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Symptom-specific amygdala hyperactivity modulates motor control network in conversion disorder.

Abstract：

:Initial historical accounts as well as recent data suggest that emotion processing is dysfunctional in conversion disorder patients and that this alteration may be the pathomechanistic neurocognitive basis for symptoms in conversion disorder. However, to date evidence of direct interaction of altered negative emotion processing with motor control networks in conversion disorder is still lacking. To specifically study the neural correlates of emotion processing interacting with motor networks we used a task combining emotional and sensorimotor stimuli both separately as well as simultaneously during functional magnetic resonance imaging in a well characterized group of 13 conversion disorder patients with functional hemiparesis and 19 demographically matched healthy controls. We performed voxelwise statistical parametrical mapping for a priori regions of interest within emotion processing and motor control networks. Psychophysiological interaction (PPI) was used to test altered functional connectivity of emotion and motor control networks. Only during simultaneous emotional stimulation and passive movement of the affected hand patients displayed left amygdala hyperactivity. PPI revealed increased functional connectivity in patients between the left amygdala and the (pre-)supplemental motor area and the subthalamic nucleus, key regions within the motor control network. These findings suggest a novel mechanistic direct link between dysregulated emotion processing and motor control circuitry in conversion disorder.

journal_name

Neuroimage Clin

journal_title

NeuroImage. Clinical

authors

Hassa T,Sebastian A,Liepert J,Weiller C,Schmidt R,Tüscher O

doi

10.1016/j.nicl.2017.04.004

subject

Has Abstract

pub_date

2017-04-27 00:00:00

pages

143-150

issn

2213-1582

pii

S2213-1582(17)30080-3

journal_volume

15

pub_type

杂志文章

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