Abstract：
:Autism Spectrum Disorder (ASD) is a brain disorder that is typically characterized by deficits in social communication and interaction, as well as restrictive and repetitive behaviors and interests. During the last years, there has been an increase in the use of magnetic resonance imaging (MRI) to help in the detection of common patterns in autism subjects versus typical controls for classification purposes. In this work, we propose a method for the classification of ASD patients versus control subjects using both functional and structural MRI information. Functional connectivity patterns among brain regions, together with volumetric correspondences of gray matter volumes among cortical parcels are used as features for functional and structural processing pipelines, respectively. The classification network is a combination of stacked autoencoders trained in an unsupervised manner and multilayer perceptrons trained in a supervised manner. Quantitative analysis is performed on 817 cases from the multisite international Autism Brain Imaging Data Exchange I (ABIDE I) dataset, consisting of 368 ASD patients and 449 control subjects and obtaining a classification accuracy of 85.06 ± 3.52% when using an ensemble of classifiers. Merging information from functional and structural sources significantly outperforms the implemented individual pipelines.
journal_name
Neuroimage Clinjournal_title
NeuroImage. Clinicalauthors
Rakić M,Cabezas M,Kushibar K,Oliver A,Lladó Xdoi
10.1016/j.nicl.2020.102181subject
Has Abstractpub_date
2020-01-01 00:00:00pages
102181issn
2213-1582pii
S2213-1582(20)30019-Xjournal_volume
25pub_type
杂志文章abstract：:Autism Spectrum Disorder (ASD) is characterized by impairments in language and social-emotional cognition. Yet, findings of emotion recognition from affective prosody in individuals with ASD are inconsistent. This study investigated emotion recognition and neural processing of affective prosody in high-functioning adu...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2014.08.025
更新日期：2014-10-05 00:00:00
abstract：:We studied the dynamic functional connectivity profile of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) compared to controls, how it differs between the two dementia subtypes, and a possible relation between dynamic connectivity alterations and temporally transient clinical symptoms in DLB. Resting stat...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.101812
更新日期：2019-01-01 00:00:00
abstract：:Pediatric traumatic brain injury often results in significant long-term deficits in mastery of reading ability. This study aimed to identify white matter pathways that, when damaged, predicted reading deficits in children. Based on the dual-route model of word reading, we predicted that integrity of the inferior front...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2015.10.009
更新日期：2015-10-19 00:00:00
abstract：OBJECTIVES:Insomnia disorder has been reclassified into short-term/acute and chronic subtypes based on recent etiological advances. However, understanding the similarities and differences in the neural mechanisms underlying the two subtypes and accurately predicting the sleep quality remain challenging. METHODS:Using ...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102439
更新日期：2020-01-01 00:00:00
abstract：:Focal cortical dysplasia is a congenital abnormality of cortical development and the leading cause of surgically remediable drug-resistant epilepsy in children. Post-surgical outcome is improved by presurgical lesion detection on structural MRI. Automated computational techniques have improved detection of focal corti...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2016.12.030
更新日期：2016-12-30 00:00:00
abstract：:Anticipation of potentially threatening social situations is a key process in social anxiety disorder (SAD). In other anxiety disorders, recent research of neural correlates of anticipation of temporally unpredictable threat suggests a temporally dissociable involvement of amygdala and bed nucleus of the stria termina...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.101735
更新日期：2019-01-01 00:00:00
abstract：:Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent and heritable psychiatric disorders. While previous studies have focussed on mapping focal or connectivity differences at the group level, the present study employed pattern recognition to quantify group separation between unaffected siblings...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2016.06.020
更新日期：2016-07-02 00:00:00
abstract：:The ventral intermediate nucleus (VIM) of the thalamus is an established surgical target for stereotactic ablation and deep brain stimulation (DBS) in the treatment of tremor in Parkinson's disease (PD) and essential tremor (ET). It is centrally placed on a cerebello-thalamo-cortical network connecting the primary mot...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.01.008
更新日期：2018-01-28 00:00:00
abstract：:Using quantitative T2* at 7 Tesla (T) magnetic resonance imaging, we investigated whether impairment in selective cognitive functions in multiple sclerosis (MS) can be explained by pathology in specific areas and/or layers of the cortex. Thirty-one MS patients underwent neuropsychological evaluation, acquisition of 7 ...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2016.11.001
更新日期：2016-11-03 00:00:00
abstract：BACKGROUND:Vestibular patients occasionally report aggravation or triggering of their symptoms by visual stimuli, which is called visually induced dizziness (VID). These patients therefore experience dizziness, discomfort, disorientation and postural unsteadiness. The underlying pathophysiology of VID is still poorly u...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2017.02.020
更新日期：2017-02-28 00:00:00
abstract：BACKGROUND:Macro- and micro-structural neuroimaging measures provide valuable information on the pathophysiology of Huntington's disease (HD) and are proposed as biomarkers. Despite theoretical advantages of microstructural measures in terms of sensitivity to pathology, there is little evidence directly comparing the t...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2012.12.001
更新日期：2012-12-09 00:00:00
abstract：OBJECTIVES:Investigating the potential of myelin repair strategies in multiple sclerosis (MS) requires an understanding of myelin dynamics during lesion evolution. The objective of this study is to longitudinally measure myelin water fraction (MWF), an MRI biomarker of myelin, in new MS lesions and to identify factors ...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2015.09.003
更新日期：2015-09-12 00:00:00
abstract：INTRODUCTION:Differentiation between self-produced tactile stimuli and touch by others is necessary for social interactions and for a coherent concept of "self". In attention-deficit-hyperactivity-disorder (ADHD), tactile hypersensitivity and social cognition problems are part of the symptomatology, but pathophysiologi...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102317
更新日期：2020-01-01 00:00:00
