, some blame themselves for their condition, resulting in feelings of low self-worth that ultimately impact their self-management behaviours. However, there are no studies examining why som...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-034758
更新日期:2020-08-05 00:00:00
abstract:BACKGROUND:Osteoporosis is an age-related disease with progressive loss of bone, leading to fragile bone. It is one of the major health issues in older adults and causes medical, social and economic impacts globally. Patients with osteoporosis have high risk of osteoporotic fractures. Low-magnitude high-frequency vibra...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-038578
更新日期:2020-12-15 00:00:00
abstract:OBJECTIVE:The study aimed to determine if and how environmental factors correlated with asthma admission rates in geographically different parts of Guangxi province in China. SETTING:Guangxi, China. PARTICIPANTS:This study was done among 7804 asthma patients. PRIMARY AND SECONDARY OUTCOME MEASURES:Spearman correlati...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-038117
更新日期:2020-10-07 00:00:00
abstract:OBJECTIVE:Financial incentives may encourage private for-profit providers to perform more caesarean section (CS) than non-profit hospitals. We therefore sought to determine the association of for-profit status of hospital and odds of CS. DESIGN:Systematic review and meta-analysis. DATA SOURCES:MEDLINE, EMBASE and the...
journal_title:BMJ open
pub_type: 杂志文章,meta分析,评审
doi:10.1136/bmjopen-2016-013670
更新日期:2017-02-17 00:00:00
abstract:OBJECTIVES:Socioeconomically deprived individuals with renal disease are less likely to receive a live-donor kidney transplant than less-deprived individuals. This qualitative study aimed to identify reasons for the observed socioeconomic disparity in live-donor kidney transplantation. DESIGN:A qualitative study using...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-010605
更新日期:2016-03-02 00:00:00
abstract:OBJECTIVES:Compared with controls, multiple sclerosis (MS) patients die, on average, 7-14 years prematurely. Previously, we reported that, 21 years after their participation in the pivotal randomised, controlled trial (RCT) of interferon β-1b, mortality was reduced by 46-47% in the two groups who received active therap...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001972
更新日期:2012-11-30 00:00:00
abstract:INTRODUCTION:Parkinson's disease (PD) is the second most common neurodegenerative disorder in developed countries. There is an increasing interest in the use of mindfulness-related interventions in the management of patients with a chronic disease. In addition, interventions that promote personal control, stress-manage...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003326
更新日期:2013-10-10 00:00:00
abstract:OBJECTIVES:To investigate the effect of adding point-of-care (POC) susceptibility testing to POC culture on appropriate use of antibiotics as well as clinical and microbiological cure for patients with suspected uncomplicated urinary tract infection (UTI) in general practice. DESIGN:Open, individually randomised contr...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2017-018028
更新日期:2017-10-16 00:00:00
abstract:BACKGROUND:To date, delirium prevalence and incidence in acute hospitals has been estimated from pooled findings of studies performed in distinct patient populations. OBJECTIVE:To determine delirium prevalence across an acute care facility. DESIGN:A point prevalence study. SETTING:A large tertiary care, teaching hos...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001772
更新日期:2013-01-07 00:00:00
abstract:INTRODUCTION:Metabolic disorder and high blood pressure are common complications globally, and specifically among people living with HIV (PLHIV). Diabetes, metabolic syndrome and hypertension are major risk factors for cardiovascular diseases and their related complications. However, the burden of metabolic syndrome, d...
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2017-016602
更新日期:2017-07-09 00:00:00
abstract:OBJECTIVES:To investigate if centre-specific levels of perinatal interventional activity were associated with neonatal and neurodevelopmental outcome at 2 years of age in two separately analysed cohorts of infants: cohort A born at 22-25 and cohort B born at 26-27 gestational weeks, respectively. DESIGN:Geographically...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-024560
更新日期:2019-03-15 00:00:00
abstract:BACKGROUND:According to new Norwegian laws, mental healthcare for adults are obligated to assess all patients who are parents and to act on their children's needs. This article describes the study protocol of implementing the interventions Family Assessment and Child Talks for children of patients in the adult psychiat...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000709
更新日期:2012-05-03 00:00:00
abstract:OBJECTIVES:To identify which information items potential participants and research nurses rank as the most important, and the reasons for this, when considering participation in a randomised controlled trial. DESIGN:Q-methodology approach alongside a think-aloud process. Using a vignette outlining a hypothetical trial...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-023303
更新日期:2018-09-05 00:00:00
abstract:OBJECTIVES:To determine the contribution of progress in averting premature deaths to the increase in life expectancy and the decline in lifespan variation. DESIGN:International comparison of national life table data from the Human Mortality Database. SETTING:40 developed countries and regions, 1840-2009. POPULATION:...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000128
更新日期:2011-07-29 00:00:00
abstract:INTRODUCTION:Clinical guidelines recommend that patients with type 1 diabetes (T1D) learn carbohydrate counting or similar methods to improve glycaemic control. Although systematic educating in carbohydrate counting is still not offered as standard-of-care for all patients on multiple daily injections (MDI) insulin the...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2019-029859
更新日期:2019-09-03 00:00:00
abstract:OBJECTIVES:This study aimed to explore barriers to accessing care, if any, among people living with HIV/AIDS (PLHA) in two districts of Bihar. We also aimed to assess attitudes towards PLHA among healthcare providers and community members. DESIGN:This qualitative study used an exploratory study design through thematic...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033790
更新日期:2019-11-25 00:00:00
abstract:OBJECTIVE:The Chief Nurse National Health Service Wales initiated a national survey of acute and community hospital patients in Wales to identify the prevalence of pressure ulcers and incontinence-associated dermatitis. METHODS:Teams of two nurses working independently assessed the skin of each inpatient who consented...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2016-015616
更新日期:2017-08-21 00:00:00
abstract:INTRODUCTION:A cancer diagnose, for example, colorectal cancer, not only affects the cancer-person stricken, but also the surrounding family. Thus, this scoping review intends to identify appropriate models of support that will guide the development of a model of support to family members during the trajectory of color...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-037633
更新日期:2020-09-03 00:00:00