Abstract：
:We studied the dynamic functional connectivity profile of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) compared to controls, how it differs between the two dementia subtypes, and a possible relation between dynamic connectivity alterations and temporally transient clinical symptoms in DLB. Resting state fMRI data from 31 DLB, 29 AD, and 31 healthy control participants were analyzed using dual regression to determine between-network functional connectivity. Subsequently, we used a sliding window approach followed by k-means clustering and dynamic network analyses to study dynamic functional connectivity. Dynamic connectivity measures that showed significant group differences were tested for correlations with clinical symptom severity. Our results show that AD and DLB patients spent more time than controls in sparse connectivity configurations with absence of strong positive and negative connections and a relative isolation of motor networks from other networks. Additionally, DLB patients spent less time in a more strongly connected state and the variability of global brain network efficiency was reduced in DLB compared to controls. There were no significant correlations between dynamic connectivity measures and clinical symptom severity. An inability to switch out of states of low inter-network connectivity into more highly and specifically connected network configurations might be related to the presence of dementia in general as it was observed in both AD and DLB. In contrast, the loss of global efficiency variability in DLB might indicate the presence of an abnormally rigid brain network and the lack of economical dynamics, factors which could contribute to cognitive slowing and an inability to respond appropriately to situational demands.
journal_name
Neuroimage Clinjournal_title
NeuroImage. Clinicalauthors
Schumacher J,Peraza LR,Firbank M,Thomas AJ,Kaiser M,Gallagher P,O'Brien JT,Blamire AM,Taylor JPdoi
10.1016/j.nicl.2019.101812subject
Has Abstractpub_date
2019-01-01 00:00:00pages
101812issn
2213-1582pii
S2213-1582(19)30162-7journal_volume
22pub_type
杂志文章abstract：:One of the most common copy number variants, the 22q11.2 microdeletion, confers an increased risk for schizophrenia. Since schizophrenia has been associated with an aberrant neural response to repeated stimuli through both reduced adaptation and prediction, we here hypothesized that this may also be the case in nonpsy...
journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2014.08.018
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2016.09.011
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2014.05.002
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2014.08.021
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.102004
更新日期：2019-01-01 00:00:00
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2015.11.017
更新日期：2015-11-26 00:00:00
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2018.05.035
更新日期：2018-05-29 00:00:00
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.01.027
更新日期：2018-02-28 00:00:00
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2017.04.004
更新日期：2017-04-27 00:00:00
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2016.06.006
更新日期：2016-06-08 00:00:00
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2016.09.012
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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更新日期：2017-12-09 00:00:00
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journal_title：NeuroImage. Clinical
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更新日期：2019-01-01 00:00:00
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journal_title：NeuroImage. Clinical
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更新日期：2012-10-04 00:00:00
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更新日期：2017-04-29 00:00:00
abstract：BACKGROUND CONTEXT:Spinal manipulation (SM) is a common treatment for neck and back pain, theorized to mechanically affect the spine leading to therapeutic mechanical changes. The link between specific mechanical effects and clinical improvement is not well supported. SM's therapeutic action may instead be partially me...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.nicl.2019.102042
更新日期：2019-01-01 00:00:00
abstract：:In the military, explosive blasts are a significant cause of mild traumatic brain injuries (mTBIs). The symptoms associated with blast mTBIs causes significant economic burdens and a diminished quality of life for many service members. At present, the distinction of the injury mechanism (blast versus non-blast) may no...
journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2019.101793
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2018.10.017
更新日期：2018-01-01 00:00:00
abstract：:Standard MRI methods are often inadequate for identifying mild traumatic brain injury (TBI). Advances in diffusion tensor imaging now provide potential biomarkers of TBI among white matter fascicles (tracts). However, it is still unclear which tracts are most pertinent to TBI diagnosis. This study ranked fiber tracts ...
journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2017.06.031
更新日期：2017-06-24 00:00:00