abstract：:Alterations in cortical development and impaired neurodevelopmental outcomes have been described following very preterm (VPT) birth in childhood and adolescence, but only a few studies to date have investigated grey matter (GM) and white matter (WM) maturation in VPT samples in early adult life. Using voxel-based morp...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2014.08.005
更新日期：2014-08-13 00:00:00
abstract：:Electrical source imaging (ESI) aims at reconstructing the electrical brain activity from scalp EEG. When applied to interictal epileptiform discharges (IEDs), this technique is of great use for identifying the irritative zone in focal epilepsies. Inaccuracies in the modeling of electro-magnetic field propagation in t...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2014.06.005
更新日期：2014-06-16 00:00:00
abstract：:Mood disorders and behavioral are broad psychiatric diagnostic categories that have different symptoms and neurobiological mechanisms, but share some neurocognitive similarities, one of which is an elevated risk for reading deficit. Our aim was to determine the influence of mood versus behavioral dysregulation on read...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2017.06.020
更新日期：2017-06-23 00:00:00
abstract：:The thalamus is crucial for sleep regulation and the pathophysiology of idiopathic generalised epilepsy (IGE), and may serve as the underlying basis for the links between the two. We investigated this using EEG-fMRI and a specific emphasis on the role and functional connectivity (FC) of the thalamus. We defined three ...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2017.07.008
更新日期：2017-07-12 00:00:00
abstract：Background:An urgent need exists for faster-acting pharmacological treatments in major depressive disorder (MDD). The glutamatergic modulator ketamine has been shown to have rapid antidepressant effects, but much remains unknown about its mechanism of action. Functional MRI (fMRI) can be used to investigate how ketamin...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.nicl.2018.07.006
更新日期：2018-07-05 00:00:00
abstract：:Cerebral autoregulation represents the physiological mechanisms that keep brain perfusion relatively constant in the face of changes in blood pressure and thus plays an essential role in normal brain function. This study assessed cerebral autoregulation in nine newborns with moderate-to-severe hypoxic-ischemic encepha...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2016.01.020
更新日期：2016-01-25 00:00:00
abstract：:A commonly carried C677T polymorphism in a folate-related gene, MTHFR, is associated with higher plasma homocysteine, a well-known mediator of neuronal damage and brain atrophy. As homocysteine promotes brain atrophy, we set out to discover whether people carrying the C677T MTHFR polymorphism which increases homocyste...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2012.09.012
更新日期：2012-10-04 00:00:00
abstract：:Methamphetamine use disorder is associated with a high likelihood of relapse. Identifying robust predictors of relapse that have explanatory power is critical to develop secondary prevention based on a mechanistic understanding of relapse. Computational approaches have the potential to identify such predictive markers...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.101794
更新日期：2019-01-01 00:00:00
abstract：:Establishing a reliable correspondence between lesioned brains and a template is challenging using current normalization techniques. The optimum procedure has not been conclusively established, and a critical dichotomy is whether to use input data sets which contain skull signal, or whether skull signal should be remo...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2013.09.007
更新日期：2013-09-30 00:00:00
abstract：:We examined the influence of dysfunctional, non-lesional white matter on cognitive performance in multiple sclerosis (MS). Forty-six MS subjects were assessed using MRI-based myelin water imaging (MWI), and average myelin water fraction (MWF) values across 20 white matter regions of interest (ROIs) were determined. A ...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.101926
更新日期：2019-01-01 00:00:00
abstract：:Noninvasive markers of brain function could yield biomarkers in many neurological disorders. Disease models constrained by coordinate-based meta-analysis are likely to increase this yield. Here, we evaluate a thalamic model of temporal lobe epilepsy that we proposed in a coordinate-based meta-analysis and extended in ...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2014.08.002
更新日期：2014-08-07 00:00:00
abstract：:There is increasing interest in developing a reliable, affordable and accessible disease biomarker of Parkinson's disease (PD) to facilitate disease modifying PD-trials. Imaging biomarkers using magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) can describe parameters such as fractional anisotropy (F...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2013.10.006
更新日期：2013-10-14 00:00:00
abstract：:Understanding abnormal resting-state functional connectivity of distributed brain networks may aid in probing and targeting mechanisms involved in major depressive disorder (MDD). To date, few studies have used resting state functional magnetic resonance imaging (rs-fMRI) to attempt to discriminate individuals with MD...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2016.02.018
更新日期：2016-03-02 00:00:00
abstract：:Children who have been diagnosed with autism spectrum disorder (ASD) often show a marked deficit in measures of social cognition. In autistic adults, measures of social cognition have been shown to relate to differences in brain synchronization (as measured by fMRI) when individuals are processing naturalistic stimuli...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102477
更新日期：2020-01-01 00:00:00
abstract：:Developmental dyslexia is a reading disorder that is associated with deficits in phonological processing, where the exact neural basis for those processing deficits remains unclear. In particular, disagreement exists whether degraded phonological representations or an impaired access to the phonological representation...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2017.10.014
更新日期：2017-10-13 00:00:00
abstract：:Increased reaction time intra-subject variability (RT-ISV) in fast decision tasks has been confirmed in patients with schizophrenia and has been hypothesized to result from a deficit in the control of attention. Here, an attentional task and functional brain imaging were used to probe the neural correlates of increase...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.101853
更新日期：2019-01-01 00:00:00
abstract：:Neurofeedback (NF), a training tool aimed at enhancing neural self-regulation, has been suggested as a complementary treatment option for neuropsychiatric disorders. Despite its potential as a neurobiological intervention directly targeting neural alterations underlying clinical symptoms, the efficacy of NF for the tr...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102301
更新日期：2020-01-01 00:00:00
